检索结果-南通市图书馆

Disease clearance in ulcerative colitis:A new therapeutic target for the future

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第13期30卷 1801-1809页

作者： Syed Adeel Hassan Neeraj Kapur Fahad Sheikh Anam Fahad Somia Jamal Division of Digestive Disease and Nutrition University of KentuckyLexingtonKY 40536United States department of pathology and laboratory medicine Montefiore Medical CenterAlbert Einstein College of MedicineNew YorkNY 10461United States Division of Primary Care Essen HealthcareNew YorkNY 10457United States department of Internal medicine Karachi Medical and Dental CollegeKarachi 74700SindhPakistan

Advancements in murine modeling systems for ulcerative colitis have diversified our understanding of the pathophysiological factors involved in disease onset and *** has fueled the identification of molecular targets,resulting in a rapidly expanding therapeutic ***,management strategies have evolved from symptomatic resolution to well-defined objective endpoints,including clinical remission,endoscopic remission and mucosal *** the incorporation of these assessment modalities has permitted targeted intervention in the context of a natural disease history and the prevention of complications,studies have consistently depicted discrepancies associated with ascertaining disease status through clinical and endoscopic *** recommendations lack consideration of histological *** simultaneous achievement of clinical,endoscopic,and histologic remission has not been fully *** has laid the groundwork for a novel therapeutic outcome termed disease clearance(DC).This article summarizes the concept of DC and its current evidence.

关键词： Inflammatory bowel disease Ulcerative colitis clinical remission Endoscopic remission Histological remission Mucosal healing Disease clearance

Microvascular structural changes in esophageal squamous cell carcinoma pathology according to intrapapillary capillary loop types under magnifying endoscopy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第8期16卷 3471-3480页

作者： Wei-Yang Shu Yan-Yan Shi Jiu-Tian Huang Ling-Mei Meng He-Jun Zhang Rong-Li Cui Yuan Li Shi-Gang Ding department of Gastroenterology Peking University Third HospitalBeijing 100191China Research Center of clinical Epidemiology Peking University Third HospitalBeijing 10019China department of Gastroenterology pathology laboratory Peking University Third HospitalBeijing 100191China department of Gastroenterology Peking University International HospitalBeijing 102206China

BACKGROUND The intrapapillary capillary loop(IPCL)characteristics,visualized using magnifying endoscopy,are commonly assessed for preoperative evaluation of the infiltration depth of esophageal squamous cell carcinoma(ESCC).Japan Esophageal Society(JES)classification is the most widely used *** structural changes are evaluated by magnifying endoscopy for the presence or absence of each morphological factor:tortuosity,dilatation,irregular caliber,and different ***,the pathological characteristics of IPCLs have not been thoroughly investigated,especially the microvascular structures corresponding to the deepest parts of the lesions'*** To investigate differences in pathological microvascular structures of ESCC,which correspond to the deepest parts of the lesions'*** Patients with ESCC and precancerous lesions diagnosed at Peking University Third Hospital were enrolled between January 2019 and April *** first underwent magnified endoscopic examination,followed by endoscopic submucosal dissection or surgical *** images were scanned using a threedimensional slice scanner,and the pathological structural differences in different types,according to the JES classification,were analyzed using nonparametric tests and *** The 35 lesions were divided into four groups according to the JES classification:A,B1,B2,and *** analyses revealed significant differences(aP0.05).However,significant differences in the short calibers,long calibers,and area of IPCL were observed between types B1 and B3(aP0.05).CONCLUSION Pathological structures of IPCLs in the deepest infiltrating regions differ among va

关键词： Esophageal squamous cell carcinoma Intrapapillary capillary loop The Japan Esophageal Society classification Magnifying endoscopy Pathological characteristics

A circular single-stranded DNA mycovirus infects plants and confers broad-spectrum fungal resistance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2024年第6期17卷 955-971页

作者： Xianhong Wang Ioly Kotta-Loizou Robert H.A.Coutts Huifang Deng Zhenhao Han Ni Hong Karim Shafik Liping Wang Yashuang Guo Mengmeng Yang Wenxing Xu Guoping Wang National Key laboratory for Germplasm Innovation&Utilization of Horticultural Crops Wuhan 430070China Hubei Hongshan laboratory Wuhan 430070China College of Plant Science and Technology Huazhong Agricultural UniversityWuhan 430070China Key Lab of Plant pathology of Hubei Province Wuhan 430070China department of Life Sciences Faculty of Natural SciencesImperial College LondonLondon SW72AZUK department of clinical Pharmaceutical and Biological ScienceSchool of Life and Medical SciencesUniversity of HertfordshireHatfield AL109ABUK department of Plant pathology Faculty of AgricultureAlexandria UniversityAlexandria 21526Egypt

Circular single-stranded DNA(ssDNA)viruses have been rarely found in fungi,and the evolutionary and ecological relationships among ssDNA viruses infecting fungi and other organisms remain *** this study,a novel circular ssDNA virus,tentatively named Diaporthe sojae circular DNA virus 1(DsCDV1),was identified in the phytopathogenic fungus Diaporthe sojae isolated from pear ***1 has a monopartite genome(3185 nt in size)encapsidated in isometric virions(21-26 nm in diameter).The genome comprises seven putative open reading frames encoding a discrete replicase(Rep)split by an intergenic region,a putative capsid protein(CP),several proteins of unknown function(P1-P4),and a long intergenic ***,the two split parts of DsCDV1 Rep share high identities with the Reps of Geminiviridae and Genomoviridae,respectively,indicating an evolutionary linkage with both *** analysis based on Rep or CP sequences placed DsCDV1 in a unique cluster,supporting the establishment of a new family,tentatively named Gegemycoviridae,intermediate to both ***1 significantly attenuates fungal growth and nearly erases fungal virulence when transfected into the host ***,DsCDV1 can systematically infect tobacco and pear seedlings,providing broad-spectrum resistance to fungal *** localization analysis revealed that DsCDV1 P3 is systematically localized in the plasmodesmata,while its expression in trans-complementation experiments could restore systematic infection of a movement-deficient plant virus,suggesting that P3 is a movement ***1 exhibits unique molecular and biological traits not observed in other ssDNA viruses,serving as a link between fungal and plant ssDNA viruses and presenting an evolutionary connection between ssDNA viruses and *** findings contribute to expanding our understanding of ssDNA virus diversity and evolution,offering potential biocontrol applications for managing crucial plant d

关键词： circular single-stranded DNA virus mycovirus virus evolution Genomoviridae Gegemycoviridae Diaporthe sojae circular DNA virus 1

CD97 inhibits osteoclast differentiation via Rap1a/ERK pathway under compression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Oral Science 2024年第1期16卷 134-144页

作者： Xuan Zhou Xinjia Cai Fengyang Jing Xuefen Li Jianyun Zhang Heyu Zhang Tiejun Li department of Oral pathology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical Sciences(2019RU034)BeijingChina Central laboratory Peking University School and Hospital of StomatologyBeijingChina

Acceleration of tooth movement during orthodontic treatment is challenging, with osteoclast-mediated bone resorption on the compressive side being the rate-limiting step. Recent studies have demonstrated that mechanoreceptors on the surface of monocytes/macrophages, especially adhesion G protein-coupled receptors (aGPCRs), play important roles in force ***, its role in the regulation of osteoclast differentiation remains unclear. Herein, through single-cell analysis, we revealed that CD97, a novel mechanosensitive aGPCR, was expressed in macrophages. Compression upregulated CD97 expression and inhibited osteoclast differentiation;while knockdown of CD97 partially rescued osteoclast differentiation. It suggests that CD97 may be an important mechanosensitive receptor during osteoclast differentiation. RNA sequencing analysis showed that the Rap1a/ERK signalling pathway mediates the effects of CD97 on osteoclast differentiation under compression. Consistently, we clarified that administration of the Rap1a inhibitor GGTI298 increased osteoclast activity, thereby accelerating tooth movement. In conclusion,our results indicate that CD97 suppresses osteoclast differentiation through the Rap1a/ERK signalling pathway under orthodontic compressive force.

关键词： CD97 osteoclast inhibited

Utilization of 3D printing technology in hepatopancreatobiliary surgery

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期25卷 123-134页

作者： Wujiang SHI Jiangang WANG Jianjun GAO Xinlei ZOU Qingfu DONG Ziyue HUANG Jialin SHENG Canghai GUAN Yi XU Yunfu CUI Xiangyu ZHONG department of Hepatopancreatobiliary Surgery the Second Affiliated Hospital of Harbin Medical UniversityHarbin150086China department of General Surgery Tangdu HospitalAir Force Medical UniversityXi’an710032China Key laboratory of Basic Pharmacology of Ministry of Education Zunyi Medical UniversityZunyi563006China Key laboratory of Functional and clinical Translational medicine Fujian Province UniversityXiamen Medical CollegeXiamen361000China department of pathology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Jiangsu Province Engineering Research Center of Tumor Targeted Nano Diagnostic and Therapeutic Materials Yancheng Teachers UniversityYancheng224007China Key laboratory of Biomarkers and In Vitro Diagnosis Translation of Zhejiang Province Hangzhou310053China Key laboratory of Gastrointestinal Cancer(Fujian Medical University) Ministry of EducationSchool of Basic Medical SciencesFujian Medical UniversityFuzhou350122China Key laboratory of Myocardial Ischemia Harbin Medical UniversityMinistry of EducationHarbin150086China

The technology of three-dimensional(3D)printing emerged in the late 1970s and has since undergone considerable development to find numerous applications in mechanical engineering,industrial design,and *** biomedical science,several studies have initially found that 3D printing technology can play an important role in the treatment of diseases in hepatopancreatobiliary *** example,3D printing technology has been applied to create detailed anatomical models of disease organs for preoperative personalized surgical strategies,surgical simulation,intraoperative navigation,medical training,and patient ***,cancer models have been created using 3D printing technology for the research and selection of chemotherapy *** the aim to clarify the development and application of 3D printing technology in hepatopancreatobiliary surgery,we introduce seven common types of 3D printing technology and review the status of research and application of 3D printing technology in the field of hepatopancreatobiliary surgery.

关键词： 3D printing Hepatopancreatobiliary surgery Organ model Cancer model

Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第20期30卷 2709-2725页

作者： Kai-Di Chen Kui-Ling Wang Chen Chen Yi-Jia Zhu Wen-Wen Tang Yu-Ji Wang Ze-Peng Chen Lin-Hai He Yu-Gen Chen Wei Zhang Jiangsu Province Hospital of Chinese medicine The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina The No.1 clinical Medical College Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina department of Colorectal Surgery Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Jiangsu Province Key laboratory of Tumor Systems Biology and Chinese medicine The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Jiangsu Collaborative Innovation Center of Chinese medicine in Prevention and Treatment of Tumor The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina

BACKGROUND Constipation,a highly prevalent functional gastrointestinal disorder,induces a significant burden on the quality of patients'life and is associated with substantial healthcare ***,identifying efficient therapeutic modalities for constipation is of paramount *** stress is a pivotal contributor to colonic dysmotility and is the underlying pathology responsible for constipation ***,we postulate that hydrogen therapy,an emerging and promising intervention,can serve as a safe and efficacious treatment for *** To determine whether hydrogen-rich water(HRW)alleviates constipation and its potential *** Constipation models were established by orally loperamide to Sprague-Dawley *** freely consumed HRW,and were recorded their 24 h total stool weight,fecal water content,and charcoal propulsion *** samples were subjected to 16S rDNA gene *** non-targeted metabolomic analysis,malondialdehyde,and superoxide dismutase levels were *** tissues were stained with hematoxylin and eosin,Alcian blue-periodic acid-Schiff,reactive oxygen species(ROS)immunofluorescence,and immunohistochemistry for cell growth factor receptor kit(c-kit),PGP 9.5,sirtuin1(SIRT1),nuclear factor-erythroid-2-related factor 2(Nrf2),and heme oxygenase-1(HO-1).Quantitative real-time PCR and western blot analysis were conducted to determine the expression level of SIRT1,Nrf2 and HO-1.A rescue experiment was conducted by intraperitoneally injecting the SIRT1 inhibitor,EX527,into constipated ***460 cells were induced with H2O2 and treated with the metabolites to evaluate ROS and SIRT1 *** HRW alleviated constipation symptoms by improving the total amount of stool over 24 h,fecal water content,charcoal propulsion rate,thickness of the intestinal mucus layer,c-kit expression,and the number of intestinal *** modulated intestinal microbiota imbalance and abnormaliti

关键词： Hydrogen-rich water Constipation Sirtuin1 Oxidative stress Gut microbiota Serum metabolites

Hotspots and research trends of Piwi-interacting RNAs from 2006 to 2023 based on bibliometric analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Medical Data Mining 2024年第3期7卷 33-45页

作者： Lu Shen Zhe-Zhong Zhang Shi-Liang Chen Ting-Yu Weng department of clinical laboratory The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310006China department of pathology The First People’s Hospital of Fuyang DistrictHangzhou 311499China

Background:Piwi-interacting RNAs(piRNAs)are a type of non-coding RNAs,initially identified in germ cells in 2006,known to bind to the Piwi family *** studies indicate their importance in genome stability,epigenetics regulation,germ cell differentiation,and tumor *** growing interest in piRNA research,there is a lack of comprehensive bibliometric studies on the *** study aims to analyze piRNA research trends from 2006 to ***:The literature regarding piRNA was sourced from the Web of Science on April 25,***,CiteSpace and a bibliometric online website(https://***/app)were employed to perform bibliometric *** maps were constructed to evaluate the collaborations among countries,institutions,authors,journals,references,keywords,and research hot ***:In this study,2549 literature were published across 464 countries and 6921 institutions,comprising 2010 articles and 539 *** United States led in publication output(n=1011,39.66%),followed by China(635,24.91%).The University of Tokyo had the most publications among all institutions(n=100,3.92%),followed by the Chinese Academy of Sciences(n=86,3.37%).Among 631 published journals,Nucleic Acids Research was the most published journal(n=83,3.26%).Siomi Mikiko C published the most articles(n=58),with Aravin Alexei A as the most co-cited *** of term co-occurrence unveiled three highly interconnected clusters,including“piRNA biogenesis and function”,“cancer and regulation”,as well as“protein and species”.The research focus has transferred from male reproductive development to tumor ***:This bibliometric analysis offered a thorough overview of the current state of piRNA research,deepening understanding of the progress in this field over the last 17 years and providing a valuable reference for scholars engaged in piRNA studies.

关键词： piRNA research trends bibliometric analysis VOSviewer CiteSpace

Microglia lactylation in relation to central nervous system diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo Le Tong Jianhong Dong Ziwei Fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina department of clinical laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina department of pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina department of clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

Hypoxia-inducible factor 1alpha and vascular endothelial growth factor in Glioblastoma Multiforme:a systematic review going beyond pathologic implications

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2024年第8期32卷 1239-1256页

作者： DIMITRA P.VAGELI PANAGIOTIS G.DOUKAS KERASIA GOUPOU ANTONIOS D.BENOS KYRIAKI ASTARA KONSTANTINA ZACHAROULI SOTIRIS SOTIRIOU MARIA IOANNOU department of Surgery Yale UniversityNew HavenCT 06510USA department of pathology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa41500Greece department of medicine Rutgers/Saint Peter’s University HospitalNew BrunswickNJ 08901USA department of Neurology Army Share Fund Hospital(NIMTS)Athens11521Greece laboratory of Embryology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa41500Greece

Glioblastoma multiforme(GBM)is an aggressive primary brain tumor characterized by extensive heterogeneity and vascular *** conditions in the tissue microenvironment are considered a pivotal player leading tumor ***,hypoxia is known to activate inducible factors,such as hypoxia-inducible factor 1alpha(HIF-1α),which in turn can stimulate tumor neo-angiogenesis through activation of various downward mediators,such as the vascular endothelial growth factor(VEGF).Here,we aimed to explore the role of HIF-1α/VEGF immunophenotypes alone and in combination with other prognostic markers or clinical and image analysis data,as potential biomarkers of GBM prognosis and treatment *** performed a systematic review(Medline/Embase,and Pubmed database search was completed by 16th of April 2024 by two independent teams;PRISMA 2020).We evaluated methods of immunoassays,cell viability,or animal or patient survival methods of the retrieved studies to assess unbiased *** used inclusion criteria,such as the evaluation of GBM prognosis based on HIF-1α/VEGF expression,other biomarkers or clinical and imaging manifestations in GBM related to HIF-1α/VEGF expression,application of immunoassays for protein expression,and evaluation of the effectiveness of GBM therapeutic strategies based on HIF-1α/VEGF *** used exclusion criteria,such as data not reporting both HIF-1αand VEGF or *** included 50 studies investigating in total 1319 GBM human specimens,18 different cell lines or GBM-derived stem cells,and 6 different animal models,to identify the association of HIF-1α/VEGF immunophenotypes,and with other prognostic factors,clinical and macroscopic data in GBM prognosis and therapeutic *** found that increased HIF-1α/VEGF expression in GBM correlates with oncogenic factors,such as miR-210-3p,Oct4,AKT,COX-2,PDGF-C,PLDO3,M2 polarization,or ALK,leading to unfavorable *** HIF-1α/VEGF expression correlates with F

关键词： Glioblastoma multiforme(GBM) Astrocytoma Grade III Astrocytoma Grade IV Hypoxia-inducible factor 1alpha(HIF-1α) Vascular endothelial growth factor(VEGF)