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Thalidomide-based multidisciplinary treatment for patients with advanced hepatocellular carcinoma:A retrospective analysis

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World Journal of Gastroenterology 2012年第5期18卷 466-471页

作者： Yang-Yuan Chen Hsu-Heng Yen Kun-Ching Chou Shun-Sheng Wu department of Gastroenterology ChinaMedical University Hospital China Medical University Taic-hung 40000 Taiwan China depart-ment of Gastroenterology Changhua Christian Medical CenterChanghua 50000 Taiwan China

AIM： To evaluate the efficacy of thalidomide in com- bination with other therapies to treat patients with ad- vanced hepatocellular carcinoma （HCC）. METHODS： We performed a retrospective analysis of all patients with HCC who were treated with thalido- mide for at least two months. The medical records of patients with HCC who were treated at our institution between April 2003 and March 2008 were reviewed. Image studies performed before and after treatment, tumor response, overall survival, and the decrease in o-fetoprotein （AFP） levels were evaluated. RESULTS： A total of 53 patients with HCC received either 100 or 200 mg/d of thalidomide. The patient population consisted of 9 women and 44 men with a median age of 61 years. Thirty patients （56.6%） were classified as Child-Pugh A, and 12 patients （22.6%） were classified as Child-Pugh B. Twenty-six patients had portal vein thrombosis （49.1%）, and 25 patients had extrahepatic metastasis （47.1%）. The median duration of thalidomide treatment was 6.0 mo. Six of the 53 patients achieved a confirmed response （11.3%）, one achieved a complete response （1.9%） and 5 achieved a partial response （9.4%）. The disease control rate （CR ＋ PR ＋ SD） was 28.3% （95% CI： 17.8-42.4）, and the median overall survival rate was 10.5 too. The 1- and 2-year survival rates were 45% and 20%, respectively. Only one complete response patient showed an im- proved overall survival rate of 66.8 mo. Sixteen patients （30.2%） showed more than a 50% decrease in their serum AFP levels from baseline, indicating a better re- sponse rate （31.3%）, disease control rate （43.8%）, and overall survival time （20.7 mo）. The therapy was well tolerated, and no significant toxicities were observed. CONCLUSION： Thalidomide was found to be safe for advanced HCC patients, demonstrating anti-tumor ac- tivity including response, survival, and AFP decreases of greater than 50% from baseline.

关键词： Thalidomide Hepatocellular carcinoma

Milan criteria are useful predictors for favorable outcomes in hepatocellular carcinoma patients undergoing liver transplantation after transarterial chemoembolization

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World Journal of Gastroenterology 2006年第43期12卷 6992-6997页

作者： Do Young Kim Moon Seok Choi Joon Hyoek Lee Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo Sung Wook Shin Sung Wook Choo Young Soo Do Jong Chul Rhee department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea depart- ment of Radiology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea

AIM: To evaluate whether the Milan criteria are useful in patients with hepatocellular carcinoma (HCC) who received transarterial chemoembolization (TACE) before liver transplantation (LT). METHODS: Thirty-six HCC patients who fulfilled the Milan criteria after having received TACE and subsequently underwent LT were included (TACE + LT group) in the study. As controls, 21 patients who also met the Milan criteria and underwent LT without prior treatment were selected (LT group). Post-LT clinical outcomes, such as HCC recurrence, survival rate, and histologic features of explanted livers, were compared between the two groups. RESULTS: Baseline characteristics were not different between the two groups. Pre-LT maximal tumor diameter in TACE + LT group was similar to that of LT group (2.0 ± 0.6 cm vs 2.3 ± 0.9 cm; P = 0.10). Post-LT histologic findings also revealed similar maximal tumor diameter in the two groups (2.4 ± 1.4 cm vs 2.3 ± 0.9 cm; P = 0.70). Explanted livers showed similar incidence of unfavorable pathologic features. The morality within 60 d after transplantation was not different between the two groups (8.3% vs 9.5%; P = 0.99). Post-LT 5-year survival rate (57% vs 74%; P = 0.70) and cumulative recurrence rate (8.3% vs 4.8%; P = 0.90) were not significantly different between the two groups. CONCLUSION: The Milan criteria are still a useful selec- tion criteria showing favorable outcomes in HCC patientsreceiving TACE before LT.

关键词： Milan criteria Hepatocellular carcinoma Transarterial chemoembolization Liver transplantation

Circulating miRNAs as biomarkers for severe acute pancreatitis associated with acute lung injury

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World Journal of Gastroenterology 2017年第41期23卷 7440-7449页

作者： Xiao-Guang Lu Xin Kang Li-Bin Zhan Li-Min Kang Zhi-Wei Fan Li-Zhi Bai depart-ment of Emergency Zhongshan Hospital Dalian University College of Basic Medicine Nanjing University of Chinese Medicine department of Hepatobiliary and Pancreatic Surgery Puer People's Hospital

AIM To identify circulating micro(mi)RNAs as biological markers for prediction of severe acute pancreatitis(SAP) with acute lung injury(ALI).METHODS Twenty-four serum samples were respectively collected and classified as SAP associated with ALI and SAP without ALI, and the mi RNA expression profiles were determined by microarray analysis. These mi RNAs were validated by quantitative reverse transcriptionpolymerase chain reaction, and their putative targets were predicted by the online software Target Scan, mi Randa and Pic Tar database. Gene ontology(GO) and Kyoto encyclopedia of genes and genomes(commonly known as KEGG) were used to predict their possible functions and pathways *** We investigated 287 mi RNAs based on microarray data analysis. Twelve mi RNAs were differentially expressed in the patients with SAP with ALI and those with SAP without ALI. Hsa-mi R-1260 b, 762, 22-3 p, 23 b and 23 a were differently up-regulated and hsa-mi R-550 a*, 324-5 p, 484, 331-3 p, 140-3 p, 342-3 p and 150 were differently down-regulated in patients with SAP with ALI compared to those with SAP without ALI. In addition, 85 putative target genes of the significantly dysregulated mi RNAs were found by Target Scan, mi Randa and Pic Tar. Finally, GO and pathway network analysis showed that they were mainly enriched in signal transduction, metabolic processes, cytoplasm and cell *** This is the first study to identify 12 circulating mi RNAs in patients with SAP with ALI, which may be biomarkers for prediction of ALI after SAP.

关键词： miRNAs Severe acute pancreatitis Acute lung injury Biomarker Microarray analysis

Preconditioning method and engineering application of large eddy simulation

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Science China(Physics,Mechanics & Astronomy) 2008年第6期51卷 667-677页

作者： LI XueSong XU JianZhong GU ChunWei Key Laboratory for Thermal Science and Power Engineering of Ministry of Education of China Depart-ment of Thermal EngineeringTsinghua UniversityBeijing 100084China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100080China

On applying large eddy simulation (LES) to engineering interest, one of the keys is to obtain two-order low-dissipation shock-capturing schemes adapted to LES. Therefore, the preconditioning method for all speed flows is adopted. However, the accuracy of preconditioned schemes is not satisfactory because of the poor per-formance of stability of preconditioning techniques especially in viscous flows. The reason of unstability is attributed to the unstability structure in the preconditioned eigenvalue matrix. Based on Roe scheme and two assumptions for low-Mach- Number flows, the new scheme named Low-Speed-Roe scheme is deduced for removing the unstability structure. Numerical experiments show that this scheme has the reasonable computational stability. For general-precision problems, Low-Speed-Roe scheme has similar behavior as the classical preconditioned Roe scheme. For simulations of high-accuracy requirement such as LES, Low-Speed- Roe scheme can obtain better results of complex flows, such as the laminar sepa-ration bubble on the suction surface of the high-loaded turbine blade T106.

关键词： preconditioning method eigenvalue matrix Low-Speed-Roe scheme large eddy simulation engineering application

Advanced multimodality imaging of inflammatory bowel disease in 2015: An update

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World Journal of Radiology 2016年第6期8卷 571-580页

作者： Emma Stanley Heather K Moriarty Carmel G Cronin depart-ment of Radiology Mater Misericordiae University Hospital

The diagnosis and effective management of inflammatory bowel disease(IBD) requires a combination clinical, endoscopic, histological, biological, and imaging data. While endoscopy and biopsy remains the gold standard for diagnosis of IBD, imaging plays a central role in the assessment of extra mural disease, in disease surveillance and in the assessment of response to medical treatments, which are often expensive. Imaging is also vital in the detection and diagnosis of disease related complications, both acute and chronic. In this review, we will describe, with illustrative images, the imaging features of IBD in adults, with emphasis on upto-date imaging techniques focusing predominantly on cross sectional imaging and new magnetic resonance imaging techniques.

关键词： Crohn’s disease Multimodality imaging Ulcerative colitis Magnetic resonance imaging Positron emission tomography Inflammatory bowel disease Cross sectional imaging

Microglia in the CNS:Immigrants from Another World

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神经损伤与功能重建 2011年第4期6卷 275-284页

作者： MARCO PRINZ ALEXANDER MILDNER depart ment of Neuropathology University of FreiburgFreiburgGermany

小胶质细胞是脑内的免疫细胞,持续监测周围环境的变化。大约100多年前,研究者们就发现了小胶质细胞,但对于其来源,学术界一直存在争议。除了在胚胎发育的早期,迁徙进入发育中的神经外胚层的粒单核细胞群之外,在成年脑组织中,新迁入的骨... 详细信息

小胶质细胞是脑内的免疫细胞,持续监测周围环境的变化。大约100多年前,研究者们就发现了小胶质细胞,但对于其来源,学术界一直存在争议。除了在胚胎发育的早期,迁徙进入发育中的神经外胚层的粒单核细胞群之外,在成年脑组织中,新迁入的骨髓细胞也是疾病的重要调节因子。因此,了解骨髓细胞从外周进入脑内及其分化为骨髓来源吞噬细胞的机制,有助于控制免疫细胞进入中枢神经系统,可能有利于疾病的控制。其中一个关键的问题是,骨髓来源的单核吞噬细胞是否具有和脑内源性免疫细胞相似的特征和作用。近年来,对小胶质细胞的生理和病理方面的研究较多,尤其是结合新基因定位技术,可以对细胞进行修饰、操控和跟踪分析,使得对小胶质细胞的生物学特性的认识有了较大的突破。本文即对相关研究进展综述如下。

关键词：小胶质细胞骨髓来源吞噬细胞单核细胞神经退行性疾病

Virtual Sewing Based on Draping Knowledge

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Journal of Donghua University(English Edition) 2007年第4期24卷 556-559页

作者：唐明浩马江丽张驰张祖芳方小卫 College of Information Science and Technology Donghua University Editorial depart ment of Journal of Donghua University Fashion Institute Donghua University ECHO Information & Technology Company Ltd.

Virtual sewing is one of the key techniques in the realization of 3D computer aided garment design. After analysis and comparison, this article brings forward a method of virtual sewing based on draping knowledge. Two new concepts are introduced. One is the conversion of garment pattern pieces’ attributes and the other is the "clothes shell"—a middleware to simplify the mapping process. Meanwhile, the method implements the mapping process and completes virtual sewing by setting anchor points and lines on the virtual model. The method has been applied to a simulation system and proved to be successful.

关键词： garment design stitching technique virtual model CAD clothes shell virtual sewing

Lysosomal-Mitochondrial Crosstalks in Apoptosis

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微循环学杂志 2009年第4期 73-74页

作者： Ulf T.Brunk depart ment of Pharmacology Link ping University

The lysosomal compartment is the center for the highly regulated autophagic turnover of all organelles and most long-lived proteins. Lysosomes were long considered stable structures that break and release their many h... 详细信息

关键词： Lysosomal-Mitochondrial Crosstalks in Apoptosis

The quantitative analysis of S100 in the brain tissue and serum following diffusebrain injury in rats

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Journal of Pharmaceutical Analysis 2007年第1期19卷 118-121页

作者：王琪黄平邢博托娅张勇攀田卫平王振原 Institute of Criminal Science Xi'an Public Security Bureau depart ment of Forensic Medicine Medical School of Xi an Jiaotong University

Objective To investigate the dynamics of the level of S100 in cerebrum,brainstem,and serum following the diffuse brain injury in rats and provide the experimental evidences for estimating injury *** ELISA was used to determine whether S100 protein is changed after diffuse brain injury in *** rats were sacrificed at 0.5 hour, 2 hours,4 hours,12 hours,24 hours,3d and 7d after diffuse brain injury and normal rats as *** The level of S100 in cerebrum,brainstem,and serum increased,followed by a decrease,and then further *** level of S100 could be detected to increase at 30 minutes and reached the peak at 4 hours after *** level decreased gradually to the normal at 1d and till 3d formed the second *** level returned to the normal at 7d following injury *** the postmortem injury groups,there were no significant changes compared to the control *** The present study showed that the time-dependent expression of S100 is obvious following diffuse brain injury in rats and suggested that S100 will be a suitable marker for diffuse brain injury age determination.

关键词： S100 diffuse brain injury ELISA