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Caerulin-induced pancreatitis in rats: Histological and genetic expression changes from acute phase to recuperation

World Journal of Gastroenterology 2006年第25期12卷 3999-4003页

作者： Javier Magaa-Gómez Guillermo López-Cervantes Ana María Calderón de la Barca departamento de Nutrición Centro de Investigación en Alimentación y desarrollo A.C. HermosilloSonoraMéxicoDepartamento de Patología Hospital Infantil del Estado de SonoraHermosilloSonoraMéxicoDepartamento de Nutrición Centro de Investigación en Alimentación y DesarrolloA.C.HermosilloSonoraMéxico

AIM： To study the histological and pancreatitis-associated protein mRNA accumulation changes of pancreas from acute phase of caerulin-induced pancreatitis to recuperation in rats. METHODS： Acute pancreatitis was induced by caerulein in male Wistar rats and followed up for 90 d by histological and mRNA analyses of pancreas. Pancreases were dissected at 0, 9, 24 h and 3, 5, 15, 30, 60, 90 d post-induction. Edema （E）, polymorphonuclear neutrophU （pIVlN） infiltration, cytoplasmic vacuolization （V）, zymogen granule depletion （ZD） and acinar disorganization （AD） were microscopically evaluated. Accumulation of pancreatitis- associated protein （PAP） and L13A mRNAs were quantified by real-time PCR. RESULTS： The main histological changes appeared at 9 h post-induction for PMN infiltration and cytoplasmic V, while at 24 h and 3 d for E and ZD, respectively. All the parameters were recovered after 5 d, except for ZD which delayed more than 30 d. The main AD was observed after 15 d and values returned to normal after 30 d. Similarly to histological changes, accumulation of the PAP mRNA was increased at 9 h with the highest accumulation at 24 h and differences disappeared after 5 d. CONCLUSION： From the acute phase to recuperation of pancreatitis, regeneration and re-differentiation of pan- creas occur and PAP expression is exclusively an acute response of pancreatitis.

关键词： Acute pancreatitis Histological changes PAP mRNA L13A mRNA

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Phytochemical screening and antioxidant activity of ethanol extract of Tithonia diversifolia(Hemsl)*** dry flowers

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Asian Pacific Journal of Tropical Biomedicine 2014年第9期4卷 740-742页

作者： Robson Miranda da Gama Marcelo Guimares Luiz Carlos de Abreu José Armando-Junior Laboratorio de Pesquisa do Curso de Farmacia Faculdade de Medicina do ABC.Avenida Principe de Gales821Vila Principe de Gales09060-870Santo AndreSPBrasil departamento de saude materno-infantil Faculdade de Saude Publica.Universidade de Sao PauloBrasil

Objective:To evaluate the antioxidant activity of extracts of dried flowers of Tithonia diversifolia(Hemsl) ***(***) dry flower-a slirubby plant belonging to the Asteraceac family and very common in Brazil,providing data to help prevent premature aging ***:The tests of phytochemical screening included total phenols,tannins,flavonoids,alkaloids and *** active antioxidant was determined by 2,2-diphenyl-1-picrylhydrazyl ***:The phytoehemical screening of *** dry flowers revealed the presence of phenolic compounds(tannins,flavonoids and total phenolsi,while alkaloids and saponins were not *** IC_(50) values showed a strong antioxidant activity of the plant ***:Therefore,this study suggests the possibility of using dry flowers extracts of *** for the prevention of cell aging,as was shown to have significant antioxidant activity.

关键词： Antioxidant activity Phytochemical screening Tithonia diversifolia(Hemsl) A.Gray

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Quality of Life in Congenital Heart Disease Patients according to Their Anatomical and Physiological Classification

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Congenital Heart Disease 2023年第2期18卷 197-206页

作者： Efrén Martínez-Quintana Hiurma Estupiñán-León Ana Beatriz Rojas-Brito Liuva Déniz-Déniz Alejandro Barreto-Martín Fayna Rodríguez-González Cardiology Service Complejo Hospitalario Universitario Insular-Materno InfantilLas Palmas de Gran Canaria35016Spain department of Medical and Surgical Sciences Faculty of Health SciencesUniversidad de Las Palmas de Gran CanariaLas Palmas de Gran Canaria35016Spain Ophthalmology Service Hospital Universitario de Gran Canaria Dr.NegrínLas Palmas de Gran Canaria35012Spain

Background:Living well is as important as living *** objective of this study is to assess quality of life(QoL)in congenital heart disease(CHD)according to current AHA/ACC anatomical and physiological ***:Cross-sectional study examining the World Health Organization QoL Bref questionnaire(WHOQoL-Bref)in consecutive outpatient CHD patients from a single ***:191 CHD patients were *** age was 28±13 years and 59%were male.44(23%),115(60%)and 33(17%)CHD patients showed mild,moderate and great anatomical defects respectively while 69(36%)patients were in physiological Stage A,27(14%)in Stage B,84(44%)in Stage C and 11(6%)in Stage *** significant differences were seen in relation the anatomical classification and the different sections of the WHOQoL-Bref *** patients in Stages C and D had significant lower physical domain scores than patients in the Stage A(psatisfaction with ***:Patients with advanced physiological stages scored lower on the physiological *** statistical significance was seen,according to the anatomical and physiological classification,in the psychological,social relationship and environmental domains.

关键词： Quality of life congenital heart disease complexity

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Diagnosis of Hypophosphatasia

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Journal of Pharmacy and Pharmacology 2018年第7期6卷 688-691页

作者： Cleiton Fantin denise Correa Benzaquem Vania Mesquita Gadelha Prazeres Laboratório de Citogenética Universidade do Estado do Amazonas Manaus 69065-001 Brasil departamento de saúde materno infantil Universidade Federal do Amazonas Manaus 69076-005 Brasil

Objective： HPP （Hypophosphatasia） is a congenital disease characterized by a deficiency of tissue-specific ALP （alkaline phosphatase）, which causes the generation of abnormal bone and tooth tissue. The clinical manifestations are variable, from neonatal forms with high mortality to milder adult forms with fractures and osteomalacia. The present study reports a clinical case of HPP, with emphasis on the physical characteristics and laboratory tests. The patient was attended at the medical genetics outpatient clinic of the Association of Parents and Friends of the Exceptional of Manaus （Associa？？o de Pais e Amigos dos Excepcionais-APAE/Manaus）. Methodology： For the case report, anamnesis, peripheral blood G-band karyotyping, Vitamin and ALP dosage and resonance examination were performed. Results： A.M.M.S, 9 years, non-consanguineous parents, no bone disease in the family, with one sister from the mother. Birth weight AGA without intercurrence. The patient presented a slight delay in psycho-motor development and was diagnosed with craniostenosis through CNS imaging examination. The physical examination, in addition to a short stature, showed dolichocephaly, frontal bossing, curved tibias and great dental compromise with many early cavities and loss of teeth. Laboratory evaluation： ALP dosage： 63/L （N = 69-325）; Vitamin B6 dosage： 27.4 （5.2-34.1）. The mother and the younger sister also had an ALP result below that expected for the age. Conclusions： The clinical phenotype and laboratory diagnosis of the patient were compatible with ICD Q78 HPP.

关键词： HPP ALP child

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Submicroscopic 11p13 deletion including the elongator acetyltransferase complex subunit 4 gene in a girl with language failure, intellectual disability and congenital malformations: A case report

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World Journal of Clinical Cases 2020年第21期8卷 5296-5303页

作者： Jaime Toral-Lopez Luz María González Huerta Olga Messina-Baas Sergio A Cuevas-Covarrubias departamento de Genética Medica Centro Medico EcatepecISSEMYMEcatepec 55000México Programa de Maestría y Doctorado en Ciencias Médicas Odontológicas y de la Salud/Hospital Infantil de MéxicoUniversidad Nacional Autónoma de MéxicoMéxico 06720México departamento de Biología Molecular Hospital General de MéxicoCuauhtémoc 06720México departamento de Oftalmología Hospital General de MéxicoCuauhtémoc 06720México Genetica Hospital General de MéxicoCuauhtémoc 06726Mexico Sergio A Cuevas-CovarrubiasPrograma de Maestría y Doctorado en Ciencias MédicasOdontológicas y de la SaludUniversidad Nacional Autónoma de MéxicoMéxico 06720Mexico

BACKGROUND We described the main features of an infant diagnosed with facial dysmorphic,language failure,intellectual disability and congenital malformations to strengthen our understanding of the ***,treatment is only rehabilitation and surgery for cleft lip and *** SUMMARY The proband was a 2-years-8-months-old *** history was negative for congenital malformations or intellectual *** patient had microcephaly,upward-slanting palpebral fissures,depressed nasal bridge,bulbous nose and bilateral cleft lip and *** magnetic resonance imaging showed cortical atrophy and band *** motor and intellectual development is delayed.A submicroscopic deletion in 11p13 involving the elongator acetyltransferase complex subunit 4 gene(ELP4)and a loss of heterozygosity in Xq25-q26.3 were *** There is no treatment for the ELP4 deletion caused by a submicroscopic 11p3 *** describe a second case of deletion of the ELP4 gene without aniridia,which confirms the association between ELP4 gene with several defects and absence of this ocular *** clinical data in the deletion of the ELP4 gene as cleft palate,facial dysmorphism,and changes at level brain could be associated to this gene or be part of the effect of the recessives genes involved in the loss of heterozygosity region of Xq25-26.3.

关键词： Submicroscopic 11p13 deletion Elongator acetyltransferase complex subunit 4 gene Language failure Intellectual disability Congenital malformations Case report

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Probable benign paroxysmal positional vertigo, spontaneously resolved:Incidence in medical practice, patients’ characteristics and the natural course

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Journal of Otology 2019年第3期14卷 111-116页

作者： M.G.Alvarez-Morujo de sande R. Gonzalez-Aguado G. Guerra-Jimenez E. Domenech-Vadillo H. Galera-Ruiz E. Figuerola-Massana A. Ramos-Macías C. Morales-Angulo A.J. Martín-Mateos E. Domínguez-Duran Hospital Universitario Puerta del Mar Cadiz Spain Hospital Universitario Marques de Valdecilla Santander Spain Complejo Hospitalario Universitario Insular materno-infantil Las Palmas de Gran Canaria Spain Hospital Universitari Joan XXIII Tarragona Spain Hospital Infanta Luisa Sevilla Spain

Background: Probable benign paroxysmal positional vertigo, spontaneously resolved (pBPPVsr), is a variant of benign paroxysmal positional vertigo (BPPV) in which there is no observable nystagmus and no vertigo with any positional maneuver. Objectives: To calculate the incidence pBPPVsr, compare the characteristics of the patients with pBPPVsr and BPPV not spontaneously resolved and describe the spontaneous resolution in the natural course of BPPV. Methods: Multicenter prospective descriptive study. During a one-year period, all patients with suspected BPPV that presented to the Neurotology Units of five participating centers were recruited. The incidence of pBPPVsr was calculated as a percentage of the total number of patients with BPPV. The prevalence of several variables was compared between pBPPVsr and BPPV not spontaneously resolved. The timing of spontaneous resolution was estimated using Kaplan-Meier curves. Results: 457 patients met the inclusion criteria. The incidence of pBPPVsr was 33.5%. It was significantly higher in males, in patients with normal bone mass and in patients who were not taking sulpiride. A rate of 18% of spontaneous resolution after the first month and 51% after the first year was found. This percentage did not change in a significant way after this moment. The curves for males, patients under 50 and patients with normal blood pressure decreased significantly faster. Conclusions: In our serie, BPPV spontaneously resolved in half of the patients with BPPV during the first year. This seemed to occur more commonly in males and could have been hindered by sulpiride intake, osteoporosis, advanced age and high blood pressure.

关键词： Benign paroxysmal positional vertigo Probable benign paroxysmal positional vertigo, spontaneously resolved Osteoporosis Sulpiride Hypertension

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-592 and -1082 interleukin-10 polymorphisms in pulmonary tuberculosis with type 2 diabetes

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Asian Pacific Journal of Tropical Medicine 2013年第7期6卷 505-509页

作者： Guadalupe García-Elorriaga Leila Vera-Ramírez Guillermo del Rey-Pineda Csar Gonzlez-Bonilla Unidad de Investigación Mdica en Inmunología e Infectología Hospital de InfectologíaCentro Mdico Nacional La Raza(CMNR)Instituto Mexicano del Seguro Social(IMSS)Mexico CityMexico Banco Central de sangre CMNRIMSSand Departamento de Infectología.Hospital Infantil de Mxico Federico Gómez.Secretaría de Salud(SSA) Mexico City.Mexico

Objective:To determine the polymorphisms of Interleukin-10(IL-10)(-592,-1082) in pulmonary tuberculosis(PTB)with and without type 2 diabetes(T2D).Methods:We studied a Mexican mestizo population of 37 patients with TB in remission(TBr) and 40 with active pulmonary TB (PTB),21 patients with TB + T2D.47 blood donors accepted,and 13 healthy health-care workers with tuberculin skin lest *** of IL-10 polymorphisms was performed by real-lime Polymerase chain ***:IL-10-592C/A presented in a greater proportion in healthy individuals than in patients with type 2 diabetes and TB in a not quite significant statistically ***-10-1082A/A presented more frequently in the group of patients with both diseases,not being statistically significant in comparison with the group of healthy subjects. Conclusions:This study describes two important new ***,it reveals that the IL-10 (-592 A/A and -592 C/C) polymorphisms were found in a greater proportion in a group of patients with T2D and TB than in healthy ***,the study provides evidence that the(-1082 G/G) polymorphism presented with greater frequency in healthy individuals than in patients with both ol these diseases.

关键词： Cytokines IL-10 Polymorphism Genotype Pulmonary tuberculosis

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The Transcervical Extended Access, a Feasible Approach for the Surgical Treatment of Benign Tumors of the Posterior Mediastinum?

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Surgical Science 2018年第3期9卷 128-133页

作者： David Perez Francisco Hernandez Jose Ramon Cano Wolker Tavarez Gara Torrent santiago Quevedo Luis Lopez department of Thoracic Surgery Insular Materno-Infantil University Hospital Las Palmas de Gran Canaria Spain

Transcervical approach for tumors of the posterior mediastinum is traditionally thought not to be indicated. Hereby we report on a case of a patient with a huge neurogenic tumor of the posterior mediastinum which was successfully excised through a transcervical extended approach and, additionally, the variety of surgical approaches used to remove tumors of the posterior mediastinum is discussed. The new refined techniques of transcervical extended mediastinal operations, which are recently gaining popularity among surgeons, allowed for a safe dissection of the tumor, thus patient could benefit from a short painless postoperative course. The authors suggest that surgeons trained in these particular techniques should consider the choice of the transcervical extended access in selected cases of benign tumors of the posterior mediastinum.

关键词： Mediastinum Neurogenic Neoplasms Thoracic Surgery Transcervical Access

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Allograft Survival without Immunosuppression in Landrace Pigs after 90 Days

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Open Journal of Organ Transplant Surgery 2013年第4期3卷 63-64页

作者： Rafael Valdés-Gonzalez Arturo Mundo Acevedo Ana L. Rodriguez-Ventura Pedro Valencia Mayoral departamento de Cirugía Universidad Nacional Autónoma de México Ciudad de México México departamento de Patología Hospital Infantil de México Mexico D.F. México Hospital infantil de México Endocrinología Mexico D.F. México

Allotransplantation is helpful in order to maintain the life in some cases, but immunosuppression causes collateral effects. In this study, we were reporting the results of allografts in Landrace pigs, which were implanted on collagen-generator devices. After 2 weeks of implantation, the devices were carried out to assess allograft viability at 30, 60 and 90 days post implant. The implanted cells were islets of Langerhans and the aim was to prove their presence by immunohistochemistry for insulin and glucagon. The results were positive at 30, 60 and 90 days post implant. It demonstrated that the collagen-generator device permits the cell viability without using anti-rejected drugs or immunomodulating cells.

关键词： Allografts Collagen-Generator device

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Cytogenetic Diagnosis and Analysis of the Clinical Profile of Individuals with Non-down Syndrome Intellectual Disability

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Journal of Pharmacy and Pharmacology 2017年第11期5卷 812-820页

作者： Fantin, C. Prazeres, V. G. M. Benzaquem, D. C. Fernandes, E. R. Q. G. S. Oliveira, D. p. Ribeiro-Lima, J. C. Laboratorio de Proteomica e Genomica Departamento de Genetica Molecular e Citogendtica Escola Superior de Ciencias da Saude Universidade do Estado do Amazonas Manaus 69065-001 Brasil departamento de saude materno infantil Universidade Federal do Amazonas Manaus 69076-005 Brasil Unidade de Laboratorio de Analises Clinieas Setor de Citogenetiea Hospital Universitario Getulio Vargas Universidade Federal do Amazonas Manaus 69076-005 Brasil

Chromosomal alterations are the main causes of genetic diseases. One of the characteristics of certain genetic syndromes is ID （intellectual disability） presented by the individual in varying degrees. The study of the ID, its etiology, association or not with chromosomal abnormalities and a clinical diagnosis associated with the examination of karyotype are important aspects to consider when providing genetic counseling for families. Due to the lack of similar studies and of easy access to cytogenetic services for the Amazonian population, this study aimed to contribute to the advancement of this line of study in the state, analyzing the karyotype of individuals with ID, not Down Syndrome treated at the APAE-Manaus and identifying the main types of chromosomal alterations in the individuals analyzed. Analyzes were performed of the clinical diagnosis through investigation of the data from the interview and medical records as well as analysis of the karyotype of 31 patients with non-Down syndrome ID, attended in the APAE-Manaus. Of these subjects, 20 were female and 11 male. The results showed only 2 cases of chromosome abnormalities are detectable by classical cytogenetics, one of mosaic Turner syndrome and one a heterochromatic variant. It is therefore necessary to complement the study with the addition of molecular techniques for the investigation of microdeletions and/or other alterations not detectable through the banding technique, mainly for individuals whose dysmorphisms indicate a suspected syndrome.

关键词： Intellectual disability classical cytogenetics G banding.

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