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SGLT2 inhibitor monotherapy alleviates hyperglycemia in heredity severe insulin resistance syndrome

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Chinese Medical Journal 2024年第11期137卷 1372-1374页

作者： Huixuan Wu Junaid Iqbal Long Li Hongli Jiang Chen Chao Meibiao Zhang Ou Li Houde Zhou department of Metabolism and endocrinology National Clinical Research Center for Metabolic DiseasesHunan Provincial Key Laboratory for Metabolic Bone DiseasesKey Laboratory of Diabetes ImmunologyMinistry of EducationThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China department of endocrinology and Metabolism The First People’s Hospital of HuaihuaHuaihuaHunan 418000China department of Metabolism and endocrinology San-Sui County Traditional Chinese Medicine HospitalQiandongnan Miao and Dong Autonomous PrefectureGuizhou 556000China

To the Editor:Hereditary severe insulin resistance syndrome(H-SIRS)shows a wide and variable clinical spectrum and results in severe complications in the endocrinological and cardiovascular *** treatments are recommended to control hyperglycemia in H-SIRS,including dietary intervention,insulin therapy,insulin sensitization,and recombinant human insulin-like growth factor-1(rhIGF-1)administration.[1]However,the heterogeneous etiology of H-SIRS leads to poor glycemic control in patients with different mutations,requiring multiple antihyperglycemic *** study described two cases diagnosed with H-SIRS and the treatment effect of multi-drug therapy and sodium-glucose cotransporter 2 inhibitor(SGLT2i)monotherapy.

关键词： SIRS cardiovascular clinical

Diabetic cardiomyopathy:Emerging therapeutic options

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World Journal of diabetes 2024年第8期15卷 1677-1682页

作者： Cornelius James Fernandez Sahana Shetty Joseph M Pappachan department of endocrinology&Metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom department of endocrinology Kasturba Medical CollegeManipal Academy of Higher EducationManipal 576104KarnatakaIndia department of endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom

Diabetic cardiomyopathy(DbCM)is a common but underrecognized complication of patients with diabetes mellitus(DM).Although the pathobiology of other cardiac complications of diabetes such as ischemic heart disease and cardiac autonomic neuropathy are mostly known with reasonable therapeutic options,the mechanisms and management options for DbCM are still not fully *** its early stages,DbCM presents with diastolic dysfunction followed by heart failure(HF)with preserved ejection fraction that can progress to systolic dysfunction and HF with reduced ejection fraction in its advanced stages unless appropriately *** from prompt control of DM with lifestyle changes and antidiabetic medications,disease-modifying therapy for DbCM includes prompt control of hypertension and dyslipidemia inherent to patients with DM as in other forms of heart diseases and the use of treatments with proven efficacy in HF.A basic study by Zhang et al,in a recent issue of the World Journal of diabetes elaborates the potential pathophysiological alterations and the therapeutic role of teneligliptin in diabetic mouse models with *** this preliminary basic study might help to improve our understanding of DbCM and offer a potential new management option for patients with the disease,the positive results from such animal models might not always translate to clinical practice as the pathobiology of DbCM in humans could be ***,such experimental studies can encourage more scientific efforts to find a better solution to treat patients with this enigmatic disease.

关键词： Diabetic cardiomyopathy Diabetic cardiomyopathy Heart failure Pathobiology Teneligliptin

Semi-volatile organic compounds in a museum in China:A non-targeted screening approach

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Science China(Technological Sciences) 2024年第9期67卷 2693-2705页

作者： SONG ZiDong NIAN LuYing SHI Meng REN XiaoPeng TANG Ming SHI AnMei HAN Ying LIU Min WANG LuYang ZHANG YinPing XU Ying FENG XiaoMeng department of Building Science Tsinghua UniversityBeijing 100084China Beijing Key Laboratory of Indoor Air Quality Evaluation and Control Beijing 100084China National Museum of China Beijing 100006China department of endocrinology Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China

Non-targeted analysis(NTA)was conducted to identify semi-volatile organic compounds(SVOCs)in a museum in China using the gas chromatography(GC)-Orbitrap-mass spectrometer(MS).Approximately 160 SVOCs were detected,of which 93 had not been reported in previous studies of museum *** of the detected SVOCs were found to be associated with the chemical agents applied in conservation treatment and the materials used in *** results of hierarchical cluster analysis(HCA)indicated a spatial variation of SVOCs in the indoor air in the museum,but there were no obvious temporal differences of SVOCs observed in indoor ***'s correlation analysis showed that several classes of SVOCs were well correlated,suggesting their common *** and plasticizers were found to be the primary sources of SVOC pollution detected in the *** with compounds in outdoor air,indoor SVOCs had a lower level of unsaturation and more portions of chemically reduced *** study is the first of its kind to comprehensively characterize SVOCs in a museum using an automated NTA approach with *** SVOCs identified in the current study are likely to be present in other similar museums;therefore,further examination of their potential impacts on cultural heritage artifacts,museum personnel,and visitors may be warranted.

关键词： non-target analysis high-resolution mass spectrometry semi-volatile organic compounds museum environment air pollutants

Influence of ear tags on the results of body composition analysis in mice

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Animal Models and Experimental Medicine 2024年第4期7卷 578-583页

作者： He Liu Yinghua Zhang Peng Zhang Weiping Teng Zhongyan Shan Yushu Li Dan Wang department of endocrinology and Metabolism and the Institute of endocrinology NHC Key Laboratory of Diagnosis and Treatment of Thyroid DiseasesThe First Hospital of China Medical UniversityShenyangChina School of Public Health China Medical University China Medical UniversityShenyangChina Shenyang Food and Drug Inspection Institute ShenyangChina

Background:The aim of this study was to investigate the influence of marking meth-ods on the outcomes of body composition analysis and provide guidance for the se-lection of marking methods in mouse body composition ***:Male C57BL/6J mice aged 6 weeks were randomly assigned for pre-and post-ear tagging *** body composition of the mice was measured using a small animal body composition analyzer,which provided measurements of the mass of fat,lean,and free ***,the mass of fat,lean and free fluid to body weight ratio was *** data analysis was conducted to obtain the range and coeffi-cient of variation in body composition measurements for each *** distribution of fat and lean tissue in the mice was also analyzed by comparing the fat-to-lean ***:(1)The mass of all body composition components in the ear tagging group was significantly lower than that in the control group.(2)There was a significant in-crease in the range and coefficient of variation of body composition measurements between the ear tagging group and the control group.(3)The fat-to-lean ratio in the ear tagging group was significantly lower than that in the control ***:Ear tagging significantly lowered the results of body composition analy-sis in mice and higher the results of measurement ***,ear tagging should be avoided as much as possible when conducting body composition analysis experi-ments in mice.

关键词： body composition analysis ear tagging labeling method stainless steel toe clipping

Bone marrow-derived mesenchymal stem cell-derived exosomeloaded miR-129-5p targets high-mobility group box 1 attenuates neurological-impairment after diabetic cerebral hemorrhage

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World Journal of diabetes 2024年第9期15卷 1979-2001页

作者： Yue-Ying Wang Ke Li Jia-Jun Wang Wei Hua Qi Liu Yu-Lan Sun Ji-Ping Qi Yue-Jia Song department of Pathology The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina department of endocrinology The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of *** role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patients with diabetes are *** this study,we investigated the regulation of BMSC-exo on hyperglycemia-induced *** To study the mechanism of BMSC-exo on nerve function damage after diabetes complicated with cerebral *** BMSC-exo were isolated from mouse BMSC *** was followed by transfection with microRNA-129-5p(miR-129-5p).BMSC-exo or miR-129-5poverexpressing BMSC-exo were intravitreally injected into a diabetes mouse model with ICH for in vivo analyses and were cocultured with high glucoseaffected BV2 cells for in vitro *** dual luciferase test and RNA immunoprecipitation test verified the targeted binding relationship between miR-129-5p and high-mobility group box 1(HMGB1).Quantitative polymerase chain reaction,western blotting,and enzyme-linked immunosorbent assay were conducted to assess the levels of some inflammation factors,such as HMGB1,interleukin 6,interleukin 1β,toll-like receptor 4,and tumor necrosis factorα.Brain water content,neural function deficit score,and Evans blue were used to measure the neural function of *** Our findings indicated that BMSC-exo can promote neuroinflammation and functional *** chip analysis of BMSC-exo identified miR-129-5p as the specific microRNA with a protective role in *** of miR-129-5p in BMSC-exo reduced the inflammatory response and neurological impairment in comorbid diabetes and ICH ***,we found that miR-129-5p had a targeted binding relationship with HMGB1 *** We demonstrated that BMSC-exo can reduce the inflammatory response after ICH with diabetes,thereby improving the neurological function of the brain.

关键词： Bone marrow mesenchymal stem cells Exosome Diabetic cerebral hemorrhage Neuroinflammation MicroRNA-129-5p High mobility group box 1

Autophagy-dependent ferroptosis may play a critical role in early stages of diabetic retinopathy

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World Journal of diabetes 2024年第11期15卷 2189-2202页

作者： Wen-Jie Sun Xue-Dong An Yue-Hong Zhang Shan-Shan Tang Yu-Ting Sun Xiao-Min Kang Lin-Lin Jiang Xue-Fei Zhao Qing Gao Hang-Yu Ji Feng-Mei Lian department of endocrinology Guang’anmen HospitalBeijing 100053China department of endocrinology Fangshan Hospital of Beijing University of Chinese MedicineBeijing 102400China department of endocrinology Changchun University of Chinese MedicineChangchun 130117Jilin ProvinceChina

Diabetic retinopathy(DR),as one of the most common and significant microvascular complications of diabetes mellitus(DM),continues to elude effective targeted treatment for vision loss despite ongoing enrichment of the understanding of its pathogenic mechanisms from perspectives such as inflammation and oxidative *** studies have indicated that characteristic neuroglial degeneration induced by DM occurs before the onset of apparent microvascular *** order to comprehensively grasp the early-stage pathological changes of DR,the retinal neurovascular unit(NVU)will become a crucial focal point for future research into the occurrence and progression of *** on existing evidence,ferroptosis,a form of cell death regulated by processes like ferritinophagy and chaperone-mediated autophagy,mediates apoptosis in retinal NVU components,including pericytes and ganglion ***-dependent ferroptosis-related factors,including BECN1 and FABP4,may serve as both biomarkers for DR occurrence and development and potentially crucial targets for future effective DR *** aforementioned findings present novel perspectives for comprehending the mechanisms underlying the early-stage pathological alterations in DR and open up innovative avenues for investigating supplementary therapeutic strategies.

关键词： Diabetic retinopathy diabetes mellitus Retinal neurovascular unit Autophagy-dependent ferroptosis Early stage Mechanisms

Obstructive sleep apnea:Overlooked comorbidity in patients with diabetes

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World Journal of diabetes 2024年第7期15卷 1448-1460页

作者： Eric D Tenda Joshua Henrina Jin H Cha Muhammad R Triono Ersananda A Putri Dahliana J Aristy Dicky L Tahapary Division of Respirology and Critical Care Department of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia Head of Research Group Artificial Intelligence and Digital Health Indonesian Medical Education and Research InstituteFaculty of Medicine University of IndonesiaDKI JakartaJakarta Pusat 10430Indonesia Division of endocrinology Metabolism and DiabetesDepartment of Internal MedicineFaculty of Medicine Universitas Indonesia-Cipto Mangunkusumo HospitalDKI JakartaJakarta Pusat 10430Indonesia

In this review article,we explore the interplay between obstructive sleep apnea(OSA)and type 2 diabetes mellitus(T2DM),highlighting a significant yet often overlooked *** delve into the pathophysiological links between OSA and diabetes,specifically how OSA exacerbates insulin resistance and disrupts glucose *** research examines the prevalence of OSA in diabetic patients and its role in worsening diabetes-related *** the importance of comprehensive management,including weight control and positive airway pressure therapy,the study advocates integrated approaches to improve outcomes for patients with T2DM and *** review underscores the necessity of recognizing and addressing OSA in diabetes care to ensure more effective treatment and better patient outcomes.

关键词： Obstructive sleep apnea Type 2 diabetes mellitus Macrovascular Microvascular Weight loss Positive airway pressure

diabetes and tuberculosis:An emerging dual threat to healthcare

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World Journal of diabetes 2024年第7期15卷 1409-1416页

作者： Sahana Shetty Joseph M Pappachan Cornelius James Fernandez department of endocrinology Kasturba Medical CollegeManipalManipal Academy of Higher EducationManipal 576104KarnatakaIndia department of endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom department of endocrinology&Metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom

Tuberculosis(TB)remains a huge global healthcare challenge even in the 21^(st) century though the prevalence has dropped in developed countries in recent *** mellitus(DM)is an important risk factor for the development and perpetuation of TB owing to the immune dysfunction in patients with *** coexistence of both diseases in the same individual also aggravates disease severity,complications,and chance of treatment failure because of gross immune alterations posed by DM as well as *** complex cellular and humoral immunological factors are involved in the dangerous interaction between TB and DM,some of which remain unknown even *** is highly important to identify the risk factors for TB in patients with DM,and vice versa,to ensure early diagnosis and management to prevent complications from this ominous *** their research study published in the recent issue of the World Journal of diabetes,Shi et al elaborate on the factors associated with the development of TB in a large cohort of DM patients from *** such research output from different regions of the world is expected to improve our knowledge to fight the health devastation posed by TB in patients with diabetes.

关键词： Tuberculosis diabetes mellitus Immune dysfunction Treatment failure Multi-drug resistant tuberculosis

Exploring the genetic basis of childhood monogenic diabetes

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World Journal of diabetes 2024年第9期15卷 1829-1832页

作者： Debmalya Sanyal department of endocrinology KPC Medical CollegeKolkata Pin 700032West BengalIndia School of Medicine University of New CastleCallaghan NSW 2308Australia

Monogenic diabetes is caused by one or even more genetic variations,which may be uncommon yet have a significant influence and cause diabetes at an early *** diabetes affects 1%to 5%of children,and early detection and genetically focused treatment of neonatal diabetes and maturity-onset diabetes of the young can significantly improve long-term health and *** etiology of monogenic diabetes in childhood is primarily attributed to genetic variations affecting the regulatory genes responsible for beta-cell *** rare instances,mutations leading to severe insulin resistance can also result in the development of *** diagnosed with specific types of monogenic diabetes,which are commonly found,can transition from insulin therapy to sulfonylureas,provided they maintain consistent regulation of their blood glucose *** have successfully devised materials and methodologies to distinguish individuals with type 1 or 2 diabetes from those more prone to monogenic *** screening with appropriate findings and interpretations is essential to establish a prognosis and to guide the choice of therapies and management of these interrelated *** review aims to design a comprehensive literature summarizing genetic insights into monogenetic diabetes in children and adolescents as well as summarizing their diagnosis and management.

关键词： Monogenic diabetes Genetic mutation Insulin resistance Beta-cell function diabetes mellitus