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p38γ regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage

Protein & Cell 2010年第6期1卷 573-583页

作者： Chia-Cheng Wu Xiaohua Wu Jiahuai Han Peiqing Sun Department of Immunology and Microbial Science The Scripps Research Institute10550 N.Torrey Pines Road.La JollaCA 92037USA Department of molecular and Experimental Medicine The Scripps Research Institute10550 N.Torrey Pines Road.La JollaCA 92037USA Key Laboratory of Ministry of Education for Cell biology and Tumor Cell Engineering School of Life SciencesXiamen UniversityXiamen 361005China dempartment of molecular biology The Scripps Research Institute10550 N.Torrey Pines Road.La JollaCA 92037USA

In eukaryotic cells,DNA damage triggers activation of checkpoint signaling pathways that coordinate cell cycle arrest and repair of damaged *** DNA damage responses serve to maintain genome stability and prevent accumulation of genetic mutations and development of *** p38 MAPK was previously implicated in cellular responses to several types of DNA ***,the role of each of the four p38 isoforms and the mechanism for their involvement in DNA damage responses remained poorly *** this study,we demonstrate that p38γ,but not the other p38 isoforms,contributes to the survival of UV-treated *** of p38γsensitizes cells to UV exposure,accompanied by prolonged S phase cell cycle arrest and increased rate of *** investigation reveal that p38γis essential for the optimal activation of the checkpoint signaling caused by UV,and for the efficient repair of UVinduced DNA *** findings have established a novel role of p38γin UV-induced DNA damage responses,and suggested that p38γcontributes to the ability of cells to cope with UV exposure by regulating the checkpoint signaling pathways and the repair of damaged DNA.

关键词： p38γ DNA damage UV DNA repair checkpoint signaling

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