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Hypoglycemic and antioxidant activities of Caesalpinia ferrea Martius leaf extract in streptozotocininduced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2015年第6期5卷 460-470页

作者： Sherien Kamal Hassan Nermin Mohammed El-Sammad Amria Mamdouh Mousa Maha Hashim Mohammed Abd el Razik Hussein Farrag Amani Nassir Eldin Hashim Victoria Werner Ulrike Lindequist Mahmoud Abd El-Moein Nawwar departement of Biochemistry National Research CentreCairo Egypt departement of Pathology National Research CentreCairo Egypt departement of phytochemistry and plant systematics National Research CentreCairo Egypt Institute of Pharmacy Pharmaceutical Biology Ernst-Moritz-Arndt-Universitt GreifswaldD-17487 Greifswald Germany

Objective: To evaluate the antidiabetic and antioxidant ef ects of aqueous ethanolic extract of Caesalpinia ferrea(C. ferrea) leaf in normal and streptozotocin(STZ) induced diabetic ***: Male Sprague-Dawley rats divided into 6 groups of 6 rats each were assigned into diabetic and non-diabetic groups. Diabetes was induced in rats by single intraperitoneal administration of STZ(65 mg/kg body weight). C. ferrea extract at the doses of 250 and 500 mg/kg body weight was orally administered to both diabetic and non-diabetic animals for a period of 30 days. After completion of experimental duration serum, liver and pancreas were used for evaluating biochemical and histopathological ***: Oral administration of C. ferrea leaf extract significantly reduced elevated serum glucose, α-amylase, liver function levels and signii cantly increased serum insulin, total protein and body weight as well as improved lipid proi le due to diabetes. Furthermore, the treatment resulted in a marked increase in glutathione peroxidase, superoxide dismutase, catalase and reduced glutathione, and diminished levels of lipid peroxidation in liver and pancreas of diabetic rats. Histopathological studies demonstrated the reduction in the pancreas and liver damage and coni rmed the biochemical i ***: From the present study, it can be concluded that the C. ferrea leaf extract ef ectively improved hyperglycaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats. Hence, it can be used in the management of diabetes mellitus.

关键词： Caesalpinia ferrea Diabetes Streptozotocin Hypoglycemia Antioxidant markers Histopathology

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New Diterpenoids from Coleus forskohlii

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Chinese Chemical Letters 2002年第8期13卷 740-743页

作者： Yun Heng SHEN Chun Suo YAO Yun Long XU State Key Laboratory of phytochemistry and plant Resources in West China Kunming 650204

Two new diterpenoids, forskolin G and H were isolated from the chloroform extract of the roots of Coleus forskohlii, and based on spectroscopic data, their structures were identified as 1a-hydroxy-6b,7b-diacetoxy-8,13... 详细信息

关键词： Coleus forskohlii diterpenoids forskolin G and H.

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Pre-and post-pollination barriers between two exotic and five native Sagittaria species:Implications for species conservation

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plant Diversity 2023年第4期45卷 456-468页

作者： Ting-Ting Zou Sen-Tao Lyu Qi-Lin Jiang Shu-He Shang Xiao-Fan Wang Laboratory of plant systematics and Evolutionary Biology College of Life SciencesWuhan UniversityWuhan 430072China

Anthropogenic introduction of species has resulted in a breakdown of geographical barriers and hybridization in previously allopatric ***,examining hybridization proneness of exotic species contributes to revealing its potential ***,reproductive barriers may be strengthened or weakened due to long-term geographical isolation for these newly sympatric ***,few studies have evaluated multiple barriers between alien and native *** this study,we quantified the importance of four pre-pollination barriers(phenological,floral traits,pollen production,and floral constancy)and four post-pollination barriers(pollen-pistil incompatibility,seed set,seed viability,and seedling survival)between two introduced and five native Sagittaria *** showed that introduced *** was cross-compatible with two native species,whereas introduced *** was incapable of hybridizing with any native *** barriers were asymmetric within species pairs and multiple barriers acted in concert to maintain species *** barriers contributed more to total reproductive isolation in native species,whereas prepollination barriers played a stronger role in total reproductive isolation for two introduced *** set was the only barrier that was positively correlated with genetic *** results provide a perspective to better understand reproductive barriers for secondary contact *** highlight the importance of monitoring hybridization events before human introduction and the possible conservation strategies to remove invasive species with hybridization proneness.

关键词： Alismataceae Introduced species Conservation Hybridization Reproductive isolation Sagittaria

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Insignin A, A Novel C_21-Steroidal Aglycone from Biondia insignis

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Chinese Chemical Letters 2000年第12期11卷 1065-1068页

作者： Yuan Hu ZHANG Yue Mao SHEN Yuan Ying WEN Ting Yun KUANG Laboratory of phytochemistry and Department of plant Biotechnology Kunming Institute of BotanyChinese Academy of SciencesKunming 650204 Laboratory of phytochemistry Institute of BotanyChinese Academy of SciencesBeijing 100093

Insignin A, a new C21-steroidal aglycone having the rare 15,16-seco pregnane skeleton was isolated from the acidic hydrolysis part of the 95% EtOH extract of Biondia insignis. It's structure was identified to be 15R,... 详细信息

关键词： Asclepiadaceae Biondia insignis C21-steroidal aglycone insignin A<

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Structural determination of eleven new preschisanartane-type schinortriterpenoids from two Schisandra species and structural revision of preschisanartanin J using NMR computation method

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Chinese Journal of Natural Medicines 2019年第12期17卷 970-981页

作者： HU Kun LI Xing-Ren TANG Jian-Wei Li Xiao-Nian PUNO Pema-Tenzin State Key Laboratory of phytochemistry and plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences

Nineteen preschisanartane-type schinortriterpenoids(SNTs),among which eleven ones were previously undescribed,were isolated from two Schisandra species,*** and *** structures were determined using 1 D and 2 D NMR spectroscopic analyses,NMR data comparison,quantum chemical calculation of NMR parameters,electronic circular dichroism(ECD),X-ray single crystal diffraction,and chemical ***,structural re-examination of a few previously reported preschisanartane-type SNTs led to the structural revision of preschisanartanin ***,it is suggested that the reported structures of arisanlactone D and schilancidilactone W should be ***,a few isolated SNTs were found to possess neurite outgrowthpromoting activities,and protective activities against neural injuries.

关键词： Schisandra sphaerandra Schisandra rubriflora Preschisanartane-type schinortriterpenoids Structural revision Quantum chemical calculation of NMR parameters

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Bishyoscyamine,one unusual dimeric tropane alkaloid from Anisodus acutangulus

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Chinese Chemical Letters 2013年第3期24卷 236-238页

作者： Chang-An Geng Yun-Bao Ma Ji-Jun Chen State Key Laboratory of phytochemistry and plant Resources in West China Kunming Institute of BotanyChinese Academy of Sciences

One unusual dimeric tropane alkalolcl, blshyoscyamme, was ISOlated from the roots o! Amsoaus acutangulus, whose structure including the absolute stereochemistry was unambiguously determined based on extensive 1D NMR and 2D NMR, HR-ESI-MS [et]D and CD spectroscopic analyses. To our knowledge, bishyoscyamine is the first example of tropane alkaloid dimer condensed by a C-N bond.

关键词： Anisodus acutangulusBishyoscyamineTropane alkaloid dimers

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Two new guaianolide-type sesquiterpenoids from Kadsura interior

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Chinese Chemical Letters 2013年第2期24卷 111-113页

作者： Ke Dong Jian-Xin Pu Xue Du Xiao-Nian Li Han-Dong Sun State Key Laboratory of phytochemistry and plant Resources in West China Kunming Institute of BotanyChinese Academy of Sciences

Received 22 November 2012 Received in revised form 25 December 2012 Accepted 2B December 2012 Available online 4 February 2013

关键词： Kadsura interior4 8 9β-Dihydroxy-1 a 5a-H-guaia-6 10( 14)-dien4β 9β 10β-Trihydroxy-1a.5a-H-guaia-6-enX-ray technique

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Chemical constituents and biological activities of lycophytes and ferns

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Chinese Journal of Natural Medicines 2019年第12期17卷 887-891页

作者： ZHU Qin-Feng ZHAO Qin-Shi State Key Laboratory of phytochemistry and plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences

Lycophytes and ferns are unique and charismatic members of many terrestrial ecosystems and occupy the pivotal position in land plant origin and *** Chinese lycophytes and ferns flora,with approximately 2000 species,contributes a substantial component to the global lycophytes and ferns diversity,with estimates of 12000 *** them,about 433 species are medicinally recorded and researches based on their phytochemical properties are important topics in natural *** paper reviewed the research history and current status of chemical constituents and biological activities of lycophytes and ferns,which had highlighted the research progress of our group.

关键词： Lycophytes Ferns Chemical constituents Biological activities Lycopodium alkaloids

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New Understanding of the Basic Theory of Traditional Chinese Medicine

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Chinese Journal of Integrative Medicine 2009年第1期15卷 7-12页

作者：周俊 State Key Laboratory of phytochemistry and plant Resources in West China Kunming Institute of BotanyChinese Academy of Sciences

Traditional Chinese medicine(TCM) plays an important role in the medical system used in health care and treatment of *** article reviews the basic theory of TCM based on its formation and *** new personal points are proposed as follows:Six Zang(六脏) theory and deemphasization of the five-element *** basic theory of Chinese herbs is also discussed.

关键词： new understanding yin-yang theory five-element theory six Zang and six Fu traditional Chinese medicine

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Two New Abietane Quinones from Isodon lophanthoides var. Micranthus

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Chinese Chemical Letters 2003年第6期14卷 591-593页

作者： Ai Hua ZHAO Sheng Hong LI Yong Wei LI Quan Bin HUAN Qin Shi ZHAO Zhong Wen LIN Han Dong SUN State Key Laboratory of phytochemistry and plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650204

The structures of two new abietane quinones, named micranthins A and B, were determined to be 7a-methoxy-14, 16-epoxy-8, 13-abietadiene-11, 12-dione (1) and 16-acetoxy-6, 7-dehydroroyleanone (2) respectively, which we... 详细信息

关键词： Isodon lophanthoides var. micranthus Labiatae abietane quinones micranthin A miranthin B.

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