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A dual-protease-triggered chemiluminescent probe for precise tumor imaging

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Chinese Chemical Letters 2025年第2期36卷 302-306页

作者： Zhihui Zhang Ru Sun Chong Bian Hongbo Wang Zhen Zhao Panpan Lv Jianzhong Lu Haixin Zhang Hulie Zeng Yuanyuan Chen Zhijuan Cao department of Pharmaceutical analysis School of PharmacyFudan University Minhang Branch Zhongshan HospitalFudan University China State Institute of Pharmaceutical Industry Shanghai Jahwa United Co. Ltd.

Imaging detection of interlinked dual proteases is imperative for precise tumor imaging, which remains challenging due to limited modification position of specific substrate and possible steric ***, we have developed a unimolecular chemiluminescent probe(LGP-CL) tandemly activated by two proteases interlinked with liver cancer to achieve precise tumor imaging. Probe LGP-CL consists of a phenoxy-dioxetane scaffold caged by a tripeptide substrate(LGP, leucine-glycine-proline) as the sensing layer, which can be cleaved sequentially by aminopeptidase N(APN) and dipeptidyl peptidase IV(DPPIV)to turn on a strong chemiluminescent signal, and silenced by specific inhibitor of each enzyme, which accounts for an integrated logic gate(AND, OR and INHIBIT). The successful cleavage of dual proteases on the metabolic site depends on the proper structure of the tripeptide substrate, as confirmed by two probes design. Probe LGP-CL(LGP as the substrate) enables the excellent “dual-lock-dual-key” fit with a382-fold enhancement of chemiluminescent emission while no obvious signal is observed by using GPLCL(GPL as the substrate). By virtue of its rapid response(several minutes), high sensitivity and good cell viability, probe LGP-CL has been utilized to evaluate upregulated levels of proteases in vitro and in living systems, especially to distinguish liver tumor cells(Hep G2) from others(LO2, MCF-7, MCF-10a and RAW264.7). Overall, the newly developed CL probe may facilitate rapid investigation into the role played by proteases in liver diseases, enabling timely selection appropriate treatment. Therefore, our work not only sheds light on the rational design of optical probes for dual protease imaging, but provides a promising tool for clinical diagnosis and even drug discovery.

关键词： Chemiluminescent Dual-protease imaging Logic gates Phenoxy-dioxetane scaffold Tripeptide substrate

RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus

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Science China(Life Sciences) 2025年第2期68卷 441-453页

作者： Xue Pang Lin Gu Qiu-Ying Han Jia-Qing Xing Ming Zhao Shao-Yi Huang Jun-Xi Yi Jie Pan Hao Hong Wen Xue Xue-Qing Zhou Zhi-Hui Su Xin-Ran Zhang Li-Ming Sun Shao-Zhen Jiang Dan Luo Ling Chen Zheng-Jie Wang Yu Yu Tian Xia Xue-Min Zhang Ai-Ling Li Tao Zhou Hong Cai Tao Li Nanhu Laboratory National Center of Biomedical AnalysisBeijing 100039China School of Basic Medical Sciences Fudan UniversityShanghai 200032China department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China

Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid(CSF)flow by beating their motile cilia *** ependymal denudation or ciliary dysfunction causes ***,we report that the deficiency of regulator of Gprotein signaling 22(RGS22)results in severe congenital hydrocephalus in both mice and ***,RGS22 is specifically expressed in ependymal cells within the *** conditional knock-out mice,we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce ***,we show that Rgs22 deficiency leads to the ependymal denudation and impaired *** phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor(LPAR)signaling under Rgs22^(-/-)condition,as the LPAR blockade effectively alleviates hydrocephalus in Rgs22^(-/-)***,our findings unveil a previously unrecognized role of RGS22 in the central nervous system,and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.

关键词： RGS22 hydrocephalus ependymal cells

Efficient catalysis of FeNiCu-based multi-site alloys on magnesium-hydride for solid-state hydrogen storage

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Chinese Chemical Letters 2025年第1期36卷 603-609页

作者： Shuai Li Liuting Zhang Fuying Wu Yiqun Jiang Xuebin Yu School of Energy and Power Instrumental Analysis CenterJiangsu University of Science and TechnologyZhenjiang 212003China department of Materials Science Fudan UniversityShanghai 200433China Max Planck Institute for Iron Research Düsseldorf 40237Germany

Hydrogen,as a cheap,clean,and cost-effective secondary energy source,performs an essential role in optimizing today’s energy *** hydride(Mg H_(2))represents an attractive hydrogen carrier for storage and transportation,however,the kinetic behavior and operating temperature remain *** this work,a dual-phase multi-site alloy(Ms A)anchored on carbon substrates was designed,and its superior catalytic effects on the hydrogen storage properties of MgH_(2) were *** analysis identified that multi-site Fe Ni_(3)/Ni Cu nanoalloys synergistically served as intrinsic drivers for the striking de/hydrogenation performance of the MgH_(2)-Ms A ***,the unique multi-metallic site structure attached to the surface of MgH_(2)provided substantial reversible channels and accessible active sites conducive to the adsorption,activation,and nucleation of H *** addition,the coupling system formed by FeNi_(3) and NiCu dual-phase alloys further enhanced the reactivity between Mg/MgH_(2) and H ***,the onset dehydrogenation temperature of Mg H_(2)+5 wt%Ms A was reduced to 195℃ and the hydrogen desorption apparent activation energy was reduced to 83.6 k J/mol.5.08 wt%H_(2) could be released at 250℃ in 20 min,reaching a high dehydrogenation rate of 0.254 wt%H_(2)/min,yet that for MgH_(2) at a higher temperature of 335℃ was only 0.145 wt%H_(2)/***,the dehydrogenated Mg H_(2)-Ms A sample could absorb hydrogen from room temperature(30℃)and charge 3.93 wt%H_(2) at 100℃ within20 min under 3.0 MPa H_(2) *** from carbon substrates,the 5 wt%Ms A doped-MgH_(2) could still maintain 6.36 wt%hydrogen capacity after 20 *** conclusion,this work provides experimental rationale and new insights for the design of efficient catalysts for magnesium-based solid-state hydrogen storage materials.

关键词： Hydrogen storage Magnesium hydride Synergistic effect Catalysis Multi-site alloys

Facile and gram-scale synthesis of single-crystal hydrogen-bonded organic frameworks as iodine adsorbents for synthesis of β-iodoethers

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Science China Chemistry 2025年

作者： Zhiye Zheng Qiuyuan Lin Shunfeng Peng Yuxuan Zhang Shuting Xu Hui Zhang Hongyu Wang department of Chemistry College of Science Center for Supramolecular Chemistry & Catalysis Shanghai University Laboratory for Microstructures Instrumental Analysis and Research Center Shanghai University

The facile synthesis of single-crystal hydrogen-bonded organic frameworks（HOFs） on a gram scale remains a significant challenge but is crucial for practical applications. Herein, we report a novel strategy to prepare two three-dimensional（3D）single-crystal HOFs at ambient temperature and pressure with gram-scale products. The imine-linked oligomers were synthesized using ionic liquids as catalysts, which self-assembled in situ to form large single crystals. The optimal material, H1,exhibited iodine uptake capacities of 6.02 and 4.44 g g-1from vapor and aqueous solutions, respectively, ranking among the highest reported HOFs. For the first time, the iodine-adsorbed H1 was used as an iodine source for synthesizing β-iodoethers,achieving excellent yields comparable to those obtained using iodine as the reactant. This study not only presents a simple method for the scalable synthesis of single-crystal HOFs but also explores a potential application of iodine-adsorbed materials in organic synthesis.

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Emission characteristics,environmental impacts and health risk assessment of volatile organic compounds from the typical chemical industry in China

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Journal of Environmental Sciences 2025年第3期149卷 113-125页

作者： Kaitao Chen Xin Gu Min Cai Weicheng Zhao Boxuan Wang Haoran Yang Xingang Liu Xingru Li analysis and Testing Center Department of ChemistryCapital Normal UniversityBeijing 100048China College of Resources Environment and Tourism Capital Normal UniversityBeijing 100048China State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 100875China

To study the volatile organic compounds(VOCs)emission characteristics of industrial enterprises in China,6 typical chemical industries in Yuncheng City were selected as research objects,including the modern coal chemical industry(MCC),pharmaceutical industry(PM),pesticide industry(PE),coking industry(CO)and organic chemical industry(OC).The chemical composition of 91 VOCs was quantitatively *** results showed that the emission concentration of VOCs in the chemical industry ranged from 1.16 to 155.59 mg/m^(3).Alkanes were the main emission components of MCC(62.0%),PE(55.1%),and OC(58.5%).Alkenes(46.5%)were important components of PM,followed by alkanes(23.8%)and oxygenated volatile organic compounds(OVOCs)(21.2%).Halocarbons(8.6%-71.1%),OVOCs(9.7%-37.6%)and alkanes(11.2%-27.0%)were characteristic components of *** largest contributor to OFP was alkenes(0.6%-81.7%),followed by alkanes(9.3%-45.9%),and the lowest onewas alkyne(0%-0.5%).Aromatics(66.9%-85.4%)were the largest contributing components to SOA generation,followed by alkanes(2.6%-28.5%),and the lowest one was alkenes(0%-4.1%).Ethylene and BTEX were the key active species in various chemical *** human health risk assessment showed workers long-term exposed to the air in the chemical industrial zone had a high cancer and non-cancer risk during work,and BTEX and dichloromethane were the largest contributors.

关键词： Industrial enterprise VOCs spectrum Reactivity Health risk

In-situ liquid-phase transmission electron microscopy for two-dimensional energy materials

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Science China Chemistry 2025年第2期68卷 414-429页

作者： Junyu Zhang Liangping Xiao Mi Lu School of Materials Science and Engineering Xiamen University of TechnologyXiamen 361024China Instrumental analysis Center Laboratory and Equipment Management DepartmentHuaqiao UniversityXiamen 361021China department of Physics Research Institute for Biomimetics and Soft MatterFujian Provincial Key Laboratory for Soft Functional MaterialsJiujiang Research InstituteXiamen UniversityXiamen 361005China

Two-dimensional(2D)materials are vital for the development of advanced materials in the next-generation energy conversion and storage ***-situ liquid-phase transmission electron microscopy(LP-TEM)acts as a powerful tool for characterizing the dynamic evolution of materials under work condition in real time and in ***,this mini-review highlights the considerable advances in the utilization of in-situ LP-TEM for studying the physical and chemical process dynamics of 2D materials,such as their nucleation growth and phase *** electrocatalytic water splitting reactions and CO_(2) electroreduction of 2D energy materials are *** underlying electrochemical reaction mechanisms of the 2D electrode materials in rechargeable batteries are discussed and ***,the current challenges and perspectives for future research are *** min-review aims to inspire and stimulate further innovation and encourage the broader adoption of LP-TEM in exploring the fascinating dynamics of 2D energy materials.

关键词： two-dimensional(2D)materials liquid-phase transmission electron microscopy electrochemical reaction electrode materials

Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder

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Science China Chemistry 2025年第1期68卷 377-384页

作者： Shiwen Liu Xuerui Wan Meng Zhao Jiaqi Wang Weilan Wu Linlin You Yonggui Yuan Qian Xu Rong Gao Key Laboratory of Environmental Medicine Engineering Ministry of EducationSchool of Public HealthSoutheast UniversityNanjing 210009China Key Laboratory of Modern Toxicology of Ministry of Education Department of Hygienic Analysis and DetectionSchool of Public HealthNanjing Medical UniversityNanjing 211166China department of Psychosomatics and Psychiatry Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009China

The measurement of amino acid and monoamine neurotransmitters(NTs)in serum plays a central role in the identification and monitoring of clinical panic disorder(PD).However,the strong polarity and chemical heterogeneity of NTs make direct extraction and rapid detection extremely ***,we developed a strategy that integrated solid phase extraction based on magnetic Fe_(3)O_(4)coated with polydopamine(Fe_(3)O_(4)@PDA)and direct analysis of mass spectrometry in real time(DART-MS)for quantification of 10 *** systematically investigated the optimal conditions of this strategy to achieve good accuracy and *** with existing magnetic solid phase extraction methods for NTs detection in biological samples,this strategy could adsorb more targets while having similar adsorption efficiencies,and the total process time was reduced by an average of 69.42%.We rapidly determined the metabolic abnormality of 6 types of NTs in the serum of PD patients and demonstrated their diagnostic *** addition,an outstanding feature of PD in which tryptophan was more metabolized by the KYN pathway and the 5-hydroxytryptamine pathway was inhibited could be elucidated by this *** results highlighted the potential ability of Fe_(3)O_(4)@PDA coupled with DART-MS to assist in the clinical diagnosis of PD.

关键词： neurotransmitters panic disorder magnetic solid phase extraction direct analysis of mass spectrometry in real time

Von Neumann Regularity and Quadratic Conorms in JB^＊-triples and C^＊-algebras

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Acta Mathematica Sinica,English Series 2008年第2期24卷 185-200页

作者： María BURGOS El Amin KAIDI Antonio Morales CAMPOY Antonio M.PERALTA Maribel RAMíREZ department of algebra and Mathematical analysis University of Almería 04120 Almería Spain department of Mathematical analysis University of Granada 18071 Granada Spain department of algebra and Mathematical analysis University of Almerǐa 04120 Almería Spain

We revise the notion of von Neumann regularity in JB^＊-triples by finding a new characterisation in terms of the range of the quadratic operator Q（a）. We introduce the quadratic conorm of an element a in a JB^＊-triple as the minimum reduced modulus of the mapping Q（a）. It is shown that the quadratic conorm of a coincides with the infimum of the squares of the points in the triple spectrum of a. It is established that a contractive bijection between JBW^＊-triples is a triple isomorphism if, and only if, it preserves quadratic conorms. The continuity of the quadratic conorm and the generalized inverse are discussed. Some applications to C^＊-algebras and von Neumann algebras are also studied.

关键词： von Neumann regularity quadratic conorm C^*-algebra JB^*-triple triple spectrum

Observer-based event-triggered formation tracking control for second-order multi-agent systems in constrained region

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Science China(Information Sciences) 2025年第2期68卷 151-169页

作者： Fenglan SUN Zhonghua XU Wei ZHU ■ KURTHS Key Lab of Intelligent analysis and Decision on Complex Systems School of ScienceChongqing University of Posts and Telecommunications Key Lab of Intelligent Air-Ground Cooperative Control for Universities in Chongqing College of AutomationChongqing University of Posts and Telecommunications department of Complexity Science Potsdam Institute for Climate Impact Research Institute of Physics Humboldt University of Berlin

In this paper, an event-triggered time-varying formation tracking control for a class of second-order nonlinear multiagent systems(MAS) operating within a constrained region is investigated. To mitigate the negative effects of external unknown disturbance, a novel disturbance observer with performance guarantees is proposed, enabling precise disturbance *** the artificial potential field(APF) method, a repulsive potential function is introduced to prevent inter-agent collisions as well as collisions with environmental obstacles. To reduce continuous communication and frequent system updates, a sliding mode technique is incorporated into the formation tracking controller, utilizing an event-triggered mechanism. The controller is also applicable to the formation control of MAS in switching-constrained regions. The achievement of the specified timevarying geometric formation is rigorously demonstrated through the Lyapunov framework. Numerical simulations are presented to validate the effectiveness of the theoretical results.

关键词： formation tracking control region constraints repulsive potential function event-triggered mechanism