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Wafer‑Scale Ag_(2)S‑Based Memristive Crossbar Arrays with Ultra‑Low Switching‑Energies Reaching biological Synapses

Nano-Micro Letters 2025年第3期17卷 328-339页

作者： Yuan Zhu Tomas Nyberg Leif Nyholm Daniel Primetzhofer Xun Shi Zhen Zhang Division of Solid‑State Electronics Department of Electrical EngineeringUppsala University75121 UppsalaSweden department of Chemistry Uppsala UniversityUppsalaSweden department of Physics and Astronomy Uppsala UniversityUppsalaSweden State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China

Memristive crossbar arrays(MCAs)offer parallel data storage and processing for energy-efficient neuromorphic ***,most wafer-scale MCAs that are compatible with complementary metal-oxide-semiconductor(CMOS)technology still suffer from substantially larger energy consumption than biological synapses,due to the slow kinetics of forming conductive paths inside the memristive *** we report wafer-scale Ag_(2)S-based MCAs realized using CMOS-compatible processes at temperatures below 160℃.Ag_(2)S electrolytes supply highly mobile Ag+ions,and provide the Ag/Ag_(2)S interface with low silver nucleation barrier to form silver filaments at low energy *** further enhancing Ag+migration in Ag_(2)S electrolytes via microstructure modulation,the integrated memristors exhibit a record low threshold of approximately−0.1 V,and demonstrate ultra-low switching-energies reaching femtojoule values as observed in biological *** low-temperature process also enables MCA integration on polyimide substrates for applications in flexible ***,the intrinsic nonidealities of the memristive units for deep learning can be compensated by employing an advanced training *** impressive accuracy of 92.6%in image recognition simulations is demonstrated with the MCAs after the *** demonstrated MCAs provide a promising device option for neuromorphic computing with ultra-high energy-efficiency.

关键词： Wafer-scale Ag_(2)S films Reactive sputter Silver nucleation Ag^(+)migration Energy-efficient neuromorphic computing

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Therapeutic potential of Carum carvi in depression,memory loss,and hippocampal sclerosis reversal in temporal lobe epilepsy

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Traditional Medicine Research 2025年第3期10卷 1-7页

作者： Muhammad Wasim Syeda Arfa Mairaj Hasan Salman Siddiqi Mahwish Fatima Saara Ahmad Fazal Manzoor Arain department of biological and Biomedical sciences The Aga Khan UniversityKarachi 74800Pakistan Maternal and Children's Health Research Institute Shunde Women and Children's HospitalGuangdong Medical UniversityFoshan 528300China

Background:Epilepsy is a disease characterized by unprovoked seizures,and it affects around 70 million people *** treatment is ineffective in one third of all epilepsy *** Lobe Epilepsy with Hippocampal Sclerosis(TLE-HS)is the most drug-resistant form of epilepsy,and it also impacts physical,mental,and psychological well-being of *** carvi extract has demonstrated anti-convulsant,anti-depressant,and anxiolytic *** study was designed to investigate if Carum carvi extract can alleviate depression and memory loss symptoms in a TLE-HS animal ***:Male Sprague Dawley rats were used to create a model of TLE-HS and Carum carvi extract treatment,along with appropriate controls,was used to test the efficacy of this herbal extract in reducing the symptoms of depression and memory ***:Forced swim test showed that Carum carvi extract treated TLE-HS rats resulted in significant improvement of the symptoms of ***,novel object recognition test showed that memory improvement did not ***:Depression significantly impacts the quality of life in TLE-HS patients,and this study has shown that Carum carvi extract should be explored further as an adjuvant treatment for TLE-HS patients to improve their quality of life.

关键词： epilepsy Carum carvi depression memory loss hippocampal sclerosis

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Bioaccessibility and health risk assessment of hydrophobic organic pollutants in soils from four typical industrial contaminated sites in China

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Journal of Environmental sciences 2025年第1期147卷 282-293页

作者： Shi-Ping Ou Xiao-Liang Liao Zi-Tao Huang Yan-Cong Hu Zongwei Cai Zhi-Feng Chen Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and HealthSchool of Environmental Science and EngineeringGuangdong University of TechnologyGuangzhou 510006China State Key Laboratory of Environmental and biological Analysis Department of ChemistryHong Kong Baptist UniversityHong Kong 999077China

There have been reports of potential health risks for people from hydrophobic organic pollutants,such as polycyclic aromatic hydrocarbons(PAHs),polychlorinated hydrocarbons(PCHs),and organophosphate flame retardants(OPFRs).When a contaminated site is used for residential housing or public utility and recreation areas,the soil-bound organic pollutantsmight pose a threat to human *** this study,we investigated the contamination profiles and potential risks to human health of 15 PAHs,6 PCHs,and 12 OPFRs in soils from four contaminated sites in *** used an in vitro method to determine the oral bioaccessibility of soil *** PAHswere found at concentrations ranging from26.4 ng/g to 987 ng/***(0.27-14.3 ng/g)and OPFRs(6.30-310 ng/g)were detected,but at low levels compared to earlier *** levels of PAHs,PCHs,and OPFRs released from contaminated soils into simulated gastrointestinal fluids ranged from 1.74%to 91.0%,2.51%to 39.6%,and 1.37%to 96.9%,*** on both spiked and unspiked samples,we found that the oral bioaccessibility of pollutantswas correlated with their logKow andmolecularweight,and the total organic carbon content and pH of *** in 13 out of 38 contaminated soil samples posed potential high risks to *** considering oral bioaccessibility,nine soils still posed potential risks,while the risks in the remaining soils became *** contribution of this paper is that it corrects the health risk of soil-bound organic pollutants by detecting bioaccessibility in actual soils from different contaminated sites.

关键词： Contaminated soil Hydrophobic organic pollutant Polycyclic aromatic hydrocarbon Oral bioaccessibility Risk assessment

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Accurate simulation of surfaces and interfaces of ten FCC metals and steel using Lennard–Jones potentials

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npj Computational Materials 2021年第1期7卷 205-219页

作者： Krishan Kanhaiya Seonghan Kim Wonpil Im Hendrik Heinz department of Chemical and biological Engineering University of Colorado at BoulderBoulderCO 80301USA departments of biological sciences Chemistryand BioengineeringLehigh UniversityBethlehemPA 18015USA

The earlier integration of validated Lennard–Jones(LJ)potentials for 8 fcc metals into materials and biomolecular force fields has advanced multiple research fields,for example,metal–electrolyte interfaces,recognition of biomolecules,colloidal assembly of metal nanostructures,alloys,and *** we introduce 12-6 and 9-6 LJ parameters for classical all-atom simulations of 10 further fcc metals(Ac,Ca(α),Ce(γ),Es(β),Fe(γ),Ir,Rh,Sr(α),Th(α),Yb(β))and stainless *** parameters reproduce lattice constants,surface energies,water interfacial energies,and interactions with(bio)organic molecules in 0.1 to 5%agreement with experiment,as well as qualitative mechanical properties under standard *** are reduced up to a factor of one hundred in comparison to earlier Lennard–Jones parameters,embedded atom models,and density functional *** also explain a quantitative correlation between atomization energies from experiments and surface energies that supports parameter *** models are computationally very efficient and applicable to an exponential space of *** with a wide range of force fields such as the Interface force field(IFF),AMBER,CHARMM,COMPASS,CVFF,DREIDING,OPLS-AA,and PCFF enables reliable simulations of nanostructures up to millions of atoms and microsecond time ***-friendly model building and input generation are available in the CHARMM-GUI Nanomaterial *** a limitation,deviations in mechanical properties vary and are comparable to DFT *** discuss the incorporation of reactivity and features of the electronic structure to expand the range of applications and further increase the accuracy.

关键词： steel metals qualitative

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PAMPHLET:PAM Prediction HomoLogous-Enhancement Toolkit for precise PAM prediction in CRISPR-Cas systems

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Journal of Genetics and Genomics 2025年第2期52卷 258-268页

作者： Chen Qi Xuechun Shen Baitao Li Chuan Liu Lei Huang Hongxia Lan Donglong Chen Yuan Jiang Dan Wang Guangdong Provincial Key Laboratory of Interdisciplinary Research and Application for Data Science BNU-HKBU United International CollegeZhuhaiGuangdong 519087China School of Biology and biological Engineering South China University of TechnologyGuangzhouGuangdong 510006China BGI Research HangzhouZhejiang 310030China BGI Research ShenzhenGuangdong 518083China College of Life sciences University of Chinese Academy of SciencesBeijing 100049China Laboratory of Integrative Biomedicine Department of BiologyFaculty of ScienceUniversity of CopenhagenCopenhagenDenmark Qingdao-Europe Advanced Institute for Life sciences BGI ResearchQingdaoShandong 266555China School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China STOmics Americas Ltd. 2904 Orchard PkwySan Jose CA 95134USA

CRISPR-Cas technology has revolutionized our ability to understand and engineer organisms,evolving from a singular Cas9 model to a diverse CRISPR toolbox.A critical bottleneck in developing new Cas proteins is identifying protospacer adjacent motif(PAM)*** to the limitations of experimental methods,bioinformatics approaches have become ***,existing PAM prediction programs are limited by the small number of spacers in CRISPR-Cas systems,resulting in low *** address this,we develop PAMPHLET,a pipeline that uses homology searches to identify additional spacers,significantly increasing the number of spacers up to *** is validated on 20 CRISPR-Cas systems and successfully predicts PAM sequences for 18 *** predictions are further validated using the DocMF platform,which characterizes protein-DNA recognition patterns via next-generation *** high consistency between PAMPHLET predictions and DocMF results for Cas proteins demonstrates the potential of PAMPHLET to enhance PAM sequence prediction accuracy,expedite the discovery process,and accelerate the development of CRISPR tools.

关键词： CRISPR-Cas Protospacer adjacentmotif Genome editing PAM prediction Computational framework

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Establishment of goat mammary organoid cultures modeling the mammary gland development and lactation

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Journal of Animal Science and Biotechnology 2025年第1期16卷 193-205页

作者： Lei Jia Wenying Zhang Tao Luo Yongtao Li Jianhong Shu Julie Strand Yuan Yue Stig Purup Jianxin Liu Hengbo Shi Zhejiang Key Laboratory of Cow Genetic Improvement&Milk Quality Research Institute of Dairy ScienceCollege of Animal SciencesZhejiang UniversityHangzhou 310058China College of Life sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou 310018China department of Animal and Veterinary sciences Aarhus UniversityTjele DK‑8830Denmark Ministry of Education Key Laboratory of Molecular Animal Nutrition Zhejiang UniversityHangzhou 310058China

Background Although several cell culture systems have been developed to investigate the function of the mam-mary gland in dairy livestock,they have potential limitations,such as the loss of alveolar structure or genetic and phe-notypic differences from their native *** these challenges is crucial for lactation *** of protocols to establish lactating organoid of livestock represents a promising goal for the *** this study,we developed a protocol to establish a culture system for mammary organoids in dairy goats to model the mammary gland development and lactation *** The organoids cultured within an extracellular matrix gel maintained a bilayer structure that closely resem-bled the native architecture of mammary *** expansion of mammary organoids was significantly promoted by growth factors containing epidermal growth factor and fibroblast growth factor 2 whereas the proliferative index of the organoids was significantly inhibited by the treatment with WNT *** stimulation with a lactogenic medium containing prolactin,the mammary organoids exhibited efficient lactation,characterized by the accumu-lation of lipid droplets in the lumen *** lactation could be sustained for more than 3 ***,the expression patterns of genes related to fatty acid synthesis and milk proteins in lactating organoids closely mirrored those observed in mammary *** observations were confirmed by data from proteomic analysis that the bulk of milk proteins was produced in the lactating *** This study is the first to establish a mammary organoid culture system modeling the mammary gland development and lactation process in *** efficient induction of lactation in ruminant mammary organoids holds promises for advancing the field of cell-based milk bio-manufacture in the food industry.

关键词： Cell-based milk production Lactation Mammary gland Organoid

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Enhancing Plant Resilience to Biotic and Abiotic Stresses through Exogenously Applied Nanoparticles:A Comprehensive Review of Effects and Mechanism

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Phyton-International Journal of Experimental Botany 2025年第2期94卷 281-302页

作者： Jalil Ahmad Muhammad Munir Nashi Alqahtani Tahira Alyas Muhammad Ahmad Sadia Bashir Fasiha Qurashi Abdul Ghafoor Hassan Ali–Dinar Institute of Vegetables and Flowers Chinese Academy of Agricultural SciencesBeijing100081China Date Palm Research Center of Excellence King Faisal UniversityAl-Ahsa31982Saudi Arabia department of Food and Nutrition sciences College of Agricultural and Food SciencesKing Faisal UniversityAl-Ahsa31982Saudi Arabia department of Botany Lahore College for Women UniversityLahorePunjab54000Pakistan department of Plant Breeding and Genetics Faculty of Agricultural SciencesGhazi UniversityDera Ghazi Khan32200Pakistan department of Botany The Woman University Multan66000Pakistan department of biological sciences University of Veterinary and Animal SciencesLahore54000Pakistan Center for Water and Environmental Studies College of Agricultural and Food SciencesKing Faisal UniversityAl-Ahsa31982Saudi Arabia

A steady rise in the overall population is creating an overburden on crops due to their global *** the other hand,given the current climate change and population growth,agricultural practices established during the Green Revolution are no longer ***,innovative practices are the prerequisite of the time struggle with the rising global food *** potential of nanotechnology to reduce the phytotoxic effects of these ecological restrictions has shown significant ***(NPs)typically enhance plant resilience to stressors by fortifying the physical barrier,optimizing photosynthesis,stimulating enzymatic activity for defense,elevating the concentration of stress-resistant compounds,and activating the expression of genes associated with defense *** this review,we thoroughly cover the uptake and translocations of NPs crops and their potential valuable functions in enhancing plant growth and development at different growth ***,we addressed how NPs improve plant resistance to biotic and abiotic ***,this review presents a thorough understanding of the significance of NPs in plants and their prospective value for plant antioxidant and crop development.

关键词： Crop abiotic stress antioxidant biotic stress nanoparticles

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Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 199-200页

作者： Srishti Chawla Mikael Molin Thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden department of Life sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and *** biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate *** calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B shows 54%identity with calcineurin B from Saccharomyces cerevisiae.

关键词： activation dinuclear conserved

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Thymus serpyllum *** Oil:Phytochemistry and in Vitro and in Silico Screening of Its Antimicrobial,Antioxidant and Anti-Inflammatory Properties

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Phyton-International Journal of Experimental Botany 2025年第1期94卷 209-227页

作者： Samiah Hamad Al-Mijalli Hanae Naceiri Mrabti Amine Elbouzidi Naglaa S.Ashmawy Amine Batbat Emad M.Abdallah Wafa Laaboudi Mohammed Aladhadh Fahad M.Alshabrmi Sulaiman Mohammed Alnasser Mohamed Addi Naoufal El Hachlafi department of Biology College of SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia department of Pharmcology Laboratory of Epidemiology and Research in Health SciencesFaculty of MedicinePharmacy and DentistrySidi Mohamed Ben Abdellah UniversityFez30000Morocco Laboratoire d’Amélioration des Productions Agricoles Biotechnologie et Environnement(LAPABE)Facultédes SciencesMoroccodes SciencesUniversitéMohammed PremierOujda60000Morocco department of Pharmaceutical sciences College of PharmacyGulf Medical UniversityAjmanP.O.Box 4184United Arab Emirates department of Pharmacognosy Faculty of PharmacyAin Shams UniversityAbbassiaCairo11566Egypt Laboratory of Applied Organic Chemistry Faculty of Sciences and TechniquesSidi Mohamed Ben Abdellah UniversityImouzzer RoadFez30000Morocco department of Biology College of ScienceQassim UniversityQassim51452Saudi Arabia High Institute of Nursing Professions and Health Techniques Fez Fez30050Morocco department of Food Science and Human Nutrition College of Agriculture and FoodQassim UniversityBuraydah51452Saudi Arabia department of Medical Laboratories College of Applied Medical SciencesQassim UniversityBuraydah51452Saudi Arabia department of Pharmacology and Toxicology College of PharmacyQassim UniversityBuraydah52571Saudi Arabia Faculty of Medicine and Pharmacy Ibn Zohr UniversityGuelmim81000Morocco

Thymus serpyllum L.,often known as wild thyme,has been used since ancient times due to its multifaceted culinary and medicinal *** is usually utilized in folk medicine to manage different health *** work aimed to investigate the chemical composition and biological characteristics of *** essential oil(EO),including its antimicrobial,antioxidant,and anti-inflammatory ***,we have prompted an in-silico simulation to reveal the underlying mode of action of these *** chemical characterization of ***(EO)by Gas Chromatography-Mass Spectrometry(GC-MS)indicated sabinene(17.33%),terpinen-4-ol(11.73%),phellandral(13.18%),and thymol(10.54%)as main *** antimicrobial screening utilized the disc-diffusion technique,MIC,and MBC *** disc-diffusion test’s results revealed significant anti-Candida activity and notable antibacterial *** MIC and MBC tests showed that *** EO effectively stops bacterial growth,including Gram-positive and Gram-negative strains and Candida *** tolerance level ratio demonstrated that this EO exhibits bactericidal and fungicidal effects on all tested bacteria and Candida ***,*** EO presented effective inhibitory activity against the 5-lipoxygenase(5-LOX)enzyme(IC50=744.19±0.1µg/mL)(p<0.05).It also effectively affected FRAP,β-carotene,DPPH,and ABTS *** light of these findings,*** holds promise for diverse applications across pharmaceuticals,nutraceuticals,and the food ***,further research and collaboration between traditional knowledge and modern medicine are crucial to fully realizing its potential benefits in these fields.

关键词： Thymus serpyllum GC-MS antimicrobial oxidative stress anti-inflammatory in silico

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Unveiling the photocatalytic marvels:Recent advances in solar heterojunctions for environmental remediation and energy harvesting

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Journal of Environmental sciences 2025年第2期148卷 283-297页

作者： Najmeh Askari Mansoureh Jamalzadeh Aghil Askari Naiyun Liu Bijan Samali Mika Sillanpaa Leigh Sheppard Haitao Li Raf Dewil department of Chemical Engineering Process and Environmental Technology LabKU LeuvenDe Nayerlaan 5 Sint-Katelijne-Waver2860Belgium department of Plastics Engineering UMass LowellLowellMA 01851USA department of Mechanical Engineering UMass LowellLowellMA 01851USA Institute for Energy Research Jiangsu UniversityZhenjiang 212013China Centre for Infrastructure Engineering Western Sydney UniversityPenrith NSW2751Australia department of biological and Chemical Engineering Aarhus UniversityGustav Wieds Vej 108000 AarhusDenmark Solar Energy Technologies Research Group Western Sydney UniversityPenrith NSW2751Australia department of Engineering Science University of OxfordParks RoadOxfordOX13PJUnited Kingdom

In the quest for effective solutions to address *** meet the escalating energy demands,heterojunction photocatalysts have emerged as a captivating and versatile *** photocatalysts have garnered significant interest due to their wideranging applications,including wastewater treatment,air purification,CO_(2) capture,and hydrogen generation via water *** technique harnesses the power of semiconductors,which are activated under light illumination,providing the necessary energy for catalytic *** visible light constituting a substantial portion(46%)of the solar spectrum,the development of visible-light-driven semiconductors has become *** photocatalysts offer a promising strategy to overcome the limitations associated with activating semiconductors under visible *** this comprehensive review,we present the recent advancements in the field of photocatalytic degradation of contaminants across diverse media,as well as the remarkable progress made in renewable energy ***,we delve into the crucial role played by various operating parameters in influencing the photocatalytic performance of heterojunction ***,we address emerging challenges and propose novel perspectives to provide valuable insights for future advancements in this dynamic research *** unraveling the potential of heterojunction photocatalysts,this reviewcontributes to the broader understanding of their applications and paves the way for exciting avenues of exploration and innovation.

关键词： Heterojunction photocatalysts Solar photocatalysis Environmental depollution Energy conversion Visible-light-driven semiconductors

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