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Effects of Epstein-Barr virus infection on the development of multiple myeloma after liver transplantation

Science China(Life Sciences) 2012年第8期55卷 735-743页

作者： ZHANG YeWei ZHAO HeWei HE Xia ZHENG SuWen WANG TaiHong YAN DongLiang SUN JingFeng LU Xiang WEN JianFei LAU Wan Yee Department of Hepatobiliary and Pancreatic Surgery Affiliated Jiangsu Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Radiotherapy Affiliated Jiangsu Caneer Hospital of Nanjlng Medical University Nanjing 210009China Department of General surgery The Second Affiliated Hospital of Nantong University Nantong 226001China departimen of geriatrics The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011China Faculty of Medicine The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina

Reduced cellular immune function in patients after liver transplantation easily results in many types of viral infections,such as Epstein-Barr ***-Barr virus is a γ-herpesvirus and is related to many malignant diseases,especially epithelial and lymph *** abnormal interaction of cluster of differentiation 40 with cluster of differentiation 40 ligand and expression of cluster of differentiation 40 ligand are considered closely related to the development of myeloma *** study explored the influence and mechanism of Epstein-Barr virus infection on the phenotype and biological behavior of myeloma cells after liver *** cytometry was used to detect coexpression of cluster of differentiation 40 and cluster of differentiation 40 ligand in 10 samples of freshly isolated multiple myeloma *** of differentiation 40 and cluster of differentiation 40 ligand were coexpressed in sample Nos.5,8,9,and 10,particularly in sample *** blot analysis was used to detect the expression of the Epstein-Barr virus antigens latent membrane protein 1 and Epstein-Barr virus nuclear antigen 2 in the multiple myeloma cell line RPMI 8226 infected with Epstein-Barr *** antigen expression indicated that Epstein-Barr virus can infect multiple myeloma virus cells in *** transcription-polymerase chain reaction revealed upregulated expression of cluster of differentiation 40 ligand on the infected RPMI 8226 cells,which may be involved in the anti-apoptosis activity of the infected *** microscopy showed that pairs of molecules of cluster of differentiation 40,cluster of differentiation 40 ligand,and latent membrane protein 1 were colocalized on the surface of the infected *** chemokine receptor 4 was upregulated on the RPMI 8226 cells after Epstein-Barr virus *** migratory ability of the infected cells improved in the presence of the chemokine stromal cell-derived factor-1α.Anti-apoptosis and migration are k

关键词： liver transplantation CD40 CD40L multiple myeloma EBV

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