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Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer

World Journal of Gastrointestinal Oncology 2024年第2期16卷 414-435页

作者： You-Wang Lu Zhao-Li Ding Rui Mao Gui-Gang Zhao Yu-Qi He Xiao-Lu Li Jiang Liu Department of Dermatology and Venereology The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Kunming Biological Diversity Regional Center of Large Apparatus and Equipments Public Technical Service CenterKunming Institute of ZoologyKunming 650223Yunnan ProvinceChina School of Stomatology Kunming Medical UniversityKunming 650500Yunnan ProvinceChina Genome Center of Biodiversity Kunming Institute of ZoologyChinese Academy of ScienceKunming 650223Yunnan ProvinceChina Department of Reproduction and Genetics The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina

BACKGROUND Aberrant methylation is common during the initiation and progression of colorectal cancer(CRC),and detecting these changes that occur during early adenoma(ADE)formation and CRC progression has clinical *** To identify potential DNA methylation markers specific to ADE and *** Here,we performed SeqCap targeted bisulfite sequencing and RNA-seq analysis of colorectal ADE and CRC samples to profile the epigenomic-transcriptomic *** Comparing 22 CRC and 25 ADE samples,global methylation was higher in the former,but both showed similar methylation patterns regarding differentially methylated gene positions,chromatin signatures,and repeated ***-grade CRC tended to exhibit elevated methylation levels in gene promoter regions compared to those in low-grade *** with RNA-seq gene expression data,we identified 14 methylation-regulated differentially expressed genes,of which only AGTR1 and NECAB1 methylation had prognostic *** Our results suggest that genome-wide alterations in DNA methylation occur during the early stages of CRC and demonstrate the methylation signatures associated with colorectal ADEs and CRC,suggesting prognostic biomarkers for CRC.

关键词： Colorectal cancer Epigenomic alteration Transcriptome Methylation-regulated differentially expressed genes

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Microbiome and metabolome dysbiosis analysis in impaired glucose tolerance for the prediction of progression to diabetes mellitus

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Journal of Genetics and Genomics 2024年第1期51卷 75-86页

作者： Boxun Zhang Xuan Zhang Zhen Luo Jixiang Ren Xiaotong Yu Haiyan Zhao Yitian Wang Wenhui Zhang Weiwei Tian Xiuxiu Wei Qiyou Ding Haoyu Yang Zishan Jin Xiaolin Tong Jun Wang Linhua Zhao Institute of Metabolic Diseases Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Faculty of Biological Science and Technology Baotou Teacher's CollegeBaotouInner Mongolia 014030China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Infinitus(China)Company Ltd GuangzhouGuangdong 510405China Affiliated hospital of Changchun University of Chinese Medicine ChangchunJilin 130021China Department of Endocrinology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Xinjiekou Community Health service Center in Xicheng District Beijing 100035China Department of Spleen and Stomach Shenzhen Traditional Chinese Medicine HospitalShenzhenGuangdong 518033China University of Chinese Academy of Sciences Beijing 100049China Beijing University of Chinese Medicine Beijing 100105China Northeast Asia Institute of Traditional Chinese Medicine Changchun University of Chinese MedicineChangchunJilin 130117China

Gut microbiota and circulating metabolite dysbiosis predate important pathological changes in glucose metabolic disorders;however,comprehensive studies on impaired glucose tolerance(IGT),a diabetes mellitus(DM)precursor,are ***,we perform metagenomic sequencing and metabolomics on 47 pairs of individuals with IGT and newly diagnosed DM and 46 controls with normal glucose tolerance(NGT);patients with IGT are followed up after 4 years for progression to *** of baseline data reveals significant differences in gut microbiota and serum metabolites among the IGT,DM,and NGT *** addition,13 types of gut microbiota and 17 types of circulating metabolites showed significant differences at baseline before IGT progressed to DM,including higher levels of Eggerthella unclassified,Coprobacillus unclassified,Clostridium ramosum,L-valine,L-norleucine,and L-isoleucine,and lower levels of Eubacterium eligens,Bacteroides faecis,Lachnospiraceae bacterium 3_1_46FAA,Alistipes senegalensis,Megaspaera elsdenii,Clostridium perfringens,α-linolenic acid,10E,12Z-octadecadienoic acid,and dodecanoic acid.A random forest model based on differential intestinal microbiota and circulating metabolites can predict the progression from IGT to DM(AUC=0.87).These results suggest that microbiome and metabolome dysbiosis occur in individuals with IGT and have important predictive values and potential for intervention in preventing IGT from progressing to DM.

关键词： Impaired glucose tolerance Diabetes mellitus Gut microbiota Metabolomics

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Reflections on COPD comorbidities

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Chinese Medical Journal 2024年第12期137卷 1504-1506页

作者： Zhenming He Yue Wang Lin Shan Yan Mou Yunhuan Liu Guanhua Ma Yanxu Wu Huili Zhu Jeffrey L.Curtis Shilei Cui Haiyan Ge Department of Pulmonary and Critical Care Medicine Huadong HospitalFudan UniversityShanghai 200040China Medical service VA Ann Arbor Healthcare SystemAnn ArborMI 48105USA Pulmonary&Critical Care Medicine Division Department of Internal MedicineUniversity of MichiganAnn ArborMI 48109USA Graduate Program in Immunology University of MichiganAnn ArborMI 48109USA

To the Editor:Chronic obstructive pulmonary disease(COPD)is a common disease among the elderly,affecting over one-third of the elderly population *** progressive decline in lung function characteristic of COPD significantly impacts the quality of life and employability of affected individuals,resulting in a substantial direct and indirect socioeconomic *** frequently has comorbidities involving other organ *** all elderly COPD patients present with one or more comorbid conditions,collectively exacerbating health and economic *** viral and bacterial infections remain the most common triggers for COPD exacerbations(ECOPD).

关键词： morbid lung collective

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Obstetric References in Disadvantaged Environments: Case of References to the University hospital Center of Kara, in Northern Togo

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Open Journal of Obstetrics and Gynecology 2024年第2期14卷 267-277页

作者： Kossi Edem Logbo-Akey Bassowa Akila Kofi Mawoulé Améwouho Ketevi Tina Yendoubé Pierre Kambote Dédé Régine Diane Ajavon Baguilane Djoauguibe Abdoul-Samadou Aboubakari Koffi Akpadza service de Gynécologie-Obstétrique CHU Kara Togo service de Gynécologie-Obstétrique CHU Campus Lomé Togo service de Gynécologie-Obstétrique CHU Sylvanus Olympio Lomé Togo service de Gynécologie-Obstétrique CHR Tomdé Kara Togo

Introduction: References are frequent and most often carried out in emergency situations. The objective of this study was to describe the epidemiological and clinical profile of obstetric referrals to the CHU-Kara. Methodology: This was a retrospective cross-sectional descriptive study conducted from September 1, 2022, to February 28, 2023, at CHU-Kara, focusing on obstetric referrals to the Gynecology-Obstetrics department. Result: 828 patients were referred for obstetric reasons out of 1295 admissions, representing a frequency of 63.9%. The average age was 25.04 years. They were primigravida (38.3%), unemployed (62.7%). Motorcycles were the main means of transportation, accounting for 53.1% of cases. The average distance to reach the referral center was 31.6 km, covered in an average of 71 minutes. In 40.7% of cases, patients had less than 4 prenatal consultations and were referred in peripartum (56.6%) for pre-eclampsia (14%), post-term pregnancy (11.8%), dystocia (10.5%). Eighty-six point nine percent (86.9%) of the referred patients were able to deliver during their stay in the department, of which 61.7% had vaginal deliveries. The maternal and perinatal mortality rates were 0.7% and 14.9%, respectively. Conclusion: Obstetric referrals to Kara University hospital are frequent during the perpartum period and are often carried out by motorbike.

关键词： Obstetric Referral Epidemiology Prognosis CHU-Kara

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PICOTEES:a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants from Chinese children cohorts

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Journal of Genetics and Genomics 2024年第2期51卷 243-251页

作者： Xinran Dong Yulan Lu Lanting Guo Chuan Li Qi Ni Bingbing Wu Huijun Wang Lin Yang Songyang Wu Qi Sun Hao Zheng Wenhao Zhou Shuang Wang Center for Molecular Medicine Children's Hospital of Fudan UniversityShanghai 201102China Key Laboratory of Birth Defects Children's Hospital of Fudan UniversityShanghai 201102China Department of Bioinformatics Hangzhou Nuowei Information Technology Co.LtdHangzhouZhejiang 310000China The Third Research Institute of the Ministry of Public Security Shanghai 200031China Xiamen Campus of Children's hospital of Fudan University XiamenFujian 361006China Institutes for Systems Genetics West China HospitalChengduSichuan 610041China Shanghai Putuo People's hospital Tongji UniversityShanghai 200060China

The growth in biomedical data resources has raised potential privacy concerns and risks of genetic information leakage. For instance, exome sequencing aids clinical decisions by comparing data through web services, but it requires significant trust between users and providers. To alleviate privacy concerns, the most commonly used strategy is to anonymize sensitive data. Unfortunately, studies have shown that anonymization is insufficient to protect against reidentification attacks. Recently, privacy-preserving technologies have been applied to preserve application utility while protecting the privacy of biomedical data. We present the PICOTEES framework, a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants (https://***:3000/). PICOTEES enables privacy-preserving queries of the phenotype spectrum for a single variant by utilizing trusted execution environment technology, which can protect the privacy of the user's query information, backend models, and data, as well as the final results. We demonstrate the utility and performance of PICOTEES by exploring a bioinformatics dataset. The dataset is from a cohort containing 20,909 genetic testing patients with 3,152,508 variants from the Children's hospital of Fudan University in China, dominated by the Chinese Han population (>99.9%). Our query results yield a large number of unreported diagnostic variants and previously reported pathogenicity.

关键词： Privacy protecti on Rare diseases in children Genetic testing Web system Trusted executi on envir onment

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Survey on the Demand for Elderly Care services of Community Residents in Beijing and Analysis of Influencing Factors

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Journal of Clinical and Nursing Research 2024年第4期8卷 79-87页

作者： Yue Zhai Xianguo Bi Weimin Liu Hong Wang Xinxin Zhang Jing Chen Beijing Century Forum hospital Capital Medical UniversityBeijing 100038China Beijing Municipal Health Commission Beijing 100053 China Beijing Longfu hospital Beijing 100010China Yang Song Township Community Health service Centre Huairou DistrictBeijing 101499China

Objective: To investigate the current situation of the demand for geriatric care services of community residents in Beijing and analyze the influencing factors to provide a reference basis for meeting the demand for diversified and professional geriatric care services. Methods: A self-made questionnaire was used to randomly survey 1558 elderly individuals at community health service centers in 8 urban districts where elderly care centers were planned to be built. The influencing factors of the different characteristics of elderly care service needs from three aspects were analyzed using a dichotomous logistic regression model: predisposing, enabling, and, need factors. Results: 69.7% of the elderly required home care services, 22.8% wanted to get care services at elderly care centers, 15.9% wanted to get care services at nursing homes, 12.3% required community care services, and 7.4% didn’t know where to access care services. 68.5% of the elderly required care services for disabilities/semi-disabilities, 58.0% for dementia, 54.7% for common diseases, 34.9% for rehabilitation training, 33.0% for plumbing care, and 7.5% for hospice care. At the same time, there were urban- rural differences in the demand for elderly care services, with suburban elderly having a higher demand for care services than those living in urban areas (P services was mainly related to age, place of residence, and gender in the causative factors, mode of residence and physical condition among able factors, and mode of care services and care needs among need factors (P services was differentiated by factors including place of residence, age, and gender. It is crucial to accurately match the demand for elderly care services, innovate the mode of elderly care services, and improve the service quality to improve the elderly health service system.

关键词： Elderly care service system Demand Population ageing Influencing factors

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针灸对子宫内膜异位症大鼠异位内膜组织UHRF1和DNMT1的影响

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Journal of Acupuncture and Tuina Science 2024年第3期22卷 204-213页

作者：李铭旸王延文邵燕婷孙祎纯胡佳玮高源李语然吴楚婷张春雁 Yueyang hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Minhang District Meilong Community Health service Center Shanghai 201108China Longhua hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China

目的:观察针灸对子宫内膜异位症(EMS)泛素样PHD和含环指结构域蛋白1(UHRF1)和DNA甲基转移酶1(DNMT1)的影响。方法:将40只Sprague-Dawley大鼠按体质量随机分为假手术组10只和造模组30只。造模组大鼠复制EMS模型后随机分为模型组、针灸组... 详细信息

目的:观察针灸对子宫内膜异位症(EMS)泛素样PHD和含环指结构域蛋白1(UHRF1)和DNA甲基转移酶1(DNMT1)的影响。方法:将40只Sprague-Dawley大鼠按体质量随机分为假手术组10只和造模组30只。造模组大鼠复制EMS模型后随机分为模型组、针灸组和孕酮组,每组10只。固定器固定各组大鼠。假手术组和模型组予以生理盐水灌胃;针灸组予以针刺血海和三阴交,艾灸关元和生理盐水灌胃;孕酮组给予地屈孕酮生理盐水混悬液灌胃。治疗28 d后,测量大鼠异位囊肿三径(长、宽及厚度)并计算体积,减掉干预前异位囊肿体积,取差值评估异位囊肿生长情况;实时荧光定量聚合酶链反应和免疫组织化学法检测正常子宫内膜、在位及异位内膜组织UHRF1、DNMT1 mRNA和蛋白水平。结果:针灸组和孕酮组异位囊肿体积差值无统计学差异(P>0.05),但均小于模型组异位囊肿体积差值(P0.05)。结论:针灸可能通过上调异位内膜组织中UHRF1 mRNA和UHRF1、DNMT1蛋白水平,使其趋于正常子宫内膜水平,从而达到缩小异位囊肿体积,治疗大鼠子宫内膜异位症的效应。

关键词：针刺疗法灸法针灸疗法子宫内膜异位症泛素样PHD和含环指结构域蛋白1 DNA甲基转移酶1 大鼠

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Clinical and Therapeutic Aspects of Inguinal Hernia in Children in the General Surgery Department of Reference Health Center in Commune I of Bamako Mali

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Surgical Science 2024年第2期15卷 54-63页

作者： Tounkara Cheickna Samake Hamidou Simpara Mama Diarra Issaka Sanogo Modibo Sidibe Souleymane Togola Modibo Dembele Bakary Tientigui Coulibaly Yacaria Togo Pierre Adégné Kante Lassana Department of General Surgery the Reference Health Center of Commune I Bamako Mali Directorate of Social Health service the Armed Forces of Mali Bamako Mali Department of Pediatric Surgery Mali Hospital Bamako Mali Department of General Surgery the Gabriel TOURE University Hospital Bamako Mali Department of Pediatric Surgery Gabriel TOURE University Hospital Bamako Mali

Inguinal hernia in children is a congenital pathology in children linked to the persistence of the peritoneo-vaginal canal in children and the NüCK canal in girls;persisting into adulthood. This work aimed to study inguinal hernia in children in the general surgery department of the Reference Health Center of Commune I of the Bamako District;to determine the frequency of inguinal hernia;describe the epidemiological, clinical and therapeutic aspects of inguinal hernias and in order to evaluate the cost of treatment. This was a prospective study from April 2017 to March 2018 during which 60 children with an inguinal hernia were collected. Inguinal hernias in children represented 9.23% of patients operated on in the department. The average age was 59.23 months with extremes of one month and 180 months and a standard deviation of 49.23 years. The male sex was dominant with a sex ratio equal to 9:1. The notion of prematurity was found in 11.7% and was associated with a testicle not in place in 1.7% of cases. 41.7% of our patients were referred by a doctor and 66.7% of patients presented with painless, intermittent inguino-scrotal swelling (83.3% of cases). The hernia was discovered before one week of life in 50% of cases. Inguinal swelling was absent in 11.7% but observed intraoperatively. The inguinal hernia was unilateral in 91.7% of cases and 70% of hernias were discovered by the parents during pushing efforts. The inguinal hernia was located on the right in 61.7% of cases. The hernia swelling was soft, painless, impulsive and reducible in 78.3% of cases. The swelling was inguino-scrotal in 58.3% of cases. The hernia was simple in 95% of patients and hernial strangulation was observed in 3 cases or 5% of cases. 98.3% of patients were ASA I. The treatment was carried out openly in all our patients including closure of the vaginal peritoneal canal in 95% of cases under general anesthesia in 98.3% of cases. The morbidity rate was 8.4% (surgical site infection: 6.7% of ca

关键词： Inguinal Hernia Child Surgery Cs Ref C I Bamako Mali

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Total body water percentage and 3rd space water are novel risk factors for training-related lower extremity muscle injuries in young males

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Chinese Journal of Traumatology 2024年第3期27卷 168-172页

作者： Liang Chen Ke-Xing Jin Jing Yang Jun-Jjie Ouyang Han-Gang Chen Si-Ru Zhou Xiao-Qing Luo Mi Liu Liang Kuang Yang-Li Xie Yan Hu Lin Chen Zhen-Hong Ni Xiao-Lan Du Department of Orthopedic Daping HospitalArmy Medical UniversityChongqing400042China Department of Rehabilitation Medicine Daping HospitalArmy Medical UniversityChongqing400042China Department of Wound Repair and Rehabilitation Medicine Center of Bone Metabolism and RepairLaboratory for Prevention and Rehabilitation of Training InjuriesState Key Laboratory of Trauma and Chemical Poisoning.Trauma CenterResearch Instiute of SurgeryDaping HospitalArmy Medical UniversityChongqing.400042China War Trauma Medical Center Daping HospitalArmy Medical UniversityChongqing400042.China Department of Military Basic Training and Army Management Army Health Service Training BaseArmy Medical UniversityChongqing400042China Department of Army Occupational Disease Laboratory for Prevention and Rehabilitation of Training InjuriesState Key Laboratory of Trauma and Chemical PoisoningResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing400042.China

Purpose:To identify the risk factors for training-related lower extremity muscle injuries in young males by a non-invasive method of body composition ***:A total of 282 healthy young male volunteers aged 18-20 years participated in this cohort *** location,degree,and injury rate were adjusted by a questionnaire based on the overuse injury assessment methods used in epidemiological studies of sports *** occurrence of training injuries is monitored and diagnosed by physicians and treated *** body composition was measured using the BodyStat QuadScan 4000 multifrequency Bio-impedance system at 5,50,100 and 200 kHz to obtain 4 impedance *** Shapiro-Wilk test was used to check whether the data conformed to a normal *** of normal distribution were shown as mean±SD and analyzed by t-test,while those of non-normal distribution were shown as median(Q1,Q3)and analyzed by Wilcoxon rank sum *** receiver operator characteristic curve and logistic regression analysis were performed to investigate risk factors for developing training-related lower extremity injuries and ***:Among the 282 subjects,78(27.7%)developed training *** extremity training injuries revealed the highest incidence,accounting for 23.4%(66 cases).These patients showed higher percentages of lean body mass(p=0.001),total body water(TBW,p=0.006),extracellular water(p=0.020)and intracellular water(p=0.010)as well as a larger ratio of basal metabolic rate/total weight(p=0.006),compared with those without lower extremity muscle *** the contrary,the percentage of body fat(p=0.001)and body fat mass index(p=0.002)were *** regression analysis showed that TBW percentage>65.35%(p=0.050,odds ratio=3.114)and 3rd space water>0.95%(p=0.045,odds ratio=2.342)were independent risk factors for lower extremity muscle ***:TBW percentage and 3rd space water measured with bio-impedance method are potential ris

关键词： Body composition Training injuries Lower extremity Bio-impedance

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Sequential or simultaneous transarterial chemoembolization and radiofrequency ablation for hepatocellular carcinoma within the Milan criteria:A retrospective real-world study

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Portal Hypertension & Cirrhosis 2024年第2期3卷 105-115页

作者： Jianwei Liu Minmin Sun Zhiliang Hu Jie Wang Caixia Lu Ya Gao Cuijuan He Yeye Wu Jian Zhai Yong Xia Xiaorong Pan Kui Wang Department of Hepatic Surgery II Third Affiliated Hospital of Naval Medical University(Eastern Hepatobiliary Surgery Hospital)ShanghaiChina Department of Hepatic Surgery I Third Affiliated Hospital of Naval Medical University(Eastern Hepatobiliary Surgery Hospital)ShanghaiChina Department of Clinical Research Institute Third Affiliated Hospital of Naval Medical University(Eastern Hepatobiliary Surgery Hospital)ShanghaiChina Department II of Interventional Radiology Third Affiliated Hospital of Naval Medical University(Eastern Hepatobiliary Surgery Hospital)ShanghaiChina Department of Hepatic Surgery IV Third Affiliated Hospital of Naval Medical University(Eastern Hepatobiliary Surgery Hospital)ShanghaiChina Shanghai Baoshan District Songnan Town Community Health service Center ShanghaiChina

Aims:Few studies have investigated differences in sequential transarterial chemoembolization(TACE),radiofrequency ablation(RFA),and simultaneous RFA-TACE for the treatment of hepatocellular carcinoma(HCC)using the Milan *** study explored the differences in safety and prognosis between sequential TACE-RFA and simultaneous ***:This retrospective real-world study included 109 patients with HCC within the Milan criteria who underwent sequential TACE-RFA(n=75)or simultaneous RFA-TACE(n=34)at the Eastern Hepatobiliary Surgery hospital between January 2017 and *** complications,length of hospital stay,and long-term prognosis were *** median follow-up duration of these patients was 39.1 *** survival(OS)and time to tumor recurrence(TTR)curves were plotted using the Kaplan−Meier method and were compared using the logarithmic rank *** risk factors for OS and tumor recurrence(TR)were analyzed using the Cox risk regression ***:Multivariate analysis showed that tumor diameter>3 cm(hazard ratio[HR]:2.201,95%confidence interval[CI]:1.106-4.378,p=0.025;HR:2.236,95%CI:1.271-3.934,p=0.005,respectively)and alphafetoprotein(AFP)>400μg/L(HR:2.362,95%CI:1.195-4.668,p=0.013;HR:1.798,95%CI:1.048-3.086,p=0.033,respectively)were independent risk factors for OS and TTR,whereas the presence of multiple tumors(HR:2.352,95%CI:1.127-4.907,p=0.023)was an independent risk factor for *** RFA-TACE did not have an effect on OS or *** propensity score-matched,comparable results were obtained and RFATACE still had no effect on OS or *** significant differences were observed in grade III/IV complications(2/75[2.7%]vs.1/34[2.9%],p=1.000)between the two ***,the RFA-TACE group had fewer complications than the TACE-RFA group(24/34[70.6%]vs.66/75[88.0%],p=0.026).The RFA-TACE group had a shorter hospital stay and less total cost during hospitalization compared with the TACE-RFA group(6.0 vs.10.0 da

关键词： complications hepatocellular carcinoma prognosis radiofrequency ablation transarterial chemoembolization

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