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Trajectories of depressive symptoms and risk of cardiovascular disease,cancer and mortality:a prospective cohort study

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General Psychiatry 2024年第3期37卷 401-411页

作者： Jiahao Min Zhi Cao Han Chen Xiaohe Wang Chenjie Xu School of public health Hangzhou Normal UniversityHangzhouChina School of public health Zhejiang University School of MedicineHangzhouChina

Background Depressive symptoms are established risk factors for various health ***,previous studies assessed depressive symptoms at a single time point,neglecting individual variations over *** To identify depressive symptoms trajectories through repeated measures and examine their associations with cardiovascular disease(CVD),cancer and *** This study included 20634 UK Biobank participants free of CVD and cancer at baseline with two or more assessments of depressive symptoms during ***-based trajectory modelling identified depressive symptoms *** CVD,cancer and mortality were followed up until 2021 through linked *** Six depressive symptoms trajectories were identified:no symptoms(n=6407),mild-stable(n=11539),moderate-stable(n=2183),severe-decreasing(n=206),moderate-increasing(n=177)and severe-stable(n=122).During a median follow-up of 5.5 years,1471 CVD cases,1275 cancer cases and 503 deaths were *** with the no symptoms trajectory,the mildstable,moderate-stable and severe-stable trajectories exhibited higher CVD risk,with hazard ratios(HRs)(95%CIs)of 1.19(1.06 to 1.34),1.32(1.08 to 1.34)and 2.99(1.85 to 4.84),***-increasing and severe-stable trajectories were associated with higher mortality risks,with HRs(95%CIs)of 2.27(1.04 to 4.93)and 3.26(1.55 to 6.88),***,the severedecreasing trajectory was not associated with higher risks of adverse *** did not find significant associations between any trajectory and *** Trajectories related to stable and increasing depressive symptoms,but not the trajectory associated with severe depressive symptoms at the initial assessment but decreasing at the follow-up,were associated with higher risks of CVD and *** severe depressive symptoms at the initial onset may mitigate CVD and mortality risks.

关键词： symptoms depress mortality

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Exosome-encapsulated lncRNA HOTAIRM1 contributes to PM_(2.5)-aggravated COPD airway remodeling by enhancing myofibroblast differentiation

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Science China(Life Sciences) 2024年第5期67卷 970-985页

作者： Huaqi Guo Luo Fei Hengyi Yu Yan Li Yan Feng Shaowei Wu Yan Wang The Ninth People’s Hospital of Shanghai Jiao Tong University School of medicine Shanghai 200011China School of public health Shanghai Jiao Tong University School of MedicineShanghai 200020China Department of Occupational and Environmental health Sciences School of Public HealthXi’an Jiao Tong University Health Science CenterXi’an 710049China

Emphysema,myofibroblast accumulation and airway remodeling can occur in the lungs due to exposure to atmospheric pollution,especially fine particulate matter(PM_(2.5)),leading to chronic obstructive pulmonary disease(COPD).Specifically,bronchial epithelium-fibroblast communication participates in airway remodeling,which results in *** increasing number of studies are now being conducted on the role of exosome-mediated cell-cell communication in disease ***,we investigated whether exosomes generated from bronchial epithelial cells could deliver information to normal stromal fibroblasts and provoke cellular responses,resulting in airway obstruction in *** studied the mechanism of exosome-mediated intercellular communication between human bronchial epithelial(HBE) cells and primary lung fibroblasts(pLFs).We found that PM_(2.5)-induced HBE-derived exosomes promoted myofibroblast differentiation in ***,the exosomal lncRNA expression profiles derived from PM_(2.5)-treated HBE cells and nontreated HBE cells were investigated using an Agilent Human LncRNA *** coculture assays and direct exosome treatment,we found that HBE cell-derived exosomal HOTAIRM1 facilitated the myofibroblast differentiation of ***,we discovered that exosomal HOTAIRM1 enhanced p LF proliferation to secrete excessive collagen secretion,leading to airway obstruction by stimulating the TGF-β/SMAD3 signaling ***,PM_(2.5)reduced FEV1/FVC and FEV1 and increased the level of serum exosomal HOTAIRM1 in healthy people;moreover,serum exosomal HOTAIRM1 was associated with PM_(2.5)-related reductions in FEV1/FVC and *** findings show that PM_(2.5)triggers alterations in exosome components and clarify that one of the paracrine mediators of myofibroblast differentiation is bronchial epithelial cell-derived HOTAIRM1,which has the potential to be an effective prevention and therapeutic target for PM_(2.5)-induced COPD.

关键词： PM2.5 exosomal lncRNAs HOTAIRM1 chronic obstructive pulmonary disease

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Adverse effects of exposure to fine particles and ultrafine particles in the environment on different organs of organisms

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Journal of Environmental Sciences 2024年第1期135卷 449-473页

作者： Jianwei Zhang Zhao Chen Dan Shan Yang Wu Yue Zhao Chen Li Yue Shu Xiaoyu Linghu Baiqi Wang Department of Occupational and Environmental health School of Public HealthTianjin Medical UniversityTianjin 300070China Department of Medical Tianjin Stomatological HospitalSchool of MedicineNankai UniversityTianjin 300041China Tianjin Key Laboratory of Environment Nutrition and Public HealthTianjin 300070China National Demonstration Center for Experimental Preventive medicine Education(Tianjin Medical University) Tianjin 300070China

Particulate pollution is a global risk factor that seriously threatens human *** particles(FPs)and ultrafine particles(UFPs)have small particle diameters and large specific surface areas,which can easily adsorb metals,microorganisms and other *** and UFPs can enter the human body in multiple ways and can be easily and quickly absorbed by the cells,tissues and *** the body,the particles can induce oxidative stress,inflammatory response and apoptosis,furthermore causing great adverse *** studies mainly take the population as the research object to study the distribution of diseases and health conditions in a specific population and to focus on the identification of influencing ***,the mechanism by which a substance harms the health of organisms is mainly demonstrated through toxicological *** epidemiological studies with toxicological studies will provide a more systematic and comprehensive understanding of the impact of PM on the health of *** this review,the sources,compositions,and morphologies of FPs and UFPs are briefly introduced in the first *** effects and action mechanisms of exposure to FPs and UFPs on the heart,lungs,brain,liver,spleen,kidneys,pancreas,gastrointestinal tract,joints and reproductive system are systematically *** addition,challenges are further pointed out at the end of the *** work provides useful theoretical guidance and a strong experimental foundation for investigating and preventing the adverse effects of FPs and UFPs on human health.

关键词： Fine particles Ultrafine particles Organs Adverse effect

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Long-Term Survival Trend of Gynecological Cancer:A Systematic Review of Population-Based Cancer Registration Data

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Biomedical and Environmental Sciences 2024年第8期37卷 897-921页

作者： Xiaohui Zhou Danni Yang Yixin Zou Dandan Tang Jun Chen Zhuoying Li Qiuming Shen Qun Xu Yongbing Xiang Department of Epidemiology&State Key Laboratory of Systems medicine for Cancer Shanghai Cancer InstituteRenji HospitalShanghai Jiaotong University School of MedicineShanghai 200032China School of public health Shanghai Jiaotong University School of MedicineShanghai 200025China School of public health Fudan UniversityShanghai 200025China health Management Center Renji HospitalShanghai Jiaotong University School of MedicineShanghai 200127China

Gynecological cancer significantly affect the health of *** review aimed to describe the global patterns and trends in the survival of patients with gynecological *** searched PubMed,Embase,Web of Science,SinoMed,and SEER for survival analyses of cancer registration data of cervical,endometrial,and ovarian cancers published between 1980 and ***,the highest 5-year observed survival rate for cervical cancer was 76.5% in Anshan,Liaoning,China(2008-2017).The 5-year observed survival rates of endometrial and ovarian cancers were higher in Finland(1995-1999,82.5%)and Singapore(1988-1992,62.0%).The 5-year relative survival rate of cervical cancer patients was higher in Haining,Zhejiang,China(2011-2014,85.8%).Korea ranked first at 89.0% and 64.5% for endometrial and ovarian cancers,*** rates have improved for cervical,endometrial,and ovarian *** aged≥75 years and those with advancedstage disease had the worst 5-year survival *** rates were better for squamous cell carcinoma in cervical cancer,for endometrial carcinoma and mucinous adenocarcinoma in endometrial cancer,and for germ cell and sex-cord stromal tumors in ovarian *** the past four decades,the survival rates of gynecological cancers have increased globally,with notable increases in cervical and endometrial *** rates are higher in developed countries,with a slow-growing *** studies should focus on improving survival,especially in ovarian cancer patients.

关键词： Survival Cancer globally

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health Risk Assessment of Employees Exposed to Chlorination By-products of Recreational Water in Large Amusement Parks in Shanghai

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Biomedical and Environmental Sciences 2024年第8期37卷 865-875页

作者： Weizhao Cao Yiming Zheng Wenxuan Zhao Lisha Shi Yunhui Zhang Lijun Zhang Jian Chen Key Lab of health Technology Assessment National Health Commission of the People’s Republic of China(Fudan University)Shanghai 200032China Key Laboratory of public health Safety Ministry of EducationSchool of Public HealthFudan UniversityShanghai 200032China Division of public health Service and Safety Assessment Shanghai Municipal Center for Disease Control and PreventionShanghai 200336China Shanghai Institute of Preventive medicine Shanghai 200336China

Objective Chlorination is often used to disinfect recreational water in large amusement parks;however,the health hazards of chlorination disinfection by-products(DBPs)to occupational populations are *** study aimed to assess the exposure status of chlorinated DBPs in recreational water and the health risks to employees of large amusement *** Exposure parameters of employees of three large amusement parks in Shanghai were investigated using a *** typical chlorinated DBPs in recreational water and spray samples were quantified by gas chromatography,and the health risks to amusement park employees exposed to chlorinated DBPs were evaluated according to the WHO's risk assessment *** Trichloroacetic acid,dibromochloromethane,bromodichloromethane,and dichloroacetic acid were detected predominantly in recreational *** carcinogenic and non-carcinogenic risks of the five DBPs did not exceed the risk *** addition,the carcinogenic and non-carcinogenic risks of mixed exposure to DBPs were within the acceptable risk *** Typical DBPs were widely detected in recreational water collected from three large amusement parks in Shanghai;however,the health risks of DBPs and their mixtures were within acceptable limits.

关键词： Risk assessment Water Environmental health Occupational exposure Chlorinated disinfection by-product

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Examining the effects of voluntary avoidance behaviour and policy-mediated behaviour change on the dynamics of SARS-CoV-2:A mathematical model

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Infectious Disease Modelling 2024年第3期9卷 701-712页

作者： Gabrielle Brankston David N.Fisman Zvonimir Poljak Ashleigh R.Tuite Amy L.Greer Department of Population medicine University of GuelphCanada Dalla Lana School of public health University of TorontoCanada Centre for Immunization Readiness Public Health Agency of CanadaOttawaOntarioCanada

Background Throughout the SARS-CoV-2 pandemic,policymakers have had to navigate between recommending voluntary behaviour change and policy-driven behaviour change to mitigate the impact of the *** individuals will voluntarily engage in self-protective behaviour when there is an increasing infectious disease risk,the extent to which this occurs and its impact on an epidemic is not *** This paper describes a deterministic disease transmission model exploring the impact of individual avoidance behaviour and policy-mediated avoidance behaviour on epidemic outcomes during the second wave of SARS-CoV-2 infections in Ontario,Canada(September 1,2020 to February 28,2021).The model incorporates an information feedback function based on empirically derived behaviour data describing the degree to which avoidance behaviour changed in response to the number of new daily cases *** Voluntary avoidance behaviour alone was estimated to reduce the final attack rate by 23.1%,the total number of hospitalizations by 26.2%,and cumulative deaths by 27.5%over 6 months compared to a counterfactual scenario in which there were no interventions or avoidance behaviour.A provincial shutdown order issued on December 26,2020 was estimated to reduce the final attack rate by 66.7%,the total number of hospitalizations by 66.8%,and the total number of deaths by 67.2%compared to the counterfactual *** Given the dynamics of SARS-CoV-2 in a pre-vaccine era,individual avoidance behaviour in the absence of government action would have resulted in a moderate reduction in disease however,it would not have been sufficient to entirely mitigate transmission and the associated risk to the population in *** action during the second wave of the COVID-19 pandemic in Ontario reduced infections,protected hospital capacity,and saved lives.

关键词： Mathematical modelling COVID-19 SARS-CoV-2 Human behaviour

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Applying Machine Learning Approach to Explore Childhood Circumstances and Self-Rated health in Old Age-China and the US,2020-2021

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China CDC weekly 2024年第11期6卷 213-218,I0008-I0013页

作者： Shutong Huo Derek Feng Thomas M.Gill Xi Chen Department of health Society&BehaviorPublic HealthUniversity of CaliforniaIrvineCAUSA Department of Statistics and Data Science Yale UniversityNew HavenCTUS Department of Internal medicine Yale School of MedicineNew HavenCTUS Department of health Policy and Management Yale School of Public HealthNew HavenCTUS Department of Economics Yale UniversityNew HavenCTUS.

Introduction:Childhood circumstances impact senior health,prompting the introduction of machine learning methods to assess their individual and collective contributions to senior ***:Using health and retirement study(HRS)and China health and Retirement Longitudinal Study(CHARLS),we analyzed 2,434 American and 5,612 Chinese participants aged 60 and *** inference trees and forests were employed to estimate the influence of childhood circumstances on self-rated health(SRH).Results:The conventional method estimated higher inequality of opportunity(IOP)values in both China(0.039,accounting for 22.67%of the total Gini coefficient 0.172)and the US(0.067,accounting for 35.08%of the total Gini coefficient 0.191).In contrast,the conditional inference tree yielded lower estimates(China:0.022,accounting for 12.79%of 0.172;US:0.044,accounting for 23.04%of 0.191),as did the forest(China:0.035,accounting for 20.35%of 0.172;US:0.054,accounting for 28.27%of 0.191).Childhood health,financial status,and regional differences were key determinants of senior *** conditional inference forest consistently outperformed others in predictive accuracy,as demonstrated by lower out-of-sample mean squared error(MSE).Discussion:The findings emphasize the need for early-life interventions to promote health equity in aging *** learning showcases the potential in identifying contributing factors.

关键词： collective inequality estimates

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A Prospective Cohort Study of Antimony Exposure and Cognitive Impairment in Older Adults—China,2017–2021

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China CDC weekly 2024年第23期6卷 537-541,I0001-I0007页

作者： Yidan Qiu Saisai Ji Chen Chen Jinhui Zhou Jun Wang Bing Wu Yuan Wei Fangyu Li Xulin Zheng Lanjing Xu Zheng Zhang Feng Zhao Guangdi Chen John SJi Yuebin Lyu Shilu Tong Xiaoming Shi Department of Big Data in health Science School of Public HealthZhejiang UniversityHangzhou CityZhejiang ProvinceChina China CDC Key Laboratory of Environment and Population health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijingChina Center for Global health School of Public HealthNanjing Medical UniversityNanjing CityJiangsu ProvinceChina Department of Epidemiology and Biostatistics School of Public HealthJilin UniversityChangchun CityJilin ProvinceChina School of public health China Medical UniversityShenyang CityLiaoning ProvinceChina Institute of Environmental health School of Public Healthand Bioelectromagnetics LaboratorySchool of MedicineZhejiang UniversityHangzhou CityZhejiang ProvinceChina Environmental Research Center Duke Kunshan UniversityKunshan CityJiangsu ProvinceChina Nicholas School of the Environment Duke UniversityDurhamNCUSA School of public health Institute of Environment and Population HealthAnhui Medical UniversityHefei CityAnhui ProvinceChina School of public health and Social Work Queensland University of TechnologyBrisbaneAustralia

What is already known about this topic?Antimony(Sb)has been identified as a new neurotoxicant that impacts neurological functions in animal ***,its effects on the human population remain *** is added by this report?The study reveals that there is an association between exposure to Sb and a higher incidence of cognitive impairment in older *** dose-response curve demonstrates that the risk of cognitive impairment consistently increased with higher levels of Sb exposure without a discernible *** are the implications for public health practice?Reducing exposure to Sb may have a beneficial effect in delaying or preventing the onset of cognitive *** intervention has the potential to significantly decrease the disease burden associated with cognitive impairment,ultimately contributing to social development.

关键词： Antimony development. exposure

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Efficacy of intraovarian autologous platelet-rich plasma administration in women with low ovarian reserve: A systematic review and meta-analysis

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Asian pacific Journal of Reproduction 2024年第2期13卷 60-67页

作者： Yasmin Sabina Sa’diah Agung Dewanto Lukman A Chandra Department of Obstetrics and Gynecology Faculty of MedicinePublic Health and NursingUniversitas Gadjah MadaYogyakartaIndonesia Department of Pharmacology and Therapy Faculty of MedicinePublic Health and NursingUniversitas Gadjah MadaYogyakartaIndonesia

Objective:To conduct a systematic examination and meta-analysis of the most reliable data from experimental studies evaluating the efficacy of autologous platelet-rich plasma(PRP)on low ovarian ***:A comprehensive search was performed utilizing pertinent search terms across electronic databases,including PubMed,Cochrane,and Google *** included studies that assigned infertile women with low ovarian reserve in experimental *** reserve parameters were measured before and after PRP injection into *** data of each study was retrieved and subsequently ***:Of 301 articles collected and reviewed,six studies were finally included in the *** PRP injection,infertile women showed a non-significant increase in anti-Mullerian hormone(AMH)level(MD=0.10;95%CI-0.04,0.23),a significant increase in antral follicular count(AFC)(MD=1.88;95%CI 0.47,3.29),and a non-significant reduction in follicle-stimulating hormone(FSH)level(MD=-0.22;95%CI-8.32,7.87).Conclusions:Autologous PRP may increase AFC,but not *** it is found beneficial in enhancing ovarian reserve(AFC),further research with strong evidence is still required.

关键词： Platelet-rich plasma Low ovarian reserve Ovarian rejuvenation

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Study on the Knowledge of Mothers or Guardians of Girls Aged 9 - 14 from the Langue de Barbarie in Saint-Louis, Senegal about Cervical Cancer and Its Relationship to HPV Vaccination in 2024

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Journal of Immune Based Therapies, Vaccines and Antimicrobials 2024年第2期13卷 17-31页

作者： Papa Djibril Ndoye Lebem Togtoga Abdourahmane Ndong Mamadou Saïdou Bah Khadim Niang departement of public health and Social medicine UFR of Health Science Gaston Berger University Saint-Louis Senegal ENDA Sant Dakar Senegal

Introduction: The relationship between knowledge of HPV and vaccination has been established. The aim of this study was to investigate the knowledge of mothers or guardians of girls aged 9 - 14 about cervical cancer and their attitudes to HPV vaccination. Methodology: This was a descriptive cross-sectional survey. The sample size was calculated using the Schwartz formula and distributed proportionally to the size of the neighbourhood population. Data was collected between 2nd to 19th January 2024 using anonymous questionnaires configured on tablets with Survey 123 software and analysed using R software. Results: A total of 799 people were interviewed. The average age of the respondents was 35.67 years, with a standard deviation of 7.08 and a range of 17 and 49 years. The information channels for cervical cancer were the media (82.8%), health facilities (47.7%) and community intermediaries (23.3%). Only 53.7% had information about the vaccine and 25.5% about the vaccination strategy. The main reason for accepting the vaccine was awareness of the seriousness of cervical cancer (55.1%). Conclusion: It is essential to take stock of knowledge about cervical cancer and attitudes to vaccination to assess the impact of interventions and redirect strategies to improve vaccination coverage. .

关键词： Cervical Cancer HPV Vaccine Knowledge Girls Senegal

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