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Chronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8^(+)T cell responses

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Cellular & Molecular Immunology 2021年第8期18卷 1956-1968页

作者： Seon-Hee Kim Rohit Singh Chungyong Han Eunjung Cho Yu I.Kim Don G.Lee Young H.Kim Sang Soo Kim Dong Hoon Shin Hye Jin You Hyeon-Woo Lee Byoung S.Kwon Beom K.Choi Division of Tumor Immunology National Cancer CenterGoyang10408Republic of Korea Graduate School of Cancer Science and Policy National Cancer CenterGoyang10408Republic of Korea Biomedicine Production Branch Program for Immunotherapy ResearchGoyang10408Republic of Korea Eutilex Institute for Biomedical Research EutilexCo.Ltd.Seoul08594Republic of Korea Division of Convergence Technology National Cancer CenterGoyang10408Republic of Korea Division of Translational Science National Cancer CenterGoyang10408Republic of Korea Institute of Oral Biology School of DentistryGraduate SchoolKyung Hee UniversitySeoul02447Republic of Korea department of medicine Tulane University Health Sciences CenterNew OrleansLA70112USA

The antitumor capabilities of agonistic anti-4-1BB mAbs have made them an attractive target for tumor ***,the adverse side effects associated with agonist antibodies have hindered their clinical ***,we aimed to study the immune-related adverse events of repeated doses and long-term use of agonistic anti-4-1BB *** show that chronic activation of 4-1BB signals induced the accumulation of IFN-γ-producing PD-1^(+)CD8^(+)T cells in the secondary lymphoid organs of tumor-bearing mice by increasing the number of dividing CD8^(+)T cells,which was beneficial for suppressing tumor growth in the early phase of anti-4-1BB ***,repeated exposure to anti-4-1BB mAbs led to granuloma development in tumor-draining lymph nodes(TDLNs)of mice due to recruitment and accumulation of macrophages via the CD8^(+)T cell-IFN-γ*** was accompanied by excessive lymph node swelling,which impaired the sequential activation of CD8^(+)T *** data provide insights into the immune-related adverse events of long-term agonist 4-1BB antibody dosing,which should be considered during the clinical development of immunomodulating therapy.

关键词： 4-1BB Costimulation Granuloma CD8 lymphocyte Macrophage

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Direct acetylation of a conserved threonine of RIN4 by the bacterial effector HopZ5 or AvrBsT activates RPM1-dependent immunity in Arabidopsis

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Molecular Plant 2021年第11期14卷 1951-1960页

作者： Arabidopsis Sera Choi Maxim Prokchorchik Hyeonjung Lee Ravi Gupta Yoonyoung Lee Eui-Hwan Chung Buhyeon Cho Min-Sung Kim Sun Tae Kim Kee Hoon Sohn department of Life Sciences Pohang University of Science and TechnologyPohang 37673Republic of Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and TechnologyPohang 37673Republic of Korea department of Plant Bioscience Life and Industry Convergence Research InstitutePusan National UniversityMiryang 50463Republic of Korea department of Botany School of Chemical and Life SciencesJamia HamdardHamdard NagarNew Delhi 110062India Division of Biotechnology Korea UniversitySeoul 02841Republic of Korea The Institute of Crop Science and Resource Conservation(INRES) University of BonnNussallee 953115 BonnGermany

Plant pathogenic bacteria deliver effectors into plant cells to suppress immunity and promote pathogen survival;however, these effectors can be recognised by plant disease resistance (R) proteins to activate innate immunity. The bacterial acetyltransferase effectors HopZ5 and AvrBsT trigger immunity in Arabidopsis thaliana genotypes lacking SUPPRESSOR OF AVRBST-ELICITED RESISTANCE 1 (SOBER1). Using an Arabidopsis accession, Tscha-1, that naturally lacks functional SOBER1 but is unable to recognise HopZ5, we demonstrate that RESISTANCE TO P. SYRINGAE PV MACULICOLA 1 (RPM1) and RPM1-INTERACTING PROTEIN 4 (RIN4) are indispensable for HopZ5- or AvrBsT-triggered immunity. Remarkably, T166 of RIN4, the phosphorylation of which is induced by AvrB and AvrRpm1, was directly acetylated by HopZ5 and AvrBsT. Furthermore, we demonstrate that the acetylation of RIN4 T166 is required and sufficient for HopZ5- or AvrBsT-triggered RPM1-dependent defence activation. Finally, we show that SOBER1 interferes with HopZ5- or AvrBsT-triggered immunity by deacetylating RIN4 T166. We have thus elucidated detailed molecular mechanisms underlying the activation and suppression of plant innate immunity triggered by two bacterial acetyltransferases, HopZ5 and AvrBsT from different bacterial pathogens.

关键词： Acetyltransferase effectors Effector-triggered immunity Immunity suppressors NLR Plant deacetylase Plant immunity

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Corrosion behaviors of thermally grown oxide films on Fe-based bulk metallic glasses

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International Journal of Minerals,Metallurgy and Materials 2012年第8期19卷 726-732页

作者： Hong-xiang Li Shan-lin Wang Yeonuk Jeong Seonghoon Yi State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China. School of Aeronautical Manufacturing Engineering Nanchang Hangkong University Nanchang 330063 China. department of Electronic Materials Science and Engineering Kyungpook National University Daegu 702-701 South Korea. department of Materials Science and Metallurgy Kyungpook National University Daegu 702-701 South Korea.

Oxide films formed on the surfaces of Fe-based bulk metallic glasses in the temperature range between 373 K and 573 K were characterized and their effects on the corrosion behaviors were investigated by microstructural and electrochemical analysis. The oxide film formed at 573 K is iron-rich oxide and it exhibits an n-type semiconductor at a higher potential than 0.35 V and a p-type semiconductor at a lower potential than 0.35 V. Capacitance measurements show that the donor density decreases with the increase in oxidation temperature, while the thickness of the space charge layer increases with the oxidation temperature rising. The result of immersion tests shows that the mass loss rate increases with the oxidation temperature rising. Therefore, the correlation between microstructure and corrosion resistance needs to be proposed because the corrosion resistance is deteriorated with the development of the oxide films.

关键词： bulk metallic glass oxide films corrosion capacitance

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Journal of Materials Science & Technology 2021年第26期85卷 95-105页

作者： Nana Kwabena Adomako Giseung Shin Nokeun Park Kyoungtae Park Jeoung Han Kim department of Materials Science and Engineering Hanbat National UniversityYuseong-guDaejeon34158Republic of Korea department of Materials Science and Engineering Pusan National UniversityGeumjeong-guBusan46241Republic of Korea School of Materials Science and Engineering Yeungnam University280 Daehak-roGyeongbuk38541Republic of Korea Rare Metal R&D Group Korea Institute of Industrial TechnologyIncheon21999Republic of Korea

High entropy alloys(HEAs)have superior mechanical properties that have enabled them to be used as structural materials in nuclear and aerospace *** a dissimilar joint design is required for these applications,we created a dissimilar joint between CoCrFeMnNi-HEA and duplex stainless steel(DSS)through laser beam welding;a technique capable of producing a sound joint between the two *** structure examination using SEM/EBSD/XRD analysis revealed that the weld metal(WM)exhibits an FCC phase regardless of the postweld heat treatment(PWHT)temperature(800 and 1000℃)without forming detrimental intermetallic compounds or *** heat-affected zone of the CoCrFeMnNi-HEA showed CrMn oxide inclusions while that of the DSS showed no ***,a lower hardness was recorded by the WM compared to the base metal after *** PWHT,the hardness of the WM,CoCrFeMnNi-HEA,and DSS decreased with an increase in the PWHT ***,the decrease in the hardness of the HEA was more significant than in the WM and *** cause for this reduction in hardness was attributed to recrystallization and grain *** addition,a strength of 584 MPa with low ductility was recorded after *** obtained strength was lower than that of the BMs,but comparable to that of the welded *** application of PWHT resulted in over a 20%increment in ductility,with only a marginal reduction in *** defo rmation mechanism in the as-weld joint was mainly dominated by dislocation while that for the PWHT joint was *** propose laser beam offset welding as a technique to improve the mechanical properties of the dissimilar joint,which will be the subject of future studies.

关键词： High entropy alloys Welding Duplex stainless steel Post-weld heat treatment

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Self‑Powered Airflow Sensor Based on Energy Harvesting of Ventilation Air in Buildings

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Advanced Fiber Materials 2023年第5期5卷 1788-1798页

作者： Moon Hyun Chung Seunghwan Yoo Woo‑Nam Jung Hakgeun Jeong Kyung‑Hwa Yoo department of Physics Yonsei University50 Yonsei‑RoSeodaemun‑GuSeoul 03722Republic of Korea Energy ICT Convergence Research department Energy Efficiency Research DivisionKorea Institute of Energy Research152 Gajeong‑RoYuseong‑GuDaejeon 34129Republic of Korea Advanced Combustion Power Lab Energy Efficiency Research DivisionKorea Institute of Energy Research152Gajeong‑RoYuseong‑GuDaejeon 34129Republic of Korea department of Mechanical Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak‑RoYuseongDaejeon 34141Republic of Korea

Heating,ventilation,and air conditioning(HVAC)systems account for one-third of the total energy consumption in office *** use of airflow measurements to control the operation of HVAC systems can reduce energy consumption;thus,a sensor capable of monitoring airflow in a duct system is *** nanogenerators(TENGs)can be utilized as self-powered sensors in airflow-driven TENGs(ATENGs)as self-powered *** employing ferroelectric materials and surface modifications,the surface charges of TENGs can be *** this study,fibrous-mat TENGs were prepared using ferroelectric materials consisting of poly(vinylidene fluoride-co-trifluoroethylene)(PVDF-TrFE)and polyamide 11(nylon-11).And these materials were subsequently ***(3,4-ethylenedioxythiophene):poly(styrenesulfonate)was added to PVDF-TrFE to enhance the ferroelectric crystalline phase.X-ray diffraction analysis revealed that this incorporation affects theβ*** addition,the surface of nylon-11 was modified using the electrospray technique for post-treatment,thereby improving the interfacial adhesion between the *** materials were then utilized in fibrous-mat ATENGs(FM-ATENGs)to demonstrate their practical *** FM-ATENGs can be effectively used in an Arduino airflowcheck sensor,showcasing their potential for application in HVAC systems,to enhance airflow control and energy efficiency.

关键词： HVAC Airflow-driven triboelectric nanogenerator Building energy harvesting Fibrous mat Airflow sensor

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Steady-state probability density function in wave turbulence under large volume limit

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Chinese Physics B 2011年第5期20卷 139-145页

作者： Yeontaek Choi Sang Gyu Jo Division of Fusion and Convergence of Mathematical Sciences National Institute for Mathematical SciencesDaejeon 305-340Republic of Korea department of Physics Kyungpook National UniversityDaegu 702-701Republic of Korea

We investigate the possibility for two-mode probability density function （PDF） to have a non-zero flux steady state solution. We take the large volume limit so that the space of modes becomes continuous. It is shown that in this limit all the steady-state twoor higher-mode PDFs are the product of one-mode PDFs. The flux of this steady-state solution turns out to be zero for any finite mode PDF.

关键词： wave turbulence probability flux multi-mode probability density function Larguerreequation

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韩国人参补充剂对高脂饲养大鼠肌肉中葡萄糖摄取的影响(英文)

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中国天然药物 2013年第5期11卷 494-499页

作者： Hyun Lyung Jung Ho Youl Kang department of Physical Education Kyungpook National University

It has been recognized that ginseng has anti-diabetic effects in skeletal muscle,but the mechanism has not been intensively *** aim of this study was to investigate the effects of korean red ginseng(Panax ginseng) supplementation on muscle glucose uptake in high-fat fed *** rats were randomly divided into two groups: a control group(CON,n=8) and a korean red ginseng group(KRG,n=8).The KRG group ingested RG extract(1 g·kg 1,6 days/week) mixed in water for two *** the two-week treatment,plasma lipid profiles,and glucose and insulin concentrations were *** triglyceride(TG) and glucose transporter 4(GLUT-4) contents were measured in the skeletal muscle and *** rate of glucose transport was determined under a submaximal insulin concentration during muscle *** FFA concentrations were significantly decreased in KRG(Pkorean red ginseng treatment(Pkorean red ginseng treatment,as evidenced by the rate of glucose transport in the epitorchealis muscle under submaximal insulin *** results suggest that while KRG supplementation could improve whole body insulin resistance and plasma lipid profiles,it is unlikely to have an effect on the insulin resistance of skeletal muscle,which is the major tissue responsible for plasma glucose handling.

关键词： korean red ginseng plasma lipids muscle glucose uptake insulin resistance

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Targeted knockout of duox causes defects in zebrafish growth, thyroid development, and social interaction

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Journal of Genetics and Genomics 2019年第2期46卷 101-104页

作者： Jong-Su Park Tae-Ik Choi Oc-Hee Kim Ted Inpyo Hong Woo-Keun Kim Won-Jae Lee Cheol-Hee Kim department of Biology Chungnam National University Biosystem Research Group Korea Institute of Toxicology School of Biological Sciences Seoul National University

Reactive oxygen species(ROS) are believed to be inevitable and toxic by-products produced during cellular respiration. However,several lines of evidence show that diverse extracellular signals can activate ROS product... 详细信息

关键词： KO In Targeted knockout of duox causes defects in zebrafish growth thyroid development and social interaction

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Gas-Liquid Interfacial Plasma engineering under dilute nitric acid to improve hydrophilicity and OER performance of nickel foam

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Progress in Natural Science:Materials International 2022年第5期32卷 608-616页

作者： Minju Kim Jihun Kim Lusha Qin Sobin Mathew Youri Han Oi Lun Li School of Materials Science and Engineering Pusan National University Engine Research Institute Hydrogen Energy Research department Engine & Machinery Business Unit Hyundai Heavy Industries Co. Ltd

The world has been moving rapidly to find new eco-friendly energy sources. Water electrolysis consists of two reactions of Oxygen Evolution Reaction(OER) and Hydrogen Evolution Reaction(HER), whereas the OER is considered the rate-limiting step. The most commercialized electrode for OER in the alkaline electrolyte is Ni foam, but its original surface is hydrophobic. It is possible to accelerate the adsorption and desorption process of reactants and products during OER by adding hydrophilic functional groups such as –OH on the surface of Ni foam. In this study, a novel Gas-Liquid Interfacial Plasma(GLIP) engineering at room temperature was successfully applied to modify the Ni foam surface dilute(1 M) HNO3solution. At a current density of 400 mA cm-2,GLIP-treated Ni foam electrodes at 1 M HNO3concentrations showed OER overpotentials of 458 mV. Among all,GLIP with 1 M HNO3treatment of 30 min showed 129 mV less overpotential than the nickel foam before treatment. In summary, GLIP can be justified as an environmentally friendly and efficient surface treatment to improve the wettability and OER performance of Ni-based electrodes in water electrolysis.

关键词： Gas−liquid interfacial plasma (GLIP) Oxygen evolution reaction Water electrolysis Plasma engineering Surface treatment Ni foam Hydrophilic

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Cerium vanadate/carbon nanotube hybrid composite nanostructures as a high-performance anode material for lithium-ion batteries

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Journal of Energy Chemistry 2021年第7期30卷 25-32页

作者： D.Narsimulu Ashok Kumar Kakarla Jae Su Yu department of Electronics and Information Convergence Engineering Institute for Wearable Convergence ElectronicsKyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 17104Republic of Korea

The pristine CeVO_(4) and CeVO_(4)/CNT hybrid composite nanostructured samples were facilely synthesized using a simple silicone oil-bath *** the X-ray diffraction results,the formation of tetragonal CeVO_(4) with an additional minor phase of V_(2)O_(5) was *** investigated as an anode material for lithium(Li)-ion batteries,the CeVO_(4)/CNT hybrid composite nanostructure(HCNS) electrode demonstrated improved Li storage performance over the pristine CeVO_(4).The Li insertion/de-insertion electrochemical reaction with the CeVO_(4) was analyzed on the basis of cyclic voltammetry *** cyclic voltammetry analysis revealed that the three-step reduction of V^(5+) to V^(3+), V^(3+) to V^(2+), and V^(2+) to V+ processes is involved and among them,only V^(5+) to V^(3+) is reversible during the Li-ion insertion into CeVO_(4).The CeVO_(4)/CNT HCNS electrode exhibited a discharge capacity as high as 443 mA h g^(-1)(capacity retention of 96.3%) over 200 cycles at 100 mA g^(-1), whereas the pristine CeVO_(4) is limited to 138 mA h g^(-1)(capacity retention of 48%).Even at a high current density of 500 mA g^(-1), the CeVO_(4)/CNT HCNS electrode delivered an excellent reversible capacity of 586.82 mA h g^(-1) after 1200 cycles.

关键词： Oil-bath synthesis CeVO_(4)/CNT hybrid composite nanostructure Anode Lithium-ion batteries

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