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Dual-responsive supramolecular photodynamic nanomedicine with activatable immunomodulation for enhanced antitumor therapy

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Acta Pharmaceutica Sinica B 2024年第2期14卷 765-780页

作者： Siqin He Lulu Wang Dongxu Wu Fan Tong Huan Zhao Hanmei Li Tao Gong Huile Gao Yang Zhou Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikou 570200China Key Laboratory of Drug-Targeting and Drug Delivery System West China School of PharmacySichuan UniversityChengdu 610041China Revvity inc. WalthamMA 02451USA School of Food and Biological engineering Chengdu UniversityChengdu 610106China

A major challenge facing photodynamic therapy(PDT) is that the activity of the immuneinduced infiltrating CD8^(+)T cells is subject to the regulatory T lymphocytes(Tregs), leaving the tumor at risk of recurrence and metastasis after the initial ablation. To augment the antitumor response and reprogram the immunosuppressive tumor microenvironment(TME), a supramolecular photodynamic nanoparticle(DACss) is constructed by the host-guest interaction between demethylcantharidin-conjugated β-cyclodextrin(DMC-CD) and amantadine-terminated disulfide-conjugated FFVLGGGC peptide with chlorin e6 decoration(Ad-ss-pep-Ce6) to achieve intelligent delivery of photosensitizer and immunomodulator for breast cancer treatment. The acid-labile β-carboxamide bond of DMC-CD is hydrolyzed in response to the acidic TME, resulting in the localized release of DMC and subsequent inhibition of *** guest molecule Ad-ss-pep-Ce6 can be cleaved by a high level of intracellular GSH, reducing photosensitizer toxicity and inc.easing photosensitizer retention in the tumor. With a significant inc.ease in the CTL/Treg ratio, the combination of Ce6-based PDT and DMC-mediated immunomodulation adequately achieved spatiotemporal regulation and remodeling of the TME, as well as improved primary tumor and in situ lung metastasis suppression with the aid of PD-1 antibody.

关键词： Photodynamic therapy Immunosuppressive microenvironment Immunomodulator Dual-responsive Supramolecularassembly Checkpointblockade

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Ballistic performance of titanium-based layered composites made using blended elemental powder metallurgy and hot isostatic pressing

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Defence Technology 2024年第09期 1-14页

作者： Pavlo Markovsky Jacek Janiszewski Dmytro Savvakin Oleksandr Stasyuk Bartosz Fikus Victor Samarov Vianey Ellison Sergey V.Prikhodko G.V.Kurdyumov Institute for Metal Physics of N.A.S.of Ukraine Jaros?aw Da browski Military University of Technology Synertech inc. Department of Materials Science and engineering University of California Los Angeles

Metal matrix composites tiles based on Ti-6Al-4V(Ti64) alloy, reinforced with 10, 20, and 40(vol%) of either TiC or TiB particles were made using press-and-sinter blended elemental powder metallurgy(BEPM) and then bonded together into 3-layer laminated plates using hot isostatic pressing(HIP). The laminates were ballistically tested and demonstrated superior performance. The microstructure and properties of the laminates were analyzed to determine the effect of the BEPM and HIP processing on the ballistic properties of the layered plates. The effect of porosity in sintered composites on further diffusion bonding of the plates during HIP is analyzed to understand the bonding features at the interfaces between different adjacent layers in the laminate. Exceptional ballistic performance of fabricated structures was explained by a significant reduction in the residual porosity of the BEPM products by their additional processing using HIP, which provides an unprecedented inc.ease in the hardness of the layered composites. It is argued that the combination of the used two technologies, BEPM and HIP is princ.pally complimentary for the materials in question with the abilities to solve the essential problems of each used individually.

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Genetic Optimization via Diverse Crossover Intelligence

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Journal of Applied Mathematics and Physics 2024年第8期12卷 2885-2903页

作者： David Webb Eric Sandgren AdvanSix inc. Parsippany New Jersey USA Systems engineering Department Donaghey College of Engineering & Information Technology University of Arkansas at Little Rock Little Rock Arkansas USA

An intelligent crossover methodology within the genetic algorithm (GA) is explored within both mathematical and finite element arenas improving both design and solution convergence time. This improved intelligent crossover outperforms the traditional genetic algorithm combined with a rule-based approach utilizing domain specific knowledge developed by Webb, et al. [1]. The encoding of the improved crossover consists of two chromosome strings within the genetic algorithm where the first string represents the design or solution string, and the second string represents chromosome crossover string intelligence. This improved crossover methodology saves the best population members or designs evaluated from each generation and applies crossover chromosome intelligence to the best saved population members paired with globally selected parents. Enhanced features of this crossover methodology employ the random selection of the best designs from the prior generation as a potential parent coupled with alternating intelligence pairing methods. In addition to this approach, two globally selected parents possess the ability to mate utilizing crossover chromosome string intelligence maintaining the integrity of a global GA search. Overall, the final population following crossover employs both global and best generation design chromosome strings to maximize creativity while enhancing the solution search. This is a modification to a conventional GA that can be translated into GA encoding. This technique is explored initially through a Base 10 mathematical application followed by the examination of plate structural optimization considering stress and displacement constraints. Results from crossover intelligence are compared with the conventional genetic algorithm and from Webb, et al. [1] which illustrates the outcome of a two phase genetic optimization algorithm.

关键词： Crossover Topological Design Structural Optimization Genetic Optimization Variable Material Design

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Interworking between Modbus and internet of things platform for industrial services

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Digital Communications and Networks 2024年第2期10卷 461-471页

作者： Sherzod Elamanov Hyeonseo Son Bob Flynn Seong Ki Yoo Naqqash Dilshad JaeSeung Song Department of Convergence engineering for Intelligent Drone Sejong UniversitySouth Korea SyncTechno inc South Korea Exacta Global Smart Solutions USA Coventry University UK

In the era of rapid development of Internet of Things(IoT),numerous machine-to-machine technologies have been applied to the industrial *** to the divergence of IoT solutions,the industry is faced with a need to apply various technologies for automation and *** fact leads to a demand for an establishing interworking mechanism which would allow smooth interoperability between heterogeneous *** of the major protocols widely used today in industrial electronic devices is ***,data generated by Modbus devices cannot be understood by IoT applications using different protocols,so it should be applied in a couple with an IoT service layer ***2M,a global IoT standard,can play the role of interconnecting various protocols,as it provides flexible tools suitable for building an interworking framework for industrial ***,in this paper,we propose an interworking architecture between devices working on the Modbus protocol and an IoT platform implemented based on oneM2M *** the proposed architecture,we introduce the way to model Modbus data as oneM2M resources,rules to map them to each other,procedures required to establish interoperable communication,and optimization methods for this *** analyze our solution and provide an evaluation by implementing it based on a solar power management use *** results demonstrate that our model is feasible and can be applied to real case scenarios.

关键词： Internet of things Interoperability Interworking Modbus oneM2M

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Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

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Light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman Jason Lynch Christopher E.Stevens Christopher Munley Chentao Li Jin Hou Hao Zhang Andrew Torma Thomas Darlington Francis Coen Kevin Li Arka Majumdar PJames Schuck Aditya Mohite Hayk Harutyunyan Joshua R.Hendrickson Deep Jariwala Department of Electrical and Systems engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR inc. BeavercreekOH45431USA Air Force Research Laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of Chemical and Biomolecular engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical engineering Columbia UniversityNew YorkNY10027USA Department of Electrical and Computer engineering University of WashingtonSeattleWA98195USA

Excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D HOIPs)are capable of forming hybrid light-matter states known as exciton-polaritons(E–Ps)when the excitonic medium is confined in an optical *** the case of 2D HOIPs,they can self-hybridize into E–Ps at specific thicknesses of the HOIP crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized E–Ps in 2D HOIPs,inc.uding their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOIP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized E–P *** E–Ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy E–Ps to lower energy E–***,we also demonstrate that E–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in E–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

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KSKV:Key-Strategy for Key-Value Data Collection with Local Differential Privacy

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Computer Modeling in engineering & Sciences 2024年第6期139卷 3063-3083页

作者： Dan Zhao Yang You Chuanwen Luo Ting Chen Yang Liu Artificial Intelligence Development Research Center Institute of Scientific and Technical Information of ChinaBeijing100038China Industry Development Department NSFOCUS Inc.BeijingChina School of Information Science and Technology Beijing Forestry UniversityBeijing100083China School of Computer Science and engineering University of Electronic Science and Technology of ChinaChengdu610054China Institute of Computing Technology China Academy of Railway Sciences Corporation LimitedBeijing10081China

In recent years,the research field of data collection under local differential privacy(LDP)has expanded its focus fromelementary data types to inc.udemore complex structural data,such as set-value and graph ***,our comprehensive review of existing literature reveals that there needs to be more studies that engage with key-value data *** studies would simultaneously collect the frequencies of keys and the mean of values associated with each ***,the allocation of the privacy budget between the frequencies of keys and the means of values for each key does not yield an optimal utility *** the importance of obtaining accurate key frequencies and mean estimations for key-value data collection,this paper presents a novel framework:the Key-Strategy Framework forKey-ValueDataCollection under ***,theKey-StrategyUnary Encoding(KS-UE)strategy is proposed within non-interactive frameworks for the purpose of privacy budget allocation to achieve precise key frequencies;subsequently,the Key-Strategy Generalized Randomized Response(KS-GRR)strategy is introduced for interactive frameworks to enhance the efficiency of collecting frequent keys through group-anditeration *** strategies are adapted for scenarios in which users possess either a single or multiple key-value ***,we demonstrate that the variance of KS-UE is lower than that of existing *** claims are substantiated through extensive experimental evaluation on real-world datasets,confirming the effectiveness and efficiency of the KS-UE and KS-GRR strategies.

关键词： Key-value local differential privacy frequency estimation mean estimation data perturbation

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Drought-Tolerant Rice at Molecular Breeding Eras:An Emerging Reality

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Rice science 2024年第2期31卷 179-189页

作者： ZHU Chengqi YE Yuxuan QIU Tian HUANG Yafan YING Jifeng SHEN Zhicheng Institute of Insect Sciences Zhejiang UniversityHangzhou 310058China Performance Plants inc. 1287 Gardiners RoadKingstonOntario K7P 3J6Canada China National Rice Research Institute Hangzhou 310006China

Rice(Oryza sativa L.)stands as the most significantly influential food crop in the developing world,with its total production and yield stability affected by environmental *** stress impacts about 45%of the world’s rice area,affecting plants at molecular,biochemical,physiological,and phenotypic *** conventional breeding method,predominantly employing single pedigree selection,has been widely utilized in breeding numerous drought-tolerant rice varieties sinc. the Green *** rapid progress in plant molecular biology,hundreds of drought-tolerant QTLs/genes have been identified and tested in rice crops under both indoor and field *** genes have been introgressed into elite germplasm to develop commercially accepted drought-tolerant varieties,resulting in the development of several drought-tolerant rice varieties through marker-assisted selection and genetically engineered *** review provides up-to-date information on proof-of-concept genes and breeding methods in the molecular breeding era,offering guidance for rice breeders to develop drought-tolerant rice varieties.

关键词： conventional breeding drought stress drought tolerant rice genetic engineering marker-assisted selection breeding

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Boosting photocatalytic water vapor splitting by the integration of porous g-C_(3)N_(4)and carbonized melamine foam

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Science China Materials 2024年第9期67卷 2957-2964页

作者： Shujian Wang Dongjie Liu Chunyang Zhang Jie Huang Shidong Zhao Kejian Lu Biao Wang Hao Peng Yitao Si Maochang Liu International Research Center for Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringXi’an Jiaotong UniversityXi’an710049China School of Chemistry and Chemical engineering Southeast UniversityNanjing211189China Suzhou Academy of Xi’an Jiaotong University Suzhou215123China Gree Altairnano New Energy inc. Zhuhai519040China

We report a photothermally-induced liquid-solid/gas-solid-decoupling photocatalytic water-splitting system,where a carbonized melamine foam(CMF)and a porous g-C_(3)N_(4)(PCN)serve as the photothermal substrate and model photocatalyst,***,liquid water is transformed into the gaseous phase over the CMF due to the photothermal effect,and the generated vapor can be split into hydrogen by PCN via the *** unique biphasic photocatalytic system exhibits a high hydrogen production rate of 368.1µmol h^(-1),which is 2.4 and 25.6 times larger than those of the traditional triphasic PCN system(151.7µmol h^(-1))and g-C_(3)N_(4)(CN)system(14.4µmol h^(-1)),*** improved photocatalytic performance is mainly attributed to the optimized energy and mass transfer at the gas-liquid-solid reaction interface,where gas products are rapidly desorbed in the photocatalytic *** work provides a novel strategy to enhance the photocatalytic performance from the perspectives of energy and mass flow.

关键词： photocatalytic photothermal mass transfer g-C_(3)N_(4) gas-solid

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New Insights into Microplastic Contamination in Different Types of Leachates: Abundances, Characteristics, and Potential Sources

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engineering 2024年第6期37卷 62-68页

作者： Lei Zhang Wentao Zhao Liang Zhang Zhenxiao Cai Ruiqi Yan Xia Yu Damià Barceló Qian Sui State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process School of Resources and Environmental EngineeringEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China PerkinElmer Inc.Shanghai 201203China Maihai Environmental Protection Technology Co. Ltd.SuzhouJiangsu 215000China Department of Environmental Chemistry Institute of Environmental Assessment and Water ResearchSpanish Council for Scientific Research(IDAEA-CSIC)Barcelona 08034Spain

Municipal solid waste(MSW)is an important destination for abandoned *** the waste disposal process,large plastic debris is broken down into microplastics(MPs)and released into the ***,current research only focuses on landfill leachates,and the occurrence of MPs in other leachates has not been ***,herein,the abundance and characteristics of MPs in three types of leachates,namely,landfill leachate,residual waste leachate,and household food waste leachate,were studied,all leachates were collected from the largest waste disposal center in *** results showed that the average MP abundances in the different types of leachates ranged from(129±54)to(1288±184)MP particles per liter(particlesL1)and the household food waste leachate exhibited the highest MP abundance(p80%)of small MPs(20–100 lm)in landfill leachates compared to other *** the best of our knowledge,this is the first study discussing the sources of MPs in different leachates,which is important for MP pollution control during MSW disposal.

关键词： Microplastics Landfill leachate Residual waste leachate Household food waste leachate Source

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Influence of heat treatment on microstructure,mechanical and corrosion behavior of WE43 alloy fabricated by laser-beam powder bed fusion

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International Journal of Extreme Manufacturing 2024年第1期6卷 258-275页

作者： Chenrong Ling Qiang Li Zhe Zhang Youwen Yang Wenhao Zhou Wenlong Chen Zhi Dong Chunrong Pan Cijun Shuai College of Mechanical and Electrical engineering Jiangxi University of Science and TechnologyGanzhou 341000People’s Republic of China School of Mechanical and Electronic engineering Suzhou UniversitySuzhou 234000People’s Republic of China Shaanxi Key Laboratory of Biomedical Metal Materials Northwest Institute for Non-ferrous Metal ResearchXi’an 710016People’s Republic of China Department of Orthopedics First Afffliated Hospital of Gannan Medical CollegeGanzhou 341000People’s Republic of China School of Mechanical and Automotive engineering South China university of technologyGuangzhou 510641People’s Republic of China State Key Laboratory of High-Performance Complex Manufacturing Central South UniversityChangsha 410083People’s Republic of China Double Medical Technology inc. Xiamen 361026People’s Republic of China

Magnesium(Mg)alloys are considered to be a new generation of revolutionary medical ***-beam powder bed fusion(PBF-LB)is suitable for fabricating metal implants withpersonalized and complicated ***,the as-built part usually exhibits undesirable microstructure and unsatisfactory *** this work,WE43 parts were firstly fabricated by PBF-LB and then subjected to heat *** a high densification rate of 99.91%was achieved using suitable processes,the as-built parts exhibited anisotropic and layeredmicrostructure with heterogeneously precipitated Nd-rich *** heat treatment,fine and nano-scaled Mg24Y5particles were ***,theα-Mg grainsunderwent recrystallization and turned coarsened slightly,which effectively weakened thetexture intensity and reduced the *** a consequence,the yield strength and ultimate tensile strength were significantly improved to(250.2±3.5)MPa and(312±3.7)MPa,respectively,while the elongation was still maintained at a high level of 15.2%.Furthermore,the homogenized microstructure reduced the tendency of localized corrosion and favoredthe development of uniform passivation ***,the degradation rate of WE43 parts was decreased by an order of ***,in-vitro cell experiments proved their favorable biocompatibility.

关键词： laser-beam powder bed fusion WE43 alloys heat treatment mechanical performance biodegradation behavior

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