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serum tumor markers expression(CA199,CA242,and CEA)and its clinical implications in type 2 diabetes mellitus

World Journal of Diabetes 2024年第2期15卷 232-239页

作者： Mei Meng Li-Li shi department of Endocrinology Hefei BOE HospitalHefei 230013Anhui ProvinceChina department of cadre ward The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Glucose and lipid metabolic disorder in patients with type 2 diabetes mellitus(T2DM)is associated with the levels of serum tumor markers of the digestive tract,such as cancer antigen(CA)***,tumor markers in T2DM are *** To evaluate the expression of serum tumor markers[CA199,CA242,and carcinoembryonic antigen(CEA)]and the clinical implications of the expression in *** For this observational study conducted at Hefei BOE Hospital,China,we enrolled 82 patients with first-onset T2DM and 51 controls between April 2019 and December *** of fasting blood glucose(FBG),tumor markers(CA199,CEA,and CA242),glycosylated hemoglobin(HbA1c),*** measured and group index levels were ***,FBG and HbA1c levels were correlated with tumor marker *** markers were tested for diagnostic accuracy in patients with>9%HbA1c using the receiver operating curve(ROC)*** The T2DM group had high serum FBG,HbA1c,CA199,and CEA levels(Psis of the two groups based on HbA1c levels(Group A:HbA1c≤9%;Group B:HbA1c>9%)revealed significant differences in CEA and CA199 levels(Ps under the ROC curve for CEA and CA199 were 0.853 and 0.809,***199,CEA,and CA242 levels positively correlated with HbA1c(r=0.308,0.426,and 0.551,respectively)and FBG levels(r=0.236,0.231,and 0.298,respectively).CONCLUsION As compared to controls,serum CEA and CA199 levels were higher in patients with ***1c and FBG levels correlated with CA199,CEA,and CA242 *** with poorly controlled blood sugar must be screened for tumor markers.

关键词： Type 2 diabetes mellitus Carcinoembryonic antigen Cancer antigen 199 Cancer antigen 242 Glycosylated hemoglobin

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Effect of a systemic intervention combined with a psychological intervention in stroke patients with oropharyngeal dysfunction

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World Journal of Psychiatry 2024年第6期14卷 904-912页

作者： Jie song Jian-Dong Wang Di Chen Jing Chen Jin-Feng Huang Mao Fang second ward Department of NeurologyThe Second Affiliated Hospital of Qiqihar Medical CollegeQiqihar 161006Heilongjiang ProvinceChina Third ward Department of NeurologyThe Second Affiliated Hospital of Qiqihar Medical CollegeQiqihar 161006Heilongjiang ProvinceChina

BACKGROUND stroke frequently results in oropharyngeal dysfunction(OD),leading to difficulties in swallowing and eating,as well as triggering negative emotions,malnutrition,and aspiration pneumonia,which can be detrimental to ***,routine nursing interventions often fail to address these issues *** and psychological interventions can improve dysphagia symptoms,relieve negative emotions,and improve quality of ***,there are few clinical reports of systemic interventions combined with psychological interventions for stroke patients with *** To explore the effects of combining systemic and psychological interventions in stroke patients with *** This retrospective study included 90 stroke patients with OD,admitted to the second Affiliated Hospital of Qiqihar Medical College(January 2022–December 2023),who were divided into two groups:regular and *** function grading(using a water swallow test),swallowing function[using the standardized swallowing assessment(ssA)],negative emotions[using the selfrating anxiety scale(sAs)and self-rating depression scale(sDs)],and quality of life(sWAL-QOL)were compared between groups before and after the intervention;aspiration pneumonia incidence was *** Post-intervention,the coalition group had a greater number of patients with grade 1 swallowing function compared to the regular group,while the number of patients with grade 5 swallowing function was lower than that in the regular group(Pst-intervention,the ssA,sAs,and sDs scores of both groups decreased,with a more significant decrease observed in the coalition group(PsWAL-QOL score in both groups increased,with a more significant increase observed in the coalition group(Pspiration and aspiration pneumonia in the coalition group was lower than that in the control group(4.44%vs 20.00%;PsION systemic int

关键词： stroke Oropharyngeal dysfunction systemic interventions Psychological intervention Curative effect Negative emotion

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Ketogenic diet therapy in children with epilepsy caused by sLC2A1 mutations:a single-center single-arm retrospective study

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World Journal of Pediatrics 2024年第5期20卷 517-524页

作者： Ying-Yan Wang Yun-Qing Zhou Li-Juan Luo Cui-Jin Wang Nan shen Hao Li Ji-Wen Wang department of Neurology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina department of Infectious Diseases Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Clinical Research ward Clinical Research CenterShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background This retrospective study assessed the efficacy and safety of ketogenic diet therapies in children with epilepsy caused by sLC2A1 genetic mutations and glucose transporter type 1 deficiency *** Pediatric patients with epilepsy symptoms admitted to our medical center between January 2017 and October 2021 were included if they presented with an sLC2A1 genetic mutation on whole-exome *** analyzed the patients’convulsions and treatment with antiepileptic *** patients were followed up at different time periods after ketogenic diet *** six patients with sLC2A1 mutations were included in this *** patients had seizures of different types and frequencies,and they took antiepileptic drugs to relieve their *** were then treated with a ketogenic diet for at least four *** analyzed epilepsy control rates at 1,2,3,6,and 12 months after ketogenic diet *** patients were seizure-free within a month of receiving the diet *** patients were followed up for six months,three were followed up for 12 months after the treatment,and there was no recurrence of epilepsy during this *** antiepileptic drug withdrawal,none of the patients experienced seizure relapse when receiving ketogenic diet treatment *** severe adverse events occurred during the *** Ketogenic diet therapy is very effective and safe for the treatment of epilepsy caused by sLC2A1 ***,patients with glucose transporter type 1 deficiency syndrome caused by sLC2A1 mutations should begin ketogenic diet treatment as soon as possible.

关键词： Epilepsy Glucose transporter type 1 Ketogenic diet sLC2A1

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Expression level of myocardial enzymes in patients with schizophrenia: Predictive value in the occurrence of violence

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World Journal of Psychiatry 2024年第9期14卷 1346-1353页

作者： Wei-Min He Xin-Yuan Zhang Wei-Gen Xie Dan-Ping Lv Qun-Di shen department of Rehabilitation ward Shaoxing Seventh People's HospitalShaoxing 312000Zhejiang ProvinceChina department of Laboratory Shaoxing Seventh People's HospitalShaoxing 312000Zhejiang ProvinceChina department of Medical Shaoxing Seventh People's HospitalShaoxing 312000Zhejiang ProvinceChina department of General Affairs Shaoxing Seventh People's HospitalShaoxing 312000Zhejiang ProvinceChina

BACKGROUND schizophrenic patients are prone to violence,frequent recurrence,and difficult to *** and behavioral abnormalities during the onset of the disease,resulting in active myocardial enzyme *** To explored the expression level of myocardial enzymes in patients with schizo-phrenia and its predictive value in the occurrence of *** A total of 288 patients with schizophrenia in our hospital from February 2023 to January 2024 were selected as the research object,and 100 healthy people were selected as the control ***’information,clinical data,and labo-ratory examination data were *** to Modified Overt Aggression scale score,patients were further divided into the violent(123 cases)and non-violent group(165 cases).REsULTs The comparative analysis revealed significant differences in serum myocardial enzyme levels between patients with schizophrenia and healthy *** the schizophrenia group,the violent and non-violent groups also exhibited different levels of serum myocardial *** levels of myocardial enzymes in the non-violent group were lower than those in the violent group,and the patients in the latter also displayed aggressive behavior in the *** Previous aggressive behavior and the level of myocardial enzymes are of great significance for the diagnosis and prognosis analysis of violent behavior in patients with *** detecting changes in these indicators,we can gain a more comprehensive understanding of a patient’s condition and treatment.

关键词： schizophrenia Myocardial enzyme index Act of violence Predict Violence prediction Aggressive behavior Clinical data analysis Biochemical markers

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Problem-solving model guided by stimulus-organism-response theory:state of mind and coping styles of depressed mothers after cesarean delivery

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World Journal of Psychiatry 2024年第6期14卷 945-953页

作者： Rui-Fang Yuan Mei-Qin Jiang Juan Li Jing-Jing Zhang department of Gynecology and Obstetrics Jiangyin People's HospitalJiangyin 214400Jiangsu ProvinceChina department of Gynecology The Fifth People's Hospital of WuxiWuxi 214000Jiangsu ProvinceChina Obstetrics and Gynecology ward II Jiangnan University Affiliated HospitalWuxi 214131Jiangsu ProvinceChina

BACKGROUND The use of a problem-solving model guided by stimulus-organism-response(sOR)theory for women with postpartum depression after cesarean delivery may inform nursing interventions for women with postpartum *** To explore the state of mind and coping style of women with depression after cesarean delivery guided by sOR *** Eighty postpartum depressed women with cesarean delivery admitted to the hospital between January 2022 and October 2023 were selected and divided into two groups of 40 cases each,according to the random number table *** the control group,the observation group adopted the problem-solving nursing model under sOR *** two groups were consecutively intervened for 12 weeks,and the state of mind,coping styles,and degree of post-partum depression were analyzed at the end of the *** The Edinburgh Postnatal Depression scale and Hamilton Depression scale-24-item scores of the observation group were lower than in the control group after care,and the level of improvement in the state of mind was higher than that of the control group(Pss in the observation group after care(26.48±3.35)was higher than that in the control group(21.73±3.20),and the level of avoidance(12.04±2.68)and submission(8.14±1.15)was lower than that in the control group(15.75±2.69 and 9.95±1.20),with significant differences(PsION Adopting the problem-solving nursing model using sOR theory for postpartum depressed mothers after cesarean delivery reduced maternal depression,improved their state of mind,and coping level with illness.

关键词： stimulus-organism-response theory Problem solving model Cesarean section Postpartum depression

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Effect of cardiac rehabilitation care after coronary intervention on cardiac function recovery and negative mood in patients with myocardial infarction

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World Journal of Clinical Cases 2024年第1期12卷 59-67页

作者： Ming Yang Yuan-Tao Huang Xi-Wen Hu Chun-Ling Wu Division of Cardiovascular First ward Departments of Internal MedicineLiyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077Hubei ProvinceChina Division of Cardiovascular First ward Departments of Internal MedicineJianli People's HospitalJianli 433300Hubei ProvinceChina department of Integrated Traditional Chinese and Western Medicine People's Hospital of Dongxihu DistrictWuhan 430040Hubei ProvinceChina

BACKGROUND Cardiovascular disease,particularly myocardial infarction(MI)profound impact on patients'quality of life and places a substantial burden on the healthcare and economy *** in medical technology have led to the emer-gence of coronary intervention as an essential method for treating *** To assess the effects of cardiac rehabilitation care on cardiac function recovery and negative emotions in MI after coronary *** This study included a total of 180 patients with MI during the period from June 2022 to July *** patients were divided into two groups:An observation group,which receiving cardiac rehabilitation care;a control group,which re-ceiving conventional *** comparing multiple observation indicators such as cardiac function indicators,blood pressure,exercise tolerance,occurrence of adverse cardiac events,and negative emotion scores between the two groups of *** the data were analyzed and compared between two *** There were 44 males and 46 females in the observation group with an average age of 36.26±9.88 yr;there were 43 males and 47 females in the control group,with an average age of 40.87±10.5 *** receiving the appropriate postoperative nursing measures,the results of the observation group showed significant improvement in several indicators compared with the control *** of cardiac function,such as left ventricular end-diastolic internal diameter and left ventricular ejection fraction were significantly better in the observation group than in the control group(Pse endurance assessment showed that the 6-minute walking test distance was significantly increased in the patients of the observation group(Pse cardiac events was significantly lower in the observation group,and negative mood scores were significantly reduced(PsION Cardiac rehabilitation care after coronary intervention has a significant positive

关键词： Myocardial infarction Coronary artery intervention Cardiac rehabilitation Cardiac function recovery Negative emotions

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Ellagic acid inhibits gastric cancer cells by modulating oxidative stress and inducing apoptosis

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Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 162-169页

作者： Jian Zheng Chun-Feng Li department of Diagnostic Radiology Division Harbin Medical University Cancer HospitalHeilongjiangChina department of Gastrointestinal surgical ward Harbin Medical University Cancer HospitalHeilongjiangChina

Objective:To evaluate the anticancer effect of ellagic acid on gastric cancer ***:MTT assay was used to evaluate the effect of ellagic acid at different concentrations(0.5-100μg/mL)on gastric cancer AGs ***-qPCR and Western blot analyses were applied to assess apoptosis(BCL-2,CAsP-3,and BAX)and autophagy(LC3,ATG5,and BECN1)in AGs cells treated with ellagic *** expression of invasion-related markers including TP53,CDKN2A,and PTEN was *** addition,cell cycle markers including cyclin A,B,D,and E were measured by *** stress markers were evaluated using ***:Ellagic acid inhibited the proliferation of AGs cells in a concentration-and time-dependent *** expression of BCL-2 was significantly decreased(PsP-3 and BAX were markedly increased(Ps cells treated with ellagic ***,this compound induced no significant changes in the expression levels of LC3,ATG5,and BECN1(P>0.05).Moreover,the oxidative stress markers including sOD,TAC,and MDA were increased by ellagic acid(Psions:Ellagic acid can inhibit cell proliferation,induce apoptosis,and modulate oxidative stress in AGs ***,further in vivo and molecular studies are needed to verify its anticancer efficacy.

关键词： Ellagic acid Gastric cancer Apoptosis Autophagy Metastasis Proliferation

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survey and clinical considerations of gender identity in lower primary school children

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World Journal of Psychiatry 2024年第1期14卷 36-43页

作者： Ya-Lin Zhang Hong-Mei Zhang Jing-Xia Xu Qi-Ying Zhou He Wang Xiao-Cheng Pan department of Pediatrics Hangzhou Ninth People’s HospitalHangzhou 311225Zhejiang ProvinceChina department of Nursing Hangzhou Children’s HospitalHangzhou 310014Zhejiang ProvinceChina Pediatric Intensive Care Unit Hangzhou Children’s HospitalHangzhou 310014Zhejiang ProvinceChina Out-patient infection Hangzhou Children’s HospitalHangzhou 310014Zhejiang ProvinceChina Traditional Chinese Medicine ward Hangzhou Children’s HospitalHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Gender consciousness directly affects the development of gender identity,which is a continuous and lifelong ***,hospitalization is a part of many children's lives and has an impact on their gender *** To investigate the current situation of gender identity in lower primary school children by conducting a survey of 202 hospitalized children in the lower grades and to provide a theoretical basis and foundation for the cultivation of gender identity and medical treatment of children based on the *** study aims to inspire clinical medical staff to scientifically and reasonably arrange hospital wards for lower primary school children and pay attention to gender protection during the medical treatment process and to help children shape a unified and clear gender identity,which will enable them to better integrate into society and promote their personality *** The gender consciousness scale for elementary and middle school students was REsULTs Gender identity was already present in lower primary school *** children's gender roles and gender equality consciousness were strong,exceeding the critical value,but their gender characteristics,gender identity,and gender ideal consciousness were *** aged 6 had the weakest gender identity,and girls had significantly stronger gender identity than *** Gender identity is already present in lower primary school children,providing a basis and inspiration for the cultivation of gender identity and medical treatment of lower primary school *** medical staff should be aware of and understand these results and should scientifically and reasonably arrange hospital wards for lower primary school children.

关键词： school-age children Gender consciousness Gender identity Hospitalization Gender weakening

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Metabolic disorders and hepatitis: Insights from a Mendelian randomization study

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World Journal of Gastrointestinal surgery 2024年第6期16卷 1775-1790页

作者： Ling-Bo Liang Xiang-Ping Liu Ting-Rui Mao Qiao-Li su General Practice ward General Practice Medical CenterWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina department of Primary Health Care The Fourth People’s Hospital of Dazhu CountyDazhou 635100Sichuan ProvinceChina

BACKGROUND Hepatitis is a systemic disease that often results in various ***-bolic disorders,the most common comorbidities in clinical practice,were selected for this *** To investigate the causal relationship between comorbidities and hepatitis trea-tment *** A total of 23583378 single nucleotide polymorphisms from 1248743 cases and related summaries of genome-wide association studies were obtained from online public databases.A two-sample Mendelian randomization(MR)was performed to investigate causality between exposure[type 2 diabetes mellitus(T2D),hyperlipidemia,and hypertension]and outcome(chronic hepatitis B or C in-fections).REsULTs The data supported the causal relationship between comorbidities and hepatitis infections,which will affect the severity of hepatitis progression and will also provide a reference for clinical *** three exposures showed a link with progression of both hepatitis B(T2D,P=0.851;hyperlipidemia,P=0.596;and hypertension,P=0.346)and hepatitis C(T2D,P=0.298;hyperlipidemia,P=0.141;and hypertension,P=0.035).CONCLUsION The results of MR support a possible causal relationship between different ex-posures(T2D,hyperlipidemia,and hypertension)and chronic hepatitis progression;however,the potential mechanisms still need to be elucidated.

关键词： Hepatitis Comorbidity Type 2 diabetes mellitus Hyperlipidemia Hypertension

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Machine learning applications in stroke medicine:advancements,challenges,and future prospectives

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Neural Regeneration Research 2024年第4期19卷 769-773页

作者： Mario Daidone sergio Ferrantelli Antonino Tuttolomondo Internal Medicine and stroke Care ward Department of Health PromotionMother and Child CareInternal Medicine and Medical SpecialtiesUniversity of Palermo Molecular and Clinical Medicine PhD Program University of Palermo

stroke is a leading cause of disability and mortality worldwide,necessitating the development of advanced technologies to improve its diagnosis,treatment,and patient *** recent years,machine learning techniques have emerged as promising tools in stroke medicine,enabling efficient analysis of large-scale datasets and facilitating personalized and precision medicine *** abstract provides a comprehensive overview of machine learning’s applications,challenges,and future directions in stroke *** introduced machine learning algorithms have been extensively employed in all the fields of stroke *** learning models have demonstrated remarkable accuracy in imaging analysis,diagnosing stroke subtypes,risk stratifications,guiding medical treatment,and predicting patient *** the tremendous potential of machine learning in stroke medicine,several challenges must be *** include the need for standardized and interoperable data collection,robust model validation and generalization,and the ethical considerations surrounding privacy and *** addition,integrating machine learning models into clinical workflows and establishing regulatory frameworks are critical for ensuring their widespread adoption and impact in routine stroke *** learning promises to revolutionize stroke medicine by enabling precise diagnosis,tailored treatment selection,and improved *** research and collaboration among clinicians,researchers,and technologists are essential for overcoming challenges and realizing the full potential of machine learning in stroke care,ultimately leading to enhanced patient outcomes and quality of *** review aims to summarize all the current implications of machine learning in stroke diagnosis,treatment,and prognostic *** the same time,another purpose of this paper is to explore all the future perspectives these techniques can provide in combating this disabling dis

关键词： cerebrovascular disease deep learning machine learning reinforcement learning stroke stroke therapy supervised learning unsupervised learning

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