检索结果-南通市图书馆

A new paradigm for diagnosis of neurodegenerative diseases: peripheral exosomes of brain origin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2022年第1期11卷 532-546页

作者： Neelam Younas Leticia Camila Fernandez Flores Franziska Hopfner Günter U.Höglinger Inga Zerr Prion Research Group Department of NeurologyNational Reference Center for Surveillance of TSEUniversitätsklinikum Göttingen:Universitätsmedizin GöttingenGeorg-August UniversityGöttingenGermanyRobert-Koch-Strasse 4037075 GöttingenGermany Hannover Medical School Medizinische Hochschule HannoverHannoverGermany German Center for Neurodegenerative Diseases(dzne) MunichGermany German Center for Neurodegenerative Diseases(dzne) GöttingenGermany.

Neurodegenerative diseases are a heterogeneous group of maladies, characterized by progressive loss of neurons. These diseases involve an intricate pattern of cross-talk between different types of cells to maintain specific signaling pathways. A component of such intercellular cross-talk is the exchange of various types of extracellular vesicles (EVs). Exosomes are a subset of EVs, which are increasingly being known for the role they play in the pathogenesis and progression of neurodegenerative diseases, e.g., synucleinopathies and tauopathies. The ability of the central nervous system exosomes to cross the blood-brain barrier into blood has generated enthusiasm in their study as potential biomarkers. However, the lack of standardized, efficient, and ultra-sensitive methods for the isolation and detection of brain-derived exosomes has hampered the development of effective biomarkers. Exosomes mirror heterogeneous biological changes that occur during the progression of these incurable illnesses, potentially offering a more comprehensive outlook of neurodegenerative disease diagnosis, progression and treatment. In this review, we aim to discuss the challenges and opportunities of peripheral biofluid-based brain-exosomes in the diagnosis and biomarker discovery of Alzheimer’s and Parkinson’s diseases. In the later part, we discuss the traditional and emerging methods used for the isolation of exosomes and compare their advantages and disadvantages in clinical settings.

关键词： Alzheimer’s disease Central nervous system Diagnosis Exosomes Blood-brain barrier Parkinson’s disease

Combination of novel RNA sequencing and sophisticated network modeling to reveal a common denominator in amyotrophic lateral sclerosis?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第11期18卷 2403-2405页

作者： Banaja P.Dash Andreas Hermann Translational Neurodegeneration Section“Albrecht Kossel” Department of NeurologyUniversity Medical Center RostockRostockGermany Center for Transdisciplinary Neurosciences Rostock University Medical Center RostockRostockGermany Deutsches Zentrum für Neurodegenerative Erkrankungen(dzne)Rostock/Greifswald RostockGermany

Amyotrophic lateral sclerosis (ALS) is one of the most dreadful neurodegenerative diseases leading to death within 1-5 years after symptom *** majority of ALS cases are sporadic(sALS),while the remaining 5-10%are familial(fALS).Genetic discoveries have identified ALScausative mutations in more than 30 genes so far(Chia et al.,2018).Indeed,the four most common mutations observed in ALS genes in Europe are the hexanucleotide expansion repeat in Chromosome9 Open Reading Frame 72 (C9ORF72),Cu-Zn superoxide dismutase 1 (SOD1),tra nsactive response DNA Binding protein 43kDa (TARDBP)and fused in sa rcoma (FUS).

关键词： diseases death

The role of DJ-1 complexes and catecholamine metabolism： relevance for familial and idiopathic Parkinson＇s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第5期13卷 815-816页

作者： Dominik Piston Matthew E.Gegg German Centre for Neurodegenerative Diseases (dzne) Bonn Germany Department of Clinical Neuroscience UCL Institute of Neurology London UK

Autosomal recessive mutations in the PARK7 gene,which encodes for the protein DJ-1,result in a loss of function and are a cause of familial Parkinson’s disease（PD）,while increased wild-type DJ-1protein levels are associated with some forms of *** functions of DJ-1 have been described,with the greatest evidence indicating that DJ-1 is a redox-sensitive protein involved in the regulation of oxidative stress and cell survival.

关键词： The role of DJ-1 complexes and catecholamine metabolism relevance for familial and idiopathic Parkinson’s disease GBA DA

Alzheimer’s disease, neural stem cells and neurogenesis: cellular phase at single-cell level

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第5期15卷 824-827页

作者： Mehmet Ilyas Cosacak Prabesh Bhattarai Caghan Kizil German Center for Neurodegenerative Diseases (dzne) Dresden Helmholtz AssociationDresdenGermany Center for Molecular and Cellular Bioengineering (CMCB) CRTDTU DresdenDresdenGermany

Alzheimer’s disease cannot be cured as of *** current understanding on the causes of Alzheimer’s disease is *** develop treatments,experimental models that represent a particular cellular phase of the disease and more rigorous scrutiny of the cellular pathological mechanisms are *** recent years,Alzheimer’s disease research underwent a paradigm *** to this tendency,Alzheimer’s disease is increasingly being conceived of a disease where not only neurons but also multiple cell types synchronously partake to manifest the *** on every cell type adds an alternative approach and hope for the efforts towards the *** stem cells and their neurogenic ability are making an appearance as a new aspect of the disease manifestation based on the recent findings that neurogenesis reduces dramatically in Alzheimer’s disease patients compared to healthy ***,understanding how neural stem cells can form new neurons in Alzheimer’s disease brains holds an immense potential for ***,this provocative idea requires further evidence and tools for ***,single cell sequencing appeared as a revolutionary tool to understand cellular programs in unprecedented resolution and it will undoubtedly facilitate comprehensive investigation of different cell types in Alzheimer’s *** this mini-review,we will touch upon recent studies that use single cell sequencing for investigating cellular response in Alzheimer’s disease and some consideration pertaining to the utilization of neural regeneration for Alzheimer’s disease research.

关键词： Alzheimer's disease mouse neural regeneration neural stem cell neurogenesis neuron single cell sequencing zebrafish

Structure of serotonin receptors:molecular underpinning of receptor activation and modulation

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第7期6卷 1950-1952页

作者： Markus Zweckstetter Alexander Dityatev Evgeni Ponimaskin Translational Structural Biology Group German Center for Neurodegenerative Diseases(DZNE)GottingenGermany Department for NMR-based Structural Biology Max Planck Institute for Biophysical ChemistryGottingenGermany Molecular Neuroplasticity Group German Center for Neurodegenerative Diseases(DZNE)MagdeburgGermany Medical Faculty Otto-von-Guericke UniversityMagdeburgGermany Center for Behavioral Brain Sciences(CBBS) MagdeburgGermany Department of Cellular Neurophysiology Hannover Medical SchoolHannoverGermany

The structural basis of the regulation of serotonin(5-hydroxy-tryptamine,5-HT)receptors by ligands and lipids is only emerging.A recent study by Xu and colleagues1 published in Nature addresses this issue by resolving five structures of 5-HT;receptor-G protein *** include 5-HT1A in the apostate,*** bound to a ligand,5-HT1A and 5-HT1D bound to serotonin or the atypical antipsychotic aripiprazole(for 5-HT1A),and 5-HT1E bound to its selective agonist BRL-54443.

关键词： serotonin lipids atypical

HMGB1, IL-1α, IL-33 and S100 proteins： dual-function alarmins

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2017年第1期14卷 43-64页

作者： Damien Bertheloot Eicke Latz Institute of Innate Immunity University Hospitals University of Bonn 53127 Bonn Germany German Center for Neurodegenerative Diseases (dzne) 53117 Bonn Germany Department of Infectious Diseases and Immunology University of Massachusetts Medical School Worcester MA 01605 USA

Our immune system is based on the close collaboration of the innate and adaptive immune systems for the rapid detection of any threats to the host. Recognition of pathogen-derived molecules is entrusted to specific germline- encoded signaling receptors. The same receptors have now also emerged as efficient detectors of misplaced or altered self-molecules that signal tissue damage and cell death following, for example, disruption of the blood supply and subsequent hypoxia. Many types of endogenous molecules have been shown to provoke such sterile inflammatory states when released from dying cells. However, a group of proteins referred to as alarmins have both intracellular and extracellular functions which have been the subject of intense research. Indeed, alarmins can either exert beneficial cell housekeeping functions, leading to tissue repair, or provoke deleterious uncontrolled inflammation. This group of proteins includes the high-mobility group box 1 protein （HMGB1）, interleukin （IL）-1α, IL-33 and the Ca^2＋-binding S100 proteins. These dual-function proteins share conserved regulatory mechanisms, such as secretory routes, post-translational modifications and enzymatic processing, that govern their extracellular functions in time and space. Release of alarmins from mesenchymal cells is a highly relevant mechanism by which immune cells can be alerted of tissue damage, and alarmins play a key role in the development of acute or chronic inflammatory diseases and in cancer development.

关键词： alarmin HMGB1 IL-1α IL-33 inflammation S100 proteins

Investigation of human organoid retina with digital holographic transmission matrix measurements

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Advanced Manufacturing) 2022年第2期3卷 33-47页

作者： Nektarios Koukourakis Felix Wagner Stefan Rothe Mike O.Karl Jürgen W.Czarske Laboratory for Measurement and Sensorsystem Technique TU DresdenDresdenGermany Competence Center for Biomedical Laser Systems(BIOLAS) TU DresdenDresdenGermany Center for Regenerative Therapies Dresden(CRTD) TU DresdenDresdenGermany German Center for Neurodegenerative Diseases(dzne)Dresden DresdenGermany Faculty of Physics TU DresdenDresdenGermany Excellence Cluster Physics of Life(PoL) TU DresdenDresdenGermany

Advanced manufacturing of retinal organoid samples from human induced pluripotent stem cells represents a promising way to study the development of retinal *** retina is an epithelium composed of different cell layers with unique optical properties and detects light by photoreceptor neurons for visual *** are still many challenges in detecting early and distinct cellular changes in retinal *** this paper,we study the capability of the optical transmission matrix,which fully describes the transition of a light field propagating through a scattering *** its rich information content,the transmission matrix is commonly just used for light delivery through scattering *** holography is employed to measure the complex light-field information of the transmitted *** demonstrate that singular value decomposition of the transmission matrix allows to discriminate phantom tissues with varying scattering *** apply these findings to retinal organoid *** of the protonophore carbonyl cyanide m-chloro-phenylhydrazone(CCCP),a known inducer of retinal damage in animals,caused cell death and structural changes in human retinal organoids,which resulted in distinct changes in the transmission *** data indicate that the analysis of the transmission matrix can distinguish pathologic changes of the retina towards the development of imaging-based biomarkers.

关键词： Transmission matrix Digital holography Retina Organoids Neurodegeneration Cell death

Fused in sarcoma-amyotrophic lateral sclerosis as a novel member of DNA single strand break diseases with pure neurological phenotypes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第1期16卷 110-112页

作者： Marcel Naumann Julian Laubenthal Andreas Hermann Translational Neurodegeneration Section“Albrecht-Kossel” Department of NeurologyUniversity Medical Center RostockUniversity of RostockRostockGermany German Center for Neurodegenerative Diseases(dzne)Rostock/Greifswald Center for Transdisciplinary Neurosciences Rostock(CTNR)University Medical Center RostockUniversity of RostockRostockGermany

Accumulation of DNA damage and genomic instability are believed to have crucial effects in neurodegenerative conditions such as Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,premature aging diseases as well as amyotrophic lateral sclerosis(ALS)and frontotemporal dementia(FTD).Until recently these studies were largely correlative in nature,though raising the possibility that defects in the DNA damage response(DDR)underlie neurodegenerative diseases.

关键词： diseases Huntington amyotrophic

Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43^(G298S) ALS mouse model

在线全文

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2019年第1期8卷 333-345页

作者： Hans-Peter Müller David Brenner Francesco Roselli Diana Wiesner Alireza Abaei Martin Gorges Karin M.Danzer Albert C.Ludolph William Tsao Philip C.Wong Volker Rasche Jochen H.Weishaupt Jan Kassubek Department of Neurology University of UlmOberer Eselsberg 45RKUD-89081 UlmGermany German Center for Neurodegenerative Diseases(dzne) UlmGermany Core Facility Small Animal MRI University of UlmUlmGermany Department of Pathology The Johns Hopkins University School of MedicineBaltimoreUSA

Background:In vivo diffusion tensor imaging(DTI)of the mouse brain was used to identify TDP-43 associated alterations in a mouse model for amyotrophic lateral sclerosis(ALS).Methods:Ten mice with TDP-43^(G298S) overexpression under control of the Thy1.2 promoter and 10 wild type(wt)underwent longitudinal DTI scans at 11.7 T,including one baseline and one follow-up scan with an interval of about *** brain-based spatial statistics(WBSS)of DTI-based parameter maps was used to identify longitudinal alterations of TDP-43^(G298S) mice compared to wt at the cohort *** were supplemented by tractwise fractional anisotropy statistics(TFAS)and histological evaluation of motor cortex for signs of neuronal ***:Alterations at the cohort level in TDP-43^(G298S) mice were observed cross-sectionally and longitudinally in motor areas M1/M2 and in transcallosal fibers but not in the corticospinal *** loss in layer V of motor cortex was detected in TDP-43^(G298S) at the later(but not at the earlier)timepoint compared to ***:DTI mapping of TDP-43^(G298S) mice demonstrated progression in motor areas M1/*** and TFAS are useful techniques to localize TDP-43^(G298S) associated alterations over time in this ALS mouse model,as a biological marker.

关键词： Diffusion tensor imaging Amyotrophic lateral sclerosis Mutant TDP-43 Fiber tracking Mouse brain