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Predicting the Prognosis and Immunotherapeutic Response of Triple-Negative Breast Cancer by Constructing a Prognostic Model Based on CD8+T Cell-Related Immune Genes

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Biomedical and Environmental Sciences 2024年第6期37卷 581-593页

作者： Nani Li Xiaoting Qiu Jingsong Xue Limu Yi Mulan Chen Zhijian Huang department of Medical Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014FujianChina department of Breast Surgical Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014FujianChina departmen of Pathology Shenzhen Longhua Maternity and Child Healthcare HospitalShenzhen 518109GuangdongChina

Objective Triple-negative breast cancer(TNBC)poses a significant challenge for treatment ***8+T cells,which are pivotal immune cells,can be effectively analyzed for differential gene expression across diverse cell populations owing to rapid advancements in sequencing *** leveraging these genes,our objective was to develop a prognostic model that accurately predicts the prognosis of patients with TNBC and their responsiveness to *** Sample information and clinical data of TNBC were sourced from The Cancer Genome Atlas and METABRIC *** the initial stage,we identified 67 differentially expressed genes associated with immune response in CD8+T ***,we narrowed our focus to three key genes,namely CXCL13,GBP2,and GZMB,which were used to construct a prognostic *** accuracy of the model was assessed using the validation set data and receiver operating characteristic(ROC)***,we employed various methods,including Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway,immune infiltration,and correlation analyses with CD274(PD-L1)to explore the model's predictive efficacy in immunotherapeutic ***,we investigated the potential underlying biological pathways that contribute to divergent treatment *** We successfully developed a model capable of predicting the prognosis of patients with *** areas under the curve(AUC)values for the 1-,3-,and 5-year survival predictions were 0.618,0.652,and 0.826,*** this risk model,we stratified the samples into high-and low-risk *** KEGG enrichment analysis,we observed that the high-risk group predominantly exhibited enrichment in metabolism-related pathways such as drug and chlorophyll metabolism,whereas the low-risk group demonstrated significant enrichment in cytokine ***,immune landscape analysis revealed noteworthy variations between(PD-L1)expression and risk scores,indicating that o

关键词： Breast Cancer Immunotherapy Prognosis CD8+T cells PD-L1

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Proper Accelerations of Time-Like Curves near a Null Geodesic

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Chinese Physics Letters 2003年第9期20卷 1437-1440页

作者：田贵花赵峥 SchoolofScience BeijingUniversityofPostsandTelecommunicationsBeijing100876 departmen-tofPhysics BeijingNormalUniversityBeijing100875

It is well known that when given a null geodesic γ0(λ) with a point r in (p,q) conjugate to p along γ0(λ), there will be a variation of γ0(λ) which can give a time-like curve from p to q. Here we prove that the time-like curves coming from the above-mentioned variation (with the second derivative β2≠0) have a proper acceleration A = (AaAa)1/2 which approaches infinity as the time-like curve approaches the null geodesic. Because the curve obtained from variation of the null geodesic must be everywhere time-like, we also discuss the constraint of the `acceleration' B0a of the variation vector field on the null geodesic γ0(λ). The acceleration B0a of the variation vector field Za on the null geodesic γ0(λ) cannot be zero.

关键词： Geodesy

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Joint application of feature extraction based on EMD-AR strategy and multi-class classifier based on LS-SVM in EMG motion classification

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第8期8卷 1246-1255页

作者： YAN Zhi-guo WANG Zhi-zhong REN Xiao-mei departmen of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200030 China

This paper presents an effective and efficient combination of feature extraction and multi-class classifier for motion classification by analyzing the surface electromyografic(sEMG) signals. In contrast to the existing methods,considering the non-stationary and nonlinear characteristics of EMG signals,to get the more separable feature set,we introduce the empirical mode decomposition(EMD) to decompose the original EMG signals into several intrinsic mode functions(IMFs) and then compute the coefficients of autoregressive models of each IMF to form the feature set. Based on the least squares support vector machines(LS-SVMs) ,the multi-class classifier is designed and constructed to classify various motions. The results of contrastive experiments showed that the accuracy of motion recognition is improved with the described classification scheme. Furthermore,compared with other classifiers using different features,the excellent performance indicated the potential of the SVM techniques embedding the EMD-AR kernel in motion classification.

关键词： Electromyografic signal Empirical mode decomposition (EMD) Auto-regression model Wavelet packet transform Least squares support vector machines (LS-SVM) Neural network

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On the correlation of the local OVII and OVI absorption lines in the spectra of active galactic nuclei

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Science China(Physics,Mechanics & Astronomy) 2016年第11期59卷 83-84页

作者： Miao Wang Taotao Fang Xiaochuan Jiang departmen of Astronomy and Institute of Theoretical Physics and Astrophysics Xiamen University

Dear Editors,Active Galactic Nuclei（AGNs）are very effective tools to study the environment both intrinsic to the central black holes of galaxies[1],or absorbing gas distributed along the sight ***,numerous highly ionized,local（z=0）metal absorption lines were detected in the X-ray spectra of background AGNs[2],providing an important method in probing hot gas and its content in and around our Galaxy.

关键词：活动星系核光谱检测吸收线星系中心热气体 AGN X射线银河系

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Synthesis of Cobalt Containing Block Copolymers Via Ring Opening Metathesis Polymerizastion (ROMP)

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Journal of Rare Earths 2004年第Z2期22卷 145-152页

作者： Bongjin Moon Minhyuk Kang departmen of Chemistry Sogang UniversityShinsoo-Dong 1-1Mapo-GuSeoul121-742Korea Departmen of ChemistrySogang UniversityShinsoo-Dong 1-1Mapo-GuSeoul121-742Korea

In order to realize a metal containing nano-structure, a block-copolymer containing alkynyl groups in one block was designed and synthesized by living ring opening metathesis polymerization (ROMP) technique. The newly developed bis-3-bromopyridine complex of Grubbs catalyst was employed in the series of polymerization and it yielded the desired polymers with great molecular weight control and narrow polydispersities. The characteristics of the block copolymers were investigated by gel permeation chromatography, H- and 13H- NMR spectroscopy. Complexation of the alkynyl group containing block copolymers by treatment with dicobalt octacarbonyl occurred smoothly in 5 min at room temperature. GPC analysis before and after cobalt complexation indicated a significant increase of the hydrodynamic volume. AFM images of the films before and after the complexation also showed a noticeable change in its morphology where grain sizes become smaller and more regular upon complexation.

关键词： ring opening metathesis polymerization (ROMP) metal containing block copolymer polynorbornene derivative

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ASYMPTOTICALLY OPTIMAL EMPIRICAL BAYES ESTIMATION FOR PARAMETERS OF TWO-SIDED TRUNCATION DISTRIBUTION FAMILIES

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Chinese Annals of Mathematics,Series B 1989年第1期10卷 94-104页

作者：韦来生 departmen of Mathematicst University of Science and Technology of China Hefei Anhui China

Consider the two-sided truncation distrbution families written in the formf（x,θ）dx=w（θ1, θ2）h（x）I[θ1,θ2]（x）dx, where θ=（θ1,θ2）.T（x）=（t1（x）, t2（x））=（min（x1,…,xm）, max（x1, …,xm））is a sufficient statistic and its marginal density is denoted by f（t）dμT. The prior distribution of θ belongs to the familyF={G:∫‖θ‖2dG（θ）n （t）, by using the kernel estimation of f（t）. Under a quite general assumption imposed upon f（t） and h（x）, it is shown that φn（t） is an asymptotically optimal EBE of θ.

关键词： truncation kernel sided estimator asymptotically prior statistic constructs assumption marginal

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Effects of High Erucic Acid Rapeseed Oil on Fatty Acid Oxidation in Rat Liver

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Biomedical and Environmental Sciences 1991年第3期4卷 262-267页

作者： ZHANGLISHI TNAYIN 等 departmentofNutrition＆FoodHygiene SchoolofPublicHealthWestChinaUniversityofMedicalSciences departmen

The effects of high erucic acid rapeseed oil (HER) on fatty acid oxidation in rat liver compared with low erucic acid rapeseed oil (LER) were studied. Weanling male SD rats were fed diets containing 20% HER or LER for 1 week or 4 weeks, or 5% HER diet for 4 weeks. The hepatic oxidation capacity of butyric acid or palmitic acid was determined by titrating the propanone produced by their oxidation. The results showed that feeding HER to rats led to an increase in the weight of liver and a decrease in the hepatic oxidation capacity of palmitic acid. Hepatic oxidation of butyric acid was not influenced by the intake of HER. The inhibitory action of HER on the oxidation of long-chain fatty acids probably resulted from the incorporation of erucic acid into mitochondrial membranes, interfering the fatty acyl-CoA transfering system on the membranes, but not from the β-oxidation enzyme system in mitochondria being directly inhibited.

关键词： Effects of High Erucic Acid Rapeseed Oil on Fatty Acid Oxidation in Rat Liver

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Pseudo four-component and regioselective synthesis of 4-amino-3,5-dicyano-6-arylphthalates using triethylamine catalyst

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Chinese Chemical Letters 2013年第6期24卷 497-499页

作者： Bagher Mohammadi Mansoor Shafieey Hamed Kazemi Ali Ramazani department of Chemistry Payame Noor University departmen of Chemistry University of Zanjan

An efficient triethylamine-catalyzed synthesis of 4-amino-3,5-dicyano-6-arylphthalates is described.A one-pot,simple pseudo four-component reaction between arylaldehydes,dialkyl acetylenedicarboxylates, and twice as m... 详细信息

关键词： Multicomponent reactions Ring closure Triethylamine Catalysis Regioselective 4-Amino-3 5-dicyano-6-arylphthalates

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Fibrin sealant for closure of mucosal penetration at the cardia during peroral endoscopic myotomy: A retrospective study at a single center

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World Journal of Gastroenterology 2017年第9期23卷 1637-1644页

作者： Wen-Gang Zhang En-Qiang Linghu Hui-Kai Li departmen of Gastroenterology Chinese PLA General HospitalBeijing 100853China

AIM To assess the efficacy and safety of fibrin sealant for closure of mucosal penetration at the cardia during peroral endoscopic myotomy(POEM).METHODS Twenty-four patients who underwent POEM and experienced mucosal injury of the cardia during the procedure were retrospectively identified. Of the 24 patients, 21 had mucosal penetration and 3 had only slight mucosal damage without penetration. The 21 patients with mucosal penetration received fibrin sealant for closure at the site of penetration. Penetration-related characteristics, treatment, and recovery were reviewed for all 21 patients to assess the efficacy and safety of fibrin sealant for closure of mucosal penetration at the cardia. Clinical data, including general characteristics, procedure-related parameters, Eckardt scores, lower esophageal sphincter pressures (LESP), and esophagogastroduodenoscopy(EGD) results, were analyzed to determine their influence on treatment success after mucosal penetration during *** All 21 patients had a solitary mucosal penetration in the cardia (12 in esophageal region of the cardia, 9 in the stomach region of the cardia, and 1 in both the esophageal and stomach regions). Twelve had ahole-like penetration and 9 had a linear penetration. For those with a hole-like penetration, the mean size was 0.14 cm2 (0.02-0.32 cm2). For those with a linear penetration, the median size was 0.37 cm (0.10-1.00 cm). Closure of the mucosal penetration using fibrin sealant was performed successfully in all 21 patients(two patients required 5 m L fibrin sealant, and the remaining 19 patients required 2.5 mL). Two patients had a nasogastric tube placed for five days after POEM; the remaining 19 patients were kept fasting for 3 d. All 21 patients were discharged after a median of 5 d(range: 5-7 d) postoperatively. During a median 42 mo (range: 9-62 mo) follow-up, all 21 patients with a mucosal penetration successfully healed without the occurrence of infection, ulcer, or esophagitis. Furth

关键词： Fibrin sealant Mucosal penetration Peroral endoscopic myotomy Efficacy Safety

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Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation

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World Journal of Gastroenterology 2017年第29期23卷 5295-5303页

作者： Philipp Ellinger Jan Stindt Carola Droge Katharina Sattler Claudia Stross Stefanie Kluge Diran Herebian Sander HJ Smits Martin Burdelski Sebastian Schulz-Jürgensen Antje Ballauff Jan Schulte am Esch Ertan Mayatepek Dieter Haussinger Ralf Kubitz Lutz Schmitt In-stitute of Biochemistry Hein-rich-Hein-e-Un-iversity Düsseldorf Medical Faculty Departmen-t of Gastroen-terology Hepatology an-d In-fectious Diseases Hein-rich-Hein-e-Un-iversity Düsseldorf departmen-t of Gen-eral Pediatrics Neon-atology an-d Pediatric Cardiology Medical Faculty Hein-rich-Hein-e-Un-iversity Düsseldorf departmen-t of Paediatrics Un-iversity Hospital Schleswig Holstein- departmen-t of Paediatrics Helios Clin-ic departmen-t of Gen-eral Surgery Hein-rich-Hein-e-Un-iversity

To investigate the relation of two different mutations to the outcome of partial external biliary diversion (PEBD) in severe bile salt export pump (BSEP) deficiency. METHODSMutations in the gene encoding BSEP leading to severe BSEP deficiency in two unrelated patients were identified by genomic sequencing. Native liver biopsies and transiently transfected human embryonic kidney (HEK) 293 cells expressing either wild-type or mutated BSEP were subjected to immunofluorescence analysis to assess BSEP transporter localization. Bile acid profiles of patient and control bile samples were generated by ultra-performance liquid chromatography-tandem mass spectrometry. Wild-type and mutant BSEP transport of [3H]-labeled taurocholate (TC) and taurochenodeoxycholate (TCDC) was assessed by vesicular transport assays. RESULTSA girl (at 2 mo) presented with pruritus, jaundice and elevated serum bile salts (BS). PEBD stabilized liver function and prevented liver transplantation. She was heterozygous for the BSEP deletion p.T919del and the nonsense mutation p.R1235X. At the age of 17 years relative amounts of conjugated BS in her bile were normal, while total BS were less than 3% as compared to controls. An unrelated boy (age 1.5 years) presenting with severe pruritus and elevated serum BS was heterozygous for the same nonsense and another missense mutation, p.G1032R. PEBD failed to alleviate pruritus, eventually necessitating liver transplantation. BS concentration in bile was about 5% of controls. BS were mainly unconjugated with an unusual low amount of chenodeoxycholate derivatives (< 5%). The patients’ native liver biopsies showed canalicular BSEP expression. Both BSEP p.T919del and p.G1032R were localized in the plasma membrane in HEK293 cells. In vitro transport assays showed drastic reduction of transport by both mutations. Using purified recombinant BSEP as quantifiable reference, per-molecule transport rates for TC and TCDC were determined to be 3 and 2 BS molecu

关键词： Familial intrahepatic cholestasis type 2 Partial external biliary diversion Bile salt export pump ATP binding cassette transporter Intrahepatic cholestasis

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