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Journal of Biosciences and Medicines 2020年第7期8卷 28-34页

作者： Monique Brigitte Ouattara Jean Hubert Bationo Martin Kiendrebeogo Odile Germaine Nacoulma Laboratoire de biochimie et Chimie Appliquées (LABIOCA) Université Joseph KI-ZERBO Unité de Formation et de Recherche en Sciences de la Vie et de la Terre Département de Biochimie-Microbiologie Ouagadougou Burkina Faso

Objective: The aim of this study is to screen chemical composition and to evaluate the acute general toxicity of leaves aqueous extracts from Sesbania pachycarpa dC. (Fabaceae), used in traditional medicine in Burkina Faso to treat malaria, helminthiasis, and aqueous extracts of the leaves from Indigofera berhautiana Gillet (Fabaceae) used to treat hepatitis and typhoid fever. Methods: Aqueous decoction of leaves from Sesbania pachycarpa dC. or Indigofera berhautiana Gillett which are the form of use recommended by traditional health practitioners, were used for tests. Aqueous extracts used to evaluate the acute toxicity, were studied on mice of strain NMRI. For the toxicity study, the doses of the aqueous extracts were respectively 5 mg/kg, 50 mg/kg, 300 mg/kg and 2000 mg/kg of body weight. Phytochemical screening was done to identify the phytochemicals contained in extracts. Results: Aqueous extracts of two species: Sesbania pachycarpa dC., Indigofera berhautiana Gillet were not toxic at the maximum dose of 2000 mg/kg of body weight. Phytochemical screening, showed coumarins, flavonoids, tannins, polyphenols compounds, steroids and/or triterpenes and saponosides in the aqueous extracts of the two species. Alkaloids were identified in Sesbania pachycarpa aqueous extract.

关键词： Sesbania pachycarpa dC. Indigofera bergautiana Gillet Aqueous Extracts Acute General Toxicity NMRI Strain Phytochemicals Compounds

Effect of the ethanolic Extract of Khaya senegalensis on Some Biochemical Parameters on Rabbit’s in Glucose Overload Condition

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American Journal of Plant Sciences 2015年第1期6卷 240-248页

作者： Essé Agossou Mélanie Ahokpe Justin Behanzin Marcellin Takin Ganiou Yessoufou Loica Zohoun Lamine Baba-Moussa Alphonse Sezan Laboratoire de Biomembranes et Signalisation Cellulaire département de Physiologie Animale Université d’Abomey-Calavi Cotonou Benin Laboratoire de Biologie et de Typage moléculaire en microbiologie département de biochimie et de Biologie Cellulaire Université d’Abomey Calavi Cotonou Benin

The effect of the ethanolic extract Khaya senegalensis on some biochemical parameters was tested in rabbits with normal glucose and glucose overload. Phytochemical screening after three batches of 6 rabbits race (TBd) were treated with the extract in oral doses of respectively 10, 25 and 50 mg/kg body weight for 30 days;three other groups receiving respectively these doses of the extract were placed under a priori temporary overload of glucose;a control group received instead distilled water treatment. Blood glucose, triglycerides and total cholesterol were measured by spectrophotometry and weight gain of the animals was performed at the beginning of the experiment and every 2 weeks during the study period. The phytochemical screening revealed the presence of polyphenolic compounds (majority) of saponins of anthracene derivatives and steroids in the extract. The test results indicate that under the dose of 50 mg/kg body weight (BW) there was a significant decrease (p d glucose after 24 hours. The extract had no effect on the lipid profile or body weight of rabbits.

关键词： Rabbit Khaya senegalensis Glucose Lipid Profile

Evaluation of Acute Toxicity, Antioxidant and Antibacterial Potential of Leaves Extracts from Two Anacardiaceae’s Species: Lannea microcarpa Engl. &K. Krause and Mangifera indica L.

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Journal of Biosciences and Medicines 2022年第10期10卷 125-134页

作者： Monique Brigitte Ouattara Jean Hubert Bationo Martin Kiendrebeogo Odile Germaine Nacoulma Laboratoire de biochimie et Chimie Appliquées (LABIOCA) Université Joseph KI-ZERBO Unité de formation et de recherche en sciences de la vie et de la terre Département de Biochimie-Microbiologie Ouagadougou Burkina Faso

Background: Leaves of Mangifera indica L or Lannea microcarpa Engl. & K. Krause are used in traditional medicine in Burkina Faso to treat bacterial, parasitic or metabolic diseases. Objective: The aim of this study is to evaluate the acute general toxicity, antioxidant potential and antibacterial activitiy of leave’s aqueous extracts from Lannea microcarpa Engl. and K. Krause and Mangifera indica L. The use of these plants in traditional medicine motivated our choice to lead scientific studies. Methods: The aqueous decoction of the leaves is the form of use recommended by traditional healers. We used the same type of extracts for studies. Acute toxicity was studied in NMRI strain mice, with the dose of 2000 mg/kg body weight, for each plant species. The antioxidant activity is evaluated by the method of reduction of radical dPPH. The phytochemical compounds were detected with specific reagent: Alcaloids with dragendorff’s reagent, Flavonoids with ammonia (NH4OH), Polyphenols and tannins are revelated by ferric chloride (FeCl3). Saponosides were revelated by their foaming power property. Bacterial inhibiting activity is tested by measuring the diameters’ inhibition of extracts on reference strains. Results: The aqueous extracts were not toxic at the maximum dose of 2000 mg/kg body weight, for each plant species. The extracts showed an antioxidant activity with an IC50, 20 μg/ml for Lannea microcarpa and 18 μg/ml for Mangifera indica. The extracts showed no bacterial activity on three strains of bacteria tested: Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The phytochemicals we have identified are for L. microcarpa: tannins and phenolics compounds, triterpenes, saponosides. We identified in M. indica’s extracts: tannins and phenolics compounds, triterpenes, saponosides and flavonoids.

关键词： Lannea microcarpa Mangifera indica Toxicity Antioxidant Activity dPPH Antibacterial Activity Phytochemical Compounds

Fermentation Effect on the Nutrient and Antinutrient Composition of Senegalia macrostachyaand Parkia biglobosaSeeds: A Comparative Study

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Food and Nutrition Sciences 2020年第7期11卷 726-740页

作者： Aimée W. d. B. Guissou Charles Parkouda Coulibaly K. Anaïs Traoré Korotimi Edwige Bahanla Oboulbiga Aly Savadogo département Technologie Alimentaire (dTA) Institut de Recherche en Sciences Appliquées et Technologies (IRSAT) Centre National de la Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso Laboratoire de biochimie et d’Immunologie Appliquée Département de Biochimie-Microbiologie Université Joseph Ki-Zerbo Ouagadougou Burkina Faso

This study aimed to evaluate the effect of the fermentation on the nutrient and antinutrient composition of Senegalia macrostachya and Parkia biglobosa seeds. For condiments production, the raw seeds were cleaned, cooked, drained, washed, cooked, drained and fermented. Results show that the pH increased (from 6.09 to 7.76 and from 6.99 to 7.92) from the onset of the fermentation till 48 h during fermentation of <

关键词： Senegalia macrostachya Parkia biglobosa Fermentation Nutrients Phytates

Production of Vinegar Mango Using Acetobacter tropicalis CRSBAN-BVA1 and CRSBAN-BVK2 Isolated from Burkina Faso

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Food and Nutrition Sciences 2023年第1期14卷 26-37页

作者： Assiètta Ouattara Marius K. Somda Cheik A. T. Ouattara Yerobessor dabiré Mahamadi Nikiéma Alfred S. Traoré Aboubakar S. Ouattara Laboratoire de microbiologie et de Biotechnologies Microbiennes (LAMBM) Centre de Recherche en Sciences Biologiques Alimentaires et Nutritionnelles (CRSBAN) Département de Biochimie et Microbiologie Université Joseph Ki-Zerbo Ouagadougou Burkina Faso Laboratoire de biochimie Biotechnologie Technologie Alimentaire et Nutrition (LABIOTAN) Centre de Recherche en Sciences Biologiques Alimentaires et Nutritionnelles (CRSBAN) Département de Biochimie et Microbiologie Université Joseph Ki-Zerbo Ouagadougou Burkina Faso Université de Fada N’Gourma Institut Supérieur du Développement Durable (ISDD) Fada N’Gourma Burkina Faso

Production and quality of vinegar from mango juice was evaluated using a two steps production procedure. The first step of fermentation was done using Saccharomyces cerevisae KVL013 for 7 days. The second step, an acetic fermentation was realized using two acetic acid bacteria: A. tropicalis CRSBAN-BVA1 and A. tropicalis CRSBAN-BVK2 for 21 days. Several parameters of the vinegar produced such as physico-chemical and sensory properties were determined. Microbial density during each step was monitored. Results showed that pH, alcoholic and acetic acid contents of vinegar were respectively 2.97%, 7% and 4.54% g/ml respectively by using A. tropicalis CRSBAN-BVA1 and 3.02%, 7% and 4.32% g/ml with A. tropicalis CRSBAN-BVK2. Sensory evaluation revealed that the vinegar was acceptable to the panellists. Results of microbial density showed that the maximum concentration of cell biomass produced was 4.32 × 108 and 4.25 × 108 CFU/ml respectively for CRSBAN-BVA1 and CRSBAN-BVK2.

关键词： Mango Saccharomyces cerevisae Acetobacter tropicalis Fermentation Vinegar

Impact of Health and Nutrition Interventions in the Prevention and Recovery of Child Malnutrition in Sub-Saharan Africa from 2010 to 2020: Review Article

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Health 2022年第7期14卷 810-831页

作者： Sibiri Bougma Fatoumata Hama-Ba Franck Garanet Jeanne d’Arc Wendmintiri Kabre Flibert Guira Hama Cissé Bakary Tarnagda Souleymane Zio Aly Savadogo département Technologie Alimentaire Institut de Recherche en Sciences Appliquées et Technologies (IRSAT) Centre National de Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso département de biochimie et microbiologie Laboratoire de Biochimie et Immunologie Appliquée (LaBIA) Université Joseph KI-ZERBO Ouagadougou Burkina Faso département Biomédical et Santé Publique Institut de Recherche en Sciences de la Santé (IRSS) Centre National de Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso département Agroalimentaire Centre Universitaire Polytechnique de Gaoua Burkina Faso

Malnutrition is still a widespread public health problem worldwide. The objective of this review is to identify the most effective nutrition programs used in the prevention and management of child malnutrition in children under five years. Also, it is to suggest courses of action to improve interventions in the fight against malnutrition. The promotion of exclusive breastfeeding and food diversification improves the mothers’ knowledge and contributes to prevention of malnutrition. Food supplementation increases the weight/height ratio of malnourished children. The two programs combined bring better results on mothers’ feeding practices and children’s anthropometric data. This review has highlighted the importance of food supplementation and nutritional education in the management and prevention of child malnutrition. In addition, the combination of several approaches to good dietary practices brings better results. Finally, primary prevention can protect children from the harmful consequences of malnutrition.

关键词： Malnutrition Nutritional Education Breastfeeding Supplementation

Global Transcriptional Profile of Tranosema rostrale Ichnovirus Genes in Infected Lepidopteran Hosts and Wasp Ovaries

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Virologica Sinica 2009年第5期24卷 478-492页

作者： Asieh Rasoolizadeh Frédéric dallaire don Stewart Catherine Béliveau Renée Lapointe Michel Cusson Natural Resources Canada Canadian Forest Service Laurentian Forestry Centre 1055 du PEPS P.O. Box 10380 Stn. Ste-Foy Québec QC G1V 4C7 Canada département de biologie Université Laval Québec QC G1V 0A6 Canada département de biochimie et microbiologie Université Laval Québec QC G1V 0A6 Canada

The ichnovirus TrIV, transmitted by the endoparasitic wasp Tranosema rostrale to its lepidopteran host during oviposition, replicates asymptomatically in wasp ovaries and causes physiological dysfunctions in parasitized caterpillars. The need to identify ichnoviral genes responsible for disturbances induced in lepidopteran hosts has provided the impetus for the sequencing and annotation of ichnovirus genomes, including that of TrIV. In the latter, 86 putative genes were identified, including 35 that could be assigned to recognized ichnoviral gene families. With the aim of assessing the relative importance of each TrIV gene, as inferred from its level of expression, and evaluating the accuracy of the gene predictions made during genome annotation, the present study builds on an earlier qPCR quantification of transcript abundance of TrIV rep ORFs, in both lepidopteran and wasp hosts, extending it to other gene families as well as to a sample of unassigned ORFs. We show that the majority (91%) of putative ORFs assigned to known gene families are expressed in infected larvae, while this proportion is lower (67%) for a sample taken among the remaining ORFs. Selected members of the TrV and rep gene families are shown to be transcribed in infected larvae at much higher levels than genes from any other TrIV gene family, pointing to their likely involvement in host subjugation. In wasp ovaries, the transcriptional profile is dominated by a rep gene and a member of a newly described gene family encoding secreted proteins displaying a novel cysteine motif, which we identified among previously unassigned ORFs.

关键词： Polydnavirus Ichnovirus Choristoneura fumiferana Tranosema rostrale Transcriptional analysis

Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells

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Cell Research 2004年第3期14卷 188-196页

作者： Cecile CORBIERE,Bertrand LIAGRE,Faraj TERRO,Jean-Louis BENEYTOUT Laboratoire de biochimie UPRES EA 1085 Faculté de Pharmacie rue du docteur Marcland 87025 Limoges Cedex France Laboratoire de biochimie UPRES EA 1085 Faculté de Pharmacie rue du docteur Marcland 87025 Limoges Cedex France Service d'Histologie et Biologic Cellulaire Faculte de Medecine rue du docteur Marcland 87025 Limoges Cedex France Laboratoire de biochimie UPRES EA 1085 Faculté de Pharmacie rue du docteur Marcland 87025 Limoges Cedex France

Previously, we demonstrated that a plant steroid, diosgenin, altered cell cycle distribution and induced apoptosis in the human osteosarcoma 1547 cell line. The objective of this study was to investigate if the antiproliferative effect of diosgenin was similar for different human cancer cell lines such as laryngocarcinoma HEp-2 and melanoma M4Beu cells. Moreover, this work essentially focused on the mitochondrial pathway. We found that diosgenin had an important and similar antiproliferative effect on different types of cancer cells. In addition, our new results show that diosgenin-induced apoptosis is caspase-3 dependent with a fall of mitochondrial membrane potential, nuclear localization of AIF and poly (AdP-ribose) polymerase cleavage. diosgenin treatment also induces p53 activation and cell cycle arrest in the different cell lines studied.

关键词： diosgenin apoptosis p53 AIF caspase cancer cells.

One-step selective synthesis of branched 1-O-alkyl-glycerol/diglycerol monoethers by catalytic reductive alkylation of ketones

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Science China Chemistry 2010年第9期53卷 1953-1956页

作者： dAYOUB Wissam LEMAIRE Marc Laboratoire de Catalyse Synthèse et Environnement Institut de Chimie et Biochimie Moléculaires et Supramoléculaires(ICBMS)CNRSUMR5246Université Lyon 1

Branched 1-O-alkyl glycerol and diglycerol monoethers were obtained in good yields and high selectivity by a straightforward catalytic reductive alkylation of glycerol with relevant ketones in the presence of 0.5 mol%... 详细信息

关键词： glycerol monoether diglycerol monoether 1-O-alkylation Pd/C reduction

does Haptoglobin Phenotype Impact Infection Mortality?

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Advances in Biological Chemistry 2022年第5期12卷 143-150页

作者： Akissi Joelle Koffi Hugues Thierno Ahiboh Philémond By delphine Gabillard Roseline Affi Francisk Kouakou André Inwoley département de biochimie et Biologie Moléculaire UFR SPB Université Félix Houphouet Boigny Ivory Coast

Introduction: The physiological status of a subject and the pathophysiology in some diseases might be under the influence of haptoglobin phenotype. The objective of this work was to determine the relationship between mortality from HIV/AIdS infection and haptoglobin phenotype in a black population in Côte d’Ivoire. Methods: The study was conducted from a retrospective panel of 933 sera/plasma from the previous workup of the ANRS 12136 TEMPRANO trial at month 0 of patients in deferred-ART arms. For each subject, we determined the serum haptoglobin concentration, haptoglobin phenotype, and other variables from patient files from the TEMPRANO trial database. Statistical tests used were Chi-2, Fischer, and Kruskal-Wallis tests for non-gaussian distribution. We used the Kaplan-Meier method for survival analysis. Results: The distributions of the haptoglobin phenotypes were 32.3% for Hp 1-1, 39.5% for Hp 2-1 and 27.2% for Hp 2-2. The blood haptoglobin concentration seemed to be associated with haptoglobin phenotypes (p-value > 5%). The survival rate at M30 and for an extended follow-up up to 6 years was independent of haptoglobin phenotype (p-value > 5%). Besides, the haptoglobin phenotypes do not appear to be associated with Cd4+ T-cell count and with hemoglobin concentration. Conclusion: Haptoglobin phenotype seems to not impact the mortality of HIV/AIdS infection. However, given the antioxidant and immunomodulatory properties of some haptoglobin phenotypes, it would be relevant to seek out possible confounding factors indirectly associated with haptoglobin phenotypes and clinical or biological infection variables.

关键词： HIV/AIdS Infection Phenotype of Haptoglobin Cd4+ Cell Counts Hemoglobin Mortality