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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TeG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TeG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TeG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TeG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

Does cypermethrin affect enzyme activity, respiration rate and walking behavior of the maize weevil （Sitophilus zeamais）？

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Insect Science 2013年第3期20卷 358-366页

作者： Ronnie Von Santos Veloso eliseu Jose G. Pereira Raul Narciso C. Guedes Maria Goreti A. Oliveira departamento de entomologia departamento de Bioquimica e Biologia Molecular Universidade Federal de Vicosa Brazil

Insecticides cause a range of sub-lethal effects on targeted insects, which are frequently detrimental to them. However, targeted insects are able to cope with insecti- cides within sub-lethal ranges, which vary with their susceptibility. Here we assessed the response of three strains of the maize weevil Sitophilus zeamais Motschulsky （Coleoptera.＂ Curculionidae） to sub-lethal exposure to the pyrethoid insecticide cypermethrin. We ex- pected enzyme induction associated with cypermethrin resistance since it would aid the resistant insects in surviving such exposure. Lower respiration rate and lower activity were also expected in insecticide-resistant insects since these traits are also likely to favor survivorship under insecticide exposure. Curiously though, cypermethrin did not affect ac- tivity of digestive and energy metabolism enzymes, and even reduced the activity of some enzymes （particularly for cellulase and cysteine-proteinase activity in this case）. There was strain variation in response, which may be （partially） related to insecticide resistance in some strains. Sub-lethal exposure to cypermethrin depressed proteolytic and mainly cellulolytic activity in the exposed insects, which is likely to impair their fitness. However, such exposure did not affect respiration rate and walking behavior of the insects （except for the susceptible strain where walking activity was reduced）. Walking activity varies with strain and may minimize insecticide exposure, which should be a concern, particularly if associated with （physiological） insecticide resistance.

关键词： insecticides insecticide resistance pyrethroids stored grain insect sub-lethal effects

FINITeLY GeNeRATeD COMMUTATIVe ARCHIMedeAN SeMIGROUPS

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Acta Mathematica Scientia 2003年第4期23卷 503-511页

作者： J.C.Rosales J.I.García-García departamento de Algebra Universidad de Granada E-18071 Granada EspanaDepartamento de Algebra Universidad de Granada E-18071 Granada Espana

In this work commutative Archimedean finitely generated semigroups axe characterized in terms of ideal extensions.

关键词： Commutative semigroups Archimedean

Proportionally Modular Diophantine Inequalities and Their Multiplicity

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Acta Mathematica Sinica,english Series 2010年第11期26卷 2059-2070页

作者： José Carlos ROSALeS Manuel Batista BRANCO Paulo VASCO departamento de lgebra Universidad de Granada departamento de Matemática departamento de Matemática Universidade de Trás-os-Montes e Alto Douro

Let I be an interval of positive rational numbers. Then the set S （I） = T ∩ N, where T is the submonoid of （Q0＋, ＋） generated by T, is a numerical semigroup. These numerical semigroups are called proportionally modular and can be characterized as the set of integer solutions of a Diophantine inequality of the form ax rood b 〈 cx. In this paper we are interested in the study of the maximal intervals I subject to the condition that S （I） has a given multiplicity. We also characterize the numerical semigroups associated with these maximal intervals.

关键词： Numerical semigroup Diophantine inequality multiplicity Frobenius number

Consequences of a two-time relativistic Bohmian model

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Communications in Theoretical Physics 2024年第7期76卷 63-73页

作者： Giuseppe Raguni departamento de Fisica Universidad de MurciaE-30071 MurciaSpain

effects of a Bohmian type quantum-relativistic theory are *** model is obtained by introducing a new and independent time parameter whose relative motions are not directly observable and cause quantum uncertainties of the physical *** the usual de Broglie-Bohm theories,the Quantum Potential does not directly affect the observable motion,but determines the one that is relative to the new time *** turns out that the Zitterbewegung of a free particle,of which a more general law is obtained,is the key example of these hidden motions and,through it,it seems possible to give physical reality to the Feynman's paths.A relativistic revision of the uncertainty principle is also derived from the theory.

关键词： Quantum Mechanics Foundations de Broglie-Bohm theory Zitterbewegung uncertainty principle verification extra dimensions

A Maschke Type Theorem for Weak Hopf Algebras

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Acta Mathematica Sinica,english Series 2008年第12期24卷 2065-2080页

作者： J.N.ALONSOLVAReZ J.M.FeRNNdeZVILABOA R.GONZLeZRODRíGUeZ A.B.RODRíGUeZRAPOSO departamento de Matemáticas Universidad de Vigo. Lagoas-Marcosende Vigo. E-36200 Spain departamento de lxebra. Universidad de Santiago de Compostela Santiago de Compostela. E-15771 Spain departamento de Matemdtica Aplicada Ⅱ. Universidad de Vigo. Lagoas-Marcosende Vigo. E-36310 Spain departamento delxebra Universidad de Santiago de CompostelaSantiago de Compostela E-15771 Spain

In this paper, we give a necessary and sufficient condition for a comodule algebra over a weak Hopf algebra to have a total integral, thus extending the classical theory developed by Doi in the Hopf algebra setting. Also, from these results, we deduce a version of Maschke＇s Theorem for （H, B）-Hopf modules associated with a weak Hopf algebra H and a right H-comodule algebra B.

关键词： Monoidal category weak Hopf algebra Hopf modules Maschke Theorem

Projections of weak braided Hopf algebras

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Science China Mathematics 2011年第5期54卷 877-906页

作者： ALONSO LVAReZ Jos Nicanor FeRNNdeZ VILABOA Jos Manuel GONZLeZ RODRíIGUeZ Ramón SONeIRA CALVO Carlos departamento de Matemticas Universidad de Vigo Vigo E-36310 Spain departamento de lxebra Universidad de Santiago de Compostela Santiago de Compostela E-15771 Spain departamento de Matemtica Aplicada II Universidad de Vigo Vigo E-36310 Spain departamento de Matemticas Universidad de Vigo Vigo E-36004 Spain

In this paper we study the projections of weak braided Hopf algebras using the notion of Yetter-Drinfeld module associated with a weak braided Hopf algebra. As a consequence, we complete the study ofthe structure of weak Hopf algebras with a projection in a braiding setting obtaining a categorical equivalencebetween the category of weak Hopf algebra projections associated with a weak Hopf algebra H living in abraided monoidal category and the category of Hopf algebras in the non-strict braided monoidal category ofleft-left Yetter-Drinfeld modules over H.

关键词： weak Yang-Baxter operator Yetter-Drinfeld module weak (braided) Hopf algebra weak Hopf algebra projection

Maschke Type Theorems for Weak Hopf Quasigroups

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Algebra Colloquium 2020年第2期27卷 213-230页

作者： J.N.Alonso Alvarez J.M.Fernández Vilaboa R.González Rodríguez departamento de Matematicas Vniversidade de Vigo Campus Universitario Lagoas-MarcosendeE-36280 VigoSpain departamento de Matematicas Universidade de Santiago de Compostela E-15771 Santiago de CompostelaSpain departamento de Matematica Aplicada II Universidade de Vigo Campus Universitario Lagoas-MarcosendeE-36310 VigoSpain

In this paper we give necessary and sufficient conditions for a comodule magma over a weak Hopf quasigroup to have a total integral,thus extending the theories developed in the Hopf algebra,weak Hopf algebra and non-associative Hopf algebra *** this result we also deduce a version of Maschke’s theorems for right(H,B)-Hopf triples associated to a weak Hopf quasigroup H and a right H-comodule magma B.

关键词： (weak)Hopf algebra (weak)Hopf quasigroup integral Maschke theorem

Modern data sources and techniques for analysis and forecast of road accidents:A review

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Journal of Traffic and Transportation engineering(english edition) 2020年第4期7卷 432-446页

作者： Camilo Gutierrez-Osorio Cesar Pedraza departamento de Ingeniena de Sistemas e Industrial Universidad Nacional de ColombiaBogotaColombia

Road accidents are one of the most relevant causes of injuries and death worldwide,and therefore,they constitute a significant field of research on the use of advanced algorithms and techniques to analyze and predict traffic accidents and determine the most relevant elements that contribute to road *** research of road accident prediction aims to respond to the challenge of offer tools to generate a more secure mobility environment,and ultimately,save *** paper aims to provide an overview of the state of the art in the prediction of road accidents through machine learning algorithms and advanced techniques for analyzing information,such as convolutional neural networks and long short-term memory networks,among other deep learning ***,in this article,a compendium and study of the most used data sources for the road accident forecast is *** a classification is proposed according to its origin and characteristics,such as open data,measurement technologies,onboard equipment and social media *** the analysis of the information,the different algorithms employed to make predictions about road accidents are listed and compared,as well as their applicability depending on the types of data being analyzed,along with the results obtained and their ease of interpretation and *** best results reported by the authors are obtained when two or more analytic techniques are combined,in such a way that analysis of the obtained results is *** the future challenges in road traffic forecasting lies the enhancement of the scope of the proposed models and predictions by the incorporation of heterogeneous data sources,that include geo spatial data,information from traffic volume,traffic statistics,video,sound,text and sentiment from social media,that many authors concur that can improve the precision and accuracy of the analysis and predictions.

关键词： Traffic engineering Data analysis Machine learning Road accident forecasting Traffic accident prediction