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Correlation between diabetic peripheral neuropathy and thyroid hormone sensitivity in elderly patients with type 2 diabetes mellitus

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World Journal of Diabetes 2025年第2期16卷 71-80页

作者： Si-Jia Fei Jing-Yi Luo Wei-Hao Wang Li-Xin Guo Qi Pan department of Endocrinology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

BACKGROUND Diabetic peripheral neuropathy(DPN)is a common complication of type 2 diabetes mellitus(T2DM),significantly affecting patients’quality of life and imposing a substantial economic *** studies have highlighted the role of thyroid hormones in diabetes complications,particularly in elderly patients with ***,the relationship between thyroid hormone sensitivity and DPN remains *** To investigate the correlation between thyroid hormone sensitivity and DPN in elderly patients with *** In a cohort of 256 elderly patients with T2DM,propensity score matching was used to balance age,sex,and diabetes *** data were collected to calculate thyroid hormone sensitivity and analyze its correlation with DPN.A random forest model was used to evaluate the diagnostic value of free triiodothyronine/free thyroxine(FT_(3)/FT_(4))for *** Patients with DPN had a lower FT_(3)/FT_(4) ratio[(0.302±0.053)vs(0.316±0.049),P=0.040].Quartile stratification showed decreasing DPN prevalence with higher FT_(3)/FT_(4) ***’s correlation analysis showed that a lower FT_(3)/FT_(4) ratio was associated with higher glycated hemoglobin,fasting blood glucose,reduced nerve conduction velocity,and electrical skin *** regression indicated a positive relationship between the median FT_(3)/FT_(4) ratio and bilateral foot electrochemical skin conductance[odds ratio(OR):1.019;95%CI:1.005-1.034;P=0.007]and sural nerve sensory amplitude(OR:1.310;95%CI:1.008-1.703;P=0.043).Receiver operating characteristic analysis using a random forest model showed that incorporating FT_(3)/FT_(4) improved predictive performance for DPN,with an area under the curve of 0.74,sensitivity of 0.79,specificity of 0.64,and accuracy of *** In elderly patients with T2DM with euthyroidism,a lower FT_(3)/FT_(4) ratio is correlated with increased DPN incidence,affecting both large and small nerve ***_(3)/FT_(4) is an effective predicto

关键词： Diabetic peripheral neuropathy Thyroid hormone sensitivity Type 2 diabetes mellitus Elderly Free triiodothyronine/free thyroxine ratio

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Effect of electroacupuncture on pain after periodontal flap surgery:a randomized controlled trial

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Journal of Traditional Chinese Medicine 2025年第1期45卷 184-191页

作者： Emre Bulut Didem ?zkal Emino?lu Yasemin ?ay?r department of Periodontology Faculty of DentistryAtatürk University department of Family Medicine Faculty of MedicineAtatürk University

OBJECTIVE: To examine the effect of electroacupuncture(EA) application on postoperative pain levels and the amount of analgesic use in patients who underwent periodontal flap surgery. METHODS: In this prospective, randomized and controlled study, patients planned for periodontal surgery were divided into two groups [EA group(n = 22): patients who received electroacupuncture and control group(n = 22): patients who did not receive electroacupuncture]. Electroacupuncture was applied bilaterally to the Hegu(LI4), Daying(ST5), and Jiache(ST5) points of the patients in the EA group immediately before and after the flap surgery for 30 min at a frequency of 50 Hz to each point at a current that the patient could tolerate. The patients in the control group underwent flap surgery without applying electroacupuncture. Patients were asked to record their pain levels on the visual analog scale and the number of analgesic tablets they took during the 7 postoperative days on the given form. RESULTS: The total mean score of pain felt in the EA group(16.60 ± 2.78) was found to be significantly lower than that in the control group(31.37 ± 2.78)(P = 0.001). No significant difference was found between the groups regarding the amount of analgesics taken(4.77 ± 4.72, 5.82 ± 3.11)(P = 0.111). CONCLUSIONS: Our study shows that electroacupuncture application is beneficial in reducing pain after periodontal flap surgery. Overall, more research is needed to fully understand the effects of electroacupuncture on postoperative pain.

关键词： analgesics electroacupuncture pain, postoperative periodontitis randomized controlled trial

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A review on recent taxonomic updates of gut bacteria associated with social bees,with a curated genomic reference database

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Insect Science 2025年第1期32卷 2-23页

作者： Chengfeng Yang Jiawei Hu Qinzhi Su Zijing Zhang Yating Du Jieni Wang Huihui Sun Benfeng Han Junbo Tang Lizhen Guo Hu Li Wanzhi Cai Hao Zheng Xin Zhou Xue Zhang department of Entomology College of Plant ProtectionChina Agricultural UniversityBeijingChina Sanya Institute of China Agricultural University Hainan ProvinceChina College of Food Science and Nutritional Engineering China Agricultural UniversityBeijingChina Beijing Laboratory of Biomedical Materials Department of Geriatric DentistryPeking University School and Hospital of StomatologyBeijingChina Hebei Key Laboratory of Animal Physiology Biochemistry and Molecular BiologyCollege of Life SciencesHebei Normal UniversityShijiazhuangChina

Honeybees and bumblebees play a crucial role as essential *** special gut microbiome of social bees is a key factor in determining the overall fitness and health of the *** bees harbor relatively simple microbial communities at the genus level,recent studies have unveiled significant genetic divergence and variations in gene content within each bacterial ***,a comprehensive and refined genomics-based taxonomic database specific to social bee gut microbiomes remains ***,we first provided an overview of the current knowledge on the distribution and function of social bee gut bacteria,as well as the factors that influence the gut population *** then consolidated all available genomes of the gut bacteria of social bees and refined the species-level taxonomy,by constructing a maximum-likelihood core genome phylogeny and calculating genome-wide pairwise average nucleotide *** the basis of the refined species taxonomy,we constructed a curated genomic reference database,named the bee gut microbe genome sequence database(BGM-GDb).To evaluate the species-profiling performance of the curated BGM-GDb,we retrieved a series of bee gut metagenomic data and inferred the species-level composition using metagenomic intra-species diversity analysis system(MIDAS),and then compared the results with those obtained from a prebuilt MIDAS *** found that compared with the default database,the BGM-GDb excelled in aligned read counts and bacterial ***,this high-resolution and precise genomic reference database will facilitate research in understanding the gut community structure of social bees.

关键词： bacterial species BGM-GDb corbiculate bees gut microbiome phylogeny phylotype

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Approved delivery strategies for biopharmaceuticals

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Chinese Chemical Letters 2025年第2期36卷 69-79页

作者： Makhloufi Zoulikha Zhongjian Chen Jun Wu Wei He School of Pharmacy China Pharmaceutical University Shanghai Skin Disease Hospital Tongji University School of Medicine department of geriatric Cardiology Jiangsu Provincial Key Laboratory of Geriatrics The First Affiliated Hospital of Nanjing Medical University

In recent years, biopharmaceuticals have witnessed remarkable advancements, transforming the landscape of therapeutic interventions. Biopharmaceuticals encompassing therapeutics generated through cutting-edge biotechnological methods have shown promising therapeutic outcomes. However, their clinical success hinges significantly on overcoming drug delivery challenges related to stability, intracellular delivery, immunogenicity, and pharmacokinetic properties. Herein, we provide an overview of various marketed macromolecules, including nucleic acids, and immunotherapeutic agents such as cytokines and monoclonal antibodies, as well as other therapeutic peptides/proteins like enzymes, hormones, and coagulation factors. Our primary focus is on elucidating the delivery challenges associated with these macromolecules and highlighting the pivotal role played by drug delivery platforms in the development of currently marketed products, offering valuable insights for both scientific research and the pharmaceutical industry.

关键词： Biopharmaceuticals Drug delivery Monoclonal antibodies Nucleic acids Proteins

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Insulin autoantibodies,D-dimer and microalbuminuria:A crosssectional,case-control study of type 2 diabetes

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World Journal of Diabetes 2025年第2期16卷 38-46页

作者： Lin-Shan Zhang Peng Yu Fei Yao Zhi-Qiang Lu Xiao-Mu Li Hong Chen department of Endocrinology Zhongshan HospitalFudan UniversityShanghai 200032China department of Endocrinology Shanghai Geriatric Medical CenterShanghai 201104China department of Endocrinology Fuzhou Hospital of Traditional Chinese MedicineFuzhou 350000Fujian ProvinceChina

BACKGROUND Type 2 diabetes mellitus(T2DM)often leads to vascular complications,such as *** role of insulin autoantibodies(IAA)and their interaction with D-dimer in this context remains *** To investigate the characteristics of IAA and its effect on albuminuria in T2DM *** We retrospectively analyzed clinical data from 115 T2DM patients with positive IAA induced by exogenous insulin,and 115 age-and sex-matched IAA-negative T2DM patients as *** scores were calculated using multivariate logistic *** variables were selected using the least absolute shrinkage and selection operator(LASSO)*** constructed a prediction model and analyzed the association between IAA and albuminuria based on demographic and laboratory *** The IAA-positive group had significantly higher D-dimer levels[0.30(0.19-0.55)mg/L vs 0.21(0.19-0.33)mg/L,P=0.008]and plasma insulin levels[39.1(12.0-102.7)μU/mL vs 9.8(5.5-17.6)μU/mL,P0.5 g/L)was 2.88(95%confidence interval:1.17-7.07)in the IAA-positive group(P interaction<0.05).CONCLUSION D-dimer elevation is an independent risk factor for abnormal albuminuria and interacts with IAA in the development of abnormal albuminuria in T2DM patients.

关键词： Insulin autoantibody Microalbuminuria D-dimer Type 2 diabetes

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Association between Non-high-density Lipoprotein Cholesterol to High-density Lipoprotein Cholesterol Ratio(NHHR)and Stroke among Adults in the USA:A Cross-Sectional NHANES Study

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Biomedical and Environmental Sciences 2025年第1期38卷 37-46页

作者： Haixia Ma Huaqiu Chen Peichang Wang department of Clinical Laboratory Xuanwu HospitalNational Clinical Research Center for Geriatric DiseasesCapital Medical UniversityBeijing 100053China National Clinical Research Center for geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijing 100053China

Objective The relationship between non-high-density lipoprotein(NHDL)cholesterol to high-density lipoprotein cholesterol(HDL-C)ratio(NHHR)and stoke remains *** study aimed to evaluate the association between the adult NHHR and stroke occurrence in the United States of America(USA).Methods To clarify the relationship between the NHHR and stroke risk,this study used a multivariable logistic regression model and a restricted cubic spline(RCS)model to investigate the association between the NHHR and stroke,and data from the National Health and Nutrition Examination Survey(NHANES)from 2005 to *** and sensitivity analyses were conducted to test the robustness of the *** This study included 29,928 adult participants,of which 1,165 participants had a history of *** regression analysis of variables demonstrated a positive association between NHHR and stroke(OR 1.24,95%CI:1.03-1.50,P=0.026).Compared with the lowest reference group of NHHR,participants in the second,third,and fourth quartile had a significantly increased risk of stroke after full adjustments(OR:1.35,95%CI:1.08-1.69)(OR:1.83,95%CI:1.42-2.36)(OR:2.04,95%CI:1.50-2.79).In the total population,a nonlinear dose-response relationship was observed between the NHHR and stroke risk(P non-linearity=0.002).This association remained significant in several subgroup *** investigation of the NHHR may enhance our understanding of stroke prevention and *** Our findings suggest a positive correlation between the NHHR and an increased prevalence of stroke,potentially serving as a novel predictive factor for *** intervention and management of the NHHR may effectively mitigate stroke *** studies are required to validate this association and further explore the underlying biological mechanisms.

关键词： NHHR Stroke NHANES Cross-sectional study

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Melatonin regulation and the function of the periodontal ligament: Future perspective and challenges

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World Journal of Stem Cells 2025年第1期17卷 86-89页

作者： Andrea Scribante Section of dentistry Department of ClinicalSurgicalDiagnostic and Paediatric SciencesUniversity of PaviaPavia 27100Italy

The present article reviews the emerging role of melatonin(MT)and the Hippo-Yes-associated protein signaling pathway in periodontal regeneration,high-lighting their potential to delay the aging process of periodontal ligament stem cells(PDLSCs).Oxidative stress and cellular senescence are major obstacles in regenerative therapies,especially in an aging ***,a potent antioxidant,restores the morphology,proliferation,and osteogenic differentiation potential of PDLSCs under oxidative stress *** research highlights how MT enhances PDLSC stemness by upregulating Yes-associated protein ex-pression,offering a promising therapeutic strategy to antagonize tissue *** addition,the article discusses the growing interest in probiotics as a complementary approach to improve oral microbiota and support tissue *** integration of MT with traditional and novel therapeutic approaches may pave the way for innovative preventive or active treatments in periodontology,aimed at reducing oxidative *** research needs to focus on translating these findings into clinical applications and promoting a deeper understanding of periodontal regeneration and cellular aging.

关键词： Cellular aging dentistry Melatonin Oxidative stress Periodontal ligament Periodontal regeneration Periodontology Cellular aging

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Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi Zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li Zhang Zheng Gang Zhang department of Neurology Henry Ford HospitalDetroitMIUSA department of Physics Oakland UniversityRochesterMIUSA department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

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Rat models of frozen shoulder:Classification and evaluation

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Animal Models and Experimental Medicine 2025年第1期8卷 92-101页

作者： Hezirui Gu Wenqing Xie Hengzhen Li Shuguang Liu Yusheng Li department of Orthopedics Xiangya HospitalCentral South UniversityChangshaChina Xiangya School of Medicine Central South UniversityChangshaChina National Clinical Research Center for geriatric Disorders Xiangya HospitalCentral South UniversityChangshaChina department of Joint Surgery Honghui HospitalXi'an Jiaotong UniversityXi'anChina

Frozen shoulder(FS),also known as adhesive capsulitis,is a condition that causes contraction and stiffness of the shoulder joint *** main symptoms are per-sistent shoulder pain and a limited range of motion in all *** symp-toms and poor prognosis affect people's physical health and quality of ***,the specific mechanisms of FS remain unclear,and there is variability in treatment methods and their ***,the early symptoms of FS are difficult to distinguish from those of other shoulder diseases,complicating early diagnosis and ***,it is necessary to develop and utilize animal models to under-stand the pathogenesis of FS and to explore treatment strategies,providing insights into the prevention and treatment of human *** paper reviews the rat models available for FS research,including external immobilization models,surgical internal immobilization models,injection modeling models,and endocrine modeling *** introduces the basic procedures for these models and compares and analyzes the advantages,disadvantages,and applicability of each modeling ***,our paper summarizes the common methods for evaluating FS rat models.

关键词： endocrine modeling injection rat model surgical internal immobilization

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Trends in dentomaxillofacial radiology

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World Journal of Radiology 2025年第1期17卷 19-31页

作者： KıvançKamburoğlu department of Dentomaxillofacial Radiology Faculty of DentistryAnkara UniversityAnkara 06500Türkiye department of Surgery and Pediatric dentistry Faculty of StomatologyAkhmet Yassewi International Kazakh Turkish UniversityTurkestan 161200Kazakhstan

Oral and maxillofacial diagnostic imaging is of paramount importance in dental clinical diagnosis,treatment planning,and follow-up *** ra-diographic examination and numerous panoramic systems are used in routine clinical dental *** beam CT is widely used and currently the method of choice in oral and maxillofacial implantology,endodontics,maxillofacial surgery,periodontics,degenerative temporomandibular joint disease,orthodontics,airway studies,sleep disorders,and forensic *** innovative laboratory re-search tool that offers three-dimensional(3D)detailed high-resolution images of in vitro teeth and neighboring structures with submicrometric accuracy is micro-computed ***-high radiation doses,long scanning times,and high costs preclude its routine clinical *** response to the high demand for a te-chnique that could provide real-time images using a cost-effective,rapid,user-friendly,and portable technique without ionizing radiation,some authors pro-posed ultrasound imaging methods as an alternative to X-ray imaging *** can be used in the dentomaxillofacial region for various diagno-stic purposes such as salivary gland and superficial tissue ***,dedicated dental magnetic resonance imaging with appropriate software,hard-ware,sequences,and field of view tailored to fit dentomaxillofacial anatomy was ***,3D printing technologies and their application in dentistry has attracted *** 3D printing a given material is added in successive layers to create a 3D *** application of this technology has the potential to decrease operation time and minimize operator bias and the possibility of proce-dural *** hot topic regarding dentomaxillofacial radiology is artificial intelligence,which is a field related to computer science dedicated to developing systems or machines that can perform tasks traditionally associated with human ***

关键词： Dentomaxillofacial radiology Diagnostic imaging Cone beam CT Ultrasonography Microcomputed tomography Dental microcomputed tomography Three-dimensional printing Artificial intelligence

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