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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria S.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdiSNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.G.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Influence of Fluoride Addition on the Composition of Solutions in Equilibrium with Acid Soils

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Pedosphere 2009年第1期19卷 60-70页

作者： A. ROMAR C. GAGO M. L. FERNNdeZ-MARCOS E. LVAREZ departamento de edafología y química agrícola University of Santiago de Compostela Campus Universitario 27002 Lugo (Spain)

Atmospheric emissions of fluoride from an aiuminium smelter-alumina refinery located on the northern coast of Galicia, NW Spain, increase the content of fluorine in soils and vegetation in the vicinity of the complex. The effects of the addition of fluoride solutions on the chemical properties of soil samples from the area surrounding the complex were investigated in laboratory experiments. Addition of fluoride to soils resulted in increases in pH and concentrations of Fe, A1, and organic matter in the equilibrium solutions and decreases in concentrations of Ca, Mg, and K. No consistent effects were observed on the Cu, Mn, or Zn concentrations. Most of the A1 in solution was bound to organic matter. Within the fraction ＂labile aluminium＇, the concentration of A1-OH complexes decreased and the A1-F complexes increased, especially A1F3 and A1F4^-, which are less toxic than Al^3＋ and A1-OH species.

关键词： aluminium speciation equilibrium soil solution fluoride pollution

Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

Green ionic metal-organic frameworks as nanocatalysts for CO_(2)fixation

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Nano Research 2025年第1期18卷 260-269页

作者： Nuria Martín Miguel Maireles-Porcar Julián Sánchez Velandia Belén Altava Francisco G.Cirujano Eduardo García-Verdugo departamento de química Inorgánica y Orgánica Universidad Jaume IAv.Sos Baynats/nCastellóde la PlanaCastellón 12071Spain

Co,Ni,and Zn iso-reticular coordination polymers of 2,5-dihydroxyterphthalic acid(H_(2)dot)can be rapidly obtained under room temperature and aqueous conditions using either sodium or ammonium hydroxide as the bases to deprotonate the *** use of metal bromides and tetrabutylammonium hydroxide(TBAOH)as the base allows the green synthesis of ionic metal-organic frameworks(MOFs),characterized by X-ray diffraction(XRD),Fourier transform infrared(FTIR),scanning electron microscopy(SEM),thermo gravimetric analysis(TGA),H-nuclear magnetic resonance(NMR),elemental analysis,and X-ray photoelectron spectroscopy(XPS),and employed in the pressure,solvent,and additive-free CO_(2)fixation to epoxides by its cycloaddition to epichlorohydrin,exhibiting a cooperative behavior between the MOF and the ionic liquid formed within the framework,achieving TONs of the confined tetrabutylammonium bromide(TBABr)up to 700.

关键词： metal-organic frameworks(MOFs) ionic liquids heterogeneous catalysis CO_(2)conversion

Soil Formation of "Atlantic Rankers" from NW Spain—A High Resolution Aluminium and Iron Fractionation Study

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Pedosphere 2008年第4期18卷 441-453页

作者： J. KAAL M. COSTA-CASAIS C. FERRO-VZquEZ X. PONTEVEDRA-POMBAL A. MARTINEZ-CORTIZAS Instituto de Estudios Galegos Padre Sarmiento Laboratorio de Arqueología del Paisaje (LAr) IEGPS-CSIC-XuGaRúa San Roque 2 15704 Santiago de Compostela (Spain). departamento de edafología y química agrícola Fac. Biología Universidad de Santiago (Spain)

Atlantic rankers belong to the group of ＂cryptopodzolic rankers＂, which are ubiquitous in the mountainous cool/temperate humid regions of Western Europe. The rankers of Galicia （NW Spain） formed by thousands of years of colluviation. The preponderance of Al-stabilised organic matter （OM） masks the horizonation and polycyclic character （i.e., stratification） of these soils. Cryptopodzolic rankers are generally thought to be the outcome of podzolisation. This soil type is part of the recent discussion on how to classify soils developed from nonvolcanic parent material having andic properties. To better understand the formation processes of these soils, the Al and Fe fractionation of four typical Atlantic rankers were studied by selective dissolution in acid NH4-oxalate, Na-pyrophosphate and the chlorides of K, La and Cu. A high-resolution sampling approach allowed us to investigate the soils in greater detail than simply sampling by horizon. The rankers studied display a distribution of Fe- and AI-OM complexes that is typical of cryptopodzolic soils. However, these organomineral associations were probably immobile due to the high Al saturation. We argue that the soils owe their characteristic chemical status to external factors rather than to translocation of organomineral associations： variations in AI-OM concentrations could be linked to changes in weathering/leaching intensity and colluviation rates caused by anthropogenic disturbances or changes in regional climate regime.

关键词： Al fractionation colluviation cryptopodzolic soil podzolisation ranker

Mercury removal using ground and calcined mussel shell

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Journal of Environmental Sciences 2013年第12期25卷 2476-2486页

作者： Susana Pea-Rodríguez Alipio Bermúdez-Couso Juan Carlos Nóvoa-Muoz Manuel Arias-Estvez María J.Fernndez-Sanjurjo Esperanza lvarez-Rodríguez Avelino Núez-delgado rea de Edafoloxía e qu' mica agr' cola. departamento de Bioloxía Vexetal e Ciencia do Solo. Univ. Vigo. Facultade de Ciencias Ourense departamento de Edafoloxía e química agrícola. Univ. Santiago de Compostela. Escola Politcnica Superior campus univ. s/n

We determined mercury retention on calcined and ground mussel shell, in presence and absence of phosphate, using batch and stirred flow chamber experiments. In batch experiments the calcined shell exhibited higher Hg adsorption, with good fitting to Freundlich equation （R^2： 0.925-0.978）; the presence of phosphate increased Hg adsorption; mercury desorption was 13% or lower, diminishing up to 2% under the presence of phosphates. In stirred flow chamber experiments calcined shell retained more Hg than ground shells （6300 vs. 4000-5200 μmol/kg）; Hg retention increased an additional 40% on calcined shell and up to an additional 70% on ground shells when phosphates were present; mercury desorption was quite similar in all shell types （20%-34%）, increasing up to 49%-60% in ground shells when phosphates were present. The higher Hg adsorption on calcined shell would be related to its calcite and dolomite concentrations; mercury-phosphate interactions would cause the increase in Hg retention when phosphates are present. Data on Hg desorption suggest that Hg retention was not easily reversible after batch experiments, increasing in the stirred flow chamber due to convective flow. Calcined and ground mussel shells could be recycled removing Hg from water, with the presence of phosphates in solution improving efficacy.

关键词： adsorption desorption heavy metals pollution mercury mollusc shell

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

development and screening of(Ca-P-Si-F)-PEO coatings for biodegradability control of Mg-Zn-Ca alloys

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Journal of Magnesium and Alloys 2022年第8期10卷 2220-2237页

作者： Lara Moreno Marta Mohedano Raul Arrabal Endzhe Matykina departamento de Ingeniería química y de Materiales Facultad de Ciencias QuímicasUniversidad Complutense de Madrid28040 MadridSpain

PEO coatings were developed on MgZnxCayalloys for biomedical applications using different treatment times and a novel transparent electrolyte containing Ca,P,Si and *** characteristics and chemical composition of studied materials were evaluated using scanning electron microscopy,X-ray diffraction and optical *** investigations were performed for uncoated and coated materials using potentiodynamic polarization,electrochemical impedance spectroscopy and hydrogen evolution measurements in three media(0.9wt.%NaCl,α-MEM and inorganic part ofα-MEM).Findings revealed that Zn-rich intermetallics favour the formation of large voids in the ***,P,F and Si are successfully incorporated into the *** consist of crystalline phases(Mg O,Mg F_(2)and Ca,Si-rich compounds)and amorphous *** and organic components ofα-MEM solution accelerate corrosion of the bare substrates but have no significant influence on the corrosion resistance of coated ***,inorganicα-MEM can be considered as an appropriate medium for fast screening of PEO *** relatively small amount of F content in the barrier layer facilitates early failure of the coatings,which show undercoating ***-rich intermetallic particles in the undercoating crevice induce a more aggressive corrosive environment and enhanced micro-galvanic couple effect with the Mg *** leads to faster degradation of the coated alloys compared to the bare substrates.

关键词： Magnesium Biomaterials Plasma electrolytic oxidation Corrosion

Temporal decay of the catalytic oxidation of methane over palladium supported on silica

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Science China Chemistry 2013年第11期56卷 1601-1607页

作者： CORTS Joaquín VALENCIA Eliana PINEDA Marcelo ARAyA Paulo departamento de Ingeniería química y Biotecnología Universidad de Chile departamento de Ciencia de Materiales Universidad de Chile

The temporal decay of the oxidation of methane(CH4-O2reaction)over palladium supported on silica is determined experimentally at different temperatures,comparing the results with those of various classical models which show the behavior of the adsorbed phase as the cause of the *** effect is visualized through Monte Carlo simulations of the CH4-O2reaction on a mixed lattice whose partial poisoning,due to the configuration of the OH groups on the surface of the adsorbate,is translated into a gradual decay of the reaction’s activity.

关键词： catalytic CH4-O2 reaction surface heterogeneity in superficial reaction Monte Carlo simulation superficial catalyticreaction CH4-O2 reaction over palladium