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Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria S.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdiSNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期 3209-3210页

作者： Marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ordó?ez-Gutiérrez Francisco Wandosell Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM) Nicolas Cabrera 1 Universidad Autónoma de Madrid Fisiología Animal Departamento de Biología Facultad de Ciencias Universidad Autónoma de Madrid department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset Solna departamento de Bioquímica y Biología Molecular Universidad Complutense de Madrid Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED)

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called "autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

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Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

Attaching CF_(3) groups to organic molecules using trifluoroacetates via ion-shielding photoelectrocatalysis

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Science China Chemistry 2024年第11期67卷 3495-3497页

作者： Paula Visiedo-Jiménez Francisco Juliá-Hernández departamento de Química Inorgánica Facultad de QuímicaUniversidad de MurciaCampus de EspinardoMurcia 30100Spain

Fluorinated molecules play a protagonist role in pharmaceuticals, agrochemicals, and materials. The incorporation of fluoroalkyl groups into organic compounds provides them with unique chemical properties that are key... 详细信息

关键词： materials groups compounds

Temporal decay of the catalytic oxidation of methane over palladium supported on silica

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Science China Chemistry 2013年第11期56卷 1601-1607页

作者： CORTS Joaquín VALENCIA Eliana PINEDA Marcelo ARAYA Paulo departamento de Ingeniería Química y Biotecnología Universidad de Chile departamento de Ciencia de Materiales Universidad de Chile

The temporal decay of the oxidation of methane(CH4-O2reaction)over palladium supported on silica is determined experimentally at different temperatures,comparing the results with those of various classical models which show the behavior of the adsorbed phase as the cause of the *** effect is visualized through Monte Carlo simulations of the CH4-O2reaction on a mixed lattice whose partial poisoning,due to the configuration of the OH groups on the surface of the adsorbate,is translated into a gradual decay of the reaction’s activity.

关键词： catalytic CH4-O2 reaction surface heterogeneity in superficial reaction Monte Carlo simulation superficial catalyticreaction CH4-O2 reaction over palladium

The inception of a Paleotethyan magmatic arc in Iberia

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Geoscience Frontiers 2015年第2期6卷 297-306页

作者： M.F.Pereira A.Castro C.Fernández IDL Departamento de Geociências ECT Universidade de évora departamento de Geología Universidad de Huelva departamento de Geodinámica y Paleontología Universidad de Huelva

This paper presents a compilation of recent U-Pb （zircon） ages of late Carboniferous-early Permian （LC EP） calc-alkaline batholiths from lberia, together with a petrogenetic interpretation of magma generation based on comparisons with Mesozoic and Tertiary Cordilleran batholiths and experimental melts. Zircon U-Pb ages distributed over the range ca. 315-280 Ma, indicate a linkage between calc-alkaline magmatism, Iberian orocline generation and Paleotethys subduction. It is also shown that Iberian LC-EP calcalkaline batholiths present unequivocal subduction-related features comparable with typical Cordilleran batholiths of the Pacific Americas active margin, although geochemical features were partially obscured by local modifications of magmas at the level of emplacement by country rock assimilation. When and how LC-EP calc-alkaline batholiths formed in Iberia is then discussed, and a new and somewhat controversial interpretation for their sources and tectonic setting （plume-assisted relamination） is suggested. The batholiths are proposed to have formed during the subduction of the Paleotethys oceanic plate （Pangaea self-subduction） and, consequently, they are unrelated to Variscan collision. The origin of the Iberian batholiths is related to the Eurasian active margin and probably represents the inception of a Paleotethvan arc in the core of Pangaea.

关键词： Permo-Carboniferous Calc-alkaline arc-related batholiths Pangaea Paleotethys subduction Variscan and Cimmerian cycles

Relationships between soil pollution by heavy metals and melanin-dependent coloration of a fossorial amphisbaenian reptile

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Integrative Zoology 2022年第4期17卷 596-607页

作者： JoséMARTÍN Pablo RECIO Gonzalo RODRÍGUEZ-RUIZ Isabel BARJA Eduardo GUTIÉRREZ Luis VGARCÍA departamento de Ecología Evolutiva Museo Nacional de Ciencias NaturalesCSICMadridSpain departamento de Zoología Facultad de BiologíaUniversidad Autónoma de MadridMadridSpain Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridMadridSpain departamento de biogeoquímica Ecología Vegetal y MicrobianaInstituto de Recursos Naturales y Agrobiología de SevillaCSICSevillaSpain

Melanin is the basis of coloration in many animals,and although it is often used in communication,thermoregulation,or camouflage,melanin has many other physiological *** example,in polluted habitats,melanin can have a detoxifying *** coloration would help to sequester in the skin the heavy metal contaminants from inside the body,which will be expelled to the exterior when the skin is ***,animals should have evolved more melanic colorations in more polluted habitats(“industrial melanism”hypothesis).We examined whether the fossorial amphisbaenian reptile,Trogonophis wiegmanni,is able to eliminate heavy metals,derived from soil pollution by seagull depositions,through sloughing its *** results suggest a covariation between levels of soil pollution by heavy metals and the concentration of heavy metals in the sloughed skins of *** suggests that amphisbaenians may expel heavy metals from their bodies when they slough the *** also tested whether amphisbaenians inhabiting soils with higher levels of heavy metal pollution had darker(melanin-dependent)body ***,contrary to predictions from the“industrial melanization”hypothesis,we found a negative relationship between soil pollution and proportions of melanic *** contradictory result could,however,be explained because heavy metals have endocrine disruption effects that increase physiological stress,and higher stress levels could result in decreased *** suggest that although amphisbaenians might have some detoxifying mechanism linked to melanin in the skin,this process might be negatively affected by stress and result ineffective under conditions of high soil pollution.

关键词： amphisbaenians coloration fossorial reptiles heavy metals melanin soil pollution

Neuroprotective effects of metalosalen complexes against oxidative stress

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Neural Regeneration Research 2021年第1期16卷 121-122页

作者： Lara Rouco Marcelino Maneiro departamento de Química Inorgánica Universidade de Santiago de CompostelaLugoSpain

Neurodegenerative diseases and oxidative stress:During the metabolic processes,O2 can accept unpaired electrons to form superoxide radical species(O2^·–),which are able to generate hydrogen peroxide(H2O2)with a fast dismutation,therefore increasing the hydroxyl radical(HO^·)*** species and other radicals(·OOH,ROO^·,RO^·,CO3^·–),which can be produced through a sequence of reactions,constitute the designated reactive species of oxygen(ROS).Oxidative stress is caused by a disequilibrium between the ROS produced and the antioxidant defence against them(catalase enzymes,superoxide dismutase(SOD)and glutathione peroxidases,in addition to other non-enzymatic antioxidants,such asα-tocopherol,ascorbic acid and carotenes).

关键词： oxidative complexes radical

Characterization of soil fauna under the influence of mercury atmospheric deposition in Atlantic Forest, Rio de Janeiro, Brazil

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Journal of Environmental Sciences 2015年第6期27卷 217-227页

作者： Andressa Cristhy Buch Maria Elizabeth Fernandes Correia Daniel Cabral Teixeira Emmanoel Vieira Silva-Filho departamento de Geoquímica Universidade Federal Fluminense Embrapa Agrobiologia BR 465 km 7

The increasing levels of mercury（Hg） found in the atmosphere arising from anthropogenic sources, have been the object of great concern in the past two decades in industrialized countries. Brazil is the seventh country with the highest rate of mercury in the *** major input of Hg to ecosystems is through atmospheric deposition（wet and dry）, being transported in the atmosphere over large distances. The forest biomes are of strong importance in the atmosphere/soil cycling of elemental Hg through foliar uptake and subsequent transference to the soil through litter, playing an important role as sink of this element. Soil microarthropods are keys to understanding the soil ecosystem, and for such purpose were characterized by the soil fauna of two Units of Forest Conservation of the state of the Rio de Janeiro, inwhich one of the areas suffer quite interference from petrochemicals and industrial anthropogenic activities and other area almost exempts of these perturbations. The results showed that soil and litter of the Atlantic Forest in Brazil tend to stock high mercury concentrations, which could affect the abundance and richness of soil fauna, endangering its biodiversity and thereby the functioning of ecosystems.

关键词： Biodiversity Litter Microarthropods Soil Trace-element