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Development and characterization of 3D-printed electroconductive pHEMA-co-MAA NP-laden hydrogels for tissue engineering

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Bio-Design and Manufacturing 2024年第3期7卷 262-276页

作者： Sara De Nitto Aleksandra Serafin Alexandra Karadimou Achim Schmalenberger John J.EMulvihill Maurice N.Collins dibris Polytechnic Inter-School Section University of Genoa16126 GenoaItaly School of Engineering Bernal InstituteUniversity of LimerickLimerick V94 T9PXIreland School of Natural Sciences Department of Biological SciencesUniversity of LimerickLimerick V94 T9PXIreland Health Research Institute University of LimerickLimerick V94 T9PXIreland AMBER University of LimerickLimerick V94 T9PXIreland

Tissue engineering(TE)continues to be widely explored as a potential solution to meet critical clinical needs for diseased tissue replacement and tissue *** this study,we developed a poly(2-hydroxyethyl methacrylate-co-methacrylic acid)(pHEMA-co-MAA)based hydrogel loaded with newly synthesized conductive poly(3,4-ethylene-dioxythiophene)(PEDOT)and polypyrrole(PPy)nanoparticles(NPs),and subsequently processed these hydrogels into tissue engineered constructs via three-dimensional(3D)*** presence of the NPs was critical as they altered the rheological properties during ***,all samples exhibited suitable shear thinning properties,allowing for the development of an optimized processing window for 3D *** were 3D printed into pre-determined disk-shaped configurations of 2 and 10 mm in height and diameter,*** observed that the NPs disrupted the gel crosslinking efficiencies,leading to shorter degradation times and compressive mechanical properties ranging between 450 and 550 *** conductivity of the printed hydrogels increased along with the NP concentration to(5.10±0.37)×10^(−7)S/*** vitro studies with cortical astrocyte cell cultures demonstrated that exposure to the pHEMA-co-MAA NP hydrogels yielded high cellular viability and proliferation ***,hydrogel antimicrobial studies with staphylococcus epidermidis bacteria revealed that the developed hydrogels affected bacterial *** together,these materials show promise for various TE strategies.

关键词： Conductive nanoparticles Hydroxyethyl methacrylate(HEMA) Ultraviolet(UV)polymerization 3D printing

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DUSM： A Method for Requirements Specification and Refinement Based on Disciplined Use Cases and Screen Mockups

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Journal of Computer Science & Technology 2018年第5期33卷 918-939页

作者： Gianna Reggio Maurizio Leotta Filippo Ricca Diego Clerissi Department of Informatics Bioengineering Robotics and Systems Engineering (DIBRIS) University of Genova Genova 16146 Italy

In this work, we present DUSM （Disciplined Use Cases with Screen Mockups）, a novel method for describing and refining requirements specifications based on disciplined use cases and screen mockups. Disciplined use cases are characterized by a quite stringent template to prevent common mistakes, and to increase the quality of the specifications. Use cases descriptions are formulated in a structured natural language, which allows to reach a good level of precision, avoiding the need for further notations and complex models. Screen mockups are precisely associated with the steps of the use cases scenarios and they present the corresponding GUIs （graphical user interfaces） as seen by the human actors before/after the steps executions, improving the comprehension and the expression of the non-functional requirements on the user interface. DUSM has been proposed and fine-tuned during several editions of a software engineering course at the University of Genova. Then, by means of a series of case studies and experiments, we validated the method and evaluated： 1） its effectiveness in improving the comprehension and, in general, the quality of the produced requirements specification, and 2） its applicability in the industry, where the method has been found useful and not particularly onerous.

关键词： requirements specification use case screen mockup empirical validation graphical user interface (GUI) user interface requirements

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A thermodynamic Approach to Rate Equations in Continuum Physics

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Journal of Physical Science and Application 2017年第6期7卷 15-23页

作者： Angelo Morro dibris University of Genoa Genova 16145 Italy

The paper addresses the formulation of rate equations, via objective time derivatives, within continuum physics. The concept of objectivity is reviewed and distinction is made with material frame-indifference whose meaning is restricted to the invariance of the balance equations relative to Galilean frames. Objective time derivatives are defined to leave the tensor character of the appropriate field invariant within the set of Euclidean frames. Rate equations are required to involve objective time derivatives and to be consistent with the second law of thermodynamics. Here the general structure of objective time derivatives is established and the known derivatives of the physical literature are shown to be particular cases. Next, to fix ideas, a rate equation is considered for the model of heat conduction via a generalization of the Maxwell-Cattaneo equation with higher-order gradients as in the Guyer-Krumhansl equation. The thermodynamic restrictions are investigated and the expected effects, of the selected derivative of the heat flux, on the stress tensor are derived.

关键词： Objective derivatives rate equations thermodynamic consistency

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Test Bench for Robotics and Autonomy： Overview and Test Results

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Journal of Mechanics Engineering and Automation 2013年第6期3卷 378-386页

作者： Andrea Merlo Andrea Biggio Giuseppe Casalino EnricaZereik Thales Alenia Space Italy Turin 10146 Italy dibris Engineering Faculty University of Genoa Genoa 16145 Italy CNR-ISSIA National Research Council Genoa 16149 Italy

In this paper, the TAS-I （Thales Alenia Space-Italy） Test Bench for Robotics and Autonomy （TBRA） is presented. It is based on a flexible and modular software architecture （Framework Engine）, in which each functional module （representing the GNC subsystems） implements a key functionality of the GNC （Guidance Navigation and Control）. Modules communicate by means of standardised interfaces designed for exchange of necessary information among the modules composing the entire system. This approach permits the interchange-ability of each subsystem without affecting the overall functionalities of the GNC system. In this paper, the TBRA system, together with the implemented functional modules will be described. Tests results will be reported and future development will be discussed.

关键词： Autonomous exploration rover test bench for robotics and autonomy framework engine.

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