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differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo diana Simón Johnny di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,tEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and tEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted tEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic tEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez María Fernanda González Ana María Avalos Lisette Leyton Cellular Communication laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced Center for Chronic diseases(ACCdiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de Ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKt)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKt/mammalian target of rapamycin(mtOR),αvβ3 integrin/PI3K/AKt/connexin 43,and Notch/PI3K/AKt *** targeting the inactivation of the PI3K/AKt cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKt pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction thy-1(Cd90)

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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Neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela Synaptic Structure laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative Neurobiology Section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (Ad) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (Schirinzi et al.,2020).Syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in Ad,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

Electronic structure of the rare-earth superstoichiometric dihydride GdH_(2.25)

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Rare Metals 2022年第8期41卷 2794-2799页

作者： Zahia Ayat Aomar Boukraa Abdelouahab Ouahab Bahmed daoudi Fac.des Mathématiques et des sciences de la Matière Lab.Développement desénergies nouvelles et renouvelables dans les zones arides et sahariennesUniversity of Ouargla30000OuarglaAlgeria département des sciences de la Matière Facultédes Sciences Exactes et des Sciences de la Nature et de la VieUniversitéMohamed Khider Biskra07000BiskraAlgeria

With the WIEN2 k simulation code,ab initio calculations of electronic structure and of equilibrium properties for the superstoichiometric rare-earth dihydride GdH_(2.25)using the full-potential linearized augmented plane-wave(FP-laPW)method within density functional theory(dFt)in generalized gradient approximation(GGA)were *** lattice parameter,bulk modulus,pressure derivative,density of states(dOS)and energy band structures were *** GGA-optimized lattice parameter agrees much better with the experimental findings than the local density approximation(LdA)*** non-negligible electronic dOS at Fermi level confirms that GdH_(2.25)has a metallic *** Fermi energy(E_(F))falls at a level where most of the states are rare-earth 5 d conduction states while negligible contributions of both interstitial(tetrahedral and octahedral)H s states are observed near *** is found that hybridization exists between s electronic orbital of both interstitial H atoms and d electronic orbitals of Gd.

关键词： Rare-earth dihydrides GdH_(2.25) density functional theory Ab initio calculations WIEN2k

On stability behaviors of 5d M-theory black objects

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Communications in theoretical Physics 2024年第5期76卷 94-101页

作者： Adil Belhaj Abderrahim Bouhouch departement de Physique Equipe des Sciences de la matiere et du rayonnementESMaR Faculte des SciencesUniversite Mohammed V de RabatRabatMorocco

Using N=2 supergravity formalism,we investigate certain behaviors of five-dimensional black objects from the compactification of M-theory on a Calabi-Yau *** manifold has been constructed as the intersection of two homogeneous polynomials of degrees(ω+2,1)and(2,1)in a product of two weighted projective spaces given by WP^(4)(ω,1,1,1,1)×P^(1).First,we determine the allowed electric charge regions of the BPS and non BPS black holes obtained by wrapping M2-branes on appropriate two cycles in such a proposed Calabi-Yau *** that,we calculate the entropy of these solutions which takes a maximal value corresponding to ω=1 defining the ordinary projective space P^(4).For generic values of ω,we show that the non BPS states are ***,we conduct a similar study of five-dimensional black *** the allowed magnetic charge regions of the BPS and non BPS black stringy solutions derived from M5-branes on dual divisors,we calculate the tension taking a minimal value for P^(4).By determining the recombination factor,we show that the non-BPS black string states are stable in the allowed regions in the magnetic charge space.

关键词： M-theory Calabi-Yau manifolds black holes black strings stability behaviors

Generation of different Classes of Multipartite Entanglement Using Cavity-QEd

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Communications in theoretical Physics 2018年第2期69卷 131-136页

作者： Mustapha Ziane Rachid El Guerbouz Fatima-Zahra Siyouri Morad El Baz Equipe sciences de la Matière et du Rayonnement Département de Physique Faculté des sciences Université Mohammed V Av.Ibn Battouta

Using a system of cavity quantum electrodynamics （QEd） we present two schemes for multipartite entan- glement generation. In the first scheme, a three-level atom is interacting with three cavities successively. In the second one, two three-level atoms are interacted with a coherent optical cavity. these protocols allow us to generate the six c/asses of tripartite entanglement （GHZ, W, A-B-C, AB-C, C-AB, and B-AC class states） by controling the interaction time between atoms and cavities. Moreover, they allow us to generate entanglement between the cavity fields degrees of freedom （from the first scheme）, and a mixed entanglement between the cavity field degrees of freedom and the atomic degrees of freedom.

关键词： entanglement coherent states cavity QE-d GHZ states W states

On M-theory on real toric fibrations

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Communications in theoretical Physics 2021年第8期73卷 67-74页

作者： A Belhaj H Belmahi M Benali S-E Ennadifi Y Hassouni Y Sekhmani Equipe des sciences de la matière et du rayonnement ESMaRDépartement de Physique Facultédes SciencesUniversitéMohammed V de RabatMorocco LHEP-MS Département de PhysiqueFaculte des SciencesUniversitéMohammed V de RabatMorocco

Borrowing ideas from elliptic complex geometry, we approach M-theory compactifications on real fibrations. Precisely, we explore real toric equations rather than complex ones exploited in F-theory and related dual models. these geometries have been built by moving real toric manifolds over real bases. Using topological changing behaviors, we unveil certain data associated with gauge sectors relying on affine lie symmetries.

关键词： real fibrations M-theory toric real manifolds affine lie symmetries

Long-term effect of fire on herbaceous species diversity in oriental beech (Fagus orientalis Lipsky) forests in northern Iran

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Forestry Studies in China 2012年第4期14卷 260-267页

作者： Mohammad Naghi AdeL Hassan POURBABAEI Ali OMIdI david POtHIER department of Forestry Natural Resources FacultyUniversity of Guilan department of Forestry Natural Resources Office Centre d'étude de la forêt (CEF) et département des sciences du bois et de la forêt Pavillon Abitibi-Price2405 rue de la TerrasseUniversité Laval

We studied the long-term impacts of natural burning on herbaceous species diversity 37 years after a fire occurred in the Roudbar forests of Guilan Province, northern Iran. Numerous studies have examined short-term changes in understory vegetation following wildfire; however, very few long-term studies are available or changes inferred from retrospective studies based on chro- nosequences. For this study, 170 ha of forest （85 ha, burned areas; 85 ha, unburned areas） were surveyed. Because the 1000 m2 plots were too large for detailed measurements of herbaceous species, we determined a sub-sample size according to the Whittaker＇s nested plot sampling protocol and minimal areas method. Hence, sub-plots of 32 m2 were used for herbaceous species measurements, which consisted of percent cover of each species based on the domin criterion. We measured plant diversity （Shannon-Wiener index）, spe- cies richness （Margalef＇s index）, and evenness （Smith-Wilson index）. Mean percent cover, together with diversity, richness and even- ness, increased markedly in burned areas compared to unburned controls. this suggests that the biodiversity of these forests could be restored within 37 years after fire. However, the abundance of invasive species such as Rubus fruticosus and Bromus benekenii increased significantly in burned areas, but these could be controlled by relevant silvicultural operations.

关键词： fire diversity richness evenness beech forest northern Iran

Forest aboveground biomass estimates in a tropical rainforest in Madagascar: new insights from the use of wood specific gravity data

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Journal of Forestry Research 2015年第1期26卷 47-55页

作者： tahiana Ramananantoandro Herimanitra P.Rafidimanantsoa Miora F.Ramanakoto département des Eaux et Foreêts Ecole Supérieure des Sciences AgronomiquesUniversité d'Antananarivo Groupe Ecole Supérieure du bois Atlanpo?le Rue Christian Pauc

to generate carbon credits under the Reducing Emissions from deforestation and forest degradation program（REdd＋）, accurate estimates of forest carbon stocks are needed. Carbon accounting efforts have focused on carbon stocks in aboveground biomass（AGB）.Although wood specific gravity（WSG） is known to be an important variable in AGB estimates, there is currently a lack of data on WSG for Malagasy tree species. this study aimed to determine whether estimates of carbon stocks calculated from literature-based WSG values differed from those based on WSG values measured on wood core samples. Carbon stocks in forest biomass were assessed using two WSG data sets：（i） values measured from 303 wood core samples extracted in the study area,（ii） values derived from international databases. Results suggested that there is difference between the field and literaturebased WSG at the 0.05 level. the latter data set was on average 16 % higher than the former. However, carbon stocks calculated from the two data sets did not differ significantly at the 0.05 level. Such findings could be attributed to the form of the allometric equation used which gives more weight to tree diameter and tree height than to WSG. the choice of dataset should depend on the level of accuracy（tier II or III） desired by REdd＋. As higher levels of accuracy are rewarded by higher prices, speciesspecific WSG data would be highly desirable.

关键词： Biomass estimates Carbon stocks data quality Madagascar REdd+ Wood specific gravity