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Effects of exercise training on glucose metabolism indicators and inflammatory markers in obese children and adolescents:A metaanalysis

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World Journal of Diabetes 2024年第6期15卷 1353-1366页

作者： Le-Yang Li Song-Mei Li Bo-Xian Pang Jun-Ping Wei Qiu-Hong Wang department of endocrinology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Graduate School Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Obesity in children and adolescents is a serious problem,and the efficacy of exercise therapy for these patients is *** To assess the efficacy of exercise training on overweight and obese children based on glucose metabolism indicators and inflammatory *** The PubMed,Web of Science,and Embase databases were searched for randomized controlled trials related to exercise training and obese children until October *** meta-analysis was conducted using RevMan 5.3 software to evaluate the efficacy of exercise therapy on glucose metabolism indicators and inflammatory markers in obese *** In total,1010 patients from 28 studies were *** therapy reduced the levels of fasting blood glucose(FBG)[standardized mean difference(SMD):-0.78;95%confidence interval(CI):-1.24 to-0.32,P=0.0008],fasting insulin(FINS)(SMD:-1.55;95%CI:-2.12 to-0.98,P<0.00001),homeostatic model assessment for insulin resistance(HOMA-IR)(SMD:-1.58;95%CI:-2.20 to-0.97,P<0.00001),interleukin-6(IL-6)(SMD:-1.31;95%CI:-2.07 to-0.55,P=0.0007),C-reactive protein(CRP)(SMD:-0.64;95%CI:-1.21 to-0.08,P=0.03),and leptin(SMD:-3.43;95%CI:-5.82 to-1.05,P=0.005)in overweight and obese *** training increased adiponectin levels(SMD:1.24;95%CI:0.30 to 2.18,P=0.01)but did not improve tumor necrosis factor-alpha(TNF-α)levels(SMD:-0.80;95%CI:-1.77 to 0.18,P=0.11).CONCLUSION In summary,exercise therapy improves glucose metabolism by reducing levels of FBG,FINS,HOMA-IR,as well as improves inflammatory status by reducing levels of IL-6,CRP,leptin,and increasing levels of adiponectin in overweight and obese *** was no statistically significant effect between exercise training and levels of TNF-α.Additional long-term trials should be conducted to explore this therapeutic perspective and confirm these results.

关键词： Exercise training Obesity Children and adolescents Glucose metabolism Inflammatory markers Meta-analysis

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Regulation of aging by NELF-A and RNA polymerase Ⅱ elongation

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Neural Regeneration Research 2024年第7期19卷 1415-1416页

作者： Chin-Tong Ong Zhen-Kai Ngian Temasek Life Sciences Laboratory and department of Biological Sciences National University of SingaporeSingaporeSingapore department of genetics Harvard Medical SchoolBostonMAUSA Institute of Molecular and Cell Biology Agency for ScienceTechnology and ResearchSingaporeSingapore

Epigenetic regulation of aging:Aging is defined as the gradual decline of physiological function and cellular integrity,causing o rganismal vulnerability to age-onset diseases and *** in different animal models have l... 详细信息

关键词： aging twelve integrity

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Prevalence and impact of diabetes and prediabetes on presentation and complications of primary hyperaldosteronism at diagnosis

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World Journal of Clinical Cases 2024年第18期12卷 3332-3339页

作者： Debmalya Sanyal Pradip Mukhopadhyay Sujoy Ghosh department of endocrinology NHRTIICS&KPC Medical CollegeKolkata 700032West BengalIndia department of endocrinology IPGME&R and SSKM HospitalKolkata 700020West BengalIndia department of endocrinology IPGME&RKolkata 700020West BengalIndia

BACKGROUND Primary hyperaldosteronism(PH)is considered to contribute to increased risk of developing type 2 diabetes mellitus(T2DM)and *** PH and DM are associated with increased risk for hypertension,cardiovascular diseases,and chronic kidney ***,data on prevalence of T2DM and prediabetes in PH,and impact of T2DM and prediabetes on presentation and cardio renal complications in PH at presentation is *** To determine the prevalence of T2DM and prediabetes in PH at diagnosis and impact on presentation and complications of *** A retrospective cohort study was conducted in tertiary care settings in individuals with confirmed diagnosis of PH at *** variables,clinical presentations,duration and degree of hypertension,complications,laboratory parameters including sodium,potassium levels,plasma aldosterone concentration(PAC),plasma renin activity(PRA),and aldosterone to renin ratio(ARR)and cardio-renal parameters were *** was done between three groups:PH with no DM(Group A)or with pre-diabetes(Group B)or with T2DM(Group C).P<0.05 was statistically *** Among 78 individuals with confirmed PH,62%had pre-diabetes or diabetes;with 37%having *** duration of T2DM was 5.97±4.7 *** mean levels of glycaemic parameters among the group A vs B vs C individuals were fasting plasma glucose(mg/dL):87.9±6.5,105.4±9.02,130.6±21.1;post prandial plasma glucose(mg/dL):122.7±9.8,154.9±14,196.7±38.0;glycated haemoglobin(%)(5.3±0.2,5.9±0.2,7.5±0.6,P<0.05),*** was no significant difference in the biochemical parameters(PAC,PRA,ARR,sodium,potassium levels),presentation and complications between the *** renal parameters or degree and duration of hypertension were comparable between the *** Significant prevalence of T2DM and prediabetes in PH at diagnosis does not impact its presentation or *** screening for undetected PH in T2DM and prediabete

关键词： Primary hyperaldosteronism Diabetes Prediabetes Hypertension Aldosterone Aldosterone to renin ratio

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Update on the STING Signaling Pathway in Developing Nonalcoholic Fatty Liver Disease

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 91-99页

作者： Wei Liu Zhili Zhang Chen Chenhui Yang Yaofu Fan Liang Qiao Shaofeng Xie Lin Cao department of endocrinology and Metabolism Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingJiangsuChina Jiangsu Province Academy of Traditional Chinese Medicine NanjingJiangsuChina

Nonalcoholic fatty liver disease(NAFLD)is a prevalent chronic liver condition with limited treatment *** caused by metabolic disturbances plays a significant role in NAFLD *** of interferon gene(STING),a critical regulator of innate immunity,induces the production of interferons and other pro-inflammatory factors by recognizing cytoplasmic DNA to defend against pathogen *** STING-mediated signaling pathway appears to play a vital role in hepatic inflammation,metabolic disorders,and even ***,pharmacological interventions targeting STING have shown improvements in the pathological state of ***,dendritic cells,natural killer cells,and T cell pathways regulated by STING present potential novel druggable targets for NAFLD *** research and development in this area may offer new therapeutic options for managing NAFLD effectively.

关键词： Stimulator of interferon gene Macrophage Innate immunity Nonalcoholic fatty liver disease

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The secretory function of adipose tissues in metabolic regulation

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Life Metabolism 2024年第2期3卷 9-23页

作者： Yang Liu Shu-Wen Qian Yan Tang Qi-Qun Tang Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences and Department of Endocrinology and Metabolism of Zhongshan HospitalFudan UniversityShanghai 200032China

In addition to their pivotal roles in energy storage and expenditure,adipose tissues play a crucial part in the secretion of bioactive molecules,including peptides,lipids,metabolites,and extracellular vesicles,in response to physiological stimulation and met-abolic *** secretory factors,through autocrine and paracrine mechanisms,regulate various processes within adipose *** processes include adipogenesis,glucose and lipid metabolism,inflammation,and adaptive thermogenesis,all of which are essential for the maintenance of the balance and functionality of the adipose tissue micro-environment.A subset of these adipose-derived secretory factors can enter the circulation and target the distant tissues to regulate appetite,cognitive function,energy expenditure,insulin secretion and sensitivity,gluconeogenesis,cardiovascular remodeling,and exercise *** this review,we highlight the role of adipose-derived secretory factors and their signaling pathways in modulating meta-bolic ***,we delve into the alterations in both the content and secretion processes of these factors under various physiological and pathological conditions,shedding light on potential pharmacological treatment strategies for related diseases.

关键词： adipokines autocrine paracrine endocrine metabolic regulation

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Patient-centered care in diabetes care-concepts,relationships and practice

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World Journal of Diabetes 2024年第7期15卷 1417-1429页

作者： Tsung-Tai Chen Wei-Chih Su Mei-I Liu department of Public Health College of MedicineFu Jen Catholic UniversityNew Taipei 24205Taiwan department of Gastroenterology Taipei Tzu-Chi HospitalNew Taipei 23142Taiwan department of Pediatric endocrinology Mackay Children's HospitalTaipei 10449Taiwan

We still do not have comprehensive knowledge of which framework of patientcentered care(PCC)is appropriate for diabetes care,which elements of PCC are evidence-based,and the mechanism by which PCC elements are associated with outcomes through *** this review,we elaborate on these *** found that for diabetes care,PCC elements such as autonomy support(patient individuality),cooperation and collaboration(system-level approach),communication and education(behavior change techniques),emotional support(biopsychosocial approach),and family/other involvement and support are critically *** of these factors are directly associated with different patient outcomes and indirectly associated with outcomes through patient *** present the practical implications of these PCC elements.

关键词： Diabetes mellitus Patient-centered care Autonomy support Patient activation Patient adherence

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Could hydrogen gas be produced using human cells?

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Clean Energy 2024年第4期8卷 34-39页

作者： Tunc Catal Istanbul Protein Research-Application and Innovation Center(PROMER) Uskudar University 34662 UskudarIstanbulTürkiye department of Molecular Biology and genetics Uskudar University 34662 UskudarIstanbulTürkiye

Although fossil fuels are widely used to meet energy needs,intensive research has been carried out in recent years on hydrogen production from renewable sources due to their decrease over time and environmental pollution *** cell technology is one of the promising current *** has been proven that various microorganisms produce energy through their natural metabolism,and that energy production is produced in biofuel cells by exoelectrogenic microorganisms that can transfer electrons to an electrode *** it has been stated that employing human cells to generate energy is feasible,it is unknown whether doing so would enable the production of *** the scope of this perspective article,the issue of hydrogen production in bioelectrolysis cells using human cells will be discussed for the first *** hydrogen production in bioelectrolysis cells using human cells is important in terms of contributing to hydrogen *** the scope of the article,promising human cell lines for hydrogen production are emphasized and hydrogen production potentials in bioelectrolysis cells using these cell lines are *** conclusion,some human cells can be used for hydrogen gas production in bioelectrolysis cells due to their bioelectrochemical and metabolic properties.

关键词： biofuel cells biotechnology hydrogen human cells

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Role of bisphosphonates in osteoporosis caused by adult growth hormone deficiency

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中南大学学报（医学版） 2024年第6期49卷 839-847页

作者： CHENG Zhiling LI Jie CHEN Zhongpei REN Wei department of endocrinology Chongqing Traditional Chinese Medicine HospitalChongqing 400011 department of endocrinology First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

In recent years,growth hormone and insulin-like growth factors have become key regulators of bone metabolism and remodeling,crucial for maintaining healthy bone mass throughout *** have shown that adult growth hormone deficiency leads to alterations in bone remodeling,significantly affecting bone microarchitecture and increasing fracture *** recombinant human growth hormone replacement therapy can mitigate these adverse effects,improving bone density,and reduce fracture risk,its effectiveness in treating osteoporosis,especially in adults with established growth hormone deficiency,seems *** inhibit bone resorption by targeting farnesyl pyrophosphate synthase in osteoclasts,and clinical trials have confirmed their efficacy in improving ***,for adult growth hormone deficiency patients with osteoporosis,the use of bisphosphonates alongside growth hormone replacement therapy is recommended.

关键词： growth hormone adult growth hormone deficiency osteoporosis bisphosphonates insulin-like growth factor 1 skeleton

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Emerging technological developments to address pest resistance in Bt cotton

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Journal of Cotton Research 2024年第3期7卷 318-333页

作者： NAGARAJ Selvarani RAJASEKARAN Ravikesavan PALANIAPPAN Jayamani RANGASAMY Selvakumar NARAYANASAMY Chitra NARAYANAN Manikanda Booapathi department of genetics and Plant Breeding Centre for Plant Breeding and Genetics(CPBG)Tamil Nadu Agricultural University(TNAU)Coimbatore 641003India Centre for Plant Breeding and genetics TNAUCoimbatore 641003India department of Pulses CPBGTNAUCoimbatore 641003India Research and Development Centre Rasi Seeds(P)Ltd.SalemAttur 636102India department of Cotton TNAUCoimbatore 641003India department of Plant Biotechnology Centre for Plant Molecular Biology and Biotechnology(CPMB&B)TNAUCoimbatore 641003India

Cotton plays a crucial role in shaping Indian economy and rural *** cotton crop is prone to numerous insect pests,necessitating insecticidal application,which increases production *** advent of the expression of Bacillus thuringiensis(Bt)insecticidal protein in cotton has significantly reduced the burden of pest without compromising environmental or human *** the introduction of transgenic cotton,the cultivated area expanded to 22 million hectares,with a 64% increase in adoption by farmers ***,Bt cotton accounts for 93% of the cultivated cotton area in ***,extensive use of Bt cotton has accelerated resistance development in pests like the pink ***,the overreliance on Bt cotton has reduced the use of broad-spectrum pesticides,favouring the emergence of secondary pests with significant *** emphasizes the urgent necessity for developing novel pest management *** high-dose and refuge strategy was initially effective for managing pest resistance in Bt cotton,but its implementation in India faced challenges due to misunderstandings about the use of non-Bt refuge *** gene pyramiding was introduced as a solution,combining mono toxin also led to instances of ***,there is a need for further exploration of biotechnological approaches to manage insect resistance in Bt *** biotechnological strategies,such as sterile insect release,RNA interference(RNAi)-mediated gene silencing,stacking Bt with RNAi,and genome editing using clustered regularly interspaced short palindromic repeats/CRISPR-associated protein(CRISPR-Cas),offer promising tools for identifying and managing resistance genes in ***,CRISPR-mediated gene drives and the development of novel biopesticides present potential avenues for effective pest management in cotton *** innovative approaches could significantly enhance the sustainability and efficacy of

关键词： Bt Cotton Gene pyramiding RNAi Modified toxin Genome editing Plant derived insecticidal protein Gene drive

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Mitochondrial DNA methylation and mitochondria-related epigenetics in neurodegeneration

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Neural Regeneration Research 2024年第2期19卷 405-406页

作者： Fabio Coppedè department of Translational Research and of New Surgical and Medical Technologies Laboratory of Medical GeneticsUniversity of PisaPisaItaly、Interdepartmental Research Center of Biology and Pathology of AgingUniversity of PisaPisaItaly

Mitochondria are cytoplasmic organelles referred to as the powerhouse of the cell because they are primarily involved in oxidative phosphorylation and energy *** are particularly abundant in tissues with high energy demands,including muscle,liver,and brain,and mitochondrial dysfunction,oxidative mitochondrial DNA(mtDNA)damage,and impaired mitochondrial dynamics have often been associated with neurodegeneration.

关键词： impaired neurodegeneration oxidative

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