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Chinese Journal of Chemistry 2024年第10期42卷 1128-1132页

作者： Chao Li Lei Chen Hongye Wang Zixi Yan Bin Lyu Weiping Lyu Changwei Jiang Dehua Lu Jiaxing Li Ning Jiao Song Song State Key Laboratory of natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityXue Yuan Rd.38Beijing 100191China

A mild and practical method for synthesizing fluorinated quinoline derivatives,which have a wide range of applications in pharmaceuticals,materials,and organic synthesis,was described through C—F bond insertion into indoles using CHBr_(2)*** simple conditions,readily availability of CHBr_(2)F,as well as the versatility of the transformations make this strategy very powerful in synthesizing 3-fluoroquinoline and *** mechanistic studies reveal that bromofluorocarbene generated in-situ under basic condition was the key intermediate.

关键词： Skeleton edit Fluorocarbene Ring expansion Quinoline Quinolone

Preliminary geological interpretation of long-wavelength magnetic anomalies over China and surrounding regions

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Earth and Planetary Physics 2024年第3期8卷 445-458页

作者： Jie Wang YanYan Yang ZhiMa Zeren Jian Wang Xin Wang YuXin Luo XuHui Shen National Institute of natural Hazards Ministry of Emergency Management of ChinaBeijing 100085China Key Laboratory of Compound and Chained natural Hazards Dynamics Ministry of Emergency Management of ChinaBeijing 100085China School of Emergency Management Science and Engineering University of Chinese Academy of SciencesBeijing 100049China National Space Science Center Chinese Academy of SciencesBeijing 100190China

Long-wavelength(>500 km)magnetic anomalies originating in the lithosphere were first found in satellite magnetic *** to the striking magnetic anomalies around the world,the long-wavelength magnetic anomalies in China and surrounding regions are relatively *** research on each of these anomalies has been quite inadequate;their geological origins remain unclear,in particular their connection to tectonic activity in the Chinese and surrounding *** focus on six magnetic high anomalies over the(1)Tarim Basin,(2)Sichuan Basin(3)Great Xing’an Range,(4)Barmer Basin,(5)Central Myanmar Basin,and(6)Sunda and Banda Arcs,and a striking magnetic low anomaly along the southern part of the Himalayan-Tibetan *** have analyzed their geological origins by reviewing related research and by detailed comparison with geological *** tectonic backgrounds for these anomalies belong to two cases:either ancient basin basement,or subduction-collision ***,the geological origins of large-scale regional magnetic anomalies are always subject to dispute,mainly because of limited surface exposure of sources,later tectonic destruction,and superposition of multi-phase events.

关键词： long-wavelength magnetic anomaly lithospheric magnetic anomaly lithospheric magnetic field model satellite magnetic survey CSES

Temporal variability of global potential water erosion based on an improved USLE model

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International Soil and Water Conservation Research 2024年第1期12卷 1-12页

作者： Jialei Li Muqi Xiong Ranhao Sun Liding Chen State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China University of Chinese Academy of sciences Beijing100049China Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing100101China

Assessing spatiotemporal variation in global soil erosion is essential for identifying areas that require greater attention and management under the effects of anthropogenic activities and climate *** erosion can be modelled using the universal soil loss equation(USLE),which includes rainfall erosivity(R-factor),vegetation cover(C-factor),topography(LS-factor),soil erodibility(K-factor),and management practices(P-factor).However,global soil erosion modeling faces numerous challenges,including data acquisition,calculation processes,and parameter calibration under different climatic and topographic ***,we presented an improved USLE-based model using highly distributed *** R-,C-,and P-factors were modified by the climate zone,country,and *** distributed model was applied to estimate the intensity and variations in global soil erosion from 1992 to *** validated the accuracy of this model by comparing simulations with measurements from 11,439 plot years of erosion *** results showed that i)the average global erosion rate was 5.78 t ha^(-1)year^(-1),with an increase rate of 4.26×10^(-3)t ha^(-1)year^(-1);ii)areas with significantly increasing erosion accounted for 16%of the land with water erosion,whereas those with significantly decreasing erosion accounted for 7%;and iii)areas with severe erosion included the western Ghats,Abyssinian Plateau,Brazilian Plateau,south and east of the Himalayas,and western coast of South *** erosion occurred mainly on the Amazon Plain and the northern coast of the *** study provides an improved water erosion prediction model and accurate information for researchers and policymakers to identify the drivers underlying changes in water erosion in different regions.

关键词： Soil erosion Distributed USLE model Rainfall erosivity Soil conservation Global change

Enhancing transboundary natural tourism resources governance:unveiling the spatial pattern and its influencing factors

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Journal of Mountain Science 2024年第3期21卷 973-986页

作者： ZHANG Shengrui ZHANG Tongyan JU Hongrun WANG Yingjie Management College Ocean University of ChinaQingdao 266100China School of Tourism and Geography Science Qingdao UniversityQingdao 266071China Institute of Geographic sciences and natural Resources Research Chinese Academy of SciencesBeijing 100101China

Tourism resources that span provincial boundaries in China play a pivotal role in regional development,yet effective governance poses persistent *** study addresses this issue by constructing a comprehensive database of transboundary natural tourism resources(TNTR)through amalgamation of diverse data *** the Getis-Ord Gi^(*),kernel density estimation,and geographical detectors,we scrutinize the spatial patterns of TNTR,focusing on both named and unnamed entities,while exploring the influencing *** findings reveal 7883 identified TNTR in China,with mountain tourism resources emerging as the predominant *** provinces,Hunan boasts the highest count,while Shanghai exhibits the *** China demonstrates a pronounced clustering trend in TNTR distribution,with the spatial arrangement of biological landscapes appearing more random compared to geological and water *** China,characterized by intricate terrain,exhibits fewer TNTR,concurrently unveiling a significant presence of unnamed natural tourism ***,administrative segmentation influences TNTR development,generating disparities in regional goals,developmental stages and intensities,and management *** response to these variations,we advocate for strengthening the naming of the unnamed transboundary tourism resources,constructing a geographic database of TNTR for government and establishing a collaborative management mechanism based on TNTR *** research contributes to elucidating the intricate landscape of TNTR,offering insights for tailored governance strategies in the realm of cross-provincial tourism resource management.

关键词： Transboundary natural tourism resources(TNTR) Spatial difference Spatial autocorrelation Governance optimization China

A generalization of Banach's lemma and its applications to perturbations of bounded linear operators

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 363-369页

作者： WANG Zi DING Jiu WANG Yu-wen School of Mathematics sciences Harbin Normal UniversityHarbin 150025China School of Mathematics and natural sciences The University of Southern MississippiHattiesburg MS 39406-5043USA Academic Committee Harbin Institute of PetroleumHarbin 150027China

Let X be a Banach space and let P:X→X be a bounded linear *** an algebraic inequality on the spectrum of P,we give a new sufficient condition that guarantees the existence of(I-P)^(-1) as a bounded linear operator on X,and a bound on its spectral radius is also *** generalizes the classic Banach *** apply the result to the perturbation analysis of general bounded linear operators on X with commutative perturbations.

关键词： Banach lemma spectral radius generalized inverse perturbation analysis

The Structures and Regulatory Roles of natural Products in Lipid Metabolism: Focus on Medicinal and Edible Plants

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Food Science and Human Wellness 2024年

作者： Xinjian Zhang Sheng Li Bodou Zhang Yu Zhang Key Laboratory of Phytochemistry and natural Medicines Kunming Institute of Botany Chinese Academy of sciences University of Chinese Academy of sciences

Lipids are essential for normal life activities and biological functions of the human body， and disorders of lipid metabolism produce a lipotoxic environment， endoplasmic reticulum (ER) stress， inflammation， and cell death， which can lead to a variety of diseases in the body. It has been found that lipid metabolism disorders are closely associated with brain injury disease， cancer， metabolic disease， cardiovascular disease (CVD)， respiratory disease and infectious disease. In recent years， many medicinal and edible plants such as Pueraria lobata， Gardenia jasminoides， Curcuma longa， citrus fruits， peanuts， etc. have shown great potential in regulating lipid metabolism and some of the hidden active components showed innovative mechanisms. AMPK， PPARγ， SIRT1， Foxp3， NLRP3， and Keap1 are increasingly recognized as therapeutic targets in the field of regulating lipid metabolism. This study aims to provide a comprehensive review of natural lipid-regulating modulators in medicinal and edible plants and their mechanism of actions， which offer valuable references for the discovery of natural lipid metabolism modulators and a therapeutic strategy for treatment of lipid metabolism-related diseases.

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TCP-1,a novel peptide to diagnose early colon cancer

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Chinese Chemical Letters 2024年第3期35卷 226-233页

作者： Hang Yu Baoying Wen Min Huang Ru Feng Libin Pan Manyi Xu Hao Lin Lin Cong Sen Zhang Yan Li Chi-Hin Cho Chongjing Zhang Xiaoguang Chen Yan Wang State Key Laboratory of Bioactive Substances and Functions of natural Medicines Institute of Materia MedicaChinese Academy of Medical SciencesBeijing 100050China School of Biomedical sciences Faculty of MedicineThe Chinese University of Hong KongHong KongChina

A nine cyclic peptide(TCP-1)showed excellent specificity for colon ***-1 binds with human tumor tissues at early stages and mice tumor with diameters of 1-4 mm,suggesting that TCP-1 may be used for early diagnosis of colon *** mechanism of the targeted binding of TCP-1 to colon cancer was also studied using immunoprecipitation,LC-MS and *** screening and identifying of the possible binding target proteins of TCP-1,keratin,typeⅡcytoskeletal 5 was speculated to be the specific binding target protein of TCP-1 in human tumor *** studies were conducted to investigate the target-mediated drug disposition of the new tumor-specific peptide by LC-MS/*** tissue distribution study showed that TCP-1 was found only in colon tumors(the target site)in tumor mice did not bind to any other *** TCP-1 to tumor markedly increased its removal rate from blood circulation but mildly extended its staying time in *** tumor mice,a lower AUC of TCP-1(reduced by almost 35%)and 2-fold higher clearance were found compared to that of normal *** proposed metabolic pathway of TCP-1 in the kidney was also determined using LC-MS^(n)-*** high specificity and low toxicity of the peptide may be caused by its extremely tight binding to the *** applications for future clinical use,including MRI and PET/CT were also explored,and this research may promote the development of colon cancer diagnostic technology research and provide new ideas and technical routes for tumor diagnostic technology.

关键词： Colon cancer TCP-1 Peptide Cytokeratin 5 Pharmacokinetics/pharmacodynamics(PK/PD)

Pd-catalyzed asymmetric carbonyl alkynylation:Synthesis of axial chiral ynones

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Chinese Chemical Letters 2024年第6期35卷 293-297页

作者： Long Jin Jian Han Dongmei Fang Min Wang Jian Liao natural Products Research Center Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China College of Chemical Engineering Sichuan UniversityChengdu 610065China University of Chinese Academy of sciences Beijing 100049China

Ynones are important skeletons in bioactive molecules and valuable building blocks for organic synthesis,thus great efforts have been devoted to their ***,introducing prochiral substrates to construct ynones bearing a chiral framework is unrealized to ***,we reported the first example of Pd/SOP-catalyzed asymmetric carbonylative alkynylation via a non-classical carbonylative Sonogashiratype approach(acyl-Pd(Ⅱ)species generated from nucleophiles).By using cyclic diaryliodonium salts as prochiral substrates,various axial chiral ynones with good functional group tolerance(39 examples),satisfied yields(71%-96%)and excellent enantioselectivities(generally 94%-99%ee)were *** of bioactive compounds,scale-up experiment and useful transformations were also conducted to demonstrate the utility of this process.

关键词： Pd-catalyzed Axial chiral ynones Cyclic diaryliodonium High-valent palladium catalyzed Asymmetric carbonyl alkynylation

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北京冬奥会的碳减排实践与启示（英文）

Science Bulletin 2024年第13期 2034-2037页

作者：廖晓勇钟帅黄洁刘竹 Ayman Elshkaki 李尤沈镭何盈利安黎朱屹东孙文昊梁涛王姣娥董金玮 Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Key Laboratory for Resources Use and Environmental Remediation Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences University of Chinese Academy of sciences Key Laboratory of Regional Sustainable Development Modeling Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Department of Earth System Science Tsinghua University

Concerns about the carbon emissions of mega-events revolve,mainly due to the impactful demonstration effects they ***, accurate monitoring of these emissions is crucial during such events [1]. The Olympic and Paralympic Winter Games Beijing2022 (hereinafter ‘‘Winter Olympics 2022") are recognized as the first Games to pay close attention to a wide range of emissions associated with all stages of the process. Applications of emerging carbon reduction technologies, such as low-carbon materials and technologies, have shown promising effects on efforts to achieve carbon neutrality [2].

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Gut flora in multiple sclerosis:implications for pathogenesis and treatment

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Neural Regeneration Research 2024年第7期19卷 1480-1488页

作者： Weiwei Zhang Ying Wang Mingqin Zhu Kangding Liu Hong-Liang Zhang Department of Neurology the First Hospital of Jilin UniversityJilin UniversityChangchunJilin ProvinceChina Department of Life sciences National Natural Science Foundation of ChinaBeijingChina

Multiple sclerosis is an inflammatory disorder chara cterized by inflammation,demyelination,and neurodegeneration in the central nervous *** current first-line therapies can help manage symptoms and slow down disease progression,there is no cure for multiple *** gut-brain axis refers to complex communications between the gut flo ra and the immune,nervous,and endocrine systems,which bridges the functions of the gut and the *** in the gut flora,termed dys biosis,can lead to systemic inflammation,leaky gut syndrome,and increased susceptibility to *** pathogenesis of multiple sclerosis involves a combination of genetic and environmental factors,and gut flora may play a pivotal role in regulating immune responses related to multiple scle *** develop more effective therapies for multiple scle rosis,we should further uncover the disease processes involved in multiple sclerosis and gain a better understanding of the gut-brain *** review provides an overview of the role of the gut flora in multiple scle rosis.

关键词： gut flora gut-brain axis multiple sclerosis pathogenesis treatment