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Studies on Toxicity,Anti-stress and Hepato-protective Properties of Kombucha Tea

Biomedical and Environmental Sciences 2001年第3期14卷 207-213页

作者： PAULINE，T. KAVIMANI，S defenceinstituteofphysiologyalliedsciences TimarpurLucknowRoadDelhi－110054India MotherTherasaInstituteofHealthScience IndiraNagarGorimeduPondichery－6India

Objective\ The objective of the study was to evaluate toxicity, anti_stress activity and hepato_protective properties of Kombucha tea. Method\ Kombucha tea was fed orally for 15 days using three different doses i.e. normal dose, five and ten times the dose. Rats were then sacrificed and various biochemical, and histological parameters were estimated. Anti_stress activity was evaluated either by 1) by exposing animals to cold and hypoxia and estimating the levels of malondialdehyde and reduced glutathione in plasma/ blood or 2) by subjecting the animals to restraint stress and recording faecal output. Hepato_toxicity was induced by challenging the animals to an acute dose of paracetamol (1 gm/kg) orally and determining the plasma levels of SGPT, SGOT and MDA. Results\ The effect of oral administration of different doses of K_tea to albino rats was examined and the results indicate that K_tea has no significant toxicity as revealed by various biochemical and histopathological parameters. K_tea has been found to prevent lipid peroxidation and fall in reduced glutathione level when rats were exposed to cold and hypoxia in simulated chamber. Further, K_tea has also been found to decrease the Wrap_restraint faecal pellet output in rats. K_tea has also been found to decrease paracetamol induced hepatotoxicity significantly. Conclusion\ The study shows that K_tea has anti_stress and hepato_protective activities.

关键词： reduced glutathione Kombucha tea oral administration lipid peroxidation restraint stress

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