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Coexistence of adeno-associated virus 2 with adenovirus 18 or herpesvirus may be associated with severe lingual papillomatosis in an immunocompromised individual

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Virologica Sinica 2024年第4期39卷 705-707页

作者： Jie-Mei Yu Ze-Yin Liang Yuan-Hui Fu Xiang-Lei Peng Yan-Peng Zheng Yu-Jun Dong Jin-Sheng He College of Life sciences and bioengineering Beijing Jiaotong UniversityBeijing100044China department of Hematology Peking University First HospitalBeijing100034China

Dear Editor,Patients undergoing allogeneic hematopoietic stem cell transplantation(HSCT)often experience a significant reduction in immune function due to factors such as severe lymphopenia,immunosuppressive treatment,and the development of graft-versus-host disease,rendering them more susceptible to severe infections(Sahin et al.,2016).Traditional diagnostic approaches are limited in sensitivity,speed,and assay targets,thus failing short of meeting the diagnostic demands(Qu et al.,2022).However,next-generation sequencing(NGS)has greatly improved the accuracy and efficiency of diagnosing various diseases(Schuler et al.,2022),and has been widely utilized for pathogen detection in samples from HSCT patients(Armstrong et al.,2019;Peng et al.,2021).In this study,we employed viral metagenomics analysis using high-throughput sequencing on fecal and tissue samples from a patient with HSCT experiencing severe lingual papillomatosis.

关键词： al. papilloma rendering

Small activating RNA delivery in vivo:Challenges,prospects,and lessons learned from siRNA delivery

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Nano Research 2024年第10期17卷 8990-9002页

作者： Shalini Pandey Patrick T.Bednarz Matthias A.Oberli Omid Veiseh department of bioengineering William Marsh Rice UniversityHouston 77030USA Xibus Systems 199 Dexter AveWatertown 02472USA

Over the last two decades,small activating RNAs(saRNAs)have quickly moved from discovery to clinical *** as 20 nucleotide long,double stranded RNA,saRNAs have the unique ability to increase gene transcription at the chromatin *** therapeutic modality has great potential as a safe and redosable alternative to gene therapy by increasing target protein expression without changing the genetic *** describe the successful in vivo saRNA delivery vectors and found that similar to small interfering RNA(siRNA)and mRNA targeting tissues outside the liver works best at the end of a *** highlight nanoparticle vectors and RNA-conjugates,where some success has been reported for non-hepatic delivery of saRNAaptamers.

关键词： small activating RNA hepatic bias lipid nanoparticles RNA-conjugates

The Nano Research Young Innovators Awards in bio-inspired nanomaterials

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Nano Research 2024年第2期17卷 417-425页

作者： Jun Chen Shuotao Wang department of bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Nano Research Young Innovators(NR45)Awards are designed to acknowledge and celebrate the achievements of young researchers under 45 years of *** individuals have made significant contributions to the field of nanoscience and *** the inaugural NR45 Awards in 2018,the journal's editorial board has recognized over a hundred innovators specializing in nanobiotechnology,nano energy,two-dimensional materials,and *** focus of the 2023 NR45 Awards is on bioinspired nanomaterials,acknowledging thirty-three outstanding young innovators for their extraordinary contributions in developing these materials with applications spanning clean energy,human healthcare,monitoring,and disease treatments,as shown in *** extend our heartfelt congratulations to all the 33 NR45 Awardees in 2023!

关键词： journal materials contributions

Utilization of pH-driven methods to fortify nanoemulsions with multiple polyphenols

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Food Science and Human Wellness 2024年第4期13卷 1943-1950页

作者： Hualu Zhou Bingjing Zheng David Julian McClements department of Food Science and Technology College of Agricultural and Environmental SciencesUniversity of GeorgiaGriffinGA 30223USA Biopolymers and Colloids Laboratory Department of Food ScienceUniversity of MassachusettsAmherstMA 01003USA department of Food Science&bioengineering Zhejiang Gongshang UniversityHangzhou 310018China

Simple but effective methods are required to incorporate multiple bioactive polyphenols into delivery systems to increase their dispersibility,stability and *** developed and tested three p Hdriven protocols for creating nanoemulsions loaded with multiple lipophilic *** protocols differed in how the different polyphenols were incorporated into the *** impact of these three methods on the formation,properties,and gastrointestinal fate of nanoemulsions loaded with curcumin,resveratrol,and quercetin was *** three methods produced nanoemulsions with similar initial particle properties:droplet diameters(0.15,0.16,and 0.15μm)and zeta-potentials(–59,–58,and–58 m V),***,the average encapsulation efficiencies(82%,88%,and 61%),gastrointestinal stabilities(83%,97%,and 29%)and bioaccessibilities(77%,90%,and 73%)for curcumin,resveratrol,and quercetin were somewhat *** particular,more quercetin degradation occurred using the approach that held it under alkaline conditions for extended *** general,the p H-driven method provides researchers with a versatile approach of incorporating multiple polyphenols with different characteristics into functional food and beverages using a simple and inexpensive method.

关键词： Polyphenols pH-Driven encapsulation Nanoemulsions Gastrointestinal fate Functional foods

Injury/ischemia-induced stem cells: up-to-date knowledge and future perspectives for neural regeneration

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Neural Regeneration Research 2025年第3期20卷 797-798页

作者： Takayuki Nakagomi Institute for Advanced Medical sciences Hyogo Medical UniversityNishinomiyaJapan department of therapeutic Progress in Brain Diseases Hyogo Medical UniversityNishinomiyaJapan

Brain injuries like ischemic stroke induce endogenous stem cell production. Although the precise traits of stem cells in pathological brains remain unclear, we previously demonstrated that injury/ischemia-induced stem... 详细信息

关键词： ischemia injuries

Jun12682,a potent SARS-CoV-2 papain-like protease inhibitor with exceptional antiviral efficacy in mice

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4189-4192页

作者： Mianling Yang Meehyein Kim Peng Zhan department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesShandong UniversityJi’nan 250012China Infectious Diseases therapeutic Research Center Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Republic of Korea

Recently,a collaborative research study published in Science,led by Jun Wang,Xufang Deng,Eddy Arnold,and Francesc Xavier Ruiz1,identified a series of potent small molecule inhibitors that specifically target SARS-CoV-2 papain-like protease(PLpro).The study demonstrated nanomolar PLpro inhibitory potency with Ki values ranging from 13.2 to 88.2 nmol/*** employing a structure-based drug design strategy,the researchers discovered an exceptionally promising compound,named Jun12682,that effectively targets both the newly discovered ubiquitin Val70(Val70Ub)-binding site and the known blocking loop(BL2)groove near the S4 subsite of ***,studies on the mechanism of action revealed that Jun12682 inhibits the deubiquitinating and deISGylating activities of PLpro,which are crucial for antagonizing the host’s innate immune response upon viral *** biology studies confirmed the“two-pronged”binding mode of Jun12682,aligning perfectly with their drug design ***,Jun12682 exhibited potent antiviral activity against SARS-CoV-2 and its variants,including nirmatrelvir-resistant mutants,in Caco-2 cells(EC50:0.44e2.02 mmol/L).It is noteworthy that its oral administration significantly improved survival rates and alleviated both lung virus loads and histopathological lesions in a lethal SARS-CoV-2 mouse *** conclusion。

关键词： SARS-CoV-2 Papain-like protease Broad-spectrum Anti-drug resistance Drug candidate

Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen Xue-Jun Li department of Biomedical sciences University of Illinois College of Medicine RockfordRockfordILUSA department of bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

Applications of silk-based biomaterials in biomedicine and biotechnology

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Engineered Regeneration 2024年第1期5卷 56-69页

作者： Punuri Jayasekhar Babu Laldinthari Suamte Biomaterials and bioengineering Research Laboratory Department of BiotechnologyMizoram UniversityPachhunga University CollegeAizawl-796001MizoramIndia department of Life sciences Mizoram UniversityPachhunga University CollegeAizawl-796001MizoramIndia

Silk-based biomaterials have gained significant importance making them a promising choice for the future of med-ical technology due to their versatility and *** can be fabricated and tailored through various processing methods such as electrospinning,freeze-drying,and 3D printing,to achieve specific properties and structures namely sponges,hydrogels,films,and scaffolds that can be utilized for different biomedical ***,a unique property of silk-based biomaterials,has been demonstrated through both in vivo and in vitro studies and to date many studies have reported the successful use of these silk-based biomaterials in different fields of *** this review,we have elaborately discussed different types of silk,their structural composition,and biophysical ***,the current review focuses on highlighting various biomedical ap-plications of engineered and fabricated silk-based biomaterials which aid in the treatment of certain infections and diseases related to skin,eyes,teeth,bone,heart,nerves,and ***,we have consolidated the advancements of silk-based biomaterials in the different fields of biotechnology such as sensors,food coating and packaging,textiles,drug delivery,and ***,the research in this field continues to expand and more significant observations must be generated with feasible results for their reliable use in different biomedical applications.

关键词： Fabrication of silk Biomaterials Biomedicine Tissue engineering Scaffolds

Recombinant vaccines:Current updates and future prospects

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Asian Pacific Journal of Tropical Medicine 2024年第8期17卷 338-350页

作者： Vivek Kumar Anuj Verma Riddhi Singh Priyanshi Garg Santosh Kumar Sharma Himanshu Narayan Singh Santosh Kumar Mishra Sanjay Kumar department of Allied Medical sciences School of Allied Medical SciencesLovely Professional UniversityPhagwaraPunjabIndia bioengineering Division of Department of Bioscience and Biomedical EngineeringIndian Institute of Technology BhilaiChhattisgarhIndia department of Biotechnology IMS Engineering CollegeGhaziabadU.P.India department of Chemistry and Biochemistry University of WindsorOntario N9B3P4Canada Biological and Biocomputational Laboratory Department of Life SciencesSharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaU.P.India department of System Biology Columbia University Irving Medical CenterNew YorkNY 10032USA department of Life sciences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaU.P.India

Recombinant technology-based vaccines have emerged as a highly effective way to prevent a wide range of *** technology improved vaccine manufacturing,rendering it more efficient and *** vaccines have multiple advantages compared to conventional *** pandemic has heightened awareness of the advantages of these vaccine technologies;trust and acceptance of these vaccines are steadily growing *** work offers an overview of the prospects and advantages associated with recombinant ***,it discusses some of the challenges likely to arise in the *** ability to target diverse pathogen classes underscores their contributions to preventing previously untreatable diseases(especially vector-borne and emerging diseases)and hurdles faced throughout the vaccine development process,especially in enhancing the effectiveness of these ***,their compatibility with emerging vaccination platforms of the future like virus-like particles and CRISPR/Cas9 for the production of next-generation vaccines may offer many *** review also reviewed the hurdles faced throughout the vaccine development process,especially in enhancing the effectiveness of these vaccines against vector-borne diseases,emerging diseases,and untreatable diseases with high mortality rates like AIDS as well as cancer.

关键词： Malaria Dengue Emerging diseases Immunoinformatics Virus-like particles CRISPR-Cas9