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Erectile Dysfunction in hemodialysis in Togo

Open Journal of nephrology 2016年第4期6卷 145-150页

作者： Kossi Akomola Sabi Béfa Noto Kadou Kaza Eyram Yoan Amekoudi Jacques Vigan Souleymane Pessinaba Kafui Avouwadan Kodjo Tengue Tchilabalo Matchona Kpatcha Dazé Apollinaire Gnionsahe departement of nephrology and hemodialysis Sylvanus Olympio University Teaching Hospital Lomé Togo departement of nephrology and hemodialysis University Teaching Hospital of Cotonou Cotonou Benin departement of Cardiology Campus University Teaching Hospital of Lomé Lomé Togo departement of Urology and Andrology Sylvanus Olympio University Teaching Hospital Lomé Togo departement of nephrology and hemodialysis University Teaching Hospital of Yopougon Abidjan Ivoiry Coast

Objectives: To determine the prevalence and risk factors of erectile dysfunction (ED) in men on hemodialysis in Togo. Methods: Prospective cross-sectional study, descriptive and analytical ranging from December 2015 to February 2016 in the hemodialysis unit of CHU SO, only dialysis center in the country. The evaluation of the ED was made through IIEF-5 questionnaire. Results: 39 men (67.2%) of 58 hemodialysis is a sex ratio M/F of 2.05. The average age was 43.5 years with extremes of 25 and 59 years. The majority of men had a profession in 19 cases (48.7%). The mean duration of dialysis was 30 months with a range of 4 months and 90 months. Initial glomerular nephropathy was in 19 cases (48.7%) and vascular in 14 cases (35.9%). 38 patients were hypertensive (97.4%) and 6 diabetic men (15.4%). The prevalence of ED was 74.3% (29 cases). ED score was less than 10 points in 14 cases (35.9%);01 case (2.6%) between 11 and 16 points;06 cases (15.4%) between 17 to 21 points;08 cases (20.5%) between 22 and 25 points;and 10 cases (25.6%) between 26 and 30 points. Age, profession and duration of dialysis were risk factors associated with ED (P 0.001). Conclusion: The prevalence of ED is very high in Togo.

关键词： Erectile Dysfunction hemodialysis Togo

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Risk Factors of Bacterial Resistance to Antibiotics in Internal Medicine and hemodialysis nephrology Services at the Edith Lucie Bongo Ondimba General Hospital

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Open Journal of nephrology 2021年第1期11卷 9-20页

作者： Gandzali-Ngabe Pierre Eric Ngoyi Ontsira Nina Gakosso Odou Philippe Loumingou Richard nephrology hemodialysis édith Lucie BONGO ONDIMBA General Hospital Oyo Congo Laboratory Hospital and University Center of Brazzaville Brazzaville Congo Laboratory édith Lucie BONGO ONDIMBA General Hospital Oyo Brazzaville Congo nephrology Brazzaville Hospital and University Center Brazzaville Congo

Introduction: Antibiotic resistance is a public health problem. It is due to multi-resistant bacteria (MRB). The objective of this study was to determine bacterial resistance to antibiotics in chronic renal failure at the Edith Lucie BONGO ONDIMBA general hospital (HGELBO). Patients, material and method: This was an analytical cross-sectional study conducted from January 1 to August 31, 2019 at the HGELBO. It concerned all patients admitted to the HGELBO with positive bacteriological samples. After a study of the sensitivity to isolated species, the patients were divided into two (02) groups: those MRB positive (+) and not MRB or negative (-). Epi Info software version 3.5.1 was used for the calculation of the rates and the comparison of the variables. The adjusted odds ratio (ORa) with a 95% confidence interval was used to measure the specific effect of each risk factor such as chronic kidney disease and diabetes, in order to rule out confounding factors. Multivariate analysis by binomial logistic regression was used. Results: There were 375 bacteriological samples from 258 patients, among them 247 patients with 235 positive samples or 63%. The eleven (11) are healthy patients. The median age was 33 with extremes ranging from 16 to 90. The female sex was predominant with a sex ratio of 0.6. The majority of MRB+ cases were found in internal medicine and nephrology with 12 cases (38.7%) and hemodialysis with 4 cases (12.9%). Urinary samples were in the majority with 74.5%. Escherichia coli was predominant in 30.3%. After studying the sensitivity to antibiotics of the 247 species included, 113 were MRB+ and 134 BMR- i.e. a frequency of 45.7%. Methicilin-resistant Staphylococcus aureus (MRSA) was predominant (51.3%). Multivariate logistic regression analysis showed that the main risk factor was antibiotic use (0Ra: 3.2 [1.9 - 5.4];p-value < 0.01). Chronic renal failure and diabetes were not risk factors for carriage. The other risk factors identifi

关键词： Risk Factors Bacterial Resistance Antibiotics Chronic Renal Failure General Hospital Edith Lucie BONGO ONDIMBA

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Renal aspergillosis in a liver transplant patient: A case report and review of literature

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World Journal of Clinical Cases 2018年第16期6卷 1155-1159页

作者： Brigita Smolovic Batric Vukcevic Damir Muhovic Marina Ratkovic Faculty of Medicine University of Montenegro Department of Gastroenterohepatology Clinical Center of Montenegro Department of nephrology and hemodialysis Clinical Center of Montenegro

BACKGROUND Aspergillosis is a frequent invasive fungal infection in liver recipients(affecting 1%-9.2% of all patients), second only to candidiasis. Significant risk factors for invasive aspergillosis in liver recipients include corticosteroid therapy, neutropenia, T-cell dysfunction, renal failure and requirement for renal replacement therapy. Aspergillus infection usually affects the lungs of liver recipients, with hematogenous dissemination occurring in 50%-60% of cases. Renal involvement is rare and is considered to occur in 0.4% of all cases of invasive *** SUMMARY This paper describes a case of a liver recipient presenting with a newly formed renal mass a year after liver transplantation. The patient underwent liver transplantation due to alcoholic liver cirrhosis, with preoperative corticosteroid therapy and postoperative immunosuppressants(tacrolimus and mycophenolate mofetil). His 1-year follow-up was uneventful, with a satisfying graft function and lack of any symptoms. During a routine follow-up abdominal ultrasound, he was diagnosed with a renal tumor. The renal ima-ging findings were inconclusive(with a differential diagnosis to renal cell carcinoma), while the computed tomography(CT) of the chest showed scar tissue in the lungs suggestive of previous inflammation. The patient underwent radical nephrectomy, with histopathological analysis showing renal aspergilloma, yielding postoperative treatment with voriconazole. His follow up was uneventful, and the chest CT did not show any change in pulmonary lesions. This case illustrates the possibility of aspergillosis affecting the lungs of liver recipients, subsequently affecting the kidney and forming an *** Clinicians should be aware of aspergilloma mimicking solid organ tumors in organ recipients.

关键词： Aspergillosis Immunosuppression Liver transplantation Nephrectomy Renal tumor Case report

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Case Report: A Severe Hypernatremia with Multiple Organ Failure, about a Clinical Observation

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Open Journal of nephrology 2017年第1期7卷 19-23页

作者： Alpha Oumar Bah Mamadou Cellou Balde Amadou Bah Alpha Oumar Barry departement of nephrology Donka National Hospital Conakry Guinea departement of nephrology-hemodialysis Chiva Hospital Foix Cedex France departement of Diabetology Donka National Hospital Conakry Guinea departement of Reanimation Donka National Hospital Conakry Guinea

A hypernatremia severity is often associated with a poor prognosis, especially if it is associated with multiple organ failure. In a country with very limited resources, the prognosis may be favorable in the absence of renal replacement. We report the case of a 63 years old woman, hypertensive and diabetic, admitted to the ICU for unconsciousness. Clinically, neurological examination notes a Glasgow of 8/15 (Y2, V2, M4) and a left hemiplegia. Temperature was 39°C. Diuresis was 100 ml during the first 24 hours. Blood pressure was 90/60 mmHg, tachycardia at 133/min. Cardiac auscultation is normal. Vascular axes were weakly perceptible. Oxygen saturation was 95%. The skin examination notes a dry skin and mucous membranes, a flattening of the superficial veins, sunken eyes and a persistent skin fold. There is no hepatomegaly or splenomegaly, or jaundice. Biological point of view note natremia: 176 mmol/L;osmolarity: 390 mosmol/kg;creatinin: 300 μmol/L;glycemia > 6 g/L;transaminases 217 UI. Diagnostics: malignant hypernatremia with a high plasma osmolarity associated with an acute anuric renal failure, hydro electrolytic disorders, an abnormal liver function, a fever of central origin and a stroke. The treatment consisted of a correction of the electrolyte disorders by infusion of isotonic and hypotonic fluids with insulin. In a country with very limited resources, the severe hypernatremia prognosis associated with anuric acute renal failure may be favorable in the absence of renal replacement.

关键词： Hypernatremia Hyperosmolar Coma Multiple Organ Failure Acute Renal Failure Diabetes

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USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells

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Current Medical Science 2024年第4期44卷 707-717页

作者： Xiao-hui YAN Yin-na ZHU Yan-ting ZHU Kidney Disease and Dialysis Center Shaanxi Provincial People's HospitalXi'an 710068China Department of nephrology The Third Affiliated Hospital of Xi'an Medical UniversityXi'an 710000China nephrology and hemodialysis Center Shaanxi Provincial People's HospitalXi'an 710068China

Objective Obesity-induced kidney injury contributes to the development of diabetic nephropathy(DN).Here,we identified the functions of ubiquitin-specific peptidase 19(USP19)in HK-2 cells exposed to a combination of high glucose(HG)and free fatty acid(FFA)and determined its association with TGF-beta-activated kinase 1(TAK1).Methods HK-2 cells were exposed to a combination of HG and ***19 mRNA expression was detected by quantitative RT-PCR(qRT-PCR),and protein analysis was performed by immunoblotting(IB).Cell growth was assessed by Cell Counting Kit-8(CCK-8)viability and 5-ethynyl-2′-deoxyuridine(EdU)proliferation *** cycle distribution and apoptosis were detected by flow *** USP19/TAK1 interaction and ubiquitinated TAK1 levels were assayed by coimmunoprecipitation(Co-IP)assays and *** In HG+FFA-challenged HK-2 cells,USP19 was highly ***19 knockdown attenuated HG+FFA-triggered growth inhibition and apoptosis promotion in HK-2 ***,USP19 knockdown alleviated HG+FFA-mediated PTEN-induced putative kinase 1(PINK1)/Parkin pathway inactivation and increased mitochondrial reactive oxygen species(ROS)generation in HK-2 ***,USP19 stabilized the TAK1 protein through ***,increased TAK1 expression reversed the USP19 knockdown-mediated phenotypic changes and PINK1/Parkin pathway activation in HG+FFA-challenged HK-2 *** The findings revealed that USP19 plays a crucial role in promoting HK-2 cell dysfunction induced by combined stimulation with HG and FFAs by stabilizing TAK1,providing a potential therapeutic strategy for combating DN.

关键词： HK-2 cells high glucose free fatty acid dysfunction USP19 deubiquitination

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Focal Segmantal Glomerulosclerosis: Epidemiological, Clinico-Biological, Pathological, Etiological, Therapeutic and Evolutionary Profiles in Dakar

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Open Journal of nephrology 2023年第2期13卷 174-195页

作者： Pierre Eric Gandzali Ngabe Djibrilla Bonkano Baoua Aida Habi Yabana Lengani Hamadoun Yattara Adama Kama Yatte Richard Loumingou Lemrabott Tall Elhadji Fary Ka Abdou Niang Boucar Diouf Department of nephrology and hemodialysis General Teaching Hospital Brazzaville Republic of the Congo Department of nephrology and hemodialysis Amirou Boubacar Diallo National Hospital Niamey Niger Department of nephrology and hemodialysis Yalgado Ouedraogo Ouagadougou Burkina Faso Department of nephrology and hemodialysis General Teaching Hospital POINT G Bamako Mali Department of nephrology Dialysis and Kydney Transplantation ARISTIDE LE DANTEC Hospital Dakar Senegal

Introduction: Focal Segmental Glomerulosclerosis (FSGS) corresponds to a clinicopathological syndrome, manifested by generally abundant proteinuria associated with hyaline deposits on part of certain glomeruli and sparing other glomeruli, with effacement of the pedicels. The general objective was to determine the prevalence of FSGS, and to give its profiles;epidemiological, clinical, biological, pathological, etiological, therapeutic and evolutionary of FSGS. Materials and Methods: This is a retrospective analytical study over a period of six years extending from January 1, 2010 to December 31, 2015 patients aged 16 or over who were hospitalized or received consultations during the study period for primary or secondary segmental and focal hyalinosis. Patients whose records were incomplete or unusable were not included in the study. Results: We have 16.54% with 158 cases of FSGS out of 6945 patients received and/or hospitalized. Of the 955 kidney biopsies distributed, the incidences of HSF were;10.15%;14.04%;15%;17.64%;20.11%;19.58% respectively in 2010;2011;2012;2013;2014 and 2015, i.e. an annual increase of around 1.25%. Renal-type edemas were found in 93.3%, the first reason for hospitalization. And ninety-six people had impaired kidney function, or 61%. The average of 24-hour proteinuria was 6.4 ± 3.69 g/24 hours. The extremes were 0.37 and 18.50 g/24h. Patients had nephrotic proteinuria in 84.86%. Non-specific FSGS or NOS (Not Other Specificities) was found in 62 cases or 39.24%, collapsing FSGS in 48 cases or 30.40%. FSGS with found causes was associated with fibrosis in 5/35 cases. Collapsing FSGSs followed by NOS FSGSs were the most corticosteroid-resistant. The evolution of the FSGS reveals that every 8 months the proteinuria decreases by half. Conclusion: Segmental and focal hyalinosis requires histological confirmation and the epidemiological, clinico-biological, etiological, therapeutic and evolutionary profiles depend on the histological (pathological) t

关键词： Proteinuria Corticotherapy Focal Segmantal Glomerulosclerosis Senegal

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Gender differences in the relationship between plasma lipids and fasting plasma glucose in non-diabetic urban Chinese popula- tion： a cross-section study

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Frontiers of Medicine 2014年第4期8卷 477-483页

作者： Jie Zheng Yuzhen Gao Yuejuan Jing Xiaoshuang Zhou Yuanyuan Shi Yanhong Li Lihua Wang Ruiying Wang Maolian Li Chuanshi Xiao Yafeng Li Rongshan Li School of Nursing Shanxi Medical University Taiyuan 030001 China Department of Cardiology Second Hospital of Shanxi Medical University Taiyuan 030001 China Department of nephrology and hemodialysis Center Second Hospital of Shanxi Medical University Taiyuan 030001 China Shanxi Renal Disease Research Institution Taiyuan 030001 China Department of Cardiology First Hospital of Shanxi Medical University Taiyuan 030001 China Department of nephrology and hemodialysis Center Shanxi Provincial People's Hospital Taiyuan 030012 China

The association between dyslipidemia and elevated fasting glucose in type 2 diabetes is well known. In non-diabetes, whether this association still exists, and whether dyslipidemia is an independent risk factor for high fasting plasma glucose （FPG） levels are not clear. This cross-sectional study recruited 3460 non-diabetic Chinese subjects （1027 men, and 2433 women, aged 35-75 years old） who participated in a health survey. Men and women were classified into tertiles by levels of plasma lipids respectively. In women, the prevalence of impaired fasting glucose （IFG） was decreased with increased HDL-C. A stepwise increase in HDL-C was associated with decreasing FPG levels （lowest tertiles, FPG： 5.376 ± 0.018; middle tertiles, 5.324± 0.018; highest tertiles, 5.276±0.018mmol/L; P = 0.001）. Reversely, FPG levels increased from lowest tertiles to highest tertiles of LDL-C, TC, and TG. we found that women in the first tertile with lower HDL-C level had a 1.75-fold increase in risk of IFG compared with non-diabetic women in the third tertile with higher HDL-C level （OR： 1.75; 95% CI： 1.20-2.56）. In men, no significant association was found. We took age, BMI, waist/hip ratio, education, smoking, alcohol drinking, and physical exercise as adjusted variables. In Chinese non-diabetic women, dyslipidemia is independently associated with high levels of FPG; TG, HDL-C, and LDL-C are predictors of IFG independent of BMI and waist/hip ratio.

关键词： dyslipidemia plasma lipids plasma fasting glucose impaired fasting glucose non-diabetes

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International Journal of Clinical Medicine 2012年第7期3卷 598-602页

作者： Gerhard Lonnemann Eike Wrenger Outpatient Clinic of nephrology Hemodialysis Center Eickenhof Langenhagen Germany Outpatient Clinic of nephrology Hemodialysis Center Eickenhof Langenhagen Germany.

Aim: This observational clinical study tested the effect of injection frequency of the biosimilar epoetin zeta on the weekly dose needed to maintain stable hemoglobin levels in chronic kidney diseases (CKD) patients on intermittent high-flux hemodialysis (HD). Patients and Methods: CKD patients (n = 33) on regular HD therapy 3 times a week were treated for 18 months with epoetin zeta i.v. The hemoglobin levels, the weekly dose as well as the injection frequency of epoetin zeta were monitored at least every two weeks. Patients were followed in three time periods: 1) extended follow-up (months 1 - 18);2) intervention phase (months 19 - 21);and 3) post intervention observation phase (months 28 - 30). During extended follow-up the majority of patients (n = 21) received only one injection of epoetin zeta per week. During the intervention phase, injection frequency was increased to 3 injections per week in all patients accompanied by a reduction in weekly doses of approximately 20% - 30%. Following a 9 month period of dose adjustment all parameters were monitored again in the post-intervention phase. Results: During the first 18 months of epoetin zeta therapy the mean hemoglobin level was stable between 11 and 12 g/dl. The mean weekly dose of epoetin zeta was 7939 IU/week in month 6 and 7909 IU/week in month 18 (p = not significant). The mean frequency (injections/week) was 1.27 in month 6 and 1.29 in month 18 (not significant). Compared to month 18, at the end of the observation at month 30, hemoglobin levels were stable, mean injection frequency increased to 2.25 (p < 0.001) and the mean weekly dose decreased to 5469 IU/week (-31.7%, p < 0.001). Conclusions: Increasing the injection frequency of the short acting biosimilar epoetin zeta to two to three injections per week reduces the weekly dose and thereby the costs of ESA therapy of renal anemia significantly.

关键词： Epoetin Zeta Renal Anemia Drug Efficiency Injection Frequency Chronic hemodialysis

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Post Hepatitis C Cirrhosis in Sub-Sahara Kidney Transplant, Treated with Sofosbuvir/Ledipasvir: Report of Case and Review of Literature

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Open Journal of nephrology 2017年第4期7卷 95-100页

作者： Tsevi Yawovi Mawufemo Lagou Amelie Delphine Tia Weu Melanie Coulibaly Pessa Nawo Albert Cherif Ibrahima Guei Monlet Cyr Ackoundou-N’Guessan Kan Clement nephrology and Dialysis Department of Teaching Hospital Sylvanus Olympio University of LomeLomeTogo nephrology Hemodialysis and Organ Transplant Departement of Yopougon Teaching HospitalUniversity Felix Houphouet BoignyAbidjanCote d’Ivoire

Background: Viral hepatitis C is a major public health problem in the world. The advent of direct-acting antivirals has revolutionized the taking in charge and prognosis of patients infected with the hepatitis C virus. The interest of this presentation is to draw attention to the problem of therapeutic care posed by viral hepatitis C in kidney transplant patients in C?te d’Ivoire, a country with limited resources where all direct-acting antivirals are not yet available. Patient observation: We report the case of a kidney transplant of 52 years old, chronic bearer of viral hepatitis C virus who after his kidney transplant presented, decompensated active cirrhosis. A treatment based on Sofosbuvir 400 mg/Ledipasvir 90 mg in this patient with genotype 2 for 12 weeks was initiated. A sustained virological response was observed 12 weeks after the end of treatment. Conclusion: Direct-acting antivirals offer the possibility of antiviral C treatment without interferon or ribavirin in cirrhotic renal transplant.

关键词： C?te D’Ivoire Direct-Acting Antivirals Kidney Transplantation Viral Hepatitis C

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MicroRNA-21 in the pathogenesis of acute kidney injury

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Protein & Cell 2013年第11期4卷 813-819页

作者： Ya-Feng Li Ying Jing Jielu Hao Nathan C Frankfort Xiaoshuang Zhou Bing Shen Xinyan Liu Lihua Wang Rongshan Li Department of nephrology and hemodialysis Center Second Hospital of Shanxi Medical UniversityTaiyuan 030001China Shanxi Renal Disease Research Institution Taiyuan 030001China Department of Blood Purifi cation General Hospital of Jinan Military Command of PLAJinan 250031China nephrology Institute of PLA Changzheng Hospital of Second Military Medical UniversityShanghai 200003China Department of Neuroscience and Neurovirology Temple University School of MedicinePhiladelphiaPA 19140USA Department of Urology Shanghai First People’s HospitalShanghai 200080China Department of nephrology and hemodialysis Center Shanxi Provincial People’s HospitalTaiyuan 030012China

Acute kidney injury(AKI),associated with significant mor-bidity and mortality,is widely known to involve epithelial apoptosis,excessive inflammation,and fibrosis in re-sponse to ischemia or reperfusion injury,which results in either chronic pathological changes or ***,it is imperative that investigations are conducted in order to fi nd effective,early diagnoses,and therapeutic targets needed to help prevent and treat ***,the mech-anisms modulating the pathogenesis of AKI still remain largely ***(miRNAs),small non-coding RNA molecules,play an important role in several fundamental biological and pathological processes by a post transcriptional regulatory function of gene ***-21(miR-21)is a recently identifi ed,typi-cal miRNA that is functional as a regulator known to be involved in apoptosis as well as inflammatory and fi brotic signaling pathways in *** a result,miR-21 is now considered a novel biomarker when diagnosing and treat-ing *** article reviews the correlative literature and research progress regarding the roles of miR-21 in AKI.

关键词： microRNA microRNA-21 gene expression acute kidney injury

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