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Biochar regulates biogeochemical cycling of iron and chromium in a soil-rice system by stimulating Geobacter and Clostridium

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Pedosphere 2024年第5期34卷 929-940页

作者： Min XU Yang LIN Jing MA Lulu LONG Chao CHEN Gang YANG Chun SONG Jun WU Xiaohong ZHANG Peng GAO College of Environmental Science Sichuan Agricultural University Soil Water and Ecosystem Sciences Department University of Florida College of Water Conservancy and Hydropower Engineering Sichuan Agricultural University department of Environmental and Occupational health University of Pittsburgh School of Public Health

In soil-rice systems,microbial reduction of iron （Fe） has been recognized as a crucial biogeochemical process that regulates Fe and chromium （Cr）translocation;however,the underlying processes are *** investigate the impacts of biochar on the biochemical cycling of Fe and Cr and their toxicity to rice,maize straw biochar was applied at 1%（weight/weight） to a paddy soil spiked with 300 mg kg-1Cr under two phosphorus （P） levels (0 or 90 mg kg-1) in a pot *** key microbial groups affecting Fe dissimilatory reduction and their environmental drivers were *** inhibited root Cr uptake by 36%,owing to the promoted iron plaque （IP） formation on the rice root *** analysis showed that Fe concentration in pore water was strongly linked to the abundances of Geobacter （r=0.81–0.94,P<0.05） and Clostridium （r=0.83–0.95,P<0.05）,indicating that Geobacter and Clostridium played essential roles in Fe *** analysis showed that labile carbon and pore water P concentrations were the key determinants influencing Fe-reducing bacterial abundances,accounting for 42%and 32%of the variation in community composition,***,biochar increased Fe and P concentrations in root cell walls,which retained more ***,Cr stress in rice under biochar treatment was relieved through increasing IP formation and altering subcellular *** mechanistic insights had important implications for reducing Cr uptake by rice.

关键词： chromium translocation iron plaque iron reduction maize straw biochar microbial reduction paddy soil phosphorus fertilization subcellular distribution

Establishing delivery route-dependent safety and efficacy of living biodrug mesenchymal stem cells in heart failure patients

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World Journal of Cardiology 2024年第6期16卷 339-354页

作者： Muhammad Candragupta Jihwaprani Idris Sula Mohamed Ahmed Charbat Khawaja Husnain Haider basic sciences SRCAl Bukayriyah 52736AlQaseemSaudi Arabia

BACKGROUND Mesenchymal stem cells(MSCs)as living biopharmaceuticals with unique properties,i.e.,stemness,viability,phenotypes,paracrine activity,etc.,need to be administered such that they reach the target site,maintaining these properties unchanged and are retained at the injury site to participate in the repair *** of delivery(RoD)remains one of the critical determinants of safety and *** study elucidates the safety and effectiveness of different RoDs of MSC treatment in heart failure(HF)based on phase II randomized clinical trials(RCTs).We hypothesize that the RoD modulates the safety and efficacy of MSCbased therapy and determines the outcome of the *** To investigate the effect of RoD of MSCs on safety and efficacy in HF *** RCTs were retrieved from six *** endpoints included mortality and serious adverse events(SAEs),while efficacy outcomes encompassed changes in left ventricular ejection fraction(LVEF),6-minute walk distance(6MWD),and pro-B-type natriuretic peptide(pro-BNP).Subgroup analyses on RoD were performed for all study *** Twelve RCTs were ***,MSC therapy demonstrated a significant decrease in mortality[relative risk(RR):0.55,95%confidence interval(95%CI):0.33-0.92,P=0.02]compared to control,while SAE outcomes showed no significant difference(RR:0.84,95%CI:0.66-1.05,P=0.11).RoD subgroup analysis revealed a significant difference in SAE among the transendocardial(TESI)injection subgroup(RR=0.71,95%CI:0.54-0.95,P=0.04).The pooled weighted mean difference(WMD)demonstrated an overall significant improvement of LVEF by 2.44%(WMD:2.44%,95%CI:0.80-4.29,P value≤0.001),with only intracoronary(IC)subgroup showing significant improvement(WMD:7.26%,95%CI:5.61-8.92,P≤0.001).Furthermore,the IC delivery route significantly improved 6MWD by 115 m(WMD=114.99 m,95%CI:91.48-138.50),*** biochemical efficacy outcomes,only the IC subgroup showed a significant reduction in pro-

关键词： Clinical trial Heart failure Mesenchymal stem cells Living biodrug Meta-analysis Stem cells Systematic review

Impact of apolipoprotein E isoforms on sporadic Alzheimer's disease:beyond the role of amyloid beta

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Neural Regeneration Research 2024年第1期19卷 80-83页

作者： Madia Lozupone Francesco Panza Neurodegenerative Disease Unit Department of Basic MedicineNeuroscienceand Sense OrgansUniversity of Bari Aldo MoroBariItaly Unit of Research Methodology and Data sciences for Population health National Institute of Gastroenterology“Saverio de Bellis”Research HospitalCastellana GrotteBariItaly

The impact of apolipoprotein E(ApoE)isoforms on sporadic Alzheimer's disease has long been studied;however,the influences of apolipoprotein E gene(APOE)on healthy and pathological human brains are not fully *** exists as three common isoforms(ApoE2,ApoE3,and ApoE4),which differ in two amino acid ***,ApoE binds cholesterol and phospholipids and ApoE isoforms display diffe rent affinities for their receptors,lipids transport and distribution in the brain and *** role of ApoE in the human depends on ApoE isoforms,brain regions,aging,and neural *** E4 is the strongest genetic risk factor for sporadic Alzheimer's disease,considering its role in influencing amyloid-beta *** exact mechanisms by which APOE gene variants may increase or decrease Alzheimer's disease risk are not fully understood,but APOE was also known to affect directly and indirectly tau-mediated neurodegeneration,lipids metabolism,neurovascular unit,and microglial *** with the biological function of ApoE,ApoE4 isoform significantly alte red signaling pathways associated with cholesterol homeostasis,transport,and ***,the rare protective APOE variants confirm that ApoE plays an important role in Alzheimer's disease *** objectives of the present mini-review were to describe classical and new roles of various ApoE isoforms in Alzheimer's disease pathophysiology beyond the deposition of amyloid-beta and to establish a functional link between APOE,brain function,and memory,from a molecular to a clinical *** genotype also exerted a heterogeneous effect on clinical Alzheimer's disease phenotype and its *** only in learning and memory but also in neuro psychiatric symptoms that occur in a premorbid *** rifying the relationships between Alzheimer's disease-related pathology with neuropsychiatric symptoms,particularly suicidal ideation in Alzheimer's disease patients,may be useful for elucid

关键词： Alzheimer's disease amyloid-beta apolipoprotein E dementia glymphatic transport lipids neuropsychiatric symptoms neurovascular unit tau protein

Global research on artificial intelligence in thyroid-associated ophthalmopathy:A bibliometric analysis

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Advances in Ophthalmology Practice and Research 2024年第1期4卷 1-7页

作者： Xiaobin Zhang department of health sciences National Natural Science Foundation of ChinaBeijingChina

Purpose:To provide an overview of global publications on artificial intelligence(AI)in thyroid-associated oph-thalmopathy(TAO)through bibliometric ***:Publications related to AI in TAO from inception until April 2023 were retrieved from the Web of Science *** trends of publications and citations,publishing performance,collaboration among countries and institutions,and the funding agencies,relevant research domains,leading journals,hotspots and their evolution were ***:A total of 55 publications were included for *** number of publications and citations continued to grow since 1998,with a significant acceleration of growth after *** is the most productive country with the highest number of productive institutions,followed by the United *** countries have the most extensive *** most relevant research domain was radiology,nuclear medicine&medical *** European Journal of Radiology was one of the most productive journals,with the most influential articles published."Thyroid-associated ophthalmopathy"and"neural network"maintain hotspots during the entire *** were more focused on clinical features during 1998 and 2016,clinical features and medical data during 2017 and 2020,and medical data and AI techniques during 2021 and ***:This study summarized the global research status regarding AI in TAO in terms of trends,countries,institutions,research domains,journals,and key *** has shown great potential in *** by funding agencies such as NSFC,China has become the most productive country in the field of AI in *** findings help researchers better understand the development of this field and provide valuable clues for future research directions.

关键词： Thyroid-associated ophthalmopathy Artificial intelligence Global publications Bibliometric analysis

Role of intravascular ultrasound and optical coherence tomography in intracoronary imaging for coronary artery disease:a systematic review

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Journal of Geriatric Cardiology 2024年第1期21卷 104-129页

作者： Maruf Sarwar Stephen Adedokun Mahesh Anantha Narayanan department of Cardiovascular sciences White River HealthBatesvilleARUSA Division of Cardiology University of Tennessee at MemphisTNUSA University of Arkansas Medical sciences Little RockARUSA

Coronary angiography has long been the standard for coronary imaging,but it has limitations in assessing vessel wall anatomy and guiding percutaneous coronary intervention(PCI).Intracoronary imaging techniques like intravascular ultrasound(IVUS)and optical coherence tomography(OCT)can overcome these *** uses ultrasound and OCT uses near-infrared light to visualize coronary pathology in unique ways due to differences in temporal and spatial *** techniques have evolved to offer clinical utility in plaque characterization and vessel assessment during ***-analyses and adjusted observational studies suggest that both IVUS and OCT-guided PCI correlate with reduced cardiovascular risks compared to angiographic guidance *** IVUS demonstrates consistent clinical outcome benefits,OCT evidence is less *** has progressed from early motion detection to high-resolution systems,with smaller compatible *** utilizes near infrared light to achieve unparalleled resolutions,but requires temporary blood clearance for optimal *** visualization and guidance make IVUS and OCT well-suited for higher risk PCI in patients with diabetes and chronic kidney disease by allowing detailed visualization of complex lesions and ensuring optimal stent deployment and positioning in PCI for patients with type 2 diabetes and chronic kidney disease,improving *** and recent advancements in zero-and low-contrast OCT techniques can reduce nephrotoxic contrast exposure,thus helping to minimize PCI complications in these high-risk patient *** and OCT provide valuable insights into coronary pathophysiology and guide interventions precisely compared to angiography *** have comparable clinical outcomes,emphasizing the need for tailored imaging choices based on clinical *** refinement and integration of intravascular imaging will likely play a pivotal role in optimizing coronary interventions and outcomes.

关键词： coronary anatomy limitations

Bulk-boundary and RPS thermodynamics from topology perspective

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Chinese Physics C 2024年第9期48卷 244-253页

作者： Jafar Sadeghi Mohammad Reza Alipour Saeed Noori Gashti Mohammad Ali S.Afshar department of Physics Faculty of Basic SciencesUniversity of Mazandaran P.O.Box 47416-95447BabolsarIran School of Physics Damghan UniversityP.O.Box ***DamghanIran

In this study,we investigate the bulk-boundary and restricted phase space(RPS)thermodynamics of Rissner-Nordstrom(R-N)AdS and 6-dimensional charged Gauss-Bonnet AdS black ***,we examine the topological characteristics of the considered black holes and compare them with the results of extended *** determine that the topological behavior of the bulk-boundary thermodynamics is the same as that of the extended thermodynamics,whereas the RPS thermodynamics exhibits a distinct ***,we demonstrate that within the RPS formalism,there is only one critical point with a topological charge of+1(Q_(t)=+1).Moreover,in the RPS formalism,the inclusion of higher-derivative curvature terms in the form of GaussBonnet gravity does not alter the topological classification of critical points in charged AdS black holes.

关键词： bulk-boundary restricted phase space topological charge thermodynamics

Effect of Eu^(3+),Bi^(3+),and Li^(+) doping on luminescent property of GdNbO_(4)

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Journal of Rare Earths 2024年第1期42卷 66-75,I0003页

作者： S.W.Wi Y.S.Lee department of Physics and Integrative Institute of basic sciences Soongsil UniversitySeoul06978Republic of Korea

We investigated the emission properties of Eu^(3+)-doped GdNbO_(4)-based oxide phosphors,aiming at improving the Eu^(3+)emission by codoping of Bi^(3+)and Li^(+).Eu^(3+)singly doped,Eu^(3+)and Bi^(3+)doubly doped,and Eu^(3+),Bi^(3+),and Li^(+)triply doped GdNbO_(4)were prepared using a high-temperature solid-state reaction *** red-orange emissions from Eu^(3+)in the singly doped samples are significantly improved by the codoping of Bi^(3+),mainly due to the energy transfer from Bi^(3+)to Eu^(3+).The additional codoping of Li^(+)is found to increase the Eu^(3+)emission *** improvement might be attributed to the increase in the photoluminescent quantum yield originating from larger grain sizes and better crystallinity.A detailed analysis of the X-ray diffraction pattern and the asymmetric ratio estimated from the photoluminescence spectra show that the local lattice environment around Eu^(3+)in GdNbO_(4)does not change significantly with the codoping of Bi^(3+)and Li^(+).Our results indicate that Li^(+)doping is a promising way to improve the emission properties of rare-earth ion-doped GdNbO_(4)phosphors.

关键词： Eu^(3+) GdNbO_(4) Codoping of Li^(+) Photoluminescence Sensitizer Rare earths

Progress in neurorehabilitation research and the support by the National Natural Science Foundation of China from 2010 to 2022

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Neural Regeneration Research 2024年第1期19卷 226-232页

作者： Qian Tao Honglu Chao Dong Fang Dou Dou School of Medicine Jinan UniversityGuangzhouGuangdong ProvinceChina School of health and Life Science University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina department of health sciences National Natural Science Foundation of ChinaBeijingChina department of Neurosurgery The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina

The National Natural Science Foundation of China is one of the major funding agencies for neuro rehabilitation research in *** study reviews the frontier directions and achievements in the field of neurorehabilitation in China and wo *** used data from the Web of Science Core Collection(WoSCC) database to analyze the publications and data provided by the National Natural Science Foundation of China to analyze funding *** addition,the prospects for neurorehabilitation research in China are *** 2010 to 2022,a total of 74,220 publications in neurorehabilitation were identified,with there being an overall upward *** this period,the National Natural Science Foundation of China has funded 476 research projects with a total funding of 192.38 million RMB to support neuro rehabilitation research in *** the support of the National Natural Science Foundation of China,China has made some achievements in neurorehabilitation *** related to neurorehabilitation is believed to be making steady and significant progress in China.

关键词： brain computer interface invasive neuromodulation National Natural Science Foundation of China(NSFC) neuroreha bilitation non-invasive brain stimulation publication rehabilitation robotics virtual reality

Dietary long-chain fatty acid metabolism boosts antitumorimmune response

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Cancer Communications 2024年第5期44卷 580-583页

作者： Jiaming Wang Xuetao Cao department of Immunology Institute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical SciencesBeijingP.R.China Institute of Immunology College of Life SciencesNankai UniversityTianjinP.R.China

Overcoming resistance to immune checkpoint blockade(ICB)therapy will pave the way for effective ICB cancer immunotherapy since a large proportion of cancer patients are not responsive to ICB immunotherapy[1].The molecular mechanisms of ICB resistance are diverse,including tumor-intrinsic resistant factors(such as genetic and epigenetic disorders),immunosuppressive/disabled factors(such as T cell exhaustion),and environmental restrictive factors(such as neuroendocrine stress and metabolic reprogramming).

关键词： metabolism cancer immune