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Comparison of lymph node number and prognosis in gastric cancer patients with perigastric lymph nodes retrieved by surgeons and pathologists

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Chinese Journal of Cancer Research 2016年第5期28卷 511-518页

作者： Lixin Jiang Zengwu Yao Yifei Zhang Jinchen Hu Dawei Zhao Huiyuan Zhai Xixun Wang Zhenbin Zhang Dong Wang Gastrointestinal surgery ward I Yantai Yuhuangding Hospital the Affiliated Hospital of Qingdao University Yantai 264000 China

Objective： To compare the numbers of positive and total lymph nodes and prognosis in gastric cancer patients whose perigastric lymph node retrieval was performed by surgeons and pathologists. Methods： We conducted a retrospective analysis of clinical and follow-up data from 1,056 patients who underwent gastric cancer D2 radical lymph node resection between January 2008 and December 2010 in the Gastrointestinal surgery Department of Yantai Yuhuangding Hospital. The follow-up ended in December 2015. Patients were divided into two groups according to the specialty of physicians who performed the postoperative perigastric lymph node retrieval： the surgeon group （475 cases） and the pathologist group （581 cases）. The numbers of positive and total perigastric lymph nodes and the 3- and 5-year survival were compared between gastric cancer patients in the two groups overall and stratified by TNM stage （AJCC 7th Edition）. Results： Overall, the numbers of positive and total lymph nodes were significantly higher in the surgeon group than in the pathologist group （6.53±4.07 vs. 4.09±3.70, P=0.021; 29.64±11.50 vs. 20.71±8.56, P〈0.001）. Further analysis showed that the total number of lymph nodes in stage Ⅰ patients （19.40±9.62 vs. 15.45±8.59, P=0.011） and the numbers of positive and total lymph nodes in stage Ⅱ（1.38±1.08 vs. 0.87±1.55, P=0.031; 25.35±10.80 vs. 16.75±8.56, P〈0.001） and stage Ⅲ patients （8.11±6.91 vs. 6.66±5.12, P=0.026; 32.34±12.55 vs. 25.45±8.31, P〈0.001） were significantly higher in the surgeon group than in the pathologist group. The survival analysis showed that the 3- and 5-year survival of stage Ⅱ and Ⅲ patients was significantly higher in the surgeon group than in the pathologist group （82.0% vs. 73.1%, 69.5% vs. 61.2%, P=0.038; 49.2% vs. 38.9%, 36.3% vs. 28.0%; P=0.045）. Conclusions： Compared with retrieval performed by pathologists, postoperative perigastrie lymph node retrieval performed by surgeons was associated with significant increase in the total l

关键词： Gastric cancer surgeon and pathologist lymph node retrieval prognosis

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Impact of failure mode and effects analysis-based emergency management on the effectiveness of craniocerebral injury treatment

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World Journal of Clinical Cases 2022年第2期10卷 554-562页

作者： Xiao-Lan Shao Ya-Zhou Wang Xiong-Hui Chen Wen-Juan Ding Department of Emergency surgery ward 48 First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Craniocerebral injuries encompass brain injuries,skull fractures,cranial soft tissue injuries,and similar ***,the incidence of craniocerebral injuries has increased dramatically due to the increased numbers of traffic accidents and aerial work injuries,threatening the physical and mental health of *** To investigate the impact of failure modes and effects analysis(FMEA)-based emergency management on craniocerebral injury treatment *** Eighty-four patients with craniocerebral injuries,treated at our hospital from November 2019 to March 2021,were selected and assigned,using the random number table method,to study(n=42)and control(n=42)*** in the control group received conventional management while those in the study group received FMEA theory-based emergency management,based on the control ***-and post-interventions,details regarding the emergency situation;levels of inflammatory stress indicators[Interleukin-6(IL-6),C-reactive protein(CRP),and procalcitonin(PCT)];incidence of complications;prognoses;and satisfaction regarding patient care were evaluated for both *** For the study group,the assessed parameters[pre-hospital emergency response time(9.13±2.37 min),time to receive a consultation(2.39±0.44 min),time needed to report imaging findings(1.15±4.44 min),and test reporting time(32.19±6.23 min)]were shorter than those for the control group(12.78±4.06 min,3.58±0.71 min,33.49±5.51 min,50.41±11.45 min,respectively;P0.05);post-intervention serum indicator levels were lower in both groups than pre-intervention ***,serum levels of IL-6(17.35±5.33 pg/mL),CRP(2.27±0.56 mg/L),and PCT(0.22±0.07 ng/mL)were low

关键词： Craniocerebral injury Failure modes and effects analysis theory Emergency management Treatment effect

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Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

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Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee Dan Cao Younghye Moon Chen Chen Nai-Kui Liu Xiao-Ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

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Early warning prevention and control strategies to reduce perioperative venous thromboembolism in patients with gastrointestinal cancer

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World Journal of Clinical Cases 2022年第10期10卷 3035-3046页

作者： Yun Lu Feng-Ying Chen Lan Cai Chun-Xia Huang Xue-Fang Shen Li-Qin Cai Xiao-Ting Li Yong-Yan Fu Juan Wei The Fifth ward of surgery Kunshan Hospital of Traditional Chinese MedicineKunshan 215300Jiangsu ProvinceChina Department of Nursing Traditional Chinese Medicine Hospital of KunshanKunshan 215300Jiangsu ProvinceChina The Fourth ward of surgery Traditional Chinese Medicine Hospital of KunshanKunshan 215300Jiangsu ProvinceChina

BACKGROUND Venous thromboembolism(VTE)is a major cause of unexpected and perioperative in-hospital *** is characterized by high morbidity,high mortality,high misdiagnosis rate,and high missed diagnosis *** is a common postoperative complication in cancer *** is preventable,and early identification of risk factors leading to VTE and appropriate early preventive actions can reduce its occurrence and ***,there is no uniform standard for the prevention and control of VTE in clinical practice,and hospitals in China lack mature and effective protocols for the assessment,prevention,and treatment of *** To explore whether an early warning program could influence the occurrence of deep vein thrombosis(DVT)*** This is a comparative retrospective cohort study,which enrolled patients who underwent laparotomic or laparoscopic gastrointestinal tumor resection for gastrointestinal cancer between January 2016 and December *** were divided into a control group and an early warning group depending on whether or not the early warning program was implemented.A venous thromboembolism prevention and control team was *** outcomes included the occurrence of DVT,the correct rate of VTE assessment,the coagulation indicators,and the mastery of VTE knowledge by the *** A total of 264 patients were included in this study,with 128 patients in the control group and 136 patients in the early warning *** occurrence rate of DVT in the early warning group was 6.6%(9/136),compared with 14.1%(18/128)in the control group(P<0.05).The correct rates of VTE risk assessment by the nurses and standard implementation rate of VTE preventive measures were 86.8%vs 65.6%and 80.2%vs 57.8%in early warning and control groups,respectively(all P<0.001).The independent factors associated with postoperative DVT occurrence were age(OR=1.083,95%CI:1.070-3.265,P=0.032),Hyperlipidemia(OR=1.127,95%CI:1.139-2.564,P=0.042),preope

关键词： Venous thromboembolism Gastrointestinal cancer Perioperative period Early warning Prevention and control

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Inhibition of Obtusifolin on retinal pigment epithelial cell growth under hypoxia

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1539-1547页

作者： Li-Fei Wang Zhong-Yang Yan Ya-Lin Li Yan-Hui Wang Sheng-Juan Zhang Xin Jia Lu Lu Yan-Xia Shang Xin Wang Yun-Huan Li Shan-Yu Li Fundus surgery ward Hebei Provincial Eye HospitalXingtai054001Hebei ProvinceChina Diabetic Eye Disease ward Hebei Provincial Eye HospitalXingtai054001Hebei ProvinceChina Corneal Disease ward Hebei Provincial Eye HospitalXingtai054001Hebei ProvinceChina

AIM: To explore the effect of Obtusifolin on retinal pigment epithelial cell growth under ***: In vitro chemical hypoxia model of ARPE-19 cells was established using cobalt chloride(CoCl2). Cell viability was tested by cell counting kit-8(CCK-8) assay. Western blot and real-time quantitative polymerase chain reaction were applied to detect proteins and mRNAs respectively. Flow cytometry was used to examine the cell cycle. Secretion of vascular endothelial growth factor(VEGF) was tested by using enzyme linked immunosorbent assay(ELISA).RESULTS: Under the chemical hypoxia model established by CoCl2, hypoxia inducible factor-1α(HIF-1α) mRNA and protein levels was up-regulated. Cell viability was increased and the proportion of S phase was higher. Obtusifolin could reduce cell viability under hypoxic conditions and arrest cells in G1 phase. Obtusifolin reduced the expression of Cyclin D1 and proliferating cell nuclear antigen(PCNA) in the hypoxic environment and increased the expression of p53 and p21. The levels of VEGF, VEGFR2 and eNOS proteins and mRNA were significantly increased under hypoxia while Obtusifolin inhibited the ***: Obtusifolin can inhibit cell growth under hypoxic conditions and down-regulate HIF-1/VEGF/eNOS secretions in ARPE-19 cells.

关键词： retinal pigment epithelial cells Obtusifolin vascular endothelial growth factor hypoxia

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Clinical application of individualized total arterial coronary artery bypass grafting in coronary artery surgery

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World Journal of Clinical Cases 2021年第19期9卷 5073-5081页

作者： Wei-Guang Chen Bai-Chun Wang Yong-Ri Jiang Ye-Yang Wang Yang Lou Second ward Department of Heart and Great Arteries SurgeryFourth Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Total arterial revascularization is associated with increased patency and long-term efficacy and decreased perioperative morbidity and mortality and incidence of cardiac-related events and sternal wound infection compared with conventional coronary artery bypass surgery(CABG),in which the left internal mammary artery(LIMA)is typically grafted to the left anterior descending artery with additional saphenous vein grafts often *** study determined whether these favorable clinical results could be realized at the authors’*** To summarize the early efficacy and clinical experience of individualized total arterial coronary artery bypass grafting *** CABG was performed on 35 patients with non-single-vessel coronary artery disease by adopting total arterial grafts at Fourth Affiliated Hospital of Harbin Medical University between April 2016 and December *** was used in 35 patients,radial artery(RA)was used in 35 patients,and right gastroepiploic artery(RGEA)was used in 9 *** complications were observed,short-term graft patency rate was followed-up,and quality of life was *** All patients underwent off-pump coronary artery bypass and the surgeries were *** of them were discharged without any complications or *** the follow-up,it was found that patients’angina symptoms were relieved and New York Heart Association classification for cardiac function was class I to class II.A total of 90 vessels were grafted with no occlusion for internal mammary artery,three occlusions for RA,and one occlusion for *** The individualized total arterial strategy based on the vessels targeting individual anatomic characteristics can achieve complete revascularization with satisfactory short-term grafting patency rate.

关键词： Total arterial revascularization Coronary artery bypass grafting Radial artery Right gastroepiploic artery

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Early Rehabilitation of Orthopedic Internal Fixation Removal in daytimeward

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Computer Systems Science & Engineering 2022年第10期43卷 219-231页

作者： Lanlan Ni Lanzheng Bian Rugang Lu Ting Chen Jinyue Xia Department of day surgery Children's Hospital of Nanjing Medical UniversityNanjing210008China Department of surgery Children's Hospital of Nanjing Medical UniversityNanjing210008China International Business Machines Corporation(IBM) NY10504USA

Children's fractures are very common,and many children's fractures need internal *** the children are treated and recovered,it needs to be internally fixed and then taken *** the development of internal fixation materials,the research of surgical methods and the improvement of surgical skills,postoperative removal of orthopedic surgery patients has gradually been included in daytime *** ensuring the safety of children's surgery,it is necessary to shorten the postoperative limb and joint function recovery time,promote the recovery of limb and joint function,the healing of wounds and bones,and reduce the occurrence of these *** order to reduce the occurrence of these complications,carry out early rehabilitation education and development early rehabilitation training is very *** paper puts forward the concept of early rehabilitation based on shared decision model,in which doctors,nurses,children and family members participate in the treatment of children before,during and after *** effect of early rehabilitation education in the daytime ward after removal of internal fixation was ***,through the analysis of the control trial also confirmed that the clinical effect of early rehabilitation in improving and optimizing the rehabilitation of fracture in children is significant.

关键词： Fractures internal fixation daytime surgery rehabilitation

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Therapeutic Mechanisms of Single Chinese Medicine Herb or Their Extracts for Extrahepatic Obstructive Jaundice

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Chinese Journal of Integrative Medicine 2014年第6期20卷 474-480页

作者：张喜平仇凤梅王霞 The 9 ward of Tumor surgery Department Zhejiang Cancer Hospital Zhejiang Chinese Medical University Department of Digestion Hangzhou First People's Hospital

Obstructive jaundice （O J） is classified as extrahepatic OJ or intrahepatic OJ. Extrahepatic OJ is attributed to a variety of intricate etiological factors. Research has begun with Chinese medicine （CM）, which can be used as an adjunctive therapy for extrahepatic OJ. Particular attention has been paid to the therapeutic effects and their mechanisms of single CM herb and relevant extracts. The roles of single CM or their extracts during adjunctive therapy for extrahepatic OJ have been described briefly, This review focuses on the effects and their mechanisms of relevant herbal medicines.

关键词： Chinese medicine extrahepatic bile duct obstructive jaundice inflammatory mediators

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Long-term follow-up of HER2 overexpression in patients with rectal cancer after preoperative radiotherapy:A prospective cohort study

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World Journal of Gastrointestinal Oncology 2022年第10期14卷 2048-2060页

作者： Nan Chen Chang-Long Li Yi-Fan Peng Yun-Feng Yao Department of Gastrointestinal surgery WardⅢKey laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China

BACKGROUND The role of HER2 overexpression in rectal cancer is *** To assess the role of HER2 overexpression in the long-term prognosis of rectal *** Data from patients with locally advanced rectal cancer who underwent total mesorectal excision after short-course radiotherapy at Beijing Cancer Hospital between May 2002 and October 2005 were collected.A total of 151 tissue samples of rectal cancer were obtained using rigid proctoscopy before neoadjuvant radiotherapy,followed by immunohistochemistry and fluorescence in situ hybridisation to determine the patients’HER2 expression *** and multivariate analyses of the associations between the clinicopathological factors and HER2 status were *** was estimated and compared using the Kaplan-Meier method based on HER2 expression status,and the differences between groups were verified using the log-rank *** A total of 151 patients were enrolled in this study.A total of 27(17.9%)patients were ultimately confirmed to be *** follow-up duration ranged from 9 mo to 210 mo,with a median of 134 *** metastasis and local recurrence occurred in 60(39.7%)and 24(15.9%)patients,***2 positivity was significantly associated with the pre-treatment lymph node stage(pre-N)(P=0.040),while there were no differences between HER2 status and age,sex,preoperative CEA levels(pre-CEA),T stage,and lympho-vascular *** terms of prognosis,HER2 overexpression was correlated with distant meta stasis(P=0.002)rather than local recurrence(P>0.05).The multivariate analysis demonstrated that elevated pre-CEA[P=0.002,odds ratio(OR)=3.277,97.5%confidence interval(CI):1.543-7.163],post N(+)(P=0.022,OR=2.437,97.5%CI:1.143-5.308)and HER2(+)(P=0.003,OR=4.222,97.5%CI:1.667-11.409)were risk factors for distant *** survival analysis showed that there were significant differences between rectal cancer patients in terms of disease-free survival(DFS)[hazard ra

关键词： HER2 Rectal cancer Distant metastasis Local recurrence Survival

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An Arc Incision Surgical Approach in Congenital Megaprepuce

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Chinese Medical Journal 2015年第4期128卷 555-557页

作者： Hou-Wei Lin Ling Zhang Hong-Quan Geng Xiao-Liang Fang Guo-Feng Xu Mao-Sheng Xu Wei Cai Department of Pediatric Urology Xinhua Hospital Shanghai 200092 China Department of day ward Renji Hospital Shanghai 200001 China

INTRODUCTION Congenital megaprepuce （CMP） is considered as a congenital penile malformation, which includes phimosis and severe ballooning of the redundant inner prepuce, conferring the typical aspect of concealed p... 详细信息

关键词： Foreskin Malformation Penis Reconstruction Surgical Technique

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