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A 30% incidence of renal cysts with varying sizes and densities in biomedical research swine is not associated with renal dysfunction

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Animal Models and Experimental Medicine 2020年第3期3卷 273-281页

作者： Belinda I.Gómez Joshua S.Little Alisa J.Leon Ian J.Stewart david M.Burmeister United States Army Institute of Surgical Research JBSA Fort Sam HoustonTXUSA david grant us air force medical center Travis Air Force BaseCAUSA Uniformed Services University of the Health Sciences BethesdaMDUSA

Background:Renal cystic disease arising from various etiologies results in fluid-filled cavities within the ***,preexisting renal dysfunction has been shown to exacerbate multiple *** swine bred for biomedical research are often clinically inspected for illness/parasites,more advanced diagnostics may aid in uncovering underlying renal ***:Computed tomography was performed in 54 female prepubertal Yorkshire swine to characterize renal cysts;urine and blood chemistry,and histology of cysts were also ***:Digital reconstruction of right and left kidneys demonstrated that roughly one-third of the animals(17/54;31%)had one or more renal *** biomarkers of renal function were not different between animals that had cysts and those that did ***,urinary glucose(P=.03)was higher and sodium(P=.07)tended to be lower in animals with cysts compared to animals without,with no differences in protein(P=.14)or potassium(P=.20).Aspiration of cystic fluid was feasible in two animals,which revealed that the cystic fluid urea nitrogen(97.6±28.7 vs 911.3±468.2 mg/dL),potassium(29.8±14.4 vs 148.2±24.85 mmol/L),uric acid(2.55±1.35 vs 11.4±5.65 mg/dL),and creatinine(60.34±17.26 vs 268.99±95.79 mg/dL)were much lower than in the *** demonstrated a cyst that markedly compresses the adjacent cortex and is lined by a single layer of flattened epithelium,bounded by fibrous connective tissue which extends into the *** is tubular atrophy and loss in these ***:This study provides valuable insight for future studies focusing on kidney function in swine bred for biomedical research.

关键词： computed tomography cyst kidney renal dysfunction swine

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Success Rate of Dental Implants Placed in the Atrophic Posterior Maxilla with Intentional Sinus Floor Perforation in Lieu of Indirect Sinus Augmentation: A Retrospective Report of 26 Consecutive Patients and Literature Review

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Open Journal of Stomatology 2017年第2期7卷 113-120页

作者： Khurram M.Shahzad Andrew Q.Madson Evan M.Shipp Andrew W.Ellis Oral and Maxillofacial Surgeon US Air Force Residency ProgramDavid Grant Medical CenterTravis Air Force BaseFairfieldCAUSA Oral and Maxillofacial Surgeon US Air Force HospitalLakenheathUK Oral and Maxillofacial Surgery Residency Program San Antonio Military Medical Center(SAMMC)San AntonioTXUSA us air force Hospital LakenheathUK

Purpose: To assess surgical success rate of placing dental implants in the atrophic posterior maxilla engaging the maxillary sinus floor in patients with inadequate posterior maxillary alveolar bone height (PMABH). Methods: 26 patients with PMABH of 7 - 10 mm had 39 implants placed between July 2012 and June 2014. These implants were placed protruding apically 1 - 3 mm into the maxillary sinus engaging the sinus floor. At stage one, implants and cover screws were placed, followed by stage two, 5 - 6 months later. The implants were considered osseo-integrated in the absence of symptoms, mobility and inflammation. Periapical radiographs were taken to rule out peri-implant radiolucency. Restorative treatment was completed 2 months thereafter. Patients were scheduled to have a dental exam (6 - 12 months after delivery of prosthesis) and the implants were evaluated clinically and radiographically. A retrospective review was conducted to assess the surgical success rate of this treatment modality. Clinic charts, radiographs and digital implant log were reviewed for all patients with PMABH of 7 - 10 mm who received dental implants in the posterior maxilla to determine the success rate of this treatment modality. Results: 26 patients who had 39 implants placed were included in the study. All implants (100%) were osseo-integrated at the time of uncovering (stage 2). None of the implants (0%) had mobility or inflammation around them. Stage 2 was successfully performed on all 39 implants (100%). All implants (100%) in these patients had been restored, and were in good condition without mobility or inflammation, and had been functioning well 6 - 12 months after restoration. Conclusion: This study suggests that a high success rate can be attained placing dental implants in the posterior maxilla while perforating and engaging the cortical maxillary sinus floor. A future prospective study that compares this technique with the internal sinus lift would likely help elucidate this su

关键词： Posterior Maxilla Implants Sinus Perforation

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Regulatory role of exosomes in colorectal cancer progression and potential as biomarkers

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Cancer Biology & Medicine 2023年第8期20卷 575-598页

作者： Juan Hui Mingzhen Zhou Guangzhou An Hui Zhang Yuanyuan Lu Xin Wang Xiaodi Zhao Department of Gastroenterology Tangdu HospitalAir Force Medical UniversityXi’an 710038China State Key Laboratory of Cancer Biology and National Clinical Research center for Digestive Diseases Xijing Hospital of Digestive DiseasesAir Force Medical UniversityXi’an 710032China Department of Radiation Protection Medicine Ministry of Education Key Laboratory of Hazard Assessment and Control in Special Operational EnvironmentFaculty of Preventive MedicineAir Force Medical UniversityXi’an 710032China Department of Traditional Chinese Medicine Tangdu HospitalAir Force Medical UniversityXi’an 710038China

Colorectal cancer(CRC)remains an enormous challenge to human health ***,the mechanism underlying CRC progression is not well *** evidence has confirmed that exosomes play a vital role in CRC progression,which has attracted extensive attention among *** addition to acting as messengers between CRC cells,exosomes also participate in the CRC immunomodulatory process and reshape immune *** stable message carriers and liquid biopsy option under development,exosomes are promising biomarkers in the diagnosis or treatment of *** this review we have described and analyzed the biogenesis and release of exosomes and current research on the role of exosomes in immune regulation and metastasis of ***,we have discussed candidate exosomal molecules as potential biomarkers to diagnose CRC,predict CRC progression,or determine CRC chemoresistance,and described the significance of exosomes in the immunotherapy of *** review provides insight to further understand the role of exosomes in CRC progression and identify valuable biomarkers that facilitate the clinical management of CRC patients.

关键词： Colorectal cancer exosome immunoregulation immunotherapy metastasis

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Impact of prehospital medical evacuation (MEDEVAC) transport time on combat mortality in patients with noncompressible torso injury and traumatic amputations: a retrospective study

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Military medical Research 2019年第1期6卷 23-30页

作者： Joseph K.Maddry Crystal A.Perez Alejandra G.Mora Jill D.Lear Shelia C.Savell Vikhyat S.Bebarta us air force En route Care Research center 59th MDW/ST Chief Scientist's Office –US Army Institute of Surgical research JBSA Ft.Sam Houston Department of Emergency Medicine San Antonio Military Medical CenterJBSA Ft. Sam Houston us air force En route Care Research center 59th MDW/ST Chief Scientist's Office –US Army Institute of Surgical researchJBSA Ft.Sam Houston Department of Emergency Medicine University of Colorado School of Medicine

Background: In combat operations, patients with traumatic injuries require expeditious evacuation to improve survival. Studies have shown that long transport times are associated with increased morbidity and mortality. Limited data exist on the influence of transport time on patient outcomes with specific injury types. The objective of this study was to determine the impact of the duration of time from the initial request for medical evacuation to arrival at a medical treatment facility on morbidity and mortality in casualties with traumatic extremity amputation and noncompressible torso injury(NCTI).Methods: We completed a retrospective review of MEDEVAC patient care records for United States military personnel who sustained traumatic amputations and NCTI during Operation Enduring Freedom between January 2011 and March 2014. We grouped patients as traumatic amputation and NCTI(AMP+NCTI), traumatic amputation only(AMP),and neither AMP nor NCTI(Non-AMP/NCTI). Analysis was performed using chi-squared tests, Fisher's exact tests,Cochran-Armitage Trend tests, Shapiro-Wilks tests, Wilcoxon and Kruskal-Wallis techniques and Cox proportional hazards regression ***: We reviewed 1267 records, of which 669 had an injury severity score(ISS) of 10 or greater and were included in the analysis. In the study population, 15.5% sustained only amputation injuries(n=104, AMP only), 10.8% sustained amputation and NCTI(n=72, AMP+NCTI), and 73.7% did not sustain either an amputation or an NCTI(n=493,Non-AMP/NCTI). AMP+NCTI had the highest mortality(16.7%) with transport time greater than 60 min. While the AMP+NCTI group had decreasing survival with longer transport times, AMP and Non-AMP/NCTI did not exhibit the same ***: A decreased transport time from the point of injury to a medical treatment facility was associated with decreased mortality in patients who suffered a combination of amputation injury and NCTI. No significant association between transport time

关键词： Transport time Non-compressible torso injury Traumatic amputation Combat

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Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas

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Cancer Biology & Medicine 2021年第1期18卷 283-297页

作者： Xianchun Gao Yanan Pan Weili Han Caie Hu Chenchen Wang Ling Chen Yong Guo Yupeng Shi Yan Pan Huahong Xie Liping Yao Jianjun Yang Jianyong Zheng Xiaohua Li Xiaonan Liu Liu Hong Jipeng Li Mengbin Li Gang Ji Zengshan Li Jielai Xia Qingchuan Zhao Daiming Fan Kaichun Wu Yongzhan Nie State Key Laboratory of Cancer Biology and National Clinical Research center for Digestive Diseases Xijing HospitalAir Force Medical University of PLAXi’an 710032China School of Life Science Northwest UniversityXi’an 710069China Department of Gastroenterology The First Affiliated Hospital of Xi’an Medical UniversityXi'an 710021China State Key Laboratory of Cancer Biology Department of PathologyXijing Hospital and School of Basic MedicineAir Force Medical University of PLAXi'an 710032China Department of medical Statistics School of Preventive MedicineAir Force Medical University of PLAXi'an 710032China

Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict ***,the prognostic value of the combined use of these two markers remains *** goal of this study was therefore to evaluate the association of these markers with outcomes based on a large cohort of patients with gastric ***:A total of 2,542 consecutive patients undergoing radical surgery for gastric or gastroesophageal junction adenocarcinoma between 2009 and 2014 were *** inflammation was quantified by the preoperative neutrophil-to-lymphocyte ratio(NLR).High systemic inflammation was defined as NLR≥3,and underweight was defined as BMI<18.5 kg/***:Among 2,542 patients,NLR≥3 and underweight were common[627(25%)and 349(14%),respectively].In the entire cohort,NLR≥3 or underweight independently predicted overall survival(OS)[hazard ratio(HR):1.236,95%confidence interval(95%CI):1.069–1.430;and HR:1.600,95%CI:1.350–1.897,respectively]and recurrence-free survival(RFS)(HR:1.230,95%CI:1.054–1.434;and HR:1.658,95%CI:1.389–1.979,respectively).Patients with both NLR≥3 and underweight(***)had much worse OS(HR:2.445,95%CI:1.853–3.225)and RFS(HR:2.405,95%CI:1.802–3.209).Furthermore,we observed similar results in subgroup analyses according to pathological stage,age,and postoperative ***:Our results showed that preoperative elevated NLR and decreased BMI had a significant negative effect on *** combined with severe inflammation could enhance *** active therapeutic measures to reduce inflammation and increase nutrition may help improve outcomes.

关键词： Gastric cancer neutrophil-to-lymphocyte ratio body mass index prognosis systemic inflammation index

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Assessment on the Effects of Hepatitis B Prevention and Control Measures in Western China:A Comparison of Three Population-based Serosurveys

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Biomedical and Environmental Sciences 2020年第10期33卷 735-744页

作者： CHEN Hui LIU Nan JI Zhao Hua PU Zhong Shu GUO Zhi Wen GAO Jie SHAO Zhong Jun LIU Yi Wen YAN Yong Ping Department of Epidemiology School of Public HealthAir Force Medical UniversityXi'an 710032ShaanxiChina Wuwei municipal center for Disease Control and Prevention Wuwei 733000GansuChina

Objective Despite the remarkable progress in efforts to control disease spread,the nationwide elimination of hepatitis B in China is still hindered by the persistently high rate of hepatitis B virus(HBV)infection in Western *** study aimed to evaluate the strategy of hepatitis B prevention and control in Western China and identify potential areas and strategies for *** Susceptible population vaccination,health education,professional training of doctors,and other prevention and control measures have been implemented in Wuwei city since *** were obtained from three representative cross-sectional serosurveys conducted in 2010,2013,and *** serum samples were subjected to enzyme-linked immunosorbent assays to detect the following seromarkers:HBV surface antigen(HBsAg),antibody against hepatitis B surface antigen(anti-HBs),and antibody against hepatitis B core antigen(anti-HBc).Estimates of variance were determined using Taylor series linearization *** The three serosurveys revealed decreases in the prevalence of HBsAg(7.19% in 2010 vs.6.51% in 2013 vs.5.87% in 2015)and anti-HBc positivity(43.89%vs.32.87%vs.28.46%)and an increase in the prevalence of anti-HBs positivity(49.07%vs.53.66%vs.53.72%)over *** 2010 to 2015,the legally reported incidence of hepatitis B in Wuwei city decreased from 686.53/100,000 to 53.72/100,***,persistently high HBsAg-positive rates(above 5.40%)were observed among subjects aged 20–69 years old in the three serosurveys;the prevalence of HBsAg was above 1% among children younger than 10 years ***,rural subjects had higher rates of HBsAg and anti-HBc positivity than their urban counterparts(6.04%vs.4.83% and 30.26%vs.20.35%,respectively)in 2015 but had a lower rate of anti-HBs positivity(49.68 vs.55.18%).Multivariate regression analysis showed that age,urban and rural areas,and education level were the main factors affecting HBV *** Although vaccine-based preve

关键词： Hepatitis B Prevention a n d control measures Serosurvey Western China

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Orthogonally woven 3D nanofiber scaffolds promote rapid soft tissue regeneration by enhancing bidirectional cell migration

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Bioactive Materials 2024年第9期39卷 582-594页

作者： Jiayi Yuan Bingbing Sun Weixing Ma Chao Cai Zhenzhen Huang Peiyi Zhou Lei Yi Lubin Liu Shixuan Chen School of Pharmacy Jiangsu Ocean UniversityLianyungang222005China Zhejiang Engineering Research center for Tissue Repair Materials Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang325001China Department of Critical Care Medicine The Air Force Characteristic Medical CenterAir Force Medical UniversityBeijing100000China Chongqing Health center for Women and Children Chongqing Obstetric and Gynecologic HospitalChongqingChina Department of Burn Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China

Repairing large-area soft tissue defects caused by traumas is a major surgical *** multifunctional scaffolds with suitable scalability and favorable cellular response is crucial for soft tissue *** this study,we developed an orthogonally woven three-dimensional(3D)nanofiber scaffold combining electrospinning,weaving,and modified gas-foaming *** developed orthogonally woven 3D nanofiber scaffold had a modular design and controlled fiber *** vitro,the orthogonally woven 3D nanofiber scaffold exhibited adjustable mechanical properties,good cell compatibility,and easy drug *** vivo,for one thing,the implantation of an orthogonally woven 3D nanofiber scaffold in a full abdominal wall defect model demonstrated that extensive granulation tissue formation with enough mechanical strength could promote recovery of abdominal wall defects while reducing intestinal *** result of diabetic wound repair experiments suggested that orthogonally woven 3D nanofiber scaffolds had a higher wound healing ratio,granulation tissue formation,collagen deposition,and *** together,this novel orthogonally woven 3D nanofiber scaffold may provide a promising and effective approach for optimal soft tissue regeneration.

关键词： Tissue regeneration Electrospinning 3D nanofiber scaffold Orthogonal weaving Cell migration

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Decoding the annulus fibrosus cell atlas by scRNA-seq to develop an inducible composite hydrogel:A novel strategy for disc reconstruction

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Bioactive Materials 2022年第8期7卷 350-363页

作者： Han Wang Di Wang Beier Luo Dong Wang Haoruo Jia Pandi Peng Qiliang Shang Jianxin Mao Chu Gao Ye Peng Lu Gan Junjie Du Zhuojing Luo Liu Yang Department of Orthopedics Xijing HospitalFourth Military Medical UniversityXi’an710032China Department of Orthopedics Air Force Medical Center100142BeijingChina Department of Spinal Surgery Changhai HospitalNaval Medical UniversityShanghai200433China medical Research Institute Northwestern Polytechnical UniversityXi’an710072China

Low back pain is one of the most serious public health problems worldwide and the major clinical manifestation of intervertebral disc degeneration(IVDD).The key pathological change during IVDD is dysfunction of the annulus fibrosus(AF).However,due to the lack of an in-depth understanding of AF biology,the methods to reconstruct the AF are very *** this study,the mice AF cell atlas were decoded by single-cell RNA sequencing to provide a guide for AF *** results first identify a new population of AF cells,fibrochondrocyte-like AF cells,which synthesize both collagen Ⅰ and collagen Ⅱ and are potential functional cells for AF *** to the dual features of the AF extracellular matrix,a composite hydrogel based on the acylation of methacrylated silk fibroin with methacrylated hyaluronic acid was *** obtain the ability to stimulate differentiation,the composite hydrogels were combined with a fibrochondrocyte-inducing ***,reconstruction of the AF defects,by the novel AF stem cell-loaded composite hydrogel,could be observed,its amount of chondroid matrices recovered to 31.7% of AF aera which is significantly higher than that in other control *** summary,this study decodes the AF cell atlas,based on which a novel strategy for AF reconstruction is proposed.

关键词： Single cell RNA-Seq Annulus fibrosus-derived stem cells Lineage tracing Composite hydrogel Annulus fibrosus reconstruction

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Visualization of real-time displacement time history superimposed with dynamic experiments using wireless smart sensors and augmented reality

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Earthquake Engineering and Engineering Vibration 2023年第3期22卷 573-588页

作者： Marlon Aguero Derek Doyle david Mascarenas Fernando Moreu Department of Civil Construction and Environmental EngineeringUniversity of New MexicoCentennial Engineering Center 3056MSC011070210 University Blvd NEAlbuquerqueNM 87131USA air force Research Laboratory Space Vehicles DirectorateKirtland Air Force BaseAlbuquerqueNM 87117USA Engineering Institute Los Alamos National LaboratoryLos AlamosNM 8754USA

Wireless smart sensors(WSS)process field data and inform inspectors about the infrastructure health and *** bridge engineering,inspectors need reliable data about changes in displacements under loads to make correct decisions about repairs and *** to displacement information in the field and in real-time remains a challenge as inspectors do not see the data in real *** data from WSS in the field undergoes additional processing and is seen at a different *** inspectors were able to see structural displacements in real-time at the locations of interest,they could conduct additional observations,creating a new,information-based,decision-making reality in the *** paper develops a new,human-centered interface that provides inspectors with real-time access to actionable structural data during inspection and monitoring enhanced by augmented reality(AR).It summarizes and evaluates the development and validation of the new human-infrastructure interface in laboratory *** experiments demonstrate that the interface that processes all calculations in the AR device accurately estimates dynamic displacements in comparison with the *** this new AR interface tool,inspectors can observe and compare displacement data,share it across space and time,visualize displacements in time history,and understand structural deflection more accurately through a displacement time history visualization.

关键词： wireless smart sensor monitoring augmented reality displacement acceleration human-infrastructure interface

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Vascular reconstruction of segmental intestinal grafts using autologous internal iliac vessels

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Gastroenterology Report 2021年第4期9卷 350-356,I0002页

作者： Guosheng Wu Yinglun Wu Mian Wang Wentong Zhang Chaoxu Liu Tingbo Liang Intestinal Transplant center The First Affiliated HospitalZhejiang University School of MedicineHangzhouP.R.China Section of Plastic Surgery Dartmouth-Hitchcock Medical CenterLebanonNHUSA State Key Laboratory of Cancer Biology&National Clinical Research center for Digestive Diseases Xijing HospitalAir Force Military Medical UniversityXi’anChina

Background The aim of this study was to assess whether the autologous internal iliac artery and vein could be used as an interpositional graft for vascular reconstruction in segmental intestinal allografts and *** Thirty-four intestinal transplants(19 living-related allografts and 15 autografts)were conducted in our programs between January 2011 and January *** characteristics,type of vascular reconstruction,and post-operative complications were *** There were 20 males and 14 females with a median age of 35 *** 34 grafts,22(64.7%)(11 allografts and 11 autografts)were revascularized using the autologous internal iliac artery and vein for *** reconstruction on the back table took 2166min to *** total operative time and cold ischemia time tended to be longer in the vascular-reconstruction group than in the direct-anastomosis group(5306226 vs 4406116 and 159649 vs 125666 min,respectively),but these differences were not *** incidence of vascular thrombosis tended to be higher in the direct-anastomosis group than in the vascular-reconstruction group(16.7%vs 0%,P=0.118).At a median follow-up of 36.9 months,no stenosis or pseudoaneurysms *** 19 allografts,acute rejection occurred in 4(21.1%)and chronic rejection occurred in 1(5.2%).Conclusions Our results indicate that the use of an autologous internal iliac interposition graft greatly facilitates intestinal graft implantation and minimizes the risk of vascular complications.

关键词： internal iliac vessel graft intestinal autotransplantation living-related intestinal transplantation

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