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The development of simulator testing for total knee replacements

Biosurface and Biotribology 2021年第2期7卷 70-82页

作者： Chase Maag Amber Metcalfe Ioan Cracaoanu Casey Wise Daniel DAuger depuy synthes WarsawIndianaUSA depuy synthes LeedsUK

Professor Duncan Dowson was a pioneer in the field of tribology and simulator *** work sparked many branches of research across *** first knee simu-lator described by Dowson was intended to measure the wear performance of early total knee replacements(TKRs).The industry has since advanced to achieve simulator designs with significant improvements including multi-station,multi-axis,multi-control,and multi-environmental *** simulators are used to test and compare not only wear,but also the kinematic/kinetic behaviour of TKRs and many other TKR design interactions prior to *** has led to changes to the design of TKRs ranging from improvements to the tibial insert to the femoral component;all,in some way,thanks to Professor Duncan Dowson's inquisitive *** article provides a selective review to show the interdependencies of research and development endeavours starting with the evolution of knee simulators,the many advances in TKRs and finally the interconnection with cadaveric motion simulators.

关键词： knee testing starting

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The impact of storage conditions upon gentamicin coated antimicrobial implants

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Journal of Pharmaceutical Analysis 2016年第6期6卷 374-381页

作者： Nicholas D. Mullins Benjamin J. Deadman Humphrey A. Moynihan Florence O. McCarthy Simon E. Lawrence Jonathan Thompson Anita R. Maguirea Department of Chemistry Analytical and Biological Chemistry Research Facility Synthesis and Solid State Pharmaceutical Centre University CollegeCork Ireland depuy synthes (Ireland) Loughbeg Ringaskiddy Co. Cork Ireland School of Pharmacy Analytical and Biological Chemistry Research Facility Synthesis and Solid State Pharmaceutical Centre University College CorkIreland

A systematic approach was developed to investigate the stability of gentamicin sulfate(GS) and GS/poly(lacticco-glycolic acid)(PLGA) coatings on hydroxyapatite *** influence of environmental factors(light,humidity,oxidation and heat) upon degradation of the drug in the coatings was investigated using liquid chromatography with evaporative light scattering detection and mass *** coated rods were found to be stable across the range of environments assessed,with only an oxidizing atmosphere resulting in significant changes to the gentamicin *** contrast,rods coated with GS/PLGA were more sensitive to storage conditions with compositional changes being detected after storage at 60 °C,75% relative humidity or exposure to *** effect of γ-irradiation on the coated rods was also investigated and found to have no significant ***,liquid chromatography–mass spectrometry analysis revealed that known gentamines C_1,C_1 aand C_2were the major degradants *** degradation of gentamicin coatings did not produce any unexpected degradants or impurities.

关键词： Gentamicin Coatings Storage stability testing LC–ELSD

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新年致辞

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中华创伤骨科杂志 2013年第1期15卷 I0010-I0010页

作者：张瑞年强生depuy synthes中国区总经理

亲爱的骨科界朋友们，很高兴有机会在《中华创伤骨科杂志》的平台上与大家交流。新年伊始，我谨代表depuy synthes的全体同仁，祝愿大家新年快乐、宏图大展!

关键词：《中华创伤骨科杂志》期刊编辑部读者

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Ionic Conduction in In3＋-doped ZrP2O7 at Intermediate Temperatures

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Chinese Journal of Chemistry 2012年第8期30卷 1826-1830页

作者：张红敏肖佳杨志杰王洪涛马桂林 Key Laboratory of Organic synthes is of Jiangsu Province College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu 215123China

A new series of Zr1-xInxP2O7 （x=0.03, 0.06, 0.09, 0.12） samples were prepared by a solid state reaction method. XRD patterns indicated that the samples of x=0.03–0.09 exhibited a single cubic phase structure, and the doping limit of In3＋ in ZrP2O7 was x=0.09. The conduction behavior was investigated in wet hydrogen using various electrochemical methods including AC impedance spectroscopy, isotope effect, gas concentration cells at intermediate temperatures （373–573 K）. The conductivities were affected by the doping levels, and increased in the order： σ （x=0.03）〈σ （x=0.12）〈σ （x=0.06）〈σ （x=0.09）. The highest conductivity was observed for the sample Zr0.91In0.09P2O7 to be 1.59×10-2 S·cm-1 in wet hydrogen at 573 K. The isotope effect also confirmed the proton conduction of the sample under water vapor-containing atmosphere. It was found that in wet hydrogen atmosphere Zr0.91In0.09P2O7 was almost pure ionic conductor, the ionic conduction was contributed mainly to proton and partially to oxide ionic. The H2/air fuel cell using x=0.09 sample as electrolyte （thickness： 1.73 mm） generated a maximum power density of 13.5 mW·cm？2 at 423 K and 16.9 mW·cm？2 at 448 K, respectively.

关键词： Zr1-xInxP2O7 ionic conduction conductivity isotope effect gas concentration cell fuel cell

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应用穿颊器口内入路微创治疗下颌骨角和升支骨折

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实用口腔医学杂志 2006年第5期22卷 589-592页

作者：王彦亮刘彦普何黎升王大章薄斌陆斌郑安周树夏第四军医大学口腔医学院颌面外科西安现在成都710032 四川大学华西口腔医学院颌面外科美国synthes公司(中国分公司)颌面外科产品部西安第四军医大学口腔医学院颌面外科西安71003

目的：观察口内和穿颊的手术入路处理下颌骨角部和升支骨折,并用小钛板坚强内固定的疗效.方法：对2004-01～2005-07间18 例连续的下颌骨角部和升支骨折患者,用穿颊器经过颊部小切口联合口内切口复位内固定.随机选取同时期的另外20 例同... 详细信息

目的：观察口内和穿颊的手术入路处理下颌骨角部和升支骨折,并用小钛板坚强内固定的疗效.方法：对2004-01～2005-07间18 例连续的下颌骨角部和升支骨折患者,用穿颊器经过颊部小切口联合口内切口复位内固定.随机选取同时期的另外20 例同类型骨折患者,仍按照传统口外入路行手术切开复位内固定,2 组间进行对比.结果：用口内和穿颊入路患者中有1 例内固定术后骨折处仍有小幅动度,还需辅以颌间固定;口外入路行内固定手术的患者中有2 例需行术后颌间固定.没有术后感染发生,没有出现需要行切开引流或需取出固定物的病例.结论：通过口内和穿颊入路行坚强内固定适用于不伴有严重错位或粉碎性骨折的下颌骨角部和升支部骨折的病例.

关键词：穿颊器下颌骨骨折口内入路

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