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Association between QRS voltages and amyloid burden in patients with cardiac amyloidosis

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Chinese medical Journal 2024年第3期137卷 365-367页

作者： Jing-Hui Li Changcheng Li Yucong Zheng Kai Yang Yan Huang Huixin Zhang Xianmei Li Xiuyu Chen Linlin Dai Tian Lan Yang Sun Minjie Lu Shihua Zhao department of Magnetic Resonance imaging Fuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China department of Radiology Taian City Central Hospital(The Affiliated Taian City Central Hospital of Qingdao University)Tai’anShandong 271099China department of Radiology Tsinghua University HospitalTsinghua UniversityBeijing 100084China department of Radiology The Fifth People’s Hospital of Huai’anHuai’anJiangsu 223001China department of Radiology Geriatric Hospital of Nanjing Medical UniversityNanjingJiangsu 210000China department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China department of Pathology Fuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

To the Editor:Cardiac amyloidosis(CA)is an infiltrative cardiomyopathy characterized by extracellular deposition of misfolded insoluble amyloid fibrils.^([1])Electrocardiography(ECG)is an essential diagnostic test characterized by low QRS voltages in CA,observed in 20–74%of patients.^([2])Cipriani et al^([3])reported that low QRS voltages could independently predict cardiovascular *** the mechanisms underlying low QRS voltages in CA remain unclear.

关键词： amyloid patients death.

T2-weighted imaging-based radiomic-clinical machine learning model for predicting the differentiation of colorectal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 819-832页

作者： Hui-Da Zheng Qiao-Yi Huang Qi-Ming Huang Xiao-Ting Ke Kai Ye Shu Lin Jian-Hua Xu department of Gastrointestinal Surgery The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina department of Gynaecology and Obstetrics The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina department of Computed Tomography/Magnetic Resonance imaging The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Centre of Neurological and Metabolic Research The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Group of Neuroendocrinology Garvan Institute of Medical ResearchSydneyNSW 2010Australia

BACKGROUND The study on predicting the differentiation grade of colorectal cancer(CRC)based on magnetic resonance imaging(MRI)has not been reported *** a non-invasive model to predict the differentiation grade of CRC is of great *** To develop and validate machine learning-based models for predicting the differ-entiation grade of CRC based on T2-weighted images(T2WI).METHODS We retrospectively collected the preoperative imaging and clinical data of 315 patients with CRC who underwent surgery from March 2018 to July *** were randomly assigned to a training cohort(n=220)or a validation cohort(n=95)at a 7:3 *** were delineated layer by layer on high-resolution *** absolute shrinkage and selection operator regression was applied to screen for radiomic *** and clinical models were constructed using the multilayer perceptron(MLP)*** radiomic features and clinically relevant variables(selected based on a significance level of Pdiagnostic *** AUC of the radiomic-clinical model was 0.862(95%CI:0.796-0.927)in the training cohort and 0.761(95%CI:0.635-0.887)in the validation *** AUC for the radiomic model was 0.796(95%CI:0.723-0.869)in the training cohort and 0.735(95%CI:0.604-0.866)in the validation *** clinical model achieved an AUC of 0.7

关键词： Radiomics Colorectal cancer Differentiation grade Machine learning T2-weighted imaging

Staging liver fibrosis with various diffusion-weighted magnetic resonance imaging models

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World Journal of Gastroenterology 2024年第9期30卷 1164-1176页

作者： Yan-Li Jiang Juan Li Peng-Fei Zhang Feng-Xian Fan Jie Zou Pin Yang Peng-Fei Wang Shao-Yu Wang Jing Zhang department of Magnetic Resonance imaging The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina Second Clinical School Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Gansu Province Clinical Research Center for Functional and Molecular imaging The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina department of Hepatology The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina MR Scientific Marketing Siemens HealthineersXi’an 710065Shaanxi ProvinceChina

BACKGROUND Diffusion-weighted imaging(DWI)has been developed to stage liver ***,its diagnostic performance is inconsistent among ***,it is worth studying the diagnostic value of various diffusion models for liver fibrosis in one *** To evaluate the clinical potential of six diffusion-weighted models in liver fibrosis staging and compare their diagnostic *** This prospective study enrolled 59 patients suspected of liver disease and scheduled for liver biopsy and 17 healthy *** participants underwent multi-b value *** main DWI-derived parameters included Mono-apparent diffusion coefficient(ADC)from mono-exponential DWI,intravoxel incoherent motion model-derived true diffusion coefficient(IVIM-D),diffusion kurtosis imaging-derived apparent diffusivity(DKI-MD),stretched exponential model-derived distributed diffusion coefficient(SEM-DDC),fractional order calculus(FROC)model-derived diffusion coefficient(FROC-D)and FROC model-derived microstructural quantity(FROC-μ),and continuous-time random-walk(CTRW)model-derived anomalous diffusion coefficient(CTRW-D)and CTRW model-derived temporal diffusion heterogeneity index(CTRW-α).The correlations between DWI-derived parameters and fibrosis stages and the parameters’diagnostic efficacy in detecting significant fibrosis(SF)were assessed and *** CTRW-D(r=-0.356),CTRW-α(r=-0.297),DKI-MD(r=-0.297),FROC-D(r=-0.350),FROC-μ(r=-0.321),IVIM-D(r=-0.251),Mono-ADC(r=-0.362),and SEM-DDC(r=-0.263)were significantly correlated with fibrosis *** areas under the ROC curves(AUCs)of the combined index of the six models for distinguishing SF(0.697-0.747)were higher than each of the parameters alone(0.524-0.719).The DWI models’ability to detect SF was *** combined index of CTRW model parameters had the highest AUC(0.747).CONCLUSION The DWI models were similarly valuable in distinguishing SF in patients with liver *** combined index of CTRW paramet

关键词： Liver fibrosis Magnetic resonance imaging Diffusion-weighted magnetic resonance Liver biopsy Significant fibrosis

CT and MRI Findings of Intracranial Cavernous Hemangioma Malformation

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Journal of Clinical and Nursing Research 2024年第7期8卷 282-286页

作者： Guoping Zhang Xiaoli Chen Center of diagnostic medical imaging Shaanxi Provincial People’s HospitalXi’an 710068Shaanxi ProvinceChina department of Neurology Shaanxi Provincial People’s HospitalXi’an 710068Shaanxi ProvinceChina

Objective:To investigate the computed tomography(CT)and magnetic resonance imaging(MRI)features of cavernous hemangioma malformation(CHM)to enhance diagnostic ***:The CT and MRI findings and clinical information of 23 patients with CHM were retrospectively ***:CT examinations were conducted in 7 cases,while MRI was utilized in 23 ***,SWI was employed in 5 cases and enhanced imaging techniques were applied in 14 *** the observed lesions,20 cases presented with a singular lesion,whereas 3 cases exhibited multiple *** lesions were located in 8 frontal lobes,6 cerebellums,2 brainstems,6 temporal lobes,1 basal ganglia,3 parieto-occipital lobes,and 2 thalamus *** nodules appeared as quasi-circular lesions with clear or well-defined *** presented as isodense lesions on CT scans,with one lesion showing peritumoral *** MRI,T1-weighted imaging(T1WI)demonstrated isointense signals,while T2-weighted imaging(T2WI)showed isointense and hyperintense ***,10 lesions exhibited a low signal ring on ***-weighted imaging(DWI)revealed nodular or isointense low signals,while susceptibility-weighted imaging(SWI)displayed enlarged areas of low *** lesions underwent contrast-enhanced scanning,with 2 lesions showing no obvious enhancement,1 lesion demonstrating mild to moderate enhancement,and 11 lesions exhibiting significant ***,6 of these enhanced lesions were surrounded by small blood ***:Cavernous hemangioma malformation is more commonly found in individual *** alone lacks specificity,making it prone to misdiagnosis.A more comprehensive evaluation of cavernous hemangioma malformation can be achieved through a combination of MRI,DWI,SWI,and enhanced examination,providing valuable references for clinical assessment.

关键词： Cavernous hemangioma malformation Intracranial CT MRI Diagnosis

Reference values of carotid intima-media thickness and arterial stiffness in Chinese adults based on ultrasound radio frequency signal: A nationwide, multicenter study

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中华医学杂志(英文版) 2024年第15期137卷 1802-1810页

作者： Xing Changyang Xie Xiujing Wu Yu Xu Lei Guan Xiangping Li Fan Zhan Xiaojun Yang Hengli Li Jinsong Zhou Qi Mu Yuming Zhou Qing Ding Yunchuan Wang Yingli Wang Xiangzhu Zheng Yu Sun Xiaofeng Li Hua Zhang Chaoxue Zhao Cheng Qiu Shaodong Yan Guozhen Yang Hong Mao Yinjuan Zhan Weiwei Ma Chunyan Gu Ying Chen Wu Xie Mingxing Jiang Tianan Yuan Lijun department of Ultrasound Medicine Tangdu Hospital Air Force Medical University Xi’an Shaanxi China department of Ultrasound Medicine The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China department of Ultrasound Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China department of Ultrasound Xi’an Hospital of Traditional Chinese Medicine Xi’an Shaanxi China Ultrasound medical Diagnosis Center Shaanxi Provincial People’s Hospital Xi’an Shaanxi China department of Ultrasound Hospital of Northwestern Polytechnical University Xi’an Shaanxi China department of Ultrasound Xi’an No. Hospital The First Affiliated Hospital of Northwest University Xi’an Shaanxi China department of Ultrasound Diagnosis The Second Affiliated Hospital Xi’an Medical College Xi’an Shaanxi China department of Ultrasound Xi’an Gem Flower ChangQing Hospital Xi’an Shaanxi China department of Ultrasound The Second Affiliated Hospital of Xi’an Jiaotong University China Xi’an Shaanxi China department of Echocardiography First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang China department of Ultrasound Renmin Hospital of Wuhan University Wuhan Hubei China department of Ultrasound Yan’an Hospital The Affiliated Hospital of Kunming Medical University Kunming Yunnan China department of Ultrasound Yan’an University Xianyang Hospital Xianyang Shaanxi China department of Function Examination Beijing University of Chinese Medicine Third Affiliated Hospital Beijing China department of Ultrasound Xi’an Central Hospital Xi’an Shaanxi China Cadre’s Wards Ultrasound department Diagnostic Ultrasound Center First Hospital of Jilin University Changchun Jilin China department of Echocardiography Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University Urumqi Xinjiang China department of Ultrasound First Affiliated Hospital of Anhui Medical University Hefei

Background: Carotid intima-media thickness (IMT) and diameter, stiffness, and wave reflections, are independent and important clinical biomarkers and risk predictors for cardiovascular diseases. The purpose of the present study was to establish nationwide reference values of carotid properties for healthy Chinese adults and to explore potential clinical ***: A total of 3053 healthy Han Chinese adults (1922 women) aged 18-79 years were enrolled at 28 collaborating tertiary centers throughout China between April 2021 and July 2022. The real-time tracking of common carotid artery walls was achieved by the radio frequency (RF) ultrasound system. The IMT, diameter, compliance coefficient, β stiffness, local pulse wave velocity (PWV), local systolic blood pressure, augmented pressure (AP), and augmentation index (AIx) were then automatically measured and reported. Data were stratified by age groups and sex. The relationships between age and carotid property parameters were analyzed by Jonckheere-Terpstra test and simple linear regressions. The major clinical determinants of carotid properties were identified by Pearson’s correlation, multiple linear regression, and analyses of ***: All the parameters of carotid properties demonstrated significantly age-related trajectories. Women showed thinner IMT, smaller carotid diameter, larger AP, and AIx than men. The β stiffness and PWV were significantly higher in men than women before forties, but the differences reversed after that. The increase rate of carotid IMT (5.5 μm/year in women and 5.8 μm/year in men) and diameter (0.03 mm/year in both men and women) were similar between men and women. For the stiffness and wave reflections, women showed significantly larger age-related variations than men as demonstrated by steeper regression slopes (allP for age by sex interaction <0.05). The blood pressures, body mass index (BMI), and triglyceride levels were identified as major clinical determinants o

关键词： Intima-media thickness Arterial stiffness Reference values Ultrasound radio frequency signal Wave reflections

Stage at diagnosis of colorectal cancer through diagnostic route:Who should be screened?

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World Journal of Gastroenterology 2024年第10期30卷 1368-1376页

作者： Nobukazu Agatsuma Takahiro Utsumi Yoshitaka Nishikawa Takahiro Horimatsu Takeshi Seta Yukitaka Yamashita Yukari Tanaka Takahiro Inoue Yuki Nakanishi Takahiro Shimizu Mikako Ohno Akane Fukushima Takeo Nakayama Hiroshi Seno department of Gastroenterology and Hepatology Kyoto University Graduate School of MedicineKyoto 606-8507Japan department of Gastroenterology and Hepatology Japanese Red Cross Wakayama Medical CenterWakayama 640-8558Japan department of Health Informatics Kyoto University School of Public HealthKyoto 606-8501Japan Institute for Advancement of Clinical and Translational Science(iACT) Kyoto University HospitalKyoto 606-8507Japan medical Support Section Medical Affairs DivisionKyoto University HospitalKyoto 606-8507Japan

BACKGROUND Colorectal cancer(CRC)is a global health concern,with advanced-stage diagnoses contributing to poor *** efficacy of CRC screening has been well-established;nevertheless,a significant proportion of patients remain unscreened,with>70%of cases diagnosed outside *** identifying specific subgroups for whom CRC screening should be particularly recommended is crucial owing to limited resources,the association between the diagnostic routes and identification of these subgroups has been less *** the Japanese cancer registry,the diagnostic routes for groups discovered outside of screening are primarily categorized into those with comorbidities found during hospital visits and those with CRC-related *** To clarify the stage at CRC diagnosis based on diagnostic *** We conducted a retrospective observational study using a cancer registry of patients with CRC between January 2016 and December 2019 at two *** diagnostic routes were primarily classified into three groups:Cancer screening,follow-up,and *** early-stage was defined as Stages 0 or *** and univariate logistic regressions were exploited to determine the odds of early-stage diagnosis in the symptomatic and cancer screening groups,referencing the follow-up *** adjusted covariates were age,sex,and tumor *** Of the 2083 patients,715(34.4%),1064(51.1%),and 304(14.6%)belonged to the follow-up,symptomatic,and cancer screening groups,*** the 2083 patients,CRCs diagnosed at an early stage were 57.3%(410 of 715),23.9%(254 of 1064),and 59.5%(181 of 304)in the follow-up,symptomatic,and cancer screening groups,*** symptomatic group exhibited a lower likelihood of early-stage diagnosis than the follow-up group[P<0.001,adjusted odds ratio(aOR),0.23;95%confidence interval(95%CI):0.19-0.29].The likelihood of diagnosis at an early stage was similar between the follow-up and cancer screening gro

关键词： Colorectal neoplasms Cancer registry diagnostic route Cancer screening Stage at diagnosis

Research progresses of dual-layer spectral detector CT for preoperative evaluation on colorectal cancer

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中国医学影像技术 2024年第8期40卷 1262-1265页

作者： LI Pengqiang LIU Nianjun ZHANG Yanli WANG Yanfei LAN Jinhui REN Huling DOU Yu LEI Junqiang The First Clinical medical College of Lanzhou University Lanzhou 730000China department of Radiology the First Hospital of Lanzhou UniversityIntelligent Imaging Medical Engineering Research Center of Gansu ProvinceAccurate Image Collaborative Innovation International Science and Technology Cooperation Base of Gansu ProvinceRadiological Clinical Medicine Research Center of Gansu ProvinceIntelligent Imaging Medical Industry Technology Center of Gansu ProvinceLanzhou 730000China

Dual-layer spectral detector CT is a new spectrum CT imaging technology based on detector being able to obtain both images similar to true plain and spectral images in one time *** reconstructed multi-parameter spectral images can not only improve image quality,enhance tissue contrast,increase the visualization and detection ability of occult lesions,but also provide qualitative and quantitative analysis of the lesions,so as to provide more imaging information and multi-dimensional diagnostic *** research progresses of dual-layer spectral detector CT for preoperative evaluation on colorectal cancer were reviewed in this article.

关键词： colorectal neoplasms tomography,X-ray computed

Evaluation of medical Prescribers’ Theoretical Knowledge on medical imaging in the Northern Region of Burkina Faso

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Open Journal of Radiology 2024年第2期14卷 33-41页

作者： Some Milckisédek Judicaël Marouruana Ouedraogo Pakisba Ali Tankoano Aïda Ida Savadogo Habibou Kindo Bassirou Ouedraogo Nina-Astrid Bamouni Yomboé Abel Diallo Ousseini department of medical imaging Ouahigouya Regional University Hospital University of Ouahigouya Ouahigouya Burkina Faso department of medical imaging Souro Sanou University Hospital Nazi Boni University Bobo Dioulasso Burkina Faso department of medical imaging Bogodogo University Hospital Joseph Ki Zerbo University Ouagadougou Burkina Faso Workers Health Office Joseph Ki Zerbo University Ouagadougou Burkina Faso department of medical imaging Yalgado Oudraogo University Hospital Joseph Ki Zerbo University Ouagadougou Burkina Faso

Introduction: medical imaging is a medical specialty that involves producing images of the human body and interpreting them for diagnostic, therapeutic purposes, and for monitoring the progress of pathologies. We aimed to assess the theoretical knowledge of doctors and interns in medical imaging in the northern region of Burkina Faso. Methodology: This was a descriptive cross-sectional survey based on a self-administered questionnaire. Prescribers knowledge was estimated based on scores derived from questionnaire responses. Results: We collected 106 questionnaires out of 163, i.e. a participation rate of 65.03%. The average knowledge score was 81.71% for the contribution of medical imaging to patient management. It was 60.02% for the indications/counter-indications of radiological examinations and 72.56% for the risks associated with exposure to radiation during these examinations. The score was 59.83% for the methods used to select the appropriate radiological examination. As regards the completeness of the clinical and biological information on the forms requesting imaging examinations, the score was 96.65%. Specialist doctors had the highest overall level of knowledge (74.68%). Conclusion: Improved technical facilities, good initial and in-service training, and interdisciplinary collaboration will help to ensure that imaging tests are properly prescribed, leading to better patient care.

关键词： Theoretical Knowledge medical imaging Northern Region Burkina Faso

Mitigating the impact of mechanisms causing neuronal degeneration

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Neuroprotection 2024年第1期2卷 1-3页

作者： Xunming Ji Piotr Walczak Johannes Boltze Beijing Institute of Brain Disorders Capital Medical UniversityBejingChina Center for Advanced imaging Research Department of Diagnostic Radiology and Nuclear MedicineUniversity of MarylandBaltimoreMarylandUSA School of Life Sciences University of WarwickCoventryUK

Primary and secondary neurodegeneration is a pathological hallmark of numerous central nervous system(CNS)*** many mechanisms leading to neurodegeneration are well understood,previous approaches aiming at providing protection from neurodegeneration were often futile.A potential explanation may be that recent research discovered additional pathomechanisms leading to ***,simply targeting single neurodegenerative mechanisms may only have minor therapeutic *** multiple neurodegenerative mechanisms may be a more viable ***,the restoration of lost brain tissue turned out to be a very complex endeavor.1 Despite making some initial progress with the use of biocompatible scaffolds and hydrogels.

关键词： Alzheimer's disease extracellular vesicles intracranial pressure microglia neurodegeneration stem cells stress stroke vascular dementia