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World Journal of Diabetes 2024年第6期15卷 1280-1290页

作者： Guang-An Li Jun Huang Li Fan department of echocardiography The Affiliated Changzhou Second People’s Hospital with Nanjing Medical UniversityChangzhou 213000Jiangsu ProvinceChina

BACKGROUND Peripheral vascular disease(PVD)is a common complication of type 2 diabetes mellitus(T2DM).Patients with T2DM have twice the risk of PVD as nondiabetic *** To evaluate left ventricular(LV)systolic function by layer-specific global longitudinal strain(GLS)and peak strain dispersion(PSD)in T2DM patients with and without *** Sixty-five T2DM patients without PVD,57 T2DM patients with PVD and 63 normal controls were enrolled in the ***-specific GLS[GLS of the epimyocardium(GLSepi),GLS of the middle myocardium(GLSmid)and GLS of the endocardium(GLSendo)]and PSD were *** operating characteristic(ROC)analysis was performed to calculate the sensitivity and specificity of LV systolic dysfunction in T2DM patients with *** calculated Pearson’s correlation coefficients between biochemical data,echocardiographic characteristics,and layer-specific GLS and *** There were significant differences in GLSepi,GLSmid and GLSendo between normal controls,T2DM patients without PVD and T2DM patients with PVD(PT2DM patients without PVD>T2DM patients with PVD in the absolute value of GLS(P<0.001).PSD differed significantly between the three groups,and the trend ranking was as follows:normal controls

关键词： Type 2 diabetes mellitus Peripheral vascular disease Speckle tracking echocardiography Global longitudinal strain Peak strain dispersion

Subclinical impairment of left ventricular myocardium function in type 2 diabetes mellitus patients with or without hypertension

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World Journal of Diabetes 2024年第6期15卷 1272-1279页

作者： Zeng-Guang Chen Guang-An Li Jun Huang Li Fan department of Cardiology The Affiliated Changzhou Second People’s Hospital with Nanjing Medical UniversityChangzhou 213000Jiangsu ProvinceChina department of echocardiography The Affiliated Changzhou Second People’s Hospital with Nanjing Medical UniversityChangzhou 213000Jiangsu ProvinceChina

BACKGROUND Cardiovascular disease has been the leading cause of morbidity and mortality for type 2 diabetes mellitus(T2DM)patients over the last *** To determine whether layer-specific global longitudinal strain(GLS)combined with peak strain dispersion(PSD)can be used to assess left ventricle(LV)myocardium systolic dysfunction in T2DM patients or without hypertension(HP).METHODS We enrolled 97 T2DM patients,70 T2DM+HP patients and 101 healthy ***-specific GLS and PSD were calculated by EchoPAC software in apical three-,four-and two-chamber *** of the epimyocardial,middle-layer and endomyocardial(GLSepi,GLSmid,and GLSendo)were measured and *** operating characteristic analysis was performed to detect LV myocardium systolic dysfunction in T2DM *** There were significant differences in GLSepi,GLSmid,GLSendo,and PSD between healthy subjects,T2DM patients and T2DM patients with HP(PT2DM patients>T2DM with HP patients in the absolute values of GLSepi,GLSmid and GLSendo(P<0.001),while PSD was ranked healthy subjects

关键词： Type 2 diabetes mellitus Hypertension Speckle tracking echocardiography Global longitudinal strain Peak strain dispersion

Implications of left atrial volume index in patients with three-vessel coronary disease:A 6.6-year follow-up cohort study

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Chinese Medical Journal 2024年第4期137卷 441-449页

作者： Ru Liu Lei Song Ce Zhang Lin Jiang Jian Tian Lianjun Xu Xinxing Feng Linyuan Wan Xueyan Zhao Ou Xu Chongjian Li Runlin Gao Rutai Hui Wei Zhao Jinqing Yuan department of Cardiology Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China department of Respiratory and Pulmonary Vascular Disease Fuwai Yunnan Cardiovascular HospitalKunmingYunnan 650102China department of Endocrinology Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China department of echocardiography Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China Information Center Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China

Background:Risk assessment and treatment stratification for three-vessel coronary disease(TVD)remain *** study aimed to investigate the prognostic value of left atrial volume index(LAVI)with the Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery(SYNTAX)score II,and its association with the long-term prognosis after three strategies(percutaneous coronary intervention[PCI],coronary artery bypass grafting[CABG],and medical therapy[MT])in patients with ***:This study was a post hoc analysis of a large,prospective cohort of patients with TVD in China,that aimed to determine the long-term outcomes after PCI,CABG,or optimal MT alone.A total of 8943 patients with TVD were consecutively enrolled between 2004 and 2011 at Fuwai Hospital.A total of 7818 patients with available baseline LAVI data were included in the ***,procedural,and follow-up data were *** primary endpoint was major adverse cardiac and cerebrovascular events(MACCE),which was a composite of all-cause death,myocardial infarction(MI),and *** endpoints included all-cause death,cardiac death,MI,revascularization,and ***-term outcomes were evaluated among LAVI quartile ***:During a median follow-up of 6.6 years,a higher LAVI was strongly associated with increased risk of MACCE(Q3:hazard ratio[HR]1.20,95%confidence interval[CI]1.06-1.37,P=0.005;Q4:HR 1.85,95%CI 1.64-2.09,P<0.001),all-cause death(Q3:HR 1.41,95%CI 1.17-1.69,P<0.001;Q4:HR 2.54,95%CI 2.16-3.00,P<0.001),and cardiac death(Q3:HR 1.81,95%CI 1.39-2.37,P<0.001;Q4:HR 3.47,95%CI 2.71-4.43,P<0.001).Moreover,LAVI significantly improved discrimination and reclassification of the SYNTAX score ***,there was a significant interaction between LAVI quartiles and treatment strategies for *** was associated with lower risk of MACCE than MT alone,regardless of LAVI *** patients in the fourth quartile,PCI was associated with significantly incre

关键词： Three-vessel coronary disease Left atrial volume index Coronary artery bypass grafting Percutaneous coronary intervention Myocardial ischemia Prognosis

First-in-human Results of the Novel Transcatheter Mitral Valve Repair System for Severe Mitral Regurgitation

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Cardiology Discovery 2024年第2期4卷 148-159页

作者： Zhi-Nan Lu Yutong Ke Yingnan Bian Jing He Wenhui Wu Xinmin Liu Yang Li Ran Liu Taiyang Luo Xunan Guo Guangyuan Song Interventional Center of vavular Heart Disease Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China echocardiography department Bejing Anzhen HospitalCapital Medical UniversityBeijing 100029China Research and Development department Enlight MedicalShanghai 201209China

Objective:To evaluate the feasibility,safety,and effectiveness of a novel edge-to-edge mitral valve repair system(the NovoClasp system)in patients with severe mitral ***:In this prospective,single-arm,first-in-human study conducted at Beijing Anzhen Hospital,data were collected from patients undergoing transcatheter edge-to-edge repair using the NovoClasp *** study candidates were patients exhibiting a mitral regurgitation severity of 3+or more and were at high-risk or contraindicated for surgical *** success and device success according to the Mitral Valve Academic Research Consortium definitions were used as primary *** safety and efficacy outcomes were prospectively assessed at device implantation,discharge,and 30 d,6 months,and 12 months ***:Between October 1,2021,and January 31,2022,11 patients were treated for moderate-to-severe(grade 3+)or severe(grade 4+)mitral regurgitation using the NovoClasp *** patients had a baseline New York Heart Association functional class oflll-lIV,with 7/11 exhibiting complex mitral valve *** patients achieved the primary endpoints of technical and device success,with a post-operative 30-d mitral regurgitation grade reduction to 2+or lower,which was maintained at 12 *** patient had minor bleeding and hematoma at the access site before discharge,and 2 patients were readmitted due to fast atrial fibrillation within 12 months *** additional cases of death,adverse cerebral or cardiovascular events,or device-related complications was observed during the ***:This study suggested the potential feasibility and safety of the NovoClasp system,showing a promising technical and device success rate,along with a decrease in mitral regurgitation severity.A further pivotal study is needed to assess the procedural and long-term outcomes.

关键词： Mitral valve insufficiency Transcatheter edge-to-edge repair Feasibility Safety

Mechanical Complications after Myocardial Infarction: A Comprehensive Review

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World Journal of Cardiovascular Diseases 2024年第1期14卷 43-60页

作者： Alexis D. Aparicio-Ortiz María Natalia Alonso-Jimenez Adrian Espejel-Guzman Aldo Cabello-Ganem Javier Serrano-Roman Santiago Luna-Alcala Nilda Espinola-Zavaleta department of Nuclear Cardiology National Institute of Cardiology Ignacio Chavez Mexico City Mexico department of echocardiography ABC Medical Center Mexico City Mexico

Mechanical complications of myocardial infarction are potentially fatal events that can occur after an acute myocardial infarction. While the introduction of primary percutaneous reperfusion and fibrinolysis has reduced the incidence of these complications to less than 1%. These complications pose significant hemodynamic consequences and necessitate prompt diagnosis. echocardiography, cardiac magnetic resonance imaging, and computed tomography are valuable tools for establishing an accurate and expedited diagnosis. Consequently, it is imperative to conduct further scientific research to enhance hemodynamic stabilization techniques such as intra-aortic balloon counterpulsation and extracorporeal membrane oxygenation, in addition to exploring new surgical procedures that can reduce mortality resulting from mechanical complications. This article aims to provide a comprehensive review of mechanical complications following myocardial infarction and their correlation with multi-imaging, facilitating a better understanding of these complications.

关键词： Infarction Mechanical Complications echocardiography Magnetic Resonance

Fabry Disease: Update, Focusing on Heart Disease by Multimodal Imaging

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World Journal of Cardiovascular Diseases 2024年第6期14卷 351-362页

作者： Adrian Espejel-Guzman Emily Rodríguez Valente Fernandez-Badillo Javier Serrano-Roman Aldo Cabello-Ganem Alexis Daniel Aparicio-Ortiz Alberto Ramon-Rios Mariali Palacios-Cruz Nilda Espinola-Zavaleta department of Nuclear Cardiology. National Institute of Cardiology Ignacio Chavez Mexico City Mexico ABC Medical Center IAP Department of Echocardiography Mexico City Mexico

Fabry disease (FD) is a rare X-linked lysosomal accumulation disorder caused by a deficiency in the enzyme alpha-galactosidase A (Gal A), resulting in excessive storage of glycosphingolipids, particularly globotriaosylceramide (Gb3). This leads to cellular dysfunction in various organs, with cardiovascular compromise being the major cause of morbidity and mortality. This study aimed to provide a comprehensive overview of FD focusing on its genetic, epidemiological, clinical, diagnostic, and therapeutic aspects. This study explored the genetic mutations associated with FD, its epidemiology, clinical phenotypes, cardiac manifestations, diagnostic approaches, and current treatment options. Background: FD is caused by mutations in GLA on the X chromosome, with over 1000 identified variants. Neonatal screening and specific studies have shown an increased incidence of FD. The clinical presentation varies between classic and late phenotypes, with cardiac involvement being a major concern, particularly in late-onset FD. Purpose: This study aimed to summarize the current knowledge on FD, emphasizing cardiac involvement, diagnostic modalities, and treatment options. Methods: A literature review of relevant studies on FD, including genetics, epidemiology, clinical presentation, diagnostic methods, and treatment options, was conducted. Results: Cardiac manifestations of FD included left ventricular hypertrophy (LVH), heart failure, arrhythmias, and sudden death. Diagnostic approaches such as electrocardiography, echocardiography, and cardiac magnetic resonance imaging play crucial roles in the early detection and monitoring of cardiac involvement. Enzyme replacement therapy (ERT) and emerging treatments have shown promise in managing FD, although challenges remain. Conclusions: FD remains a challenging condition in cardiology, with under-diagnosis being a concern. Early detection and specific therapy are essential to improve patient outcomes. echocardiography and cardiac MRI ar

关键词： Fabry Disease Hypertrophic Cardiomyopathy echocardiography Cardiac Magnetic Resonance Imaging Enzyme Replacement Therapy

Vaccination against coronavirus disease 2019 in patients with pulmonary hypertension:A national prospective cohort study

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Chinese Medical Journal 2024年第6期137卷 669-675页

作者： Xiaohan Wu Jingyi Li Jieling Ma Qianqian Liu Lan Wang Yongjian Zhu Yue Cui Anyi Wang Cenjin Wen Luhong Qiu Yinjian Yang Dan Lu Xiqi Xu Xijie Zhu Chunyan Cheng Duolao Wang Zhicheng Jing department of Cardiology State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China department of echocardiography National Center for Cardiovascular DiseasesFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China department of Pulmonary Circulation Shanghai Pulmonary HospitalTongji University School of MedicineShanghai 200433China department of Cardiology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China department of Clinical Sciences Liverpool School of Tropical MedicineLiverpoolUnited Kingdom

Background:Coronavirus disease 2019(COVID-19)has potential risks for both clinically worsening pulmonary hypertension(PH)and increasing ***,the data regarding the protective role of vaccination in this population are still *** study aimed to assess the safety of approved vaccination for patients with ***:In this national prospective cohort study,patients diagnosed with PH(World Health Organization[WHO]groups 1 and 4)were enrolled from October 2021 to April *** primary outcome was the composite of PH-related major adverse *** used an inverse probability weighting(IPW)approach to control for possible confounding factors in the baseline characteristics of ***:In total,706 patients with PH participated in this study(mean age,40.3 years;mean duration after diagnosis of PH,8.2 years).All patients received standardized treatment for PH in accordance with guidelines for the diagnosis and treatment of PH in *** them,278 patients did not receive vaccination,whereas 428 patients completed the vaccination *** of the participants were infected with COVID-19 during our study ***,398 patients received inactivated severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccine,whereas 30 received recombinant protein subunit *** adjusting for baseline covariates using the IPW approach,the odds of any adverse events due to PH in the vaccinated group did not statistically significantly increase(27/428[6.3%]vs.24/278[8.6%],odds ratio=0.72,P=0.302).Approximately half of the vaccinated patients reported at least one post-vaccination side effects,most of which were mild,including pain at the injection site(159/428,37.1%),fever(11/428,2.6%),and fatigue(26/428,6.1%).Conclusions:COVID-19 vaccination did not significantly augment the PH-related major adverse events for patients with WHO groups 1 and 4 PH,although there were some tolerable side effects.A large-scale randomized controlled trial is warr

关键词： Coronavirus disease COVID-19 Pulmonary hypertension Vaccination

Pseudomonas aeruginosa-related effusive-constrictive pericarditis diagnosed with echocardiography:A case report

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World Journal of Clinical Cases 2022年第21期10卷 7577-7584页

作者： Jin-Ling Chen Dan-E Mei Cai-Gui Yu Zhi-Yu Zhao department of echocardiography Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

BACKGROUND Effusive-constrictive pericarditis(ECP)is an uncommon pericardial *** echocardiographic examination may provide helpful information not only for diagnosing but also for managing *** has various etiologies;however,Pseudomonas aeruginosa(***)infection has not been reported as a cause to ***,we present a rare case of ECP caused by *** infection,which was followed up using *** SUMMARY A 30-year-old man was admitted to our hospital with a 2-mo history of cough,dyspnea,bloating,palpitations,and lower-extremity *** patient was initially diagnosed with pericardial effusion by transthoracic *** of pericardial effusion was performed to relieve the clinical symptoms.A follow-up echocardiogram showed that the pericardial effusion had decreased;however,the right atrial pressure continued to increase,and signs of constrictive pericarditis were observed upon a more comprehensive ***,the diagnosis of ECP was established based on the comprehensive pre-and postpericardiocentesis echocardiographic *** urgent pericardectomy was subsequently performed,which significantly relieved the patient's clinical symptoms,and the signs of pericardial constriction on echocardiography *** effusion and pericardial culture showed growth of *** ECP induced by *** infection remains a rare *** presence of echocardiographic features of constrictive pericarditis after pericardiocentesis therapy is highly indicative of ECP.

关键词： Effusive-constrictive pericarditis Pseudomonas aeruginosa infection echocardiography Case report

echocardiography in the diagnosis of Shone’s complex and analysis of the causes for missed diagnosis and misdiagnosis

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World Journal of Clinical Cases 2022年第11期10卷 3369-3378页

作者： Ye-Dan Li Hong Meng Kun-Jing Pang Mu-Zi Li Nan Xu Hao Wang Shou-Jun Li Jun Yan department of echocardiography Fuwai HospitalBeijing 100037China department of Cardiovascular Surgery Fuwai HospitalBeijing 100037China

BACKGROUND Shone’s complex is a rare syndrome characterized by congenital left heart defects that can differ among the *** To use echocardiography in the diagnosis of Shone’s complex and analyze the causes of missed diagnosis and *** This was a retrospective study of patients who underwent echocardiography and repair surgery from February 14,2008,to November 22,*** patients were followed once a year at the outpatient clinic after *** Sixty-six patients were *** patients were 2.7(0.8-5.6)years of age,and 54.5%were ***(15.2%)had a history of heart *** most common heart defect was the Annulo-Leaflet mitral ring(ALMR)(50/66,75.8%),followed by coarctation of the aorta(CoA)(43/66,65.2%).The patients had a variety of combinations of *** two(3.0%)patients had all four *** of the patients had a family history of congenital heart *** preoperative echocardiographic findings were examined against the intraoperative *** missed an ALMR in 31 patients(47.0%),a parachute mitral valve(PMV)in one patient(1.5%),subaortic stenosis in one patient(1.5%),and CoA in two patients(3.0%).CONCLUSION echocardiography is an effective method to diagnose the Shone’s *** to this disease’s complexity and interindividual variability, Improving the understanding of thedisease can reduce misdiagnosis and missed diagnosis.

关键词： Shone’s syndrome Congenital heart disease Mitral valve echocardiography Left heart Misdiagnosis

Prenatal Diagnosis of an Apically Located Congenital Left Ventricular Aneurysm: A Rare Case

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Congenital Heart Disease 2024年第1期19卷 123-129页

作者： Yücel Kaya And Yavuz Hasan Berkan Sayal Büşra Tsakir Gökalp Kabacaoğlu Kadriye NilayÖzcan department of Perinatology Antalya Education and Research HospitalUniversity of Health SciencesAntalyaTurkey department of Perinatology Faculty of MedicineSüleyman Demirel UniversityIspartaTurkey

Congenital ventricular aneurysm is a very rare cardiac anomaly.A diagnosis can be made during the prenatal period using fetal *** study presents a very rare apically located left ventricular aneurysm case,and the relevant literature was reviewed and *** this case,a 35-year-old,gravida 2,parity 1 preg-nant woman at 24 weeks of gestation,displayed a wide aneurysmal image in the left ventricular apical wall on fetal *** was a 1.79 mm muscular ventricular septal defect at the apical region of the interven-tricular *** the course of the color Doppler ultrasonography examination,an aberrantﬁbrous band within the left ventricle and consequent turbulentﬂow during systole were *** baby,born via cesarean section at 37 weeks of gestation,is now in its postnatal seventh ***,during echocardiographic follow-ups,changes have been observed,including mild to moderate mitral insufﬁciency and a decrease in systolic *** theseﬁndings,the clinical condition remains *** is of great importance to use a multidis-ciplinary approach in managing these rare cases that could lead to potential adverse outcomes during the antena-tal or postnatal periods.

关键词： Heart aneurysm prenatal diagnosis echocardiography congenital heart defects left ventricle