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Like a G6-nal:transcriptional control of G-protein coupled receptors during oligodendroglial development

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Neural regeneration research 2025年第7期20卷 2001-2002页

作者： Tim Aberle Michael Wegner Institut f.r.Biochemie Friedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Multilayered control of myelination:Quick,saltatory conduction of action potentials along nerve fibers requires the electrical insulation of axons by myelinating *** the central nervous system,this role is taken up by *** are marked by the expression of the lineage determinants Sox10 and Olig2 and arise from oligodendrocyte precursor cells(OPCs)during embryonal *** the majority of OPCs diff.r.ntiate into mature oligodendrocytes when nearby axonal segments require myelination,a small subpopulation of OPCs persist as a progenitor ***,the timing of myelination and maintenance of the OPC pool both need to be precisely *** transcription factors either positively or negatively affect oligodendrocyte diff.r.ntiation and maintenance of the OPC pool as components of a complex gene regulatory network(reviewed in Sock and Wegner,2021).Network activity is additionally influenced by extracellular signaling molecules that bind to receptors on the oligodendroglial cell surface and activate intracellular signaling *** the receptors are linked to the network is poorly understood so f.r.but pivotal to understanding the overall regulation of central nervous system(CNS)myelination in response to environmental *** insights were recently gained f.r.Gpr37(Schmidt et al.,2024),a G-protein coupled receptor(GPCr)with known relevance in diff.r.ntiating oligodendrocytes(Yang et al,2016).

关键词： gained insulation conduction

Translocator protein and neurodegeneration: insights from Alzheimer’s disease

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Neural regeneration research 2025年第4期20卷 1090-1091页

作者： Arpit Kumar Pradhan rainer rupprecht Gerhard rammes Klinik f.r.Anaesthesiologie und Intensivmedizin der Technischen Universität München Klinikum rechts der IsarMunichGermany Graduate School of Systemic Neurosciences Ludwig-Maximilians-Universität MünchenMartinsriedGermany department of Psychiatry and Psychotherapy University RegensburgRegensburgGermany

The 18 kda translocator protein(TSPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell prolif.r.tion,and maintenance of mitochondrial health(rupprecht et al.,2022,2023).TSPO is expressed in both peripheral organs and the central nervous system,with a more pronounced expression in tissues that produce *** main reason why TSPO has garnered so much attention is because it plays a key role in neurosteroidogenesis by transf.r.ing cholesterol from the outer to the inner mitochondrial membrane,which is the rate-limiting step in neurosteroid synthesis.A cholesterol-recognizing amino acid consensus domain has been identified in the cytosolic C terminus of the TSPO protein by both in vitro and site-directed mutagenesis experiments(Li et al.,2001).However,the role of TSPO in the process of neurosteroid synthesis has been challenged by several studies,particularly TSPO knockout models,which suggest that TSPO removal does not affect the phenotype or the system’s viability(Tu et al.,2014).However,ligands targeting TSPO have been shown to enhance levels of neurosteroids which suggests that neurosteroidogenesis is one of the major functional roles mediated by the TSPO protein.

关键词： cholesterol organs

THE rEGULAr COMPONENTS Of THE AUSLANdEr-rEITEN QUIVEr Of A TILTEd ALGEBrA

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Chinese Annals of Mathematics,Series B 1988年第1期9卷 1-18页

作者： CLAUS MICHAEL rLNGEL fakultt f.r.Mathematik Universitt d-4800 bielefeld 1 West-germany

Let B be a connected finite-dimensional hereditary algebra of infinite *** is shown that there exists a regular tilting B-module if and only if B is wild andhas at least three simple *** this way,the author determines the possible f.r. ofregular components which arise as a connecting component of the Auslander-reitenquiver Γ(A)of a tilted algebra *** second result asserts that f.r.a tilted algebra A,any regular component of Γ(A)which is not a connecting component,is quasi-serial.

关键词： Th THE rEGULAr COMPONENTS Of THE AUSLANdEr-rEITEN QUIVEr Of A TILTEd ALGEBrA

A Brief Overview of Hard-Thermal-Loop Perturbation Theory

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Communications in Theoretical Physics 2012年第3期57卷 409-421页

作者：苏楠 fakultt f.r.Physik Universitt BielefeldD-33615 BielefeldGermany

The poor convergence of quantum field theory at finite temperature has been one of the main obstacles in the practical applications of thermal QCd f.r.*** we briefly review the progress of hard-thermal-loop perturbation theory (HTLpt) in reorganizing the perturbative expansion in order to improve the *** quantum mechanical anharmonic oscillator is used as a simple example to show the breakdown of weak-coupling expansion,and variational perturbation theory is introduced as an effective resummation scheme f.r.divergent weak-coupling *** discuss HTLpt thermodynamic calculations f.r.QEd,pure-glue QCd,and QCd with N f=3 up to three-loop *** results suggest that HTLpt provides a systematic framework that can be used to calculate both static and dynamic quantities f.r.temperatures relevant at LHC.

关键词： thermal field theory resummation hard thermal loops

Application of.r.active Ion Etching to the fabrication of Microstructure on Mo/Si Multilayer

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Chinese Physics Letters 1999年第9期16卷 665-666页

作者： LE Zi-chun L.dreeskornfeld S.rahn r.Segler U.Kleineberg U.Heinzmann Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012 fakultät f.r.Physik Universität BielefeldUniversitatsstraβe 25D-33615 BielefeldGermany

Mo/Si muitilayer mirrors(30 periods,doublelayer thickness 7nm)with the AZ-Pf514 resist pattern whose smallest lines and spaces structure was 0.5pm were etched by reactive ion etching(rIE)in a fluorinated *** etch rate,selectivity and etch profile were investigated as a function of the gas mixture,pressure,and plasma rf *** groove depth and the etch proHle were investigated by an atomic f.r.e microscope bef.r. rIE,after rIE and after resist removal.

关键词： Mo/Si smallest selectivity

The Short Local Algebras of dimension 6 with Non-projective reflexive Modules

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Communications in Mathematics and Statistics 2023年第2期11卷 195-227页

作者： Claus Michael ringel fakultät f.r.Mathematik Universität BielefeldPO Box 10013133501 BielefeldGermany

Let A be a finite-dimensional local algebra over an algebraically closed field,let J be the radical of *** modules we are interested in are the finitely generated left *** are always reflexive,and an algebra is self-injective iff allmodules are *** discuss the existence of non-projective reflexive modules in case A is not *** assume that A is short(this means that J^(3)=0).In a joint paper with Zhang Pu,it has been shown that 6 is the smallest possible dimension of A that can occur and that in this case the following conditions have to be satisfied:J^(2)is both the left socle and the right socle of A and there is no unif.r. ideal of length *** present paper is devoted to showing the converse.

关键词： Short local algebra reflexive module Gorenstein-projective module Bristle Atom Bar Bristle-bar layout

An inverted triplesalen ligand by a convergent synthesis and its influence on trinuclear fe_3~Ⅲ complexes

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Science China Chemistry 2012年第6期55卷 951-966页

作者： fELdSCHEr Bastian KrICKEMEYEr Erich MOSELAGE Marc THEIL Hubert HOEKE Veronika KAISEr Yvonne STAMMLEr Anja BGGE Hartmut GLASEr Thorsten Lehrstuhl f.r.Anorganische Chemie I Fakultt für Chemie Universitt Bielefeld Universittsstr. 25 D-33615 Bielefeld Germany

The inverted triplesalen ligand H6feldMe has been synthesized from 2,4,6-trif.r.yl-phloroglucinol and a ketimine salen half-unit in a convergent synthesis. NMr, Ir, and UV-vis spectroscopy reveal that this ligand is not in the O-protonated tau- tomer but in the N-protonated tautomer with substantial heteroradialene contribution. This ligand and the conventional triple- salen ligand H6talent-au2 have been used to synthesize the trinuclear fem complexes [（feldMe）（feCl）3] and [（talent-Bu2）（feC1）3], respectively. The molecular structures of these complexes were obtained by single-crystal X-ray dif.r.ction. Two trinuclear fem complexes of [（feldMe）（feCl）3] dimerize via two fe-phenolate bonds, whereas due to steric hindrance no dimerization is observed f.r.[（talent-Bu2）（feC1）3]. The structural data also reveal some heteroradialene contribution in the trinuclear complexes. Whereas UV-vis and MOlSbauer spectroscopy are not suitable to distinguish between the two complexes, fT-Ir spectra show characteristic features due to the diff.r.nt substitution patterns of the conventional and the inverted triplesalen ligands. Another handle is provided by electrochemistry. Whereas both complexes exhibit an irreversible oxidation wave （0.94 V vs. fc＋/fc f.r.[（feldMe）（feC1）3] and 0.84 V vs. fc~/fc f.r.[（talent-Bu2）（feC1）3]）, which is assigned to the oxidation of the central backbone, higher potential oxidations are reversible f.r.[（talent-Bu2）（feC1）3]） but irreversible f.r.[（feldMe）（feC1）3]. This is attributed to the reversible oxidation of the terminal phenolates in the di-tert-butyl substituted [（talentBu2）（feCl）3] in contrast to the mono-methyl-substituted phenolates in [（feld^ae）（feC1）3]. The magnetic properties of [（talen^-Bu2）（feC1）3] reveal a very small f.r.omagnetic coupling with significant zero-field splitting of the feul S = 5/2 ions. In contrast, the dimerization of two trinu- clear complexes in [（feldMe）（feCl）3] results in antif.r.omagnetic interactions between the two pheno

关键词： magnetic properties iron complexes spin-polarization triplesalen

Leader-follower: Human-centered intention-guided controller f.r.novel SuperLimb with application to load-carrying scenarios

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Science China Technological Sciences 2025年第1期 325-338页

作者： Qinghua ZHANG Xianglong LI Hongwei JING Kerui SUN Yuancheng LI Sikai ZHAO Lele LI Haotian JU Ziqi WANG rui WU Tianjiao ZHENG Jie ZHAO Yanhe ZHU The State Key Laboratory of.r.botics and System Harbin Institute of Technology The Learning Algorithms and Systems Laboratory School of Engineeringécole Polytechnique Fédérale de Lausanne

Supernumerary robotic arms(SuperLimb) are a new type of wearable robot that works closely with humans as a third hand to augment human operation capability. Accurate conveyance of wearers' intentions, allocation of.r.les, and humancentered interaction considerations are the key points in the process of human–SuperLimb collaboration. This paper proposes a human-centered intention-guided leader–follower controller that relies on the dynamic modeling of SuperLimb with application to load-carrying scenarios. The proposed leader–follower controller takes the human as the leader and the SuperLimb as the follower, achieving effective inf.r.ation communication, autonomous coordination, and good f.r.e compliance between SuperLimb, humans, and the environment under human safety assurance. f.r.t, the human–SuperLimb dynamic system is modeled to achieve f.r.e interaction with the environment and wearer. Second, to achieve the precise intention extraction of humans, pose data from five visual odometry sensors are fused to capture the human state, the generalized position, the velocity of hands, and the surface electromyography signals from two myoelectric bracelets sensors are processed to recognize the natural hand gestures during load-carrying scenarios by a designed Swin transf.r.er network. Then, based on the real-time distance detection between human and mechanical limbs, the security assurance and f.r.e-compliant interaction of the human–SuperLimb system are realized. finally, the human hand muscle intention recognition, human–robot safety strategy verification,and comparative load-carrying experiments with and without the proposed method are conducted on the SuperLimb *** showed that the task parameters are well estimated to produce more reasonable planning trajectories, and SuperLimb could well understand the wearer's intentions to switch diff.r.nt SuperLimb actions. The proposed sensor-based human–robot communication framework motivates future studies of o

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On the Small Time Asymptotics of the dynamical Φ_(1)^(4)Model

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Acta Mathematica Sinica,English Series 2021年第3期37卷 436-446页

作者： Bing Guang CHEN Xiang Chan ZHU Academy of Mathematics and Systems Science Chinese Academy of ScienceBeijing 100190P.R.China department of Mathematics University of BielefeldD-33615 BielefeldGermany

In this paper,we establish a small time large deviation principle(small time asymptotics)f.r.the dynamicalΦ_(1)^(4)model,which not only involves study of the space-time white noise with intensity√ε,but also the inv... 详细信息

关键词： Φ_(1)^(4)model space-time white noise small time asymptotics large deviation