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Thymic carcinoma:review and update

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 476-487页

作者： Kirill Karlin Phillip D.Michaels Department of pathology Beth Israel Deaconess Medical CenterBostonMA 02115USA

Thymic carcinoma(TC)is a rare thymic epithelial neoplasm with an aggressive clinical *** are many recognized histologic subtypes as described by the fifth edition of the World Health Organization(WHO)Classification of Thoracic Tumors;however,given the rarity of this tumor group,diagnosis remains a challenge,especially on limited tissue ***,rare variants of TC are continuing to be established,particularly in the era of molecular ***,histologic subtypes are described as the rare subtypes of TC in the context of their immunoprofile,cytogenetic or molecular features,clinical presentation,and ensuing challenges.

关键词： Thymic carcinoma NUT carcinoma thymus KIT thymoma

Case report of a traumatic rectal neuroma

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Gastroenterology Report 2016年第4期4卷 331-333,I0003页

作者： Thomas Curran Vitaliy Poylin Robert Kane Anna Harris Jeffrey DGoldsmith Deborah Nagle Department of Surgery Division of Colorectal SurgeryBeth Israel Deaconess Medical CenterBostonMAUSA Department of Radiology Beth Israel Deaconess Medical CenterBostonMAUSA Department of pathology Beth Israel Deaconess Medical CenterBostonMAUSA

Traumatic neuroma is a well-recognized complication of lower extremity amputation,yet has also been noted to occur *** report a clinical case and English-language literature review of traumatic rectal neuroma,a well-k... 详细信息

关键词： Traumatic rectal neuroma transanal endoscopic microsurgery

GOAL: the comprehensive gene ontology analysis layer

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Science China(Information Sciences) 2016年第7期59卷 86-93页

作者： Jong Cheol JEONG George LI Xue-Wen CHEN Department of pathology Harvard Medical School Beth Israel Deaconess Medical Center Bioinformatics and Computational Life Sciences Laboratory University of Kansas Department of Computer Science Wayne State University

Homogeneity or heterogeneity of cells is the most fundamental and important features of analyzing biological associations of genes and gene products. Recent bioinformatics technology requires an automated high-throughput analysis application that can handle massively produced data from next generation sequences and dramatically increased size of public proteomic/genomic databases. Although Gene ontology(GO) database has been newly spotlighted on its wide coverage of machine-readable terminologies, its complex DB schema and vast amount of applications utilizing GO without deep considerations of GO term relations dilute the actual power of GO-based analysis and resulted in misleading/under estimated outcomes. Meanwhile, our recent studies showed that BSM score, a new way of measuring functional similarity, clearly outperformed existing conventional methods. However, implementing BSM score that requires integrating multiple databases and calculating scoring matrix is not trivial and even difficult for bioinformatics experts; therefore, a web-based graphical user interface(GUI) tool, Gene Ontology Analysis Layer(GOAL: http://***/chenlab/goal) is introduced to provide user-friendly GO application powered by state of art functional similarity metric,BSM score.

关键词： gene ontology molecular function functional similarity network-based analysis BSM score

Calcium channels caught in peripheral glia’s tug-of-war on axon regeneration in Drosophila

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Neural Regeneration Research 2025年第2期20卷 475-476页

作者： Jackson Powell Tobias Steinschaden Rose Horowitz Yuanquan Song Raymond G.Perelman Center for Cellular and Molecular Therapeutics The Children’s Hospital of PhiladelphiaPhiladelphiaPAUSA The Neuroscience Graduate Group University of PennsylvaniaPhiladelphiaPAUSA Department of pathology and Laboratory Medicine University of PennsylvaniaPhiladelphiaPAUSA Medical University of Vienna Center for Brain ResearchDepartment of NeuroimmunologyViennaAustria

Neural damage or degeneration is at the crux of many diseases,and treatment of these diseases will require the development of therapeutics to enhance and guide neural *** intrinsic and extrinsic factors dictate a neuron’s ability to regenerate,and the combination of these factors results in the great regenerative capacity of the peripheral nervous system(PNS)and the poor regenerative capacity of the central nervous system(CNS)following *** the core of a neuron’s function is its ability to relay electrochemical signals,and a neuron’s excitability is a key factor in its ability to *** works have focused on the changes in neuronal electrophysiological properties,firing patterns,and ion flux after injury,which differentially activate signaling pathways at the core of *** role of glia in neuron regeneration has long been studied.

关键词： degeneration firing system

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pathology of alcoholic liver disease, can it be differentiated from nonalcoholic steatohepatitis?

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World Journal of Gastroenterology 2014年第44期20卷 16474-16479页

作者： Puja Sakhuja Department of pathology GB Pant Hospital

The liver involvement in alcoholic liver disease(ALD) classically ranges from alcoholic steatosis, alcoholic hepatitis or steatohepatitis, alcoholic cirrhosis and even hepatocellular carcinoma. The more commonly seen histologic features include macrovesicular steatosis, neutrophilic lobular inflammation, ballooning degeneration, Mallory-Denk bodies, portal and pericellular fibrosis. Nonalcoholic steatohepatitis(NASH) is a condition with similar histology in the absence of a history of alcohol intake. Although the distinction is essentially based on presence or absence of a history of significant alcohol intake, certain histologic features favour one or the other diagnosis. This review aims at describing the histologic spectrum of alcoholic liver disease and at highlighting the histologic differences between ALD and NASH.

关键词： Alcoholic liver disease Steatosis Steatohepatitis Fibrosis Cirrhosis Hepatocellular carcinoma Non-alcoholic steatohepatitis

Gastrointestinal B-cell lymphomas:From understanding B-cell physiology to classification and molecular pathology

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World Journal of Gastrointestinal Oncology 2012年第12期4卷 238-249页

作者： Xavier Sagaert Thomas Tousseyn Rhonda K Yantiss Department of pathology University Hospitals Leuven Department of pathology and Laboratory Medicine Weill Cornell Medical College

The gut is the most common extranodal site where lymphomas arise. Although all histological lymphoma types may develop in the gut, small and large B-cell lymphomas predominate. The sometimes unexpected finding of a lymphoid lesion in an endoscopic biopsy of the gut may challenge both the clinician (who is not always familiar with lymphoma pathogenesis) and the pathologist (who will often be hampered in his/her diagnostic skill by the limited amount of available tissue). Moreover, the past 2 decades have spawned an avalanche of new data that encompasses both the function of the reactive B-cell as well as the pathogenic pathways that lead to its neoplastic counterpart, the B-cell lymphoma. Therefore, this review aims to offer clinicians an overview of B-cell lymphomas in the gut, and their pertinent molecular features that have led to new insights regarding lymphomagenesis. It addresses the question as how to incorporate all presently available information on normal and neoplastic B-cell differentiation, and how this knowledge can be applied in daily clinical practice (e.g., diagnostic tools, prognostic biomarkers or therapeutic targets) to optimalise the managment of this heterogeneous group of neoplasms.

关键词： B-cell Non-Hodgkin’s lymphomas Gut Molecular pathology

A challenging case of alpha-fetoprotein-result discrepancies in a patient with chronic hepatitis B

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Gastroenterology Report 2020年第6期8卷 484-486,I0003页

作者： Pir A.Shah Allison Onken Rizwan Ishtiaq Muhammad H.Maqsood Shyam S.Patel Karen J.Campoverde Reyes Adrianna Z.Herskovits Daryl T.Y.Lau Department of Medicine Liver CenterDivision of GastroenterologyBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Department of pathology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Introduction Alpha-fetoprotein(AFP)is the most abundant serum protein found in the human fetus,produced by the yolk sac and the liver[1].The levels of maternal serum AFP reach a peak value at28-32 weeks of gestation and decrease rapidly after birth and usually drop to the normal at 8-12 months of *** normal serum AFP level for an adult is<20 ng/mL[2].In contrast,livertumor cells usually synthesize and secrete an increased level of *** ultrasound and AFP are generally recommended as the screening modality for HCC for patients at risk for development of hepatocellular carcinoma(HCC)[1].AFP-L3,an isoform of AFP that binds Lens culinaris agglutinin,can be particularly useful in the early identification of aggressive HCC[2].These assays,however,can generate false-positive and false-negative AFP *** patients with advanced HCC,20%had normal AFP levels,whereas some patients with liver diseases had significant AFP elevation without liver cancer in long-term surveillance[3].Elevated AFP levels could be associated with active liver diseases with hepatocyte regeneration[4,5].In that setting,the AFP level will decline with improvement of the underlying liver *** case illustrated the dilemma and uncertainties as a result of persistent abnormal AFP values after extensive clinical investigations.

关键词：甲胎蛋白 fetus false

Subtle presentation of active primary biliary cirrhosis in chronic hepatitis B:a case report

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Gastroenterology Report 2017年第2期5卷 157-160,I0002页

作者： Asad Javaid Mugilan Poongkunran Felicia D.Allard Win Kyaw Htet Htet Maung Daryl Lau Department of Medicine Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA a Department of pathology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

We are describing an interesting case of two chronic liver diseases in a 48-year-old Chinese *** chronic hepatitis B is a common entity in Asia,the patient was later found to have active,asymptomatic primary biliary cirrhosis due to a persistently elevated alkaline phosphatase level after optimal hepatitis B virus DNA suppression on antiviral *** report emphasizes the importance of keeping a high index of suspicion for another potential liver disease process even after a patient has been successfully treated for a primary liver *** vigilance,especially in atypical clinical presentations,can result in early accurate diagnosis and prompt treatment.

关键词： primary biliary cirrhosis chronic hepatitis B cholestatic disease alkaline phosphatase anti-mitochondrial antibodies

The pathology of urinary bladder lesions with an inverted growth pattern

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Chinese Journal of Cancer Research 2016年第1期28卷 107-121页

作者： Aitao Guo Aijun Liu Xiaodong Teng Department of pathology Chinese PLA General Hospital Beijing 100853 China Department of pathology the First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310058 China

Inverted lesions in the urinary bladder have been the source of some difficulty in urological pathology. The two common ones are von Brunn＇s nests and cystitis cystic/cystitis glandularis, which are considered normal variants of urothelium. Apart from them, a number of other rare urothelial lesions with inverted growth pattern occur in the urinary bladder. Some of them are only reactive conditions, just as pseudocarcinomatous hyperplasia. Some are benign tumors, namely inverted papilloma. Whereas others are malignant neoplasms, including inverted papillary urothelial neoplasm of low malignant potential （PUNLMP）, non-invasive inverted papillary urothelial carcinoma （low-grade and high-grade）, and invasive urothelial carcinoma （inverted, nested and big nested variants）. Because of the overlapping morphological features of all the inverted lesions mentioned above, even between high-grade invasive carcinoma and psendoearcinomatous hyperplasia which are only a kind of reactive conditions, it is very important for the surgical pathologist to recognize and be familiar with these inverted lesions in urinary bladder. In this article, we review these spectrums of inverted lesions of the urinary bladder. Emphasis is placed on histogenesis, morphology, differential diagnosis of these lesions, and the pathologic grading of the non-invasive inverted neoplasms, such as inverted papilloma, inverted PUNLMP, non-invasive inverted papillary urothelial carcinoma with low-grade, and non-invasive inverted papillary urothelial carcinoma with high-grade.

关键词： Von Brunn's nests pseudoeaicinomous hyperplasia inverted papilloma inverted papillary urothelial neoplasm of low malignant potential (PUNLMP) inverted urothelial carcinoma

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