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Rapamycin Treatment Attenuates Angiotensin Ⅱ-induced Abdominal Aortic Aneurysm Formation via VSMC Phenotypic Modulation and Down-regulation of ERK1/2 Activity

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Journal of Huazhong University of science and Technology(Medical sciences) 2018年第1期38卷 93-100页

作者： Fei-fei LI Xiao-ke SHANG Xin-ling DU Shu CHEN department of cardiovascular Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

The aim of the present study is to address the effect of rapamycin on abdominal aortic aneurysm（AAA） and the potential mechanisms. A clinically relevant AAA model was induced in apolipoprotein E-deficient（ApoE-/-） mice, in which miniosmotic pump was implanted subcutaneously to deliver angiotensin Ⅱ（Ang Ⅱ） for 14 days. Male ApoE-/-mice were randomly divided into 3 groups： saline infusion, Ang Ⅱ infusion, and Ang Ⅱ infusion plus intraperitoneal injection of rapamycin. The diameter of the supra-renal abdominal aorta was measured by ultrasonography at the end of the infusion. Then aortic tissue was excised and examined by Western blotting and histoimmunochemistry. Ang Ⅱ with or without rapamycin treatment was applied to the cultured vascular smooth muscle cells（VSMCs） in vitro. The results revealed that rapamycin treatment significantly attenuated the incidence of Ang Ⅱinduced-AAA in ApoE-/-mice. Histologic analysis showed that rapamycin treatment decreased disarray of elastin fibers and VSMCs hyperplasia in the medial layer. Immunochemistry staining and Western blotting documented the increased phospho-ERKl/2 and ERK1/2 expression in aortic walls in Ang Ⅱ induced-AAA,as well as in human lesions. Whereas in the rapamycintreated group, decreased phospho-ERK1/2 expression level was detected. Moreover, rapamycin reversed Ang Ⅱ-induced VSMCs phenotypic change both in vivo and in vitro. Based on those results, we confirmed that rapamycin therapy suppressed Ang Ⅱ-induced AAA formation in mice, partially via VSMCs phenotypic modulation and down-regulation of ERK1/2 activity.

关键词： rapamycin abdominal aortic aneurysm angiotensin Ⅱ extracellular signal-regulated kinase vascular smooth muscle cells phenotypic modulation

Current Status of and Opinions on Heart Transplantation in China

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Current Medical science 2021年第5期41卷 841-846页

作者： Yong-feng SUN Zhi-wen WANG Jing ZHANG Jie CAI Feng SHI Nian-guo DONG department of cardiovascular Surgery Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

The purpose of this review is to provide a comprehensive update on recent advances in heart transplantation in *** advances in pharmacologic and device treatment of chronic heart failure,long-term morbidity and mortality remain high,and many patients progress to end-stage heart *** transplantation has become standard treatment for selected patients with end-stage heart failure,though challenges still ***,multiple advances over the past few years will improve the survival and quality-of-life of heart transplant *** article elaborates on the specific characteristics of heart transplantation in China,the current issues,development trends,and related experiences with heart transplantation in Wuhan Union Hospital.

关键词： heart transplant China current status

A new scorpion polypeptide enhances the binding of radiolabeled-ryanodine on ryanodine receptor in sarcoplasmic reticulum of rabbit skeletal muscle

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Chinese science Bulletin 1997年第2期42卷 147-151页

作者： Seiko Kawano Yoshiyuki Hirayama Masayasu Hiraoka Akihiko Kuniyasu Hitoshi Nakayama department of cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanDepartment of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanDepartment of Cardiovascular Diseases M R 1 Tokyo Medical and Dental University JapanFaculty of Pharmaceutical Science Hokkaido University Japan Faculty of Pharmaceutical Science Kumamoto University Japan

RYANODINE is a toxic alkaloid from the plant Ryania speciosa Vahl. It selectively binds to the Ca2+ release channel on skeletal and cardiac heavy sarcoplasmic reticulum （HSR） and has

关键词： scorpion Buthus martensi Karsch ryanodine receptor toxic polypeptide.

Genetic Analysis of Variants of the MYH6 Gene Promoter in Congenital Atrial Septal Defects

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Congenital Heart Disease 2023年第1期18卷 7-21页

作者： Ji-Yang Zuo Huan-Xin Chen Zhi-Gang Liu Qin Yang Guo-Wei He Clinical School of cardiovascular Disease Department of Cardiovascular SurgeryTEDA International Cardiovascular HospitalTianjin Medical UniversityTianjin300457China The Institute of cardiovascular Diseases&department of cardiovascular Surgery TEDA International Cardiovascular HospitalTianjin University&Chinese Academy of Medical SciencesTianjin300457China

Background:Atrial septal defect(ASD)is one of the common congenital heart *** MYH6 gene has a critical role in cardiac development but the role of MYH6 promoter variants in patients with ASD has not been ***:In 613 subjects including 320 ASD patients,we investigated the MYH6 gene promoter variants and verified the effect on gene expression by using cellular functional experiments and bioinformatics ***:Eleven variants were identified in the MYH6 gene promoter,of which four variants were found only in ASD patients,and two variants(g.3434G>C and g.4524C>T)were identified for the first *** functional experiments indicated that all four variants reduced the transcriptional activity of the MYH6 gene promoter(p<0.05).Subsequent analysis through the JASPAR(A database of transcription factor binding profiles)suggests that these variants may alter transcription factor binding sites,which may in turn lead to changes in myocardin subunit expression and ASD ***:Our study for the first time focuses on variants in the promoter region of the MYH6 gene in Chinese patients with ASD and the discovered variants have functional *** study provides new insights in the role of the MYH6 gene promoter region to better understand the genetic basis of ASD formation and facilitates clinical diagnosis.

关键词： Atrial septal defect MYH6 genetic variants congenital heart disease

Outcomes of Three Different Minimal Invasive Approaches for Secundum Atrial Septal Defect Closure: A Single Institute Experience

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Current Medical science 2021年第6期41卷 1225-1230页

作者： Hao HONG Long WU Xiao-ke SHANG Wei SU Nian-guo DONG department of cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective:The aims of this retrospective study were to investigate and evaluate the safety and efficacy of three approaches for closure of secundum atrial septal defect(ASD).Methods:In this study,we reviewed clinical data for transcatheter occlusion(TCO,n=63),transthoracic occlusion(TTO,n=55),and right anterolateral minithoracotomy(RALT,n=60)techniques used for ASD *** compared the safety and efficacy of the three ***:ASD size in the TTO group was similar to that in the RALT group(P=0.645)and significantly larger than that in the TCO group(P<***1).The RALT group had more non-central types of ASD than the TTO and TCO groups(P=O.019 and P<***1).The operative time in the TTO group was shorter than that in the TCO and RALT groups(P<***1 and P<0.001).The ventilation time and intensive care unit duration were shorter in the TTO group than in the RALT group(P<***1 and P<***1).Hospital duration in the TCO group was shorter than that in the TTO and RALT groups(P<***1 and P<***1).There were no residual shunt and mortality in any group in hospital or during *** was no significant difference in the incidence of total complications among the three groups(P=0.738).Conclusion:TCO,TTO,and RALT can be performed with favorable cosmetic and clinical results for closing *** patient selection is an important factor for successful *** techniques are promising alternatives to standard median sternotomy and merit additional study.

关键词： transcatheter occlusion transthoracic occlusion right anterolateral minithoracotomy secundum atrial septal defect

Role of Neuroimmune Interactions in COVID-19-related cardiovascular Damage

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Current Medical science 2022年第3期42卷 555-560页

作者： Xing CHEN Wei-hua QIAO Hong CAO Jia-wei SHI Xin-ling DU Nian-guo DONG department of cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Coronavirus disease 2019(COVID-19)has caused a global pandemic impacting over 200 countries/regions and more than 200 million patients *** the infected patients,there is a high prevalence of COVID-19-related cardiovascular ***,the specific mechanisms linking cardiovascular damage and COVID-19 remain *** COVID-19 pandemic also has exacerbated the mental health burden of *** the close association between neuroimmune interactions and cardiovascular disease,this review assessed the complex pathophysiological mechanisms connecting neuroimmune interactions and cardiovascular *** was revealed that the mental health burden might be a pivotal accomplice causing COVID-19-associated cardiovascular ***,the proinflammatory status of patients with a terrible mood state is closely related to overdrive of the hypothalamus-pituitary-adrenal(HPA)axis,sympathovagal imbalance,and endothelial dysfunction,which lead to an increased risk of developing cardiovascular injury during ***,during the prevention and treatment of cardiovascular complications in COVID-19 patients,particular attention should be given to relieve the mental health burden of these patients.

关键词： neuroimmune interactions COVID-19 mental health burden autonomic nervous system endothelial dysfunction

Application of Endoscopic Vein Harvesting in Obese Patients Undergoing Coronary Artery Bypass Grafting

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Current Medical science 2018年第4期38卷 691-696页

作者： Peng BAI Yi-xuan WANG Si CHEN Jin-ping LIU Nian-guo DONG Jun-wei LIU department of cardiovascular Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

This study aims to evaluate the clinical outcomes of endoscopic vein harvesting （EVH） for coronary artery bypass grafting （CABG） in obese patients. Totally, 153 obese patients who underwent EVH （n=81） or standard bridging technique （SBT, n=72） in CABG surgery from May 2012 to October 2014 in our hospital were enrolled in this retrospective non-randomized controlled study. The general situation of operation, postoperative complications and short medium-term outcomes were analyzed. The baseline characteristics were similar between these two groups （P〉0.05）. There were no statistical differences in total operation time （226±28 min vs. 224±30 min, P〉0.05）, number of damaged vessels （0.12±0.05 vs. 0.16±0.06, P〉0.05） and short medium-term outcomes including revascularization rate （1.25% vs. 2.78%, P〉0.05）, vessel dysfunction rate （11.25% vs. 11.11%, P〉0.05） and mortality （0.00% vs. 0.00%, P〉0.05）. Use of EVH was associated with significant reduction of total harvesting time （41±6 min vs. 63±11 min, P〈0.05）, incision length （4.4±1.1 cm vs. 18.2±4.5 cm, P〈0.05） and postoperative lower extremity complications （P〈0.05）. EVH can reduce the risk of wound complications, whereas does not influence short- and medium-term outcomes in obese patients. It can be considered a reliable procedure of harvesting vessel conduits for obese patients undergoing CABG.

关键词： minimally invasive endoscopy saphenous vein harvesting obesity coronary artery bypass grafting

A nanoplatform with oxygen self-supplying and heat-sensitizing capabilities enhances the efficacy of photodynamic therapy in eradicating multidrug-resistant biofilms

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Journal of Materials science & Technology 2024年第2期169卷 209-219页

作者： Haixin Zhang Yi Zou Kunyan Lu Yan Wu Yuancheng Lin Jingjing Cheng Chunxia Liu Hong Chen Yanxia Zhang Qian Yu State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China department of cardiovascular Surgery of the First Affiliated Hospital and Institute for cardiovascular science Suzhou Medical College of Soochow UniversitySoochow UniversitySuzhou 215007China

Bacterial biofilms,especially those caused by multidrug-resistant bacteria,have emerged as one of the greatest dangers to global public *** acceleration of antimicrobial resistance to conventional an-tibiotics and the severe lack of new drugs necessitates the development of novel agents for biofilm *** therapy(PDT)is a promising non-antibiotic method for treating bacterial ***,its application in biofilm eradication is hampered by the hypoxic microenvironment of biofilms and the physical protection of extracellular polymeric *** this study,we develop a composite nanoplatform with oxygen(O_(2))self-supplying and heat-sensitizing capabilities to improve the PDT efficacy against ***_(2)/ICG@PDA nanoparticles(CIP NPs)are fabricated by combining calcium peroxide(CaO_(2))with the photosensitizer indocyanine green(ICG)via electrostatic interactions,followed by coating with polydopamine(PDA).The CIP NPs can gradually generate O_(2)in response to the acidic microenvironment of the biofilm,thereby alleviating its hypoxic *** near-infrared(NIR)irradiation,the nanoplatform converts O_(2)into a significant amount of singlet oxygen(^(1)O_(2))and heat to eradicate *** generated heat enhances the release of O_(2),accelerates the generation of^(1)O_(2)in PDT,increases cell membrane permeability,and increases bacterial sensitivity to^(1)O_(2).This nanoplatform significantly improves the efficacy of PDT in eradicating biofilm-dwelling bacteria without fostering drug *** on biofilm eradication demonstrate that this nanoplatform can eradicate over 99.9999%of methicillin-resistant Staphylococcus aureus(MRSA)biofilms under 5-min NIR ***,these integrated advantages enable the system to promote the healing of MRSA biofilm-infected wounds with negligible toxicity in vivo,indicating great promise for overcoming the obstacles associated with bacterial biofilm eradication.

关键词： Bacterial biofilm Multidrug-resistant bacteria Photodynamic therapy Oxygen supplying Photothermal therapy

Injectable decellularized extracellular matrix hydrogel loaded with exosomes encapsulating curcumin for prevention of cardiac fibrosis after myocardial infarction

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Journal of Materials science & Technology 2023年第36期167卷 50-58页

作者： Yuanyuan Wang Jingjing Wang Chunxia Liu Jingjing Li Kunyan Lu Qian Yu Yanxia Zhang Zhenya Shen department of cardiovascular Surgery of the First Affiliated Hospital and Institute for cardiovascular science Suzhou Medical College of Soochow UniversitySoochow UniversitySuzhou 215007China State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China

Excessive cardiac fibrosis impairs cardiac repair after myocardial infarction(MI).In this work,an in-jectable composite hydrogel integrating natural biomaterials,exosomes,and bioactive molecules is de-veloped to prevent or alleviate cardiac ***,a natural molecule with antifibrotic activity,is encapsulated in the exosomes that are isolated from bone marrow-derived mesenchymal stem cells to enhance its water solubility and *** composite exosomes are efficiently internalised by fibroblasts and effectively inhibit their transition to myofibroblasts in *** porcine cardiac extracellular matrix(dECM)hydrogel is used as the carrier for delivering these composite exosomes to the infarcted myocardium,not only improving the retention of exosomes but also providing mechani-cal support and structural *** of this hydrogel into the infarcted heart of a mouse MI model leads to a decrease in collagen deposition,alleviation of fibrosis,a reduction in infarct size,and an improvement in cardiac *** reported composite hydrogel comprising natural materials and biomolecules exhibits good biocompatibility and ***,this study demonstrates that the dECM hydrogel is a suitable platform for the local delivery of antifibrotic biomolecule-encapsulating exo-somes to prevent myocardial fibrosis after MI and have great potential for the treatment of MI in clinical settings.

关键词： Myocardial fibrosis Myocardial infarction Decellularized extracellular matrix Exosomes Curcumin