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全国第6届中西医结合传染病学术会议

作者： Shu Zhang Wenxiang Huang department of infecious diseases The First Affiliated Hospital of Chongqing Medical University

Objective We conduced an investigation and analysis of the clinical and etiological characteristics of community-acquired intra-abdominal infections(C-IAIs)and hospital-acquired or nosocomial intra-abdominal infections(N-IAIs)in a comprehensive hospital to understand the characteristics,pathogen composition,and drug resistance of community-and hospital-acquired abdominal infections and to provide reference for clinical

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Comprehensive Humoral and Cellular Immune Responses to SARS-CoV-2 Variants in Diverse Chinese Population

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Research 2022年第2期2022卷 61-69页

作者： Jiwei Li Jing Wu Qiuyue Long Yan'an Wu Xiaoyi Hu Yukun He Mingzheng Jiang Jia Li Lili Zhao Shuoqi Yang Xiaoyong Chen Minghui Wang Jianshi Zheng Fangfang Wu Ruiliang Wu Lihong Ren Liang Bu Houzhao Wang Ke Li Lijuan Fu Guojun Zhang Yali Zheng Zhancheng Gao department of Respiratory Crilical Care and Sleep MedicineXiang'an Hospial of Xiamen UniersityXiamenFujianChina School of Medicine Xiamen University.XiamenFujianChina department of Cimical Laboratory Xiang'an Hospial of Xiamen UniversityXiamenFuijianChina department of Respiratory and Critical Care Medicine Peking University People's HospitalBejingChina department of Thoracic Surgery Xiang an Hospital of Xiamen University.Xiamen FujianChina department of Pediatrics Xiang'an Haspital of Xiamen UniversityXiamenFujianChina department of Crical Care Medicine Xiang'an Hospial of Xiamen UriversityXiamenFujanChina Deparment of infecious diseases Xiang'an Hospital of Xiamen UniversiyXiamenFujianChina Cancer Research Center and The department of Breast Thyroid Surgery Xiang'an Hospital of Xiamen UntiversityXiamenFujianChina

The SARS-CoV-2 variants have been emerging and have made great challenges to current vaccine and pandemic control *** is urgent to understand the current immune status of various Chinese populations given that the preexisting immunity has been established by national vaccination or ex posure to past *** sera from 85 individuals(including 21 convalescents of natural infection,15 cases which suffered a breakthrough infection after being fully vaccinated,and 49 healthy vaccinees),we showed signifcantly enhanced neutralizing activities against SRAS-CoV-2 variants in convalescent sera,especially those who had been fully *** neut ralizing antibodies against Omicron were detectable in 75%of convalescents and 4.9%of healthy vaccinees(p=0.006),with a GMT of 289.5,180.9-463.3,and 42.6,31.3-59,***,the neutralizing activities were weaker in young convalescents(aged<18y),with a detectable rate of 50%and a GMT of 46.4 against *** also examined and found no *** neutralizing activities in vaccinated SARS-CoV-I survivors.A booster dose could further increase the breadth and magnitude of neutralization against WT and variants of concern(VOCs)to different *** addition,we showed that COVID-19-inactivated vaccines can elicit Omicron-specific T-cell *** positive rates of ELISpot reactions were 26.7%(4/15)and 43.8%(7/16)in the full vaccination group and the booster vaccination group,respectively,although without statistically significant *** neutralizing antibody titers declined while T-cell responses remain consistent over 6 *** findings will inform the optimization of public health vaccination and intervention strategies to protect diverse populations against SARS-CoV-2 *** infection significantly boosted neutralizing activities against SARS-CoV-2 variants a compared to booster immunization with inaclivated ***-induced vir us-specific T-cell imm

关键词： immunity vaccine protective

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A creatinine-based model for predicting recurrent bleeding after modified percutaneous transhepatic variceal embolization in patients with cirrhosis

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Journal of Interventional Medicine 2022年第2期5卷 95-102页

作者： Kun Ji Xin Li Hanlong Zhu Si Zhao Pengchao Zhan Yang Shi Shuwen Ye Bingcan Xie Yuyuan Zhang Peng Yu Zhigang Ren Juan Ding Xinwei Han Zhen Li Hepaobilary and Pancreatic Ientionod Treatment Center Divston of Heptbiliay and Pancreatic SurgenyThe Pirst fliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Deprtnent of Inteventional Radiology The First Aftlated Hospital of Zhengzhou UntversityZhengzhouHenan ProvinceChina department of Gastroenterology and Hpatology Jinling HopitalMedical School of Nanjing UneversiyNanjing210002Jiangsu ProvinceChina Deparment of Gastroenterology filiated Drum Tower Hospitadl of Nanying University Medical SchooNajin 210008Jiangsu ProvinceChina department of infecious diseases The Frst Afilated Hosital of Zhengzhou UniversityZhengzhouHenan ProvinceChina department of Qualiy Conurol The Pirnt Afllated Hospital of Zhengzhou UnivesiyZhenghouHenarn ProwinceChina

Background:Patients who survive initial esophagogastric variceal bleeding(EVB)are at an increased risk of recurrent bleeding and death;however,a reliable predictive model is *** aimed to develop a model for rebleeding prediction in patients with EVB after modified percutaneous transhepatic variceal embolization(PTVE)with ***:A total of 122 patients with EVB who underwent PTVE from January 2015 to November 2020 were *** logistic analyses were conducted to determine independent risk factors for nomogram *** discrimination,calibration,and clinical utility of the nomogram were compared with the Model for End-stage Liver Disease score(MELD)and the Child–Pugh *** stratification was performed according to the ***:Rebleeding within 3 months of PTVE occurred in 32 patients(26.2%).Independent rebleeding indicators included prior history of endoscopic therapy,Child–Pugh score,partial splenic embolization,and creatinine *** nomogram incorporating these four predictors achieved excellent calibration and discriminatory abilities,with a concordance index of 0.85,which was confirmed to be 0.83 through bootstrapping *** nomogram demonstrated superior discrimination and clinical applicability than the MELD and Child–Pugh *** shown in the Kaplan–Meier curves,high-risk patients had a high probability of rebleeding(P<0.001).Conclusions:The creatinine-based nomogram had a superior ability to predict rebleeding after PTVE in patients with *** stratification may help identify high-risk patients and lead to the earlier implementation of aggressive treatments and formulation of intensive follow-up plans.

关键词： Esophagogastric varices Percutaneous transhepatic variceal embolization Nomogram Prediction

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