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Sexual audience affects male's reproduction investment without consequences on reproductive outputs

Insect Science 2022年第4期29卷 1170-1180页

作者： Philippe Louâpre Karen Muller Soline Bettencourt-Amarante denis Thiery Jérôme Moreau UMR CNRS 6282 Biogeosciences UniversitéBourgogne Franche-ComtéDijonFrance INRA UMR 1065 santéet Agroecologie du Vignoble Institut des Science de la Vigne et du VinVillenave d'OrnonCedexFrance INRA UMR 1065 SaveUniversitéde BordeauxBordeaux Sciences AgroVillenave d'OrnonCedexFrance

Males evolved plastic strategies to respond to male-male competition and exhibit adaptive traits and behaviors maximizing their access to the females and limiting sperm *** behaviors allow males to express quick responses to current sexual audience,that is,the number of nearby conspecifics prone to *** contrast,physiological responses are frequently delayed because they are constrained by the time and resources having to be mobilized to produce and export sperm and associated *** is especially critical in species for which males produce *** we investigated in what extend moth males(the tortricid moth Lobesia botrana)producing spermatophores exhibit plastic behavioral and physiological responses to different sexual audiences before and during mating and the consequences for their reproductive *** found that males adjusted their mating behaviors and spermatophore size to a potentially elevated risk of sperm competition perceived before *** addition,males responded to the closed presence of females during mating by reducing their mating ***,the various behavioral and physiological responses we highlighted here were not fully reflected in their reproductive performance as we did not reveal any effect on fecundity and fertility of their *** selective pressure exerted on males experiencing male-male competition could thus be sufficient to trigger adjustment in male mating behaviors but constrains physiological responses according to the perception of competition.

关键词： Lobesia borrund male-male compeition mating behavior sexual conflict sexual scletion sperm competition

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Expérience des parents faceàl’accompagnement pédiatrique en HAd:étude exploratoire qualitative Parents’Experience of Pediatric Home Care:A Qualitative Exploratory Study

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Psycho-Oncologie 2024年第2期18卷 137-146页

作者： Laure Salomé Jérémy Martin Camille Baussant-Crenn Cécile Flahault Institut de psychologie UniversitéParis CitéBouologne-Billancourt92774France Fondation Oeuvre de la Croix Saint-Simon Service d’hospitalisationàdomicileParis75019France Laboratoire de Psychopathologie et Processus de santéUR4057 UniversitéParis CitéBoulogne-Billancourt92774France

Aim:To investigate parents’experience of home care for children in oncology in order to identify the benefits,expectations,and possible difficulties *** and methods:A qualitative method was adopted,with non-directive interviews conducted with nine participants,then analyzed using thematic content ***:The main recurring themes in the discourse include:(1)relief,(2)positive representation of home,(3)positive representation of home care,and(4)negative representation of home *** these parents,home care appears to be positive overall,even though the introduction of home care is often reported as a source of stress for ***:These results must be interpreted with caution,but they do support previous research and highlight certain recommendations for further improving this experience,particularly for parents,but also for the sick child and the family.

关键词： Home care parents oncology pediatric children

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No touch radiofrequency ablation for hepatocellular carcinoma:a conceptual approach rather than an iron law

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 132-135页

作者： Olivier Seror Unitéde Radiologie Interventionnelle Hôpital AvicenneHôpitaux Universitaires Paris-Seine-Saint-DenisAssistance Publique Hôpitaux de ParisBobignyFrance UnitéMixte de Recherche 1162 Génomique Fonctionnelle des Tumeurs SolidesInstitut National de la Santéet de la Recherche MédicaleParis 7ParisFrance Unitéde Formation et de Recherche santéMédecine et Biologie Humaine UniversitéParis 13Communautéd’Universités et Etablissements Sorbonne Paris CitéBobignyFrance

Using conventional intra-tumoral radiofrequency ablation(IT-RFA)for the treatment of hepatocellular carcinoma(HCC)3 cm or smaller,high local tumor recurrence rates have been reported(up to 20%)despite initial complete ablation rates reaching 95%.This prompted the recommendation of no touch RFA(NT-RFA)for this indication in clinical practice since 2006(1).The rationale of NT-RFA is based on the assumption that the insertion of electrodes no longer inside but deliberately just outside the borders of the tumors could allow achieving more consistent tumoral ablation with safety margins,hence preventing further secondary local progression from unablated extranodular peripheral microscopic tumoral foci(2).

关键词： prompt ablation hence

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Impact of Health and Nutrition Interventions in the Prevention and Recovery of Child Malnutrition in Sub-Saharan Africa from 2010 to 2020: Review Article

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Health 2022年第7期14卷 810-831页

作者： Sibiri Bougma Fatoumata Hama-Ba Franck Garanet Jeanne d’Arc Wendmintiri Kabre Flibert Guira Hama Cissé Bakary Tarnagda Souleymane Zio Aly Savadogo département Technologie Alimentaire Institut de Recherche en Sciences Appliquées et Technologies (IRSAT) Centre National de Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso département de Biochimie et Microbiologie Laboratoire de Biochimie et Immunologie Appliquée (LaBIA) Université Joseph KI-ZERBO Ouagadougou Burkina Faso département Biomédical et santé Publique Institut de Recherche en Sciences de la Santé (IRSS) Centre National de Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso département Agroalimentaire Centre Universitaire Polytechnique de Gaoua Burkina Faso

Malnutrition is still a widespread public health problem worldwide. The objective of this review is to identify the most effective nutrition programs used in the prevention and management of child malnutrition in children under five years. Also, it is to suggest courses of action to improve interventions in the fight against malnutrition. The promotion of exclusive breastfeeding and food diversification improves the mothers’ knowledge and contributes to prevention of malnutrition. Food supplementation increases the weight/height ratio of malnourished children. The two programs combined bring better results on mothers’ feeding practices and children’s anthropometric data. This review has highlighted the importance of food supplementation and nutritional education in the management and prevention of child malnutrition. In addition, the combination of several approaches to good dietary practices brings better results. Finally, primary prevention can protect children from the harmful consequences of malnutrition.

关键词： Malnutrition Nutritional Education Breastfeeding Supplementation

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Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: A multicenter study of 412 patients

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World Journal of Gastroenterology 2006年第45期12卷 7319-7325页

作者： Thomas decaens Franoise Roudot-Thoraval Solange Bresson-Hadni Carole meyer Jean Gugenheim Francois durand Pierre-Henri Bernard Olivier Boillot Philippe Compagnon Yvon Calmus Jean Hardwigsen Christian ducerf Georges Philippe Pageaux Sébastien dharancy Olivier Chazouillères daniel Cherqui Christophe duvoux Service d'Hépatologie et de Gastroentérologie AP-HP Hpital Henri Mondor Créteil Unité INSERM 581 France département de santé Publique AP-HP Hpital Henri Mondor Créteil France Service d’Hépatologie Hpital Jean Minjoz Besanon France Service de Transplantation Hpital HautefeuilleStrasbourg France Service de Chirurgie digestive Hpital L’Ar-chet 2 Nice France Service d’Hépatologie AP-HP Hpital Beau-jon Clichy France Service d’Hépatologie et de Gastroentéro-logie H?pital Pellegrin Bordeaux France Service de Chirurgie digestive Hpital Edouard Herriot Lyon France Service de Chirurgie digestive Hpital Ponchaillou Rennes France Service de Chirurgie digestive AP-HP HpitalCochin Paris France Service de Chirurgie digestive Hpital laConception Marseille France Service de Chirurgie digestive Hpital de laCroix Rousse Lyon France Fédération Médico-Chirurgicale deMaladies de l’Appareil digestif Hpital Saint-Eloi MontpellierFrance Service d’Hépatologie et de Gastroentérologie H?pital Claude Huriez Lille France Service d’Hépatologie AP-HP Hpital SAntoine Paris France Service de Chirurgie Générale et digestive APHP Hopital Henri Mondor Créteil France

AIM： To assess pre-orthotopic liver transplantation （OLT） factors that could be evaluated pre-operatively or controlled post-operatively associated with hepatocellular carcinoma （HCC） recurrence and disease-free survival after liver transplantation （LT）.MetHOdS： Four hundred and twelve patients transplanted for HCC between 1988 and 1998 in 14 French centers, who survived the postoperative period were studied. Kaplan meier estimates were calculated for 24 variables potentially associated with recurrence of HCC. Uni- and multivariate analyses were conducted to identify independent predictors of recurrence. RESULTS： Overall 5-year disease-free survival was 57.1%. By univariate analysis, variables associated with disease-free survival were： presence of cirrhosis （P = 0.001）, etiology of liver disease （P = 0.03）, α fetoprotein level （〈 200, 200 to 2000, or 〉 2000; P 〈 0.0001）, y-GT activity （N, N to 2N or 〉 2N; P = 0.02）, the number of nodules （1, 2-3 or ≥ 4; P = 0.02）, maximal diameter of the largest nodule （〈 3 cm, 3 to 5 cm or 〉 5 cm; P 〈 0.0001）, the sum of the diameter of the nodules （〈 3 cm, 3 to 5 cm, 5 to 10 cm or 〉10 cm; P 〈 0.0001）, bilobar location （P = 0.01）, preoperative portal thrombosis （P 〈 0.0001）, peri-operative treatment of the tumor （P = 0.002） and chemoembolization （P = 0.03）, tumor differentiation （P = 0.01）, initial type of calcineurin inhibitor （P = 0.003）, the use of antilymphocyte antibodies （P = 0.02）, rejection episodes （P = 0.003） and period of LT （P 〈 0.0001）. By multivariate analysis, 6 variables were independently associated with HCC recurrence： maximal diameter of the largest nodule （P 〈 0.0001）, time of LT （P 〈 0.0001）, tumor differentiation （P 〈 0.0001）, use of anti-lymphocyte antibody （ATG） or anti-Cd3 antibody （OKT3）（P = 0.005）, preoperative portal thrombosis （P = 0.06） and the number of nodules （P = 0.06）. CONCLUSION： This study identifies immunosuppression, through the use of ATG or OKT3, as a predictive factor of tumor recur

关键词： Immunosuppression Hepatocellular carcinoma Tumor differentiation Liver transplantation

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mener des recherches pluridisciplinaires en SHS dans le domaine du cancer:quels leviers,quels freins?Conducting Multidisciplinary SHS Research in the Field of Cancer:Strengths and Barriers?

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Psycho-Oncologie 2024年第2期18卷 101-107页

作者： Sylvie dolbeault Manon Fontaine diane Boinon Service Psycho-Oncologie et Social Département de Soins de SupportInstitut CurieParis75005France SHARE PSL UniversityParis75005France CESP UniversitéParis SaclayVillejuif91190France Institut la Personne en Médecine Institut de Recherche Saint LouisUniversitéParis CitéParis75013France Institut de Psycho-Oncologie Gustave RoussyVillejuif94805France Laboratoire de Psychopathologie et Processus de santé UniversitéParis CitéBoulogne-Billancourt92100France

This paper summarizes the work held at the Cancéropôle Ile-de-France's annual SHS research seminar on the theme:Pluridisciplinarity and methods for SHS research in thefield of *** clarifying the concepts of pluri-,inter-,and transdisciplinarité,it aimed to describe how this type of research is carried out in practice,addressing successively:the role of stakeholders and their respective positions,the need for a shared language,the various temporalities involved and task sharing,the interview and analysis methods as well as the implication of *** highlighted the personal qualities required to practice this type of research,such as psychologicalﬂexibility and adaptability,a strong desire for collaborative work,acceptance of risk,and a humble stance.

关键词： SHS research interdisciplinarity pluridisciplinarity strengths and barriers oncology

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dimensions of hepatocellular carcinoma phenotypic diversity

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World Journal of Gastroenterology 2018年第40期24卷 4536-4547页

作者： Romain désert Natalia Nieto Orlando Musso Institut NumeCan Université de Rennes 1 Institut national de la recherche agronomique (INRA) Institut national de la santé et de la recherche médicale (INSERM) department of Pathology Department of Medicine (Gastroenterology and Hepatology) University of Illinois at Chicago

Hepatocellular carcinoma(HCC) is the 3^(rd) leading cause of cancer-related death worldwide. More than 80% of HCCs arise within chronic liver disease resulting from viral hepatitis, alcohol, hemochromatosis, obesity and metabolic syndrome or genotoxins. Projections based on Western lifestyle and its metabolic consequences anticipate a further increase in incidence, despite recent breakthroughs in the management of viral hepatitis. HCCs display high heterogeneity of molecular phenotypes, which challenges clinical management. However, emerging molecular classifications of HCCs have not yet formed a unified corpus translatable to the clinical practice. Thus, patient management is currently based upon tumor number, size, vascular invasion, performance status and functional liver reserve. Nonetheless, an impressive body of molecular evidence emerged within the last 20 years and is becoming increasingly available to medical practitioners and researchers in the form of repositories. Therefore, the aim this work is to review molecular data underlying HCC classifications and to organize this corpus into the major dimensions explaining HCC phenotypic diversity. Major efforts have been recently made worldwide toward a unifying "clinically-friendly" molecular landscape. As a result, a consensus emerges on three major dimensions explaining the HCC heterogeneity. In the first dimension, tumor cell proliferation and differentiation enabled allocation of HCCs to two major classes presenting profoundly different clinical aggressiveness. In the second dimension, HCC microenvironment and tumor immunity underlie recent therapeutic breakthroughs prolonging patients' survival. In the third dimension,metabolic reprogramming, with the recent emergence of subclass-specific metabolic profiles, may lead to adaptive and combined therapeutic approaches. Therefore, here we review recent molecular evidence, their impact on tumor histopathological features and clinical behavior and highlight the r

关键词： Liver metabolism Liver zonation Hepatocellular carcinoma classification Wnt/β-catenin TP53 Tumor microenvironment Inflammation Tumor immunity Hepatocyte proliferation Hepatocyte differentiation

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Analysis of Adverse Reactions Related to drugs and Vaccines Received at the National Centre for Pharmacovigilance from 2009 to 2016 in Togo

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Pharmacology & Pharmacy 2018年第8期9卷 344-356页

作者： Yao Potchoo Mouhoudine Yerima Tante T. Gnandi Mounerou Mounerou Salou Aboudoulatif diallo Batoyema Bakoma Atani T. Nyansa Mireille Prince-david département des Sciences Pharmaceutiques Faculté des Sciences de la Santé Université de Lomé Lomé Togo direction de la Pharmacie du Médicament et des Laboratoires Ministère de la Santé et de la Protection Sociale Lomé Togo Comité de Bioéthique et de la Recherche en santé Ministère de la Santé et de la Protection Sociale Lomé Togo

Objectives: To assess the received suspected adverse events occurring upon treatment with drugs and vaccines, at National Centre for Pharmacovigilance, in Togo, from 2009 to 2016. Methods: A crossover study was conducted in order to collect data about patients, drugs, suspected adverse events and notifiers. Suspected adverse events were classified using med dRA 19.1. Notification’s circumstances were classified into Public Health Programs’ campaigns and routine practice. data were collated into Excel spreadsheet and processed with SPSS software. Key Findings: Regional distribution is irregular. Of the 322 collected report forms, paramedics have notified 60.8% of the cases. Adult patients were the most represented (70.2%). Public Health Programs campaigns provided 72.6% versus 27.4% for routine practice including Neglected Tropical diseases (41.4%), immunization (27.7%), tuberculosis (25.9%) and 4.5% for HIV. Skin disorders were the most prevalent suspected adverse events (147 sheets;45.7%) followed by general disorders and administration site disorders (29.8%) and gastro-intestinal disorders (12.7%). General anti-infective drugs for systemic use, antiparasites, and insecticides were the most reported class of medications (161 sheets;44.7%). Conclusions: A thorough follow-up of pharmacovigilance launched activities is needed to build a sustainable adverse effect’s surveillance system and routine practice has to be strengthened.

关键词： medicines Vaccines Routine Health Care Public Health Program Adverse Events Reporting Pharmacovigilance

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Cabozantinib and the moving field of systemic treatments in advanced hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2019年第1期8卷 53-55页

作者： Manon Allaire Jean Charles Nault Service d’hépato-gastroentérologie et de nutrition CHU Cote de NacreCaenFrance UMR 1149 Centre de Recherche sur l’inflammationFacultéde Médecine BichatParisFrance Service d’hépatologie CHU de jean VerdierBondyFrance UMR 1162 Génomique Fonctionnelle des Tumeurs SolidesInstitut National de la Santéet de la Recherche MédicaleParisFrance

Most of patients with hepatocellular carcinoma(HCC),are diagnosed at an advanced-stage explaining the poor prognosis of this cancer with a median survival without treatment around 8 months(1-3).Currently,two systemic multi-kinase inhibitors with anti-proliferative and antiangiogenic effects are available as first line treatments in advanced *** first one,Sorafenib,was the only available systemic treatment available during one decade and was associated with an improvement of overall survival of around 3 months compared to placebo(4,5).The second one,lenvatinib,showed a similar median overall survival compared to Sorafenib in a non-inferiority phase-3 trial(6).No second line was available during several years due to toxicity or absence of efficacy of the different drugs tested in multicentric phase 3 randomized controlled trials.

关键词： hepatocellular treatment drugs

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Retinoid receptor-related orphan receptor alpha： a key gene setting brain circuits

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Neural Regeneration Research 2018年第5期13卷 791-794页

作者： Tania Vitalis Jean Mariani PROTECT Institut National de la Santé et de la Recherche Médicale Université Paris Diderot Paris France Université Pierre et Marie Curie Sorbonne Université Paris France Centre National de la Recherche Scientifique Unité Mixte de Recherche 8256 Institut de Biologie de Paris Seine (IBPS) Biological adaptation and ageing (B2A) Team Brain Development Repair and Ageing Paris France Assistance Publique - Hopitaux de Paris Départements Hospitalo-Universitaires FAST Institut de la Longévité Ivry-Sur-Seine France

The retinoid receptor-related orphan receptor alpha（RORα） is thought to act as a constitutive activator of transcription by binding to the ROR response element（RORE） of target genes. Several mouse models in which RORα is defective have revealed the decisive roles of RORα on the development, maturation and neuroprotection of various cerebral regions including the cerebellar and somatosensory systems. We have recently shown that RORα is needed for accurate thalamic sensory system organization and somatosensory cortex development. The phenotype of various RORα deficient mice models（staggerer mutant or mouse lacking RORα in specific somatosensory regions） is, in part, reminiscent of what has been described in mice lacking thyroid hormone triiodothyronine（T3）. As in in vitro studies or in other models, our studies strongly suggest that the T3/RORα-pathway, among others, is in part responsible for the staggerer phenotype. We have indeed identified some genes that were both regulated by T3 and RORα and that are known to be implicated in the cerebellar or somatosensory system development. Moreover, several groups have shown that RORα is at the crossroad of many biological processes and pathologies, including psychiatric and degenerative disorders. In particular, defective RORα-signalling has been demonstrated in humans to be associated with the emergence of autistic-like disorders. We believe that determining the appropriate amount of RORα activity could be crucial in detecting and preventing the emergence of specific brain diseases.

关键词： cerebellum cerebral cortex development maturation neuroprotection psychiatric disorders somatosensory system

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