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Hippo-YAP/TAZ signaling in breast cancer:Reciprocal regulation of microRNAs and implications in precision medicine

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Genes & Diseases 2024年第2期11卷 760-771页

作者： Farzad Sadri Seyede fatemeh Hosseini Zohreh Rezaei Mohammad Fereidouni Student research Committee Birjand University of Medical SciencesBirjand ***Iran Tabas School of Nursing Birjand University of Medical SciencesBirjand ***Iran department of Biology University of Sistan and BaluchestanZahedan ***Iran Cellular and Molecular research Center Birjand University of Medical SciencesBirjand ***Iran

Breast cancer is a molecularly heterogeneous disease and the most common female *** recent years,therapy approaches have evolved to accommodate molecular diversity,with a focus on more biologically based therapies to minimize negative *** regulate cell fate in human breast cells,the Hippo signaling pathway has been associated with the alpha subtype of estrogen *** pathway regulates tissue size,regeneration,and healing,as well as the survival of tissue-specific stem cells,proliferation,and apoptosis in a variety of organs,allowing for cell *** signaling is mediated by the kinases MST1,MST2,LATS1,and LATS2,as well as the adaptor proteins SAV1 and *** kinases phosphorylate the downstream effectors of the Hippo pathway,yes-associated protein(YAP),and transcriptional coactivator with PDZ-binding motif(TAZ),suppressing the expression of their downstream target *** Hippo signaling pathway kinase cascade plays a significant role in all *** the principles of this kinase cascade would prevent the occurrence of breast *** recent years,small noncoding RNAs,or microRNAs,have been implicated in the development of several malignancies,including breast *** interconnections between miRNAs and Hippo signaling pathway core proteins in the breast,on the other hand,remain poorly *** this review,we focused on highlighting the Hippo signaling system,its key parts,its importance in breast cancer,and its regulation by miRNAs and other related pathways.

关键词： Breast cancer Hippo signaling Large tumor suppressor kinase 1 microRNAs PDZ-binding motif Yes-associated protein

Overview of the Synthesis, Characterization, and Application of Tannin-Glyoxal Adhesive for Wood-Based Composites

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Journal of Renewable Materials 2024年第7期12卷 1165-1186页

作者： Awanda Wira Anggini Rita Kartika Sari Efri Mardawati Tati Karliati Apri Heri Iswanto Muhammad Adly Rahandi Lubis research Center for Biomass and Bioproducts National Research and Innovation AgencyCibinong16911Indonesia department of Forest Products Faculty of Forestry and EnvironmentIPB UniversityBogor16680Indonesia department of Agro-Industrial technology Universitas PadjadjaranBandung45363Indonesia research Collaboration Center for Biomass and Biorefinery BRIN and Universitas PadjadjaranBandung45363Indonesia School of Life sciences and technology Institut Teknologi BandungBandung40132Indonesia department of Forest Products technology Faculty of ForestryUniversitas Sumatera UtaraMedan20355Indonesia

More than a century after its initial synthesis,urea-formaldehyde(UF)resins still have dominant applications as adhesives,paints,and ***,formaldehyde in this industry produces formaldehyde emissions that are dangerous to *** have spent the last decade replacing formaldehyde and phenol with environmentally friendly substances such as glyoxal and tannin to create bio-based *** review covers recent advances in synthesizing glyoxal tannin-based resins,especially those made from sustainable raw material substitutes and changes made to synthetic processes to improve mechanical *** efficacy of using tannin-glyoxal adhesives in producing wood-based composites has been *** glyoxylate reaction forms cross-linked bridges between the aromatic sites of the tannin and glyoxal molecular *** tannin adhesive with a greater percentage of glyoxal than tannin will produce an adhesive with better *** gel time reduces as the hardener concentration rises from 7.5%to 15%when glyoxal is used in ***,excessive amounts of glyoxal will result in a decrease in viscosity *** exhibits faster delivery degradation when it reaches a maximum temperature of approximately 130°C,although it initiates the curing process slightly slower at 110°*** glyoxal to tannin-based adhesives can improve the mechanical properties of composite *** wet shear strength of the resulting plywood is increased by 105.4%with the addition of 5-weight percent tannin-based resin with glyoxal as a cross-linker in Soy Protein *** glyoxal as a hardener,the panels produced showed good internal bond strengths(>0.35 MPa)and met the international standard specifications for interior-grade panels.

关键词： Bio-based adhesives glyoxal tannin wood adhesives wood-based composites

Limit load and failure mechanisms of a vertical Hoek-Brown rock slope

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 1106-1111页

作者： Jim Shiau Warayut Dokduea Suraparb Keawsawasvong Pitthaya Jamsawang School of Engineering University of Southern QueenslandToowoomba4350QLDAustralia department of Civil Engineering Faculty of EngineeringKing Mongkut’s University of Technology ThonburiBangkokThailand research Unit in sciences and Innovative Technologies for Civil Engineering Infrastructures Department of Civil EngineeringThammasat School of EngineeringThammasat UniversityPathumthani12120Thailand Soil Engineering research Center Department of Civil EngineeringKing Mongkut’s University of Technology North BangkokBangkok10800Thailand

The problem considered in this short note is the limit load determination of a vertical rock *** classical limit theorem is employed with the use of adaptive finite elements and nonlinear programming to determine upper and lower bound limit loads of a Hoek-Brown vertical rock *** objective function of the mathematical programming problem is such as to optimize a boundary load,which is known as the limit load,resembling the ultimate bearing capacity of a strip *** focusing on the vertical slope,parametric studies are carried out for several dimensionless ratios such as the dimensionless footing distance ratio,the dimensionless height ratio,and the dimensionless rock strength ratio.A comprehensive set of design charts is presented,and failure envelopes shown with the results explained in terms of three identified failure mechanisms,*** face,the toe,and the Prandtl-type *** novel results can be used with great confidence in design practice,in particularly noting that the current industry-based design procedures for the presented problem are rarely found.

关键词： Bearing capacity Rock slope Vertical slope Finite element limit analysis Hoek-Brown yield criterion

Plant RNA-binding proteins:Phase separation dynamics and functional mechanisms underlying plant development and stress responses

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Molecular Plant 2024年第4期17卷 531-551页

作者： Sheng Fan Yu Zhang Shaobo Zhu Lisha Shen Temasek Life sciences Laboratory 1 Research LinkNational University of Singapore1 Research LinkSingapore 117604Singapore department of Biological sciences National University of Singapore14 Science Drive 4Singapore 117543Singapore

RNA-binding proteins(RBPs)accompany RNA from synthesis to decay,mediating every aspect of RNA metabolism and impacting diverse cellular and developmental processes in *** RBPs undergo phase separation along with their bound RNA to form and function in dynamic membraneless biomolecular condensates for spatiotemporal coordination or regulation of RNA *** evidence suggests that phase-separating RBPs with RNA-binding domains and intrinsically disordered regions play important roles in plant development and stress ***,we summarize the current knowledge about how dynamic partitioning of RBPs into condensates controls plant development and enables sensing of experimental changes to confer growth plasticity under stress conditions,with a focus on the dynamics and functional mechanisms of RBP-rich nuclear condensates and cytoplasmic granules in mediating RNA *** also discuss roles of multiple factors,such as environmental signals,protein modifications,and N6-methyladenosine RNA methylation,in modulating the phase separation behaviors of RBPs,and highlight the prospects and challenges for future research on phase-separating RBPs in crops.

关键词： RNA-binding proteins phase separation biomolecular condensates RNA metabolism development stress resilience

Geomorphic signatures and active tectonics in western Saurashtra,Gujarat,India

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Geodesy and Geodynamics 2024年第1期15卷 82-99页

作者： Bikramaditya Mondal Mery Biswas Soumyajit Mukherjee Mohamedharoon A.Shaikh department of Earth sciences Indian Institute of Technology BombayMumbai 400076MaharashtraIndia department of Geography Presidency UniversityKolkata 700073West BengalIndia

Active tectonics in an area includes ongoing or recent geologic *** paper investigates the tectonic influence on the subsidence,uplift and tilt of western Saurashtra through morphotectonic analysis of ten watersheds along with characteristics of relief and drainage *** 7-9 to the north(N)are tectonically active,which can be linked with the North Kathiawar Fault System(NKFS)and followed by watersheds 6,10,1,4 and ***-length gradient index and sinuosity index indicate the effect of tectonic events along the master streams in watersheds *** R^(2)values of the linear curve fit for watershed 7 indicate its master stream is much more tectonically active than the *** R^(2)curve fitting model and earthquake magnitude/depth analysis confirm the region to be *** reactivation of the NKFS most likely led to the vertical movement of western Saurashtra.

关键词： Active tectonics Geomorphology Western Saurashtra Archeology North kathiawar fault system

Microwave-accelerated direct regeneration of LiCoO_(2)cathodes for Li-ion batteries

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Science China Chemistry 2024年第7期67卷 2181-2189页

作者： Xueshan Hu Yun-Chao Yin Chao Li Lihui Zhou Lin Yang Yitian Feng Daxian Zuo Chenhui Ning Das Soham Sheng Dai Longbin Qiu Lin Zeng Haw Jiunn Woo Jiayu Wan Future Battery research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240China department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China Centre for Ionics University of Malaya Department of PhysicsFaculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint research Center School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China department of Natural and Applied sciences Duke Kunshan UniversityKunshan 215316China

Recycling spent lithium-ion batteries is integral to today's low-carbon environmental protection *** concept of direct regeneration,acknowledged for its environmental sustainability,economic viability,and consistent performance of recycled materials,is gaining *** study presents an efficient and nondestructive approach by utilizing an ultrafast microwave technology to directly regenerate spent lithium cobaltate(LCO)cathode *** contrast to conventional furnacebased processes,this method significantly reduces the regeneration *** subjecting the spent LCO mixed with lithium sources to three microwave heating cycles(at approximately 1,350 K),LCO regeneration is achieved,yielding a specific capacity of 140.8 mAh g^(-1)(0.2 C)with a robust cycle *** further environmental and economic benefits,the ultrafast microwave technology holds scientific promise for directly regenerating cathode materials,while establishing competitiveness for industrial applications.

关键词： battery recycling spent lithium cobaltate microwave directly regeneration cathode materials

Characterization of physicochemical and immunogenic properties of allergenic proteins altered by food processing:a review

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Food Science and Human Wellness 2024年第3期13卷 1135-1151页

作者： Enning Zhou Qiangqiang Li Dan Zhu Gang Chen Liming Wu Institute of Apicultural research Chinese Academy of Agricultural SciencesBeijing 100093China department of Food Science University of OtagoDunedin 9016New Zealand School of Food and Health Beijing Technology and Business UniversityBeijing 100048China

Food allergens are mainly naturally-occurring proteins with immunoglobulin E(IgE)-binding *** the structural and immunogenic characteristics of allergenic proteins is essential in assessing whether and how food processing techniques reduce *** here discuss the impacts of food processing technologies on the modification of physicochemical,structural,and immunogenic properties of allergenic *** techniques for characterizing changes in these properties of food allergens are *** processing helps to reduce allergenicity by aggregating or denaturing proteins,which masks,modifies,or destroys antigenic epitopes,whereas,it cannot eliminate allergenicity completely,and sometimes even improves allergenicity by exposing new ***,most food processing techniques have been tested on purified food allergens rather than food products due to potential interference of other food *** provide guidance for further development of processing operations that can decrease the allergenicity of allergenic food proteins without negatively impacting the nutritional profile.

关键词： Food allergens Protein structural characterization Immunogenicity evaluation Food processing modification

Geochemical modeling to aid experimental design for multiple isotope tracer studies of coupled dissolution and precipitation reaction kinetics

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Acta Geochimica 2024年第1期43卷 1-15页

作者： Mingkun Chen Peng Lu Yongchen Song Chen Zhu department of Earth and Atmospheric sciences Indiana UniversityBloomingtonIN 47405USA School of Energy and Power Engineering Dalian University of TechnologyDalian 116024China EXPEC Advanced research Center Saudi Aramco31311 DhahranSaudi Arabia

It is a challenge to make thorough but efficient experimental designs for the coupled mineral dissolution and precipitation studies in a multi-mineral system, because it is difficult to speculate the best experimental duration, optimal sampling schedule, effects of different experimental conditions, and how to maximize the experimental outputs prior to the actual experiments. Geochemical modeling is an efficient and effective tool to assist the experimental design by virtually running all scenarios of interest for the studied system and predicting the experimental outcomes. Here we demonstrated an example of geochemical modeling assisted experimental design of coupled labradorite dissolution and calcite and clayey mineral precipitation using multiple isotope tracers. In this study, labradorite(plagioclase) was chosen as the reactant because it is both a major component and one of the most reactive minerals in basalt. Following our isotope doping studies of single minerals in the last ten years, initial solutions in the simulations were doped withmultiple isotopes(e.g., Ca and Si). Geochemical modeling results show that the use of isotope tracers gives us orders of magnitude more sensitivity than the conventional method based on concentrations and allows us to decouple dissolution and precipitation reactions at near-equilibrium condition. The simulations suggest that the precise unidirectional dissolution rates can inform us which rate laws plagioclase dissolution has followed. Calcite precipitation occurred at near-equilibrium and the multiple isotope tracer experiments would provide near-equilibrium precipitation rates, which was a challenge for the conventional concentration-based experiments. In addition, whether the precipitation of clayey phases is the rate-limiting step in some multi-mineral systems will be revealed. Overall, the modeling results of multimineral reaction kinetics will improve the understanding of the coupled dissolution–precipitation in the mu

关键词： Kinetics Feldspar Isotope doping Near-equilibrium CO_(2)sequestration Basalt

Real-Time Prediction of Urban Traffic Problems Based on Artificial Intelligence-Enhanced Mobile Ad Hoc Networks(MANETS)

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Computers, Materials & Continua 2024年第5期79卷 1903-1923页

作者： Ahmed Alhussen Arshiya S.Ansari department of Computer Engineering College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia department of Information technology College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia

Traffic in today’s cities is a serious problem that increases travel times,negatively affects the environment,and drains financial *** study presents an Artificial Intelligence(AI)augmentedMobile Ad Hoc Networks(MANETs)based real-time prediction paradigm for urban traffic *** are wireless networks that are based on mobile devices and may *** distributed nature of MANETs and the power of AI approaches are leveraged in this framework to provide reliable and timely traffic congestion *** study suggests a unique Chaotic Spatial Fuzzy Polynomial Neural Network(CSFPNN)technique to assess real-time data acquired from various sources within *** framework uses the proposed approach to learn from the data and create predictionmodels to detect possible traffic problems and their severity in real ***-time traffic prediction allows for proactive actions like resource allocation,dynamic route advice,and traffic signal optimization to reduce *** framework supports effective decision-making,decreases travel time,lowers fuel use,and enhances overall urban mobility by giving timely information to pedestrians,drivers,and urban *** simulations and real-world datasets are used to test the proposed framework’s prediction accuracy,responsiveness,and *** results show that the suggested framework successfully anticipates urban traffic issues in real-time,enables proactive traffic management,and aids in creating smarter,more sustainable cities.

关键词： Mobile AdHocNetworks(MANET) urban traffic prediction artificial intelligence(AI) traffic congestion chaotic spatial fuzzy polynomial neural network(CSFPNN)