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Role of copper chelating agents: between old applications and new perspectives in neuroscience

Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly department of Engineering management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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Artificial neural network (ANNs) and mathematical modelling of hydration of green chickpea

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Information Processing in Agriculture 2021年第1期8卷 75-86页

作者： Yogesh Kumar Lochan Singh Vijay Singh Sharanagat Ayon Tarafdar department of food Engineering National Institute of Food Technology Entrepreneurship and ManagementHaryanaIndia department of Agriculture and environmental Sciences National Institute of Food Technology Entrepreneurship and ManagementHaryanaIndia

The present study was aimed to model the hydration characteristics of green chickpea(GC)using mathematical modelling and examine predictive ability of artificial neural network(ANN)*** of GC was performed at different temperatures 25,35,45,55 and 65℃.Different mathematical models were tested for the hydration at different *** ANN modelling,the hydration time and hydration temperature were used as input variables and moisture ratio,moisture content and hydration ratio were taken as output *** model best described the hydration behavior at 25℃;while hydration at high-temperature was better described by Page model and Ibarz et *** optimum temperature obtained for hydration was 35℃.Effective mass diffusion coefficient(D_(e))increased from 1.5510^(-11)-1.7910^(-9) m^(2)/s with the increase in the hydration *** low activation energy(39.66 kJ/moL)shows the low-temperature sensitiveness of *** temperature hydration(25℃)required higher time(>200 min)to achieve the equilibrium moisture content(EMC),however high temperature hydration(35–65℃)reduced the EMC time(150 min).ANN was used to predict the hydration behavior and K fold cross validation was performed to check the over fitting of ANN *** show that the LOGSIGMOID transfer function showed better performance when used at the hidden layer input node in conjunction to both PURELIN and *** was found suitable for moisture ratio(MR)and hydration ratio(HR)prediction,as opposed to PURELIN for moisture content(MC)*** model prediction was obtained when the number of neurons in the hidden layer for MC,MR and HR was 12,8 and 15,*** and ANN modelling results are useful to improve/predict the MC,MR and HR during hydration process of GC at different temperature and other similar process.

关键词： Green chickpea Water absorption Hydration temperature ANN modeling

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Advanced analytical determination of volatile organic compounds (VOC) and other major contaminants in water samples using GC-Ion Trap MS

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Journal of environmental Sciences 2001年第1期13卷 25-36页

作者： Koroma, B. M. Wang, Kai-xiong Jinya, D. D. Laboratory of Socioeconomic Science of food production Nagoya University Japan department of environmental Engineering Zhejiang University Hangzhou 310029 China. E-mail:[email protected] Kitakyushu Institute of environmental Sciences Kitakyushu City Japan

The GC-Ion Trap MS is recently one of the most efficient instrumental analysis recommended for understanding the chemistry of these organic compounds, not only in water but even in the food chain and other environmental media (air and soil). Results of the experiment conducted on water samples from Kuguri and Yatsutani sampling stations showed considerably higher levels of organic enrichment (COD=10 mg/L and 11 mg/L respectively). Total concentrations of Pb (0.072 mg/L and 0.093 mg/L) and Cd (0.004 mg/Land 0.011 mg/L) on the other hand, invariably exceeded the maximum allowable concentrations for human health and the living environment (Pb=0.005 mg/L; Cd=0.001 mg/L respectively). And the toxicity levels for these contaminants at LC_50 showed critical impact on rainbow trout (hypersensitive species) at 0.14 mg/L for Pb and 0.007 mg/L for Cd in 96 hours respectively. Although these major contaminants including phenol and 3-, 4-cresol, showed relatively higher toxicity impact in the experimental media, it would remain contentious to justify any associated potential dangers without regular routine water monitoring, at least for a period of one year. Nevertheless, the data could serve as a benchmark through which other phenomena can easily be investigated.

关键词： www Advanced analytical determination of volatile organic compounds and other major contaminants in water samples using GC-Ion Trap MS VOC EB GC

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Accuracy of two optical chlorophyll meters in predicting chemical composition and in vitro ruminal organic matter degradability of Brachiaria hybrid,Megathyrsus maximus, and Paspalum atratum

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Animal Nutrition 2017年第1期3卷 67-76页

作者： Martin P.Hughes Victor Mlambo Cicero H.O.Lallo Nasreldin A.D.Basha Ignatius V.Nsahlai Paul G.A.Jennings department of food production Faculty of Food and AgricultureUniversity of the West Indies department of Animal Science School of Agricultural SciencesFaculty of AgricultureScience and TechnologyNorth-West University Open Tropical Forage-Animal production Laboratory Department of Food ProductionFaculty of Food and AgricultureUniversity of the West Indies department of Animal & Poultry Science School of AgriculturalEarth and Environmental SciencesCollege of AgricultureEngineering and ScienceUniversity of KwaZulu-Natal department of Animal Nutrition Faculty of Animal Production Shampat CampusUniversity of Khartoum MARJEN Consulting Group

The objective of this study was to determine the accuracy and reliability of 2 optical chlorophyll meters:FieldScout CM 1,000 NDVI and Yara N-Tester, in predicting neutral detergent fibre(NDF), acid detergent fibre(ADF), acid detergent lignin(ADL), acid detergent insoluble nitrogen(ADIN) and in vitro ruminal organic matter degradability(IVOMD) of 3 tropical grasses. Optical chlorophyll measurements were taken at 3 stages(4, 8 and 12 weeks) of regrowth in Brachiaria hybrid, and Megathyrsus maximus and at 6 and 12 weeks of regrowth in Paspalum atratum(cv. Ubon). Optical chlorophyll measurements showed the highest correlation(r = 0.57 to 0.85) with NDF concentration. The FieldScout CM 1,000 NDVI was better than the Yara N-Tester in predicting NDF(R^2 = 0.70) and ADF(R^2 = 0.79) concentrations in Brachiaria hybrid and NDF(R^2 = 0.79) in M. maximus. Similarly, FieldScout CM 1,000 NDVI produced better estimates of 24 h IVOMD(IVOMD_(24 h)) in Brachiaria hybrid(R^2 = 0.81) and IVOMD_(48 h) in Brachiaria hybrid(R^2 = 0.65) and M. maximus(R^2 = 0.75). However, these prediction models had relatively low concordance correlation coefficients, i.e., CCC >0.90, but random errors were the main source of bias. It was,therefore, concluded that both optical chlorophyll meters were poor and unreliable predictors of ADIN and ADL concentrations. Overall, the FieldScout CM 1,000 NDVI shows potential to produce useful estimates of IVOMD_(24h) and ADF in Brachiaria hybrid and IVOMD_(48 h) and NDF concentrations in M. maximus.

关键词： Optical chlorophyll measurements Chemical composition Prediction model Tropical grass

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Bioactive profile of borno brown Vigna unguiculata grains as influenced by pre-harvest synthetic chemicals

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food Bioscience 2022年第1期45卷 223-231页

作者： Temitope Omolayo Fasuan Nneka Nkechi Uchegbu Titilope Modupe Olagunju Oyenike Olubunmi Falola department of Animal Health and production Technology Federal College of Animal Health and Production TechnologyIbadanNigeria department of food Science and Technology University of NigeriaNsukkaNigeria department of Agricultural and environmental Engineering Obafemi Awolowo UniversityIle-IfeNigeria

This study investigated the impact of pre-harvest synthetic chemical treatments on the post-harvest bioactive contents,pasting,colour,and thermal properties of borno brown ***(L.)Walp *** of borno brown ***(L.)Walp was planted on an already ploughed,harrowed and ridged plot of land with a portion cultivated as organic and another *** 90 days,mature grains were harvested and analyzed using standard *** showed that a total of 44.33 g bioactive compounds/100g grain was present in the organic borno brown *** grains whereas,20.56 g bioactive compounds/100g grain was present in the non-organic(control).The identified bioactive compounds in the organic grains included[heneicosane(4.50g/100g grain)];[12-Methyl-E,E-2,13-octadecadien-1-ol(4.09/100g grain)];[3-(2-Hydroxy-6-methylphenyl)-4(3H)-quinazolinone(7.40 g/100g grain)];[Methaqualone(9.08 g/100g grain)].The non-organic contained[heneicosane(4.07g/100g grain)];[3-(2-Hydroxy-6-methylphenyl)-4(3H)-quinazolinone(5.09 g/100g grain)];[Methaqualone(10.61 g/100g grain)].Flavonoids,alkaloids,total phenolic,2,2-diphenyl-1-picryl-hydrazl(DPPH)and ferric ion reducing antioxidant power(FRAP)contents of the organic grains were 19 mgRE/100g,3.40 mg/100g,1550 mgGAE/100g,2840μmolTEAC/100g,and 20.08 mmol Fe^(2+)/100g,*** non-organic grains had flavonoids(11.31 mgRE/100g),alkaloids(1.86 mg/100g),total phenolic(1110 mgGAE/100g),DPPH(1779μmolTEAC/100g)and FRAP(12.24 mmol Fe^(2+)/100g).The peak viscosity of 111.52 RVU,final viscosity(141.25 RVU)and pasting temperature(82.01℃)were obtained for the organic grains while non-organic had peak viscosity of 93.10RVU,final viscosity(95.20 RVU)and pasting temperature(80.10℃).The colour parameters L^(*),a^(*),b^(*)and ΔE were 73.10,0.68,14.47 and 12.98 for the organic and 84.25,0.30,21.10,and 0.00,respectively for non-organic *** thermal property showed enthalpy(ΔH)and peak temperature(T_(p))of 3.12 J/g and 78.25℃ f

关键词： Borno brown Vigna unguiculata grains Organic Bioactive compounds Phenolic compound profile Antioxidant activities Pasting property

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production of functional spent hen protein hydrolysate powder and its fortification in food supplements: A waste to health strategy

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food Bioscience 2022年第6期50卷 2015-2022页

作者： Deepak Kumar Ayon Tarafdar Yogesh Kumar Sneh Lata Dass Sunil Pareek Prarabdh C.Badgujar department of food Science and Technology National Institute of Food Technology Entrepreneurship and ManagementKundliSonipat131028HaryanaIndia Livestock production and management Section ICAR-Indian Veterinary Research InstituteIzatnagar–Bareilly2431 22Uttar PradeshIndia School of Basic Sciences&Research Department of Life SciencesSharda UniversityGreater NoidaUttar Pradesh201306India department of Agriculture and environmental Sciences National Institute of Food Technology Entrepreneurship and ManagementKundliSonipat131028HaryanaIndia department of food Engineering National Institute of Food Technology Entrepreneurship and ManagementKundliSonipat131028Haryana

Spent hens are discarded from the poultry industry as they lose their ability to lay eggs and are rendered unsuitable for consumption due to poor meat quality. This work provides a strategy to utilize spent hen meat by developing protein hydrolysates with enhanced antioxidative properties for developing functional protein supplement which was previously unexplored. Spent hen meat was hydrolysed using two proteases (alcalase and flavourzyme) followed by drying (spray and freeze drying). Hydrolysate powders thus generated were further characterized for their physico-chemical and functional attributes. Particle size and morphology were more prominently affected by drying method while the functional properties were influenced by the enzyme type. The solubility, antioxidant activity and bioaccessibility of spray dried spent hen hydrolysate powder developed using flavourzyme (SD-SPHF) was found superior to those developed using alcalase. Hydrophobic amino acids with rich antioxidant activity were also found to be higher in SD-SPHF. Considering higher functionality of SD-SPHF, it was incorporated @10% in whey protein supplement and was found to be acceptable from a sensory viewpoint. The study highlights that spent hen protein hydrolysate powders can be effectively utilized for the development of economic functional food supplements after suitable biotechnological interventions.

关键词： Antioxidative activity Drying Fortification Bioacessibility Amino acid profiling Protein supplements

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Chemical Properties and Biochemical Activity of Colonized and Abandoned Litter-Feeding Termite(Macrotermes spp.) Mounds in Chromic Cambisol Area on the Borana Plateau, Ethiopia

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Pedosphere 2014年第3期24卷 399-407页

作者： L.MENICHETTI L.LANDI P.NANNIPIERI T.KATTERER H.KIRCHMANN G.RENELLA department of Soil and Environment Swedish University of Agricultural Sciences department Agrifood production and environmental Sciences University of Florence

Termite （Macrotermes spp.） mounds are complex biological habitats originated by the termite activity and possessing peculiar physical, chemical and biochemical properties. In this study we examined the concentration of nutrients and the biochemical activity of abandoned soil and mounds colonized by termites of the genera Macroterrnes located in the Borana District, Ethiopia. To elucidate the magnitude and persistence of the termite-induced effects, we also studied an abandoned mound, previously colonized by termites of the same genera formed on the same soil. Results confirmed that termite-colonized mounds are ＇hot spots＇ of nutrient concentration and microbial activity in tropical soils. This is due to the termite driven litter input and decomposition. The abandoned mounds showed higher microbial biomass and activity and displayed a nutrient redistribution and a greater microbial activity than the adjacent soils. These findings allowed us to hypothesize a model of nutrient cycling in colonized soils and a partition of the relative roles of termites and soil microorganisms in nutrient location and turnover in tropical soils. These results may be also useful for the optimal management of termite-colonized soils.

关键词： enzyme activity microbial activity microbial biomass nutrient cycling nutrient turnover

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Methionine sources and genotype affect embryonic intestinal development,antioxidants,tight junctions,and growth-related gene expression in chickens

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Animal Nutrition 2024年第1期16卷 218-230页

作者： James K.Lugata Sawadi F.Ndunguru Gebrehaweria K.Reda Xénia E.Ozsváth Eszter Angyal Levente Czeglédi Gabriella Gulyás Renáta Knop János Oláh Zoltán Mészár Rita Varga Brigitta Csernus Csaba Szabó department of Animal Nutrition and Physiology Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary department of Animal Husbandry Faculty of Agriculture and Food Sciences and Environmental ManagementUniversity of DebrecenDebrecenHungary Faculty of Agriculture and food Sciences and environmental management Doctoral School of Animal ScienceUniversity of DebrecenDebrecenHungary Institutes for Agricultural Research and Educational Farm University of DebrecenDebrecenHungary department of Anatomy Histology and EmbryologyFaculty of MedicineUniversity of DebrecenDebrecenHungary department of Evolutionary Zoology and Human Biology Faculty of Science and TechnologyUniversity of DebrecenDebrecenHungary

Methionine(Met)is an essential and first limiting amino acid in the poultry diet that plays a significant role in chicken embryonic development and *** present study examined the effect of in ovo injection of DL-Met and L-Met sources and genotypes on chicken embryonic-intestinal development and *** eggs of the two genotypes,TETRA-SL layer hybrid(TSL)—commercial layer hybrid and Hungarian Partridge colored hen breed(HPC)—a native genotype,were randomly distributed into four treatments for each *** treatment groups include the following:1)control non-injected eggs(NoIn);2)saline-injected(SaIn);3)DL-Met injected(DLM);and 4)L-Met injected(LM).The in ovo injection was carried out on 17.5 d of embryonic development;after hatching,eight chicks per group were sacrificed,and the jejunum was extracted for *** results showed that both DLM and LM groups had enhanced intestinal development as evidenced by increased villus width,villus height,and villus area(P<0.05)compared to the *** DLM group had significantly reduced crypt depth,glutathione(GSH)content,glutathione S-transferase 3 alpha(GST3),occludin(OCLN)gene expression and increased villus height to crypt depth ratio in the TSL genotype than the LM group(P<0.05).The HPC genotype has overexpressed insulin-like growth factor 1(IGF1)gene,tricellulin(MD2),occludin(OCLN),superoxide dismutase 1(SOD1),and GST3 genes than the TSL genotype(P<0.05).In conclusion,these findings showed that in ovo injection of Met enhanced intestinal development,and function,with genotypes responding differently under normal *** also influenced the expression of intestinal antioxidants,tight junction,and growth-related genes.

关键词： DL-Methionine L-Methionine In ovo injection Intestinal development Poultry

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Socio-economic importance and utilization of Spondias mombin in Nigeria

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Asian Pacific Journal of Tropical Medicine 2010年第3期3卷 232-234页

作者： Adedokun MO Oladoye AO Oluwalana SA Mendie Ⅱ department of Forestry & Wildlife management College of Environmental ManagementUniversity of Agriculture

Objective:To investigate the socio-economics and medicinal utilization of Spondia monbin, commonly known as plum in English and iyeye in ***:Three communities were selected in Abeokuta which was Itoku,Kuto,and Omida using purposive random sampling technique because of the concentration of users in the *** questionnaire was administered to randomly selected marketers,consumers and herbalists from the three *** and marketing margin were descriptively ***:The results showed that the leaves were being used for child birth aid,cough,sore throat,efu dudu,antiseptic soap,malaria and *** bark uses included child birth aid,inflammation concoction, fever,stomachic,malaria,and efu *** uses of the fruit included cure for dizziness, stomachic,eaten as food,and *** seed were also being used for child birth aid,fibroid, and *** marketing margin analyses revealed that trading on the plants was profitable with the bark having the highest margin which showed the level of its ***: The study reveals the medicinal potentials and the socioeconomic importance of Spondia mombin hence the need to conserve the species from unsustainable exploitation to ensure its availability.

关键词： Spondia mombin Trado-medical practitioners Market margin Medicinal uses Marketers

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Maternal body condition during latepregnancy is associated with in utero development and neonatal growth of Holstein calves

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Journal of Animal Science and Biotechnology 2021年第3期12卷 984-994页

作者： A.S.Alharthi D.N.Coleman I.A.Alhidary M.M.Abdelrahman E.Trevisi J.J.Loor department of Animal production College of Food and Agriculture SciencesKing Saud UniversityRiyadh 11451Saudi Arabia department of Animal Sciences and Division of Nutritional Sciences University of IllinoisUrbanaIL 61801USA department of Animal Sciences Food and Nutrition(DIANA)Faculty of AgricultureFood and Environmental ScienceUniversitàCattolica del Sacro Cuore29122 PiacenzaItaly

Background:Nutritional management in the dry period can alter body condition score(BCS)in dairy cows,a subjective measure of body *** such,differences in BCS during late-pregnancy not only mirror nutrient utilization by fat depots,but also can play important roles on the metabolic and hormonal *** investigated the association between cow BCS during late-pregnancy on developmental parameters and blood variables of neonatal ***-nine multiparous Holstein cows were retrospectively divided by prepartal BCS into normal BCS≤3.25(NormBCS;3.02±0.17,n=30)or high BCS≥3.75(HighBCS;3.83±0.15,n=19)*** samples were collected from cows at−10 d relative to *** weight,hip and wither height,hip width and body length were measured at birth and weekly through weaning(42 d of age)and until 9 weeks of *** blood samples were collected from the jugular vein at birth(before receiving colostrum,0 d),24 h after first colostrum and at 7,21,42 and 50 d of *** data were subjected to ANOVA using the mixed procedure of *** statistical model included day,BCS,and their ***:Dry matter intake(kg/d or%of body weight)during the last 4 weeks of pregnancy was lower(P≤0.06)in HighBCS *** concentrations of fatty acids,ceruloplasmin,and nitric oxide were greater overall(P0.05)in daily starter intake and average daily gain due to maternal ***:Overall,results highlight an association between BCS during late-gestation on in utero calf development and postna

关键词： Metabolism Neonate Nutritional programming Transition cow

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