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Anticataractogenic effect of hesperidin in galactose-induced cataractogenesis in Wistar rats

World Journal of Ophthalmology 2016年第1期6卷 1-9页

作者： Ramar Manikandan Munuswamy Arumugam departmen of zoology University of Madras

AIM: To explore the anticataractogenic potential of hesperidin, a flavanone, in galactose-induced ***: In this study, cataract was induced by administering galactose enriched food in a set of rats. Effect of different dosages of hesperidin(25, 50 and 75 mg/kg body weight) were administered simultaneously with galactose in prevention of cataract was determined in another set. In both sets of animals, the levels of peroxidation, oxidants(NO and OH), antioxidants(enzymatic: Superoxide dismutase, catalase, glutathione S-transferase, GPx and non-enzymatic: Reduced glutathione, vitamin E), aldose reductase and sorbitol were determined in the eye lens. In addition, glucose and lipid peroxidation levels were also tested in serum. The quantitative changes in lens inducible nitric oxide synthase(iN OS) and its expression were also determined using Western blot and real-time polymerase chain reaction ***: Galactose enriched food produced cataract in both the eye lens as a sequel to elevated serum glucose. Simultaneous administration of hesperidin not only reduced serum glucose but also prevented cataract development, through reduced levels of reactive oxygen species(NO and OH) and i NOS expression as well as elevated enzymic and non-enzymic antioxidants were observed in the eye ***: These results indicate the preventive effect of hesperidin against cataract in hyperglycemic rats.

关键词： Antioxidants Oxidative stress Galactoseinduced cataract Free radicals Hesperidin Eye lens

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