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Rare diaphragmatic tumor mimicking liver mass

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World Journal of Gastrointestinal Surgery 2014年第2期6卷 33-37页

作者： Shalini Thapar Arvind Ahuja Archana Rastogi department of Radiodiagnosis Institute of Liver and Biliary Sciences department of hepatopathology Institute of Liver and Biliary Sciences

Primary tumors of the diaphragm are quite rare. About 150 cases have been reported in the literature. Fibrosarcomas are the commonest malignant neoplasms of the diaphragm; however, only a few(less than 20) cases have been reported to date. We present the case of an extremely rare tumor of the diaphragm mimicking a liver mass. The patient, a young 28-year-old woman, presented with an 8-month-history of mildly progressive upper abdominal pain and early fullness after meals. Computed tomography scan of the abdomen revealed a mass located in the region of the left lobe of the liver with non visualized left lobe and partial vascular supply of the mass from the left hepatic artery. The tumor was also seen to draw its vascularity from bilateral internal mammary arteries. Surgical excision and hepatectomy was planned, keeping in mind the diagnosis of an atypical left hepatic mass. Laparotomy revealed a left diaphragmatic tumor growing caudally into the upper abdomen, compressing and splaying the liver along the left medial surface where the tumorwas virtually adherent to it. Successful excision of the mass and subsequent histopathological and immunochemistry examination of the specimen revealed low grade fibromyxoid sarcoma of the diaphragm. This case highlights the unusual presentation of a diaphragmatic mesenchymal tumor and how it can be mistaken as an atypical liver mass. It also emphasizes the tumoral vascular supply as an indicator of its organ of origin.

关键词： Diaphragmatic tumor Low grade Fibro-myxoid sarcoma Liver mass Atypical liver mass Com-puted tomography

Osteopontin expression is associated with hepatopathologic changes in Schistosoma japonicum infected mice

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World Journal of Gastroenterology 2011年第46期17卷 5075-5082页

作者： Bo-Lin Chen Gui-Ying Zhang Wei-Jian Yuan Shi-Ping Wang Yue-Ming Shen LU Yan Huan Gu Jia Li department of Gastroenterology Xiangya Hospital Central South University Changsha 410008 Hunan Province China department of Pathogenic Biology College of Xiangya Basic Medicine Central South University Changsha 410008 Hunan Province China department of Gastroenterology Changsha Central Hospital Changsha 410004 Hunan Province China

AIM:To investigate osteopontin expression and its association with hepatopathologic changes in BALB/C mice infected with Schistosoma ***:The schistosomal hepatopathologic mouse model was established by abdominal infection with schistosomal *** samples were obtained from mice sacrif iced at 6,8,10,14,and 18 wk after *** histopathological changes were observed with hematoxylin-eosin and Masson trichrome *** expression of osteopontin was determined with im-munohistochemistry,reverse transcription-polymerase chain reaction,and Western *** expressionof α-smooth muscle actin(α-SMA)and transforming growth factor-β1(TGF-β1)were determined by *** of osteopontin ex-pression with other variables(α-SMA,TGF-β1,hepato-pathologic features including granuloma formation and degree of liver f ibrosis)were ***:Typical schistosomal hepatopathologic changes were induced in the *** changes in the expression of osteopontin were observed at week *** expression increased,peaked at week 10(Phepatopathology and may promote granuloma formation and liver fi brosis through an un-explored mechanism.

关键词： Schistosoma japonicum, Granuloma Liverfibrosis Osteopontin BALB/C mice

Organoids of liver diseases: From bench to bedside

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World Journal of Gastroenterology 2019年第16期25卷 1913-1927页

作者： Li-Jun Wu Zi-Yan Chen Yi Wang Jun-Gang Zhao Xiao-Zai Xie Gang Chen department of Hepatobiliary Surgery The First Affiliated Hospital Wenzhou Medical University Research Center of Evidence-Based Medicine and Clinical Epidemiology School of Public Health and Management Wenzhou Medical University

Understanding the occurrence, development, and treatment of liver diseases is the main goal of hepatopathology research. Liver diseases are not only diverse but also highly heterogeneous among individuals. At present, research on liver diseases is conducted mainly through cell culture, animal models, pathological specimens, etc. However, these methods cannot fully reveal the pathogenic mechanism and therapeutic characteristics of individualized liver *** advances in three-dimensional cell culture technology(organoid culture techniques) include pluripotent stem cells and adult stem cells that are cultured in vitro to form self-organizing properties, making it possible to achieve individualized liver disease research. This review provides a comprehensive overview of the development of liver organoids, the existing and potential applications of liver regenerative medicine, the pathogenesis of liver disease heterogeneity, and drug screening.

关键词： Organoids Liver diseases Individualized research Liver cancer Threedimensional cell culture Liver organoids

Use of Telemedicine in Postgraduate Pathology Education

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International Journal of Clinical Medicine 2013年第6期4卷 304-308页

作者： Asaranti Kar Tushar Kar Priyadarshini Biswal Kaumudee Pattanaik Pallavi Bhuyan Rajashree Mallick B. N. Mohanty department of Pathology Shriramachandra Bhanj Medical College Cuttack Odisha Pin-753007 India.

Objective: Telemedicine is the use of telecommunication for medical diagnosis, treatment, health education and research. Telepathology is diagnostic pathology at a distance. It functions with images viewed on a video monitor rather than directly through a microscope. Many years have passed since the evolution of telepathology. But no study has yet been done to evaluate the benefits postgraduates got through this. Therefore this study is undertaken to analyse the different impacts of telepathology on the postgraduate learning. Material and Methods: The study was done in Telemedicine Center of S. C. B. Medical College, Cuttack over a period of 9 years. The telepathology service was carried out by store and forward method using a CCD, a large computer server and a huge bandwidth network service (VSAT). The sessions with SGPGI, Lucknow were analysed and the benefits of postgraduates were studied. Results: The number of sessions held was 95. Out of which 92 sessions were with SGPGI. It included 202 cases transmitted from Lucknow and 186 cases from S. C. B. Medical College, Cuttack. The postgraduates had a chance to exposure to rare cases in renal pathology, dermatopathology and hepatopathology. The overall concordance rate with glass slide diagnosis was 87%. Conclusion: The diagnostic expertise through light microscopy and tele-images are not the same. But the telepathology system increased the ability of image analysis, histopathologic diagnosis of our postgraduates and also exposed them to many rare and interesting cases.

关键词： Histopathologic Diagnosis Postgraduates Telepathology