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Quantitative trait loci analysis of glucosinolate,sugar,and organic acid concentrations in Eruca vesicaria ***

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Molecular Horticulture 2022年第1期2卷 287-302页

作者： Luke Bell Martin Chadwick Manik Puranik Richard Tudor Lisa Methven Carol Wagstaff School of Agriculture Policy&DevelopmentCrop SciencesUniversity of ReadingReadingUK School of Chemistry Food&PharmacyFood&Nutritional SciencesUniversity of ReadingReadingUK Elsoms Seeds ltd. SpaldingUK

Eruca vesicaria *** is a leafy vegetable of the Brassicaceae family known for its *** in grow-ing conditions,leaf age,agronomic practices,and variety choice lead to inconsistent quality,especially in content of isothiocyanates(ITCs)and their precursor glucosinolates(GSLs).We present the first linkage and Quantitative Trait Loci(QTL)map for Eruca,generated using a population of 139 F_(4) lines.A significant environmental effect on the abun-dance of primary and secondary metabolites was observed,with uk-grown plants containing significantly higher concentrations of glucoraphanin,malic acid,and total ***-grown plants were characterized by higher concentrations of glucoerucin,indolic GSLs,and low monosaccharides.20 QTL were identified and associated with robust SNP *** genes putatively associated with the synthesis of the GSL 4-methoxyglucobrassicin(4MGB)were identified as candidate regulators underlying *** revealed that orthologs of MYB51,IGMT1 and IGMT4 present on LG1 are associated with 4MGB concentrations in *** research illustrates the utility of the map for identifying genes associated with nutritional composition in Eruca and its value as a genetic resource to assist breed-ing programs for this leafy vegetable crop.

关键词： Rocket Arugula Brassicaceae Glucoraphanin Malic acid 4-methoxyglucobrassicin

Nano-precision metrology of X-ray mirrors with laser speckle angular measurement

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Light(Science & Applications) 2021年第10期10卷 1915-1927页

作者： Hongchang Wang Simone Moriconi Kawal Sawhney Diamond Light Source ltd Harwell Science and Innovation CampusDidcot OX110DEUK department of Engineering Science University of OxfordParks RoadOxford OX13PJUK

X-ray mirrors are widely used for synchrotron radiation,free-electron lasers,and astronomical *** short wavelength and grazing incidence impose strict limits on the permissible slope *** polishing techniques have already produced mirrors with slope errors below 50 nrad root mean square(rms),but existing metrology techniques struggle to measure ***,we describe a laser speckle angular measurement(SAM)approach to overcome such *** also demonstrate that the angular precision of slope error measurements can be pushed down to 20nrad rms by utilizing an advanced sub-pixel tracking ***,SAM allows the measurement of mirrors in two dimensions with radii of curvature as low as a few hundred ***,the instrument based on SAM is compact,low-cost,and easy to integrate with most other existing X-ray mirror metrology instruments,such as the long trace profiler(LTP)and nanometer optical metrology(NOM).The proposed nanometrology method represents an important milestone and potentially opens up new possibilities to develop next-generation super-polished X-ray mirrors,which will advance the development of X-ray nanoprobes,coherence preservation,and astronomical physics.

关键词： millimeter metrology speckle

Efficiency of a Modular Cleanroom for Space Applications

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Fluid Dynamics & Materials Processing 2024年第3期20卷 547-562页

作者： Matthew R.Coburn Charlie Young Chris Smith Graham Schultz Miguel Robayo Zheng-Tong Xie Faculty of Engineering and Physical Sciences University of SouthamptonSouthamptonSO171BJUK Plastron uk ltd. Westcott Venture ParkWestcottHP180XBUK Renewable Energy Group University of ExeterExeterTR109FEUK

A prototype cleanroom for hazardous testing and handling of satellites prior to launcher encapsulation,satisfying the ISO8 standard has been designed and analyzed in terms of *** Reynolds Averaged Navier-Stokes(URANS)models have been used to study the related flow field and particulate matter(PM)*** outcomes of the URANS models have been validated through comparison with equivalent large-eddy *** attention has been paid to the location and shape of the air intakes and their orientation in space,in order to balance the PM convection and diffusion inside the *** a cyclone-type flow pattern inside the cleanroom is a key to maintaining a high ventilation efficiency.

关键词： Diffuser LES PM RANS unsteady flow exponential decay

Use of multiscale particle simulations in the design of nuclear plant decommissioning

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Particuology 2011年第4期9卷 358-364页

作者： Richard A. Williams Xiaodong Jia Peter Ikin David Knight Institute of Particle Science and Engineering School of Process Environmental and Materials Engineering University of Leeds LS2 9iT UK Structure Vision ltd. Leeds Innovation Centre 103 Clarendon Road Leeds LS2 9DF UK

The application of a digital modelling method that can faithfully take account of three-dimensional shape and inherent physical and chemical properties of each particulate component provides an essential tool in decommissioning design. This is useful in handling of high, medium and low level radioactive waste. The processes involve making decisions on where to cut existing plant components and then how to pack these components into boxes, which are then cemented and kept for long term storage as the level of radioactive declines with time. We illustrate the utility of the method and its ability to take data at plant scale （m-scale） and then deduce behaviours at sub millimetre scale in the packed containers. A variety of modelling approaches are used as a part of this approach including cutting algorithms, geometric and dynamic （distinct element） force models, and lattice Boltzmann methods. These methods are applicable to other complex particulate systems including simulation of waste, building recycling, heap leaching and related minerals processes. The paper introduces the basic concepts of this multi-scale and multi-model approach.

关键词： Cementation Digital packing Digipac Discrete element modelling Nuclear waste NuPlant Particle shape

Configurations and Control of Traction Motors for Electric Vehicles:A Review

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Chinese Journal of Electrical Engineering 2017年第3期3卷 1-17页

作者： Saqib Jamshed Rind Yaxing Ren Yihua Hu Jibing Wang Lin Jiang department of Electrical Engineering and Electronics The University of LiverpoolL693BXUK Sicher Elevator Co. Ltd.Huzhou 313009China

In recent decades,worldwide global warming and reduction in petroleum resources have accelerated researcher’s attention to produce alternative sustainable and environmentally clean transportation *** of vehicular technology is capable of curbing the environmental pollution problem in an efficient and effective way,due to high efficiency electric motors,development and advancement in the field of power electronic devices,digital signal processing and advanced control *** article presents a comprehensive review on different configurations/architecture of electric vehicles(EVs)and hybrid electric vehicles(HEVs),traction motors for electric propulsion system and high performance speed sensorless control of traction *** basic architecture key components of hybrid vehicle and different power train configurations with respect to applications and limitations are *** integral part of electric propulsion system,traction motor classes for desired operational characteristics and limitations are summarized from a system perspective with the latest *** performance traction motor control techniques are discussed with respect to automotive ***,speed sensorless control techniques research trends as well as an extensive review on rotor speed estimation techniques for robust and efficient sensorless traction drive control are *** article provides state of the art key global trends and tradeoff of various technologies with future trends and potential areas of research.

关键词： Electric vehicle architecture vehicle powertrain configurations traction motors traction drive control motor sensorless control

Identification and machine learning prediction of knee-point and knee-onset in capacity degradation curves of lithium-ion cells

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Energy and AI 2020年第1期1卷 64-73页

作者： Paula Fermin-Cueto Euan McTurk Michael Allerhand Encarni Medina-Lopez Miguel F.Anjos Joel Sylvester Goncalo dos Reis School of Mathematics University of EdinburghThe King’s BuildingsEdinburghUK Dukosi ltd. Quantum CourtResearch Avenue SouthHeriot Watt University Research ParkEdinburghUK Institute for Infrastructure and Environment School of EngineeringUniversity of EdinburghThe King’s BuildingsEdinburghUK Centro de Matematica e Aplicações(CMA) FCTUNLPortugal

High-performance batteries greatly benefit from accurate,early predictions of future capacity loss,to advance the management of the battery and sustain desirable application-specific performance characteristics for as long as ***-ion cells exhibit a slow capacity degradation up to a knee-point,after which the degradation ac-celerates rapidly until the cell’s *** capacity degradation data,we propose a robust method to identify the knee-point within capacity fade *** a new approach to knee research,we propose the concept‘knee-onset’,marking the beginning of the nonlinear degradation,and provide a simple and robust identifica-tion mechanism for *** link cycle life,knee-point and knee-onset,where predicting/identifying one promptly reveals the *** data featuring continuous high C-rate cycling(1C–8C),we show that,on average,the knee-point occurs at 95%capacity under these conditions and the knee-onset at 97.1%capacity,with knee and its onset on average 108 cycles *** the critical identification step,we employ machine learning(ML)techniques for early prediction of the knee-point and *** models predict knee-point and knee-onset quantitatively with 9.4% error using only information from the first 50 cycles of the cells’*** models use the knee-point predictions to classify the cells’expected cycle lives as short,medium or long with 88–90% accuracy using only information from the first 3–5 *** accuracy levels are on par with existing literature for End-of-Life prediction(requiring information from 100-cycles),nonetheless,we address the more complex problem of knee *** estimations are enriched with confidence/credibility *** uncertainty regarding the ML model’s estimations is quantified through prediction *** yield risk-criteria insurers and manufacturers of energy storage applications can use for battery *** classification model provides a tool for cell man-ufacturers

关键词： Lithium-ion battery degradation Knee-point Knee-onset Machine learning Uncertainty quantification

A Review on Electric Vehicle Charging Infrastructure development in the uk

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Journal of Modern Power Systems and Clean Energy 2020年第2期8卷 193-205页

作者： Tianjin Chen Xiao-Ping Zhang Jianji Wang Jianing Li Cong Wu Mingzhu Hu Huiping Bian XU JI Power Co. Ltd.XuchangChina department of Electronic Electrical and Systems EngineeringUniversity of BirminghamBirminghamUK State Grid Shandong Electric Power Company LinyiChina

This paper focuses on the development of electric vehicle(EV)charging infrastructure in the uk,which is a vital part of the delivering ultra-low-emission vehicle(ULEV)and will transition into low emission energy systems in the near *** a brief introduction to global landscape of EV and its infrastructure,this paper presents the EV development in the *** then unveils the government policy in recent years,charging equipment protocols or standards,and existing EV charging *** topologies of charging infrastructure are ***,three important factors to be considered in a typical site,i.e.,design,location and cost,are discussed in ***,the management and operation of charging infrastructure including different types of business models are *** but not least,challenges and future trends are discussed.

关键词： Electric vehicle(EV) charging point charging infrastructure smart charging

Phagocytosed Polyhedrin-Cytokine Cocrystal Nanoparticles Provide Sustained Secretion of Bioactive Cytokines from Macrophages

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Biodesign Research 2021年第1期2021卷 47-58页

作者： Astrid Wendler Nicholas James Michael H.Jones Christian Pernstich Cell Guidance Systems ltd. Maia BuildingBabraham Research CampusCambridge CB223ATUK

Many cells possess the ability to engulf and incorporate particles by *** active process is characteristic of microorganisms as well as higher order *** mammals,monocytes,macrophages,and microglia are among the so-called professional *** addition,cells such as fibroblast and chondrocytes are classified as nonprofessional *** phagocytes play important roles in both the innate and adaptive immune responses,wound healing,and tissue ***,these cells are increasingly studied as targets and vectors of therapeutic intervention to treat a range of *** phagocytes are notoriously difficult to transfect limiting their study and ***,efforts have shifted towards the development of nanoparticles to deliver a cargo to phagocytic cells via ***,this approach carries significant technical challenges,particularly for protein *** have focused on the development of nanoscale cocrystalline protein depots,known as PODS®,that contain protein cargos,including ***,we show that PODS are readily phagocytosed by nonprofessional as well as professional phagocytic cells and have attributes,such as highly sustained release of cargo,that suggest potential utility for the study and exploitation of phagocytic cells for drug *** and macrophages that ingest PODS retain normal characteristics including a robust chemotactic ***,the PODS-cytokine cargo is secreted by the loaded cell at a level sufficient to modulate the behavior of surrounding nonphagocytic *** results presented here demonstrate the potential of PODS nanoparticles as a novel molecular tool for the study and manipulation of phagocytic cells and for the development of Trojan horse immunotherapy strategies to treat cancer and other diseases.

关键词： sustained healing professional

Thermodynamics of clayedrug complex dispersions: Isothermal titration calorimetry and high-performance liquid chromatography

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Journal of Pharmaceutical Analysis 2020年第1期10卷 78-85页

作者： Ana-Maria Totea Juan Sabin Irina Dorin Karl Hemming Peter R.Laity Barbara R.Conway Laura Waters Kofi Asare-Addo School of Applied Sciences Department of PharmacyUniversity of HuddersfieldQueensgateHuddersfieldHD13DHUK AFFINImeter Edificio EmprendiaCampus VidaSantiago de CompostelaSpain Malvern Panalytical ltd. MalvernUK School of Applied Sciences Department of ChemistryUniversity of HuddersfieldQueensgateHuddersfieldHD13DHUK department of Materials Science and Engineering University of SheffieldSir Robert Hadfield BuildingMappin StreetSheffieldS13JDUK

An understanding of the thermodynamics of the complexation process utilized in sustaining drug release in clay matrices is of great *** characterisation techniques as well as isothermal calorimetry were utilized in investigating the adsorption process of a model cationic drug(diltiazem hydrochloride,DIL)onto a pharmaceutical clay system(magnesium aluminium silicate,MAS).X-ray powder diffraction(XRPD),attenuated total reflectance Fourier transform infrared spectroscopy(ATRFTIR)and optical microscopy confirmed the successful formation of the DIL-MAS *** quantification from the complexes demonstrated variable behaviour in the differing media used with DIL degrading to desacetyl diltiazem hydrochloride(DC-DIL)in the 2 M HCl *** also,the authors report for the first time two binding processes that occurred for DIL and MAS.A competitor binding model was thus proposed and the thermodynamics obtained suggested their binding processes to be enthalpy driven and entropically *** information is of great importance for a formulator as care and consideration should be given with appropriate media selection as well as the nature of binding in complexes.

关键词： Clay-drug complex dispersions Magnesium aluminium silicate Diltiazem hydrochloride Isothermal titration calorimetry High performance liquid chromatography