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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria S.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdiSNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

Adding time-calibrated branch lengths to the Asteraceae supertree

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Journal of Systematics and Evolution 2010年第4期48卷 271-278页

作者： Rubén TORICES rea de Botánica Departamento de Ciencias AgroforestalesUniversidad de Valladolid

New inference techniques,such as supertrees,have improved the construction of large phylogenies,helping to reveal the tree of *** addition,these large phylogenies have enhanced the study of other evolutionary questions,such as whether traits have evolved in a neutral or adaptive way,or what factors have influenced ***,supertrees usually lack branch lengths,which are necessary for all these issues to be ***,divergence times within the largest family of flowering plants,namely the Asteraceae,are reviewed to estimate time-calibrated branch lengths in the supertree of this *** inconsistency between estimated dates of basal branching events and the earliest asteraceous fossil pollen record was *** addition,the impact of different methods of branch length assignment on the total number of transitions between states in the reconstruction of sexual system evolution in Asteraceae was *** least for this dataset,different branch length assignation approaches influenced maximum likelihood(ML)reconstructions only and not Bayesian ***,the selection of different branch length information is not arbitrary and should be carefully assessed,at least when ML approaches are being *** reviewed divergence times and the estimated time-calibrated branch lengths provide a useful tool for future phylogenetic comparative and macroevolutionary studies of Asteraceae.

关键词： Asteraceae character mapping divergence times sexual systems trait evolution

On the intraspecific variability in basal metabolism and the food habits hypothesis in birds

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Current Zoology 2010年第6期56卷 759-766页

作者： F. BOZINOVIC P. SABAT Center for Advanced Studies in Ecology and Biodiversity LINC-Globaland Departamento de EcologíaFacultad de Ciencias BiológicasPontificia Universidad Católica de Chile Center for Advanced Studies in Ecology and Biodiversity LINC-Globaland Departamento de EcologíaFacultad de Ciencias BiológicasPontificia Universidad Catolica de Chile departamento de ciencias Ecológicas Facultad de CienciasUniversidad de Chile

The food habits hypothesis （FHH） stands as one of the most striking and often-cited interspecific patterns to emerge from comparative studies of endothermic energetics. The FHH identifies three components of diet that potentially produce variability in mass-independent BMR, i.e. food quality, food availability, and food predictability or environmental productivity. The hypothesis predicts that species with diets of low energy content and/or low digestibility should evolve low mass-independent BMRs. The effects of food habits on BMR have been widely investigated at the interspecific level, but the variation between individuals and populations has been largely ignored. Our focus is to compare predictions derived from interspecific studies with data collected from within-species studies to explore the mechanisms and functional significance of adaptive responses predicted by the food-habits hypothesis among birds. We conclude that if BMR is correlated with daily energy expenditure, then organisms that can lower BMR will reduce daily energy expenditure and hence, food requirements. Birds that lower BMR in stressful environments may increase survival. Nevertheless, the mechanism （s） by which birds eating a low quality diet reduce BMR and whether lower BMR affects fitness remain to be determined [Current Zoology 56 （6）： 759-766, 2010].

关键词： Intraspecific comparisons Avian energetics Food habits hypothesis Diet Basal metabolic rate

Green's Function for Periodic Solutions in Alternately Advanced and delayed Differential Systems

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Acta Mathematicae Applicatae Sinica 2020年第4期36卷 936-951页

作者： Kuo-Shou CHIU departamento de Matematica Facultad de Ciencias BasicasUniversidad Metropolitana de Ciencias de la EducacionSantiagoChile

In this paper we investigate the existence of the periodic solutions of a nonlinear differential equation with a general piecewise constant argument,in short dePCAG,that is,the argument is a general step *** consider the critical case,when associated linear homogeneous system admits nontrivial periodic *** of existence of periodic solutions of such equations are *** the process we use the Green?s function for periodic solntions and convert the given dePCAG into an equivalent integral *** we construct appropriate mappings and employ Krasnoselskii's fixed point theorem to show the existence of a periodic solution of this type of nonlinear differential *** also use the contraction mapping principle to show the existence of a unique periodic *** examples are given to show the feasibility of our results.

关键词： piecewise constant arguments Green's function periodic solutions hybrid equations fixed point theorems

On generalized impulsive piecewise constant delay differential equations

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Science China Mathematics 2015年第9期58卷 1981-2002页

作者： CHIU Kuo-Shou departamento de Matemtica Facultad de Ciencias Bsicas Universidad Metropolitana de Ciencias de la Educación

A variation of parameters formula with Green function type and Gronwall type integral inequality are proved for impulsive differential equations involving piecewise constant delay of generalized type. Some results for piecewise constant linear and nonlinear delay differential equations with impulsive effects are *** include existence and uniqueness theorems, a variation of parameters formula, integral inequalities, the oscillation property and some applications.

关键词： impulsive differential equation piecewise constant delay of generalized type variation of parameters formula Gronwall integral i

Statistical evaluation of fluoride contamination in groundwater resources of Santiago del Estero Province, Argentina

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Geoscience Frontiers 2020年第6期11卷 2197-2205页

作者： K.Rondano Gómez C.E.López Pasquali G.Paniagua González P.Fernández Hernando R.M.Garcinuño Martínez departamento de ciencias Básicas Facultad de Ciencias ForestalesUniversidad Nacional de Santiago Del EsteroArgentina departamento de ciencias Analíticas Facultad de CienciasUniversidad Nacional de Educación a DistanciaSpain departamento de Química Analítica Facultad de Agronomía y AgroindustriasUniversidad Nacional de Santiago Del EsteroArgentina

This study investigates the suitability of statistical techniques for evaluating the fluoride content and the groundwater quality from Robles department(RD)and Banda department(BD)in Santiago del Estero(Argentina).For the original statistical study,evaluation of nine parameters(fluoride,pH,conductivity,atmospheric and water temperature,total dissolved solids,chloride,hardness,and alkalinity)of 110 collected underground water samples from 23 dispersed rural areas was *** samples were obtained by sampling taken from wells at different *** levels were determined by a standard colorimetric method in two seasonal periods,the dry(from April to September)and rainy(from October to March)*** analytical results obtained for physicochemical parameters such as pH,total dissolved solids(TDS),and temperature does not reveal any notable difference between the rainy and dry seasons *** both seasons,the atmospheric temperature average was 22℃.With respect to fluoride content,approximately 50%of the analysed groundwater samples exceeded the limit established by current legislation(1.0 mg/L),obtaining concentration levels in the range of 0.01-2.80 mg/*** study demonstrates the usefulness of the univariate statistical method(quartiles calculation,interquartile range IQR),multivariate principal component analysis(PCA),and cluster analysis to establish a better understanding of the state of the contamination of the waters in the region studied.

关键词： Source water protection Santiago del Estero Multivariate statistical analysis Fluoride Spectrophotometry

The role of Islet-1 in cell specification,differentiation,and maintenance of phenotypes in the vertebrate neural retina

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Neural Regeneration Research 2015年第12期10卷 1951-1952页

作者： Gervasio Martín-Partido Javier Francisco-Morcillo departamento de Biología Celular Facultad de CienciasUniversidad de Extremadura

Many blinding diseases,such as retinitis pigmentosa,age-related macular degeneration,and glaucoma involve the permanent loss of retinal neurons,especially photoreceptors or the centrally projecting retinal ganglion **... 详细信息

关键词： cell RGCs The role of Islet-1 in cell specification,differentiation,and maintenance of phenotypes in the vertebrate neural retina