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Snowmelt Flood Mapping and Land Surface Short-Term Dynamics Assessment in a “Before-During-After” Scenario Based on Radar and Optical Satellite Imagery: Case Study Around the Lewisville Lake (dallas/Fort Worth Metropolitan, Texas, USA)

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Advances in Remote Sensing 2023年第1期12卷 1-28页

作者： Alfred Homère Ngandam Mfondoum Roseline Batcha Stats’NMaps Private Consulting Firm Dallas USA Department of Geography University of Yaoundé I Yaoundé Cameroon

The main goal of this study has been to map flood and assess land surface short-term dynamics in relation with snowy weather. The two recent snowfall events, which happened in, February 14th and 15th, of year 2021, and February 3rd and 4th, of year 2022, were chosen. A pre-analysis correlation was assumed between, the snow events, recurrency of floods, and changes in the land surface characteristics (i.e., wetness, energy, temperature), in a “Before-During-After” scenario. Active and passive microwave satellites data such as, Sentinel-1 synthetic aperture radar (SAR), Sentinel-2 multispectral instrument (MSI) and Landsat-9 Operation Land Imager-2/Thermal Infrared Sensors-2 (OLI-2/TIRS-2), as well as cloud databased global models for water and urban layers were used. The first step of processing was thresholding of SAR image, at 0.25 cutoff, based on bimodal histogram distribution, followed by the change analysis. The following processing consisted in the images transformation, by computing the tasseled cap transformation wetness (TCTw) and the surface albedo on MSI image. In addition, the land surface temperature (LST) was modeled from OLI-2/TIRS-2 image. Then, a 5th order polynomial regression was computed, between TCTw as dependent variable and, albedo and LST as independent variables. As a first result, an area of 5.6 km2 has been mapped as recurrently flooded from the two years assessment. The other output highlighted a constant increase of wetness (TCTw), considered most influential on land surface dynamics, comparatively to energy exchange (albedo) and temperature (LST). The “After” event dependency between the three indicators was highest, with a correlation coefficient, R2 = 0.682, confirming the persistence of wetness after-snowmelt. Validation over topographic layers confirmed that, recurrently flooded areas are mostly distributed on, lowest valley depth points, farthest distances

关键词： Snowmelt Flood Short-Term Dynamics Radar Optical Lewisville Lake

The dallas Donation after Circulatory Death Transplantation Summit:expanding donation after circulatory death procedures through process improvement,broader utilization,and innovation

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 824-836,I0009页

作者： Michele Finotti Anji Wall Anthony D’Alessandro Gary Schwartz Chris Sonnenday David Goldberg Ashish Shah Peter Friend Jeff P.Orlowski Greg McKenna Steve Newton Brad Adams William C.Chapman Amit Mathur Marwan Abouljoud Tim Pruett Amelia Hessheimer James F.Trotter Sumeet K.Asrani Giuliano Testa Simmons Transplant Institute Baylor University Medical CenterDallasTXUSA Hepatobiliary and General Surgery Unit Regional Hospital TrevisoDISCOGUniversity of PaduaPaduaItaly Division of Transplantation Department of SurgeryUniversity of Wisconsin School of Medicine and Public HealthMadisonWIUSA Department of Thoracic Surgery and Lung Transplantation Baylor University Medical CenterCenter for Advanced Heart and Lung DiseaseDallasTXUSA Department of Surgery University of MichiganAnn ArborMIUSA Division of Digestive Health and Liver Diseases Department of MedicineUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Cardio-Thoracic Surgery Vanderbilt University Medical CenterNashvilleTNUSA Nuffield Department of Surgical Sciences University of OxfordOxfordUK LifeShare Transplant Donor Services of Oklahoma Oklahoma CityOKUSA Administration Baylor University Medical CenterDallasTXUSA Southwest Transplant Alliance DallasTXUSA Department of Surgery/Transplantation Washington UniversitySt.LouisMOUSA Division of Transplant Surgery Department of SurgeryMayo Clinic ArizonaAlix School of MedicinePhoenixAZUSA Divisions of Transplant and Hepatobiliary Surgery Henry Ford HospitalDetroitMIUSA Department of Surgery University of MinnesotaMinneapolisMNUSA General and Digestive Surgery Hospital Universitario La PazIdiPAZMadridSpain

Despite a significant increase in utilization over the past decade,the number of donation after circulatory death(DCD)organs that are procured and transplanted in the United States(US)remains well below its *** is still room for expansion,as utilizing DCD organs to the fullest extent is currently the most viable solution to the persistent mismatch between supply and demand in *** convened a multidisciplinary transplantation summit to examine various aspects of DCD,with faculty members from around the world with clinical and academic interest in DCD donation and transplantation,including abdominal and cardiothoracic surgeons,organ procurement organization directors,hepatologists,and *** conference focused on identifying barriers to DCD organ utilization and strategies to overcome these *** divide the barriers to DCD utilization into three mains categories:(Ⅰ)policy and process variation;(II)logistical and transportation challenges;and(Ⅲ)higher risk perceptions related to DCD *** each barrier,we proposed a variety of solutions,providing an overview of the status of DCD donation in the US and suggestions on how to increase the use of *** is a specific focus on ex situ machine perfusion,normothermic regional perfusion,and other opportunities to expand DCD utilization without negatively impacting recipient outcomes.

关键词： Donation after circulatory death donation(DCD donation) marginal graft donor pool machine perfusion(MP)

超重和肥胖的不同指标与动脉粥样硬化患病之间的关系:dallas心脏研究

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世界核心医学期刊文摘（心脏病学分册） 2007年第12期3卷 57-页

作者： See R. Abdullah S.M. McGuire D.K. J.A. de Lemos 黄欣 Division of Cardiology Department of Internal Medicine the University of Texas Southwestern Medical Center Dallas TX United States.Dr

目的:本研究拟在大规模人群队列中评估超重和肥胖的不同指标与动脉粥样硬化患病之间的关系。背景:虽然肥胖与心血管性死亡有关,但是尚不清楚这种关系是否由增加的动脉粥样硬化负荷所介导。方法:使用来自dallas心脏研究的资料,作者评估... 详细信息

目的:本研究拟在大规模人群队列中评估超重和肥胖的不同指标与动脉粥样硬化患病之间的关系。背景:虽然肥胖与心血管性死亡有关,但是尚不清楚这种关系是否由增加的动脉粥样硬化负荷所介导。方法:使用来自dallas心脏研究的资料,作者评估了性别特异性的肥胖指标犤即体重指数(BMI)、腰围(WC)、腰臀比(WHR)犦与动脉粥样硬化患病之间的关系,

关键词：动脉粥样硬化动脉硬化 dallas 心脏多变量校正

The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling Zhong Wenjiao Tai Meng-Lu Liu Shuaipeng Ma Tianjin Shen Yuhua Zou Chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

Operation of natural gas and electricity networks with line pack

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Journal of Modern Power Systems and Clean Energy 2019年第5期7卷 1056-1070页

作者： Junyang MI Mohammad E.KHODAYAR Southern Methodist University DallasTXUSA

This paper addresses the coordinated operation of natural gas and electricity networks considering the line pack flexibility in the natural gas *** problem is formulated as a mixed integer linear programming *** objective is to minimize the operation cost of natural gas and electricity networks considering the price of the natural gas *** decomposition is used to solve the formulated *** master problem minimizes the startup and shutdown costs as well as the operation cost of the thermal units other than the gasfired generation units in the electricity *** first subproblem validates the feasibility of the decisions made in the master problem in the electricity *** if there is any violation,feasibility Benders cut is generated and added to the master *** second subproblem ensures the feasibility of the decisions of the master problem in the natural gas transportation network considering the line pack *** last sub-problem ensuresthe optimality of the natural gas network operation problem considering the demand of the gas-fired generation units and line *** nonlinear line pack and flow constraints in the feasibility and optimality subproblems of natural gas transportation network are linearized using Newton-Raphson *** presented case study shows the effectiveness of the proposed *** is shown that leveraging the stored gas in the natural gas pipelines would further reduce the total operation cost.

关键词： Benders decomposition Line pack flexibility Natural gas transportation network Unit commitment

Apoer2/Lrp8:the undercover cop of synaptic homeostasis

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Neural Regeneration Research 2024年第12期19卷 2563-2564页

作者： Gordon C.Werthmann Joachim Herz Department of Molecular Genetics and Center for Translational Neurodegeneration Research University of Texas Southwestern Medical Center at DallasDallasTXUSA Department of Neuroscience Department of Neurology University of Texas Southwestern Medical Center at dallas DallasTXUSA

Apolipoprotein E receptor 2(ApoER2)is a receptor for the protein ApoE,the most common genetic risk factor for late-onset Alzheimer's disease(AD).It is also a key modulator of syna ptic homeostasis,in part through its effect on the expression of neuronal genes including those implicated in AD and other neuropsychiatric *** this perspective,we highlight several genes affected by ApoER2 and its alternatively spliced forms and how aberrant expression can be rescued by the reintroduction of the ApoER2 intracellular domain in the mouse hippocampus.

关键词： homeostasis ApoE Alzheimer

A programmable microfluidic platform to monitor calcium dynamics in microglia during inflammation

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Microsystems & Nanoengineering 2024年第4期10卷 285-296页

作者： Adam Shebindu Durga Kaveti Linda Umutoni Gia Kirk Michael D.Burton Caroline N.Jones Department of Bioengineering University of Texas at DallasRichardsonTX 75080USA Department of Biomedical Engineering UT Southwestern Medical CenterDallasTX 75390USA Department of Neuroscience University of Texas at DallasRichardsonTX 75080USA

Neuroinflammation is characterized by the elevation of cytokines and adenosine triphosphate(ATP),which in turn activates *** immunoregulatory molecules typically form gradients in vivo,which significantly influence microglial behaviors such as increasing calcium signaling,migration,phagocytosis,and cytokine *** microglial calcium signaling in the context of inflammation holds the potential for developing precise therapeutic strategies for neurological ***,the current calcium imaging systems are technically challenging to operate,necessitate large volumes of expensive reagents and cells,and model immunoregulatory molecules as uniform concentrations,failing to accurately replicate the in vivo *** this study,we introduce a novel calcium monitoring micro-total analysis system(CAM-μTAS)designed to quantify calcium dynamics in microglia(BV2 cells)within defined cytokine *** programmable pneumatically actuated lifting gate microvalve arrays and a Quake valve,CAM-μTAS delivers cytokine gradients to microglia,mimicking *** device automates sample handling and cell culture,enabling rapid media changes in just 1.5 s,thus streamlining the experimental *** analyzing BV2 calcium transient latency to peak,we demonstrate locationdependent microglial activation patterns based on cytokine and ATP gradients,offering insights contrasting those of non-gradient-based perfusion *** harnessing advancements in microsystem technology to quantify calcium dynamics,we can construct simplified human models of neurological disorders,unravel the intricate mechanisms of cell-cell signaling,and conduct robust evaluations of novel therapeutics.

关键词： lifting dynamics offering

Is plate tectonics needed to evolve technological species on exoplanets?

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Geoscience Frontiers 2016年第4期7卷 573-580页

作者： Robert J.Stern Geoscience Department University of Texas at Dallas

As we continue searching for exoplanets, we wonder if life and technological species capable of communicating with us exists on any of them. As geoscientists, we can also wonder how important is the presence or absence of plate tectonics for the evolution of technological species. This essay considers this question, focusing on tectonically active roclw （silicate） planets, like Earth, Venus, and Mars. The development of technological species on Earth provides key insights for understanding evolution on exoplanets, including the likely role that plate tectonics may play. An Earth-sized silicate planet is likely to experience several tectonic styles over its lifetime, as it cools and its lithosphere thickens, strengthens, and becomes denser. These include magma ocean, various styles of stagnant lid, and perhaps plate tectonics. Abundant liquid water favors both life and plate tectonics. Ocean is required for early evolution of diverse single-celled organisms, then colonies of cells which specialized further to form guts, ap- pendages, and sensory organisms up to the complexity of fish （central nervous system, appendages, eyes）. Large expanses of dry land also begin in the ocean, today produced above subduction zones in juvenile arcs and by their coalescence to form continents, although it is not clear that plate tectonics was required to create continental crust on Earth. Dry land of continents is required for further evolution of technological species, where modification of appendages for grasping and manipulating, and improve- ment of eyes and central nervous system could be perfected. These bioassets allowed intelligent crea- tures to examine the night sky and wonder, the beginning of abstract thinking, including religion and science. Technology arises from the exigencies of daily living such as tool-making, agriculture, clothing, and weapons, but the pace of innovation accelerates once it is allied with science. Finally, the importance of plate tectonics for devel

关键词： Plate tectonics Exoplanets Planetary science Intelligent life

Activating Connexin43 gap junctions primes adipose tissue for therapeutic intervention

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3063-3072页

作者： Yi Zhu Na Li Mingyang Huang Xi Chen Yu AAn Jianping Li Shangang Zhao Jan-Bernd Funck Jianhong Cao Zhenyan He Qingzhang Zhu Zhuzhen Zhang Zhao VWang Lin Xu Kevin W.Williams Chien Li Kevin Grove Philipp E.Scherer Touchstone Diabetes Center Department of Internal Medicinethe University of Texas Southwestern Medical Center at DallasDallasTX 75390USA Division of Cardiology Department of Internal Medicinethe University of Texas Southwestern Medical Center at DallasDallasTX 75390USA Division of Hypothalamic Research Department of Internal Medicinethe University of Texas Southwestern Medical Center at DallasDallasTX 75390USA Quantitative Biomedical Research Center Department of Population and Data Sciencesthe University of Texas Southwestern Medical Center at DallasDallasTX 75390USA Department of Pediatrics the University of Texas Southwestern Medical Center at DallasDallasTX 75390USA Novo Nordisk Research Center SeattleWA 98109USA Children’s Nutrition Research Center Department of PediatricsBaylor College of MedicineHoustonTX 77030USA Department of Cell Biology the University of Texas Southwestern Medical Center at DallasDallasTX 75390USA

Adipose tissue is a promising target for treating obesity and metabolic ***,pharmacological agents usually fail to effectively engage adipocytes due to their extraordinarily large size and insufficient vascularization,especially in obese *** have previously shown that during cold exposure,connexin43(Cx43)gap junctions are induced and activated to connect neighboring adipocytes to share limited sympathetic neuronal input amongst multiple *** reason the same mechanism may be leveraged to improve the efficacy of various pharmacological agents that target adipose *** an adipose tissue-specific Cx43 overexpression mouse model,we demonstrate effectiveness in connecting adipocytes to augment metabolic efficacy of theβ_(3)-adrenergic receptor agonist Mirabegron and ***,combing those molecules with the Cx43 gap junction channel activator danegaptide shows a similar enhanced *** light of these findings,we propose a model in which connecting adipocytes via Cx43 gap junction channels primes adipose tissue to pharmacological agents designed to engage ***,Cx43 gap junction activators hold great potential for combination with additional agents targeting adipose tissue.

关键词： GJA1 Adipose tissue Gap junction Connexin43 FGF21 β3-Adrenergic receptor agonist Obesity Type 2 diabetes