检索结果-南通市图书馆

Interest of d-dimer level,severity of COVId-19 and cost of management in Gabon

World Journal of Critical Care medicine 2025年第1期14卷 91-99页

作者： Berthe A Iroungou Arnaud Nze O Helga M Kandet Y Neil-Michel Longo-Pendy Nina d mezogho-Obame Annicet-Clotaire dikoumba Guignali L Mangouka UnitéMixte de Recherche Centre International de Recherches Médicales de Franceville et le Service de SantéMilitaireLibreville 20404EstuaireGabon AP-HP Health Economics Research UnitHtel Dieu HospitalParis 75004Ilede-FranceFrance Laboratory Hôpital D'Instruction des Armées D'AkandaLibreville 20404EstuaireGabo Unitéde Recherche enÉcologie de la santé Centre Interdisciplinaire de Recherches Médicales de FrancevilleFranceville 769Gabon Laboratory Hôpital D'Instruction des Armées Omar Bongo OndimbaLibreville 20404EstuaireGabon department of medecine Polyvalente Hôpital D'Instruction des Armées Omar Bongo OndimbaLibreville 20404EstuaireGabon

BACKGROUNd Coronavirus disease 2019(COVId-19)is strongly associated with an increased risk of thrombotic events,including severe outcomes such as pulmonary *** d-dimer levels are a critical biomarker for assessing this *** Gabon,early implementation of anticoagulation therapy and d-dimer testing has been crucial in managing *** study hypothesizes that elevated ddimer levels are linked to increased COVId-19 *** To determine the impact of d-dimer levels on COVId-19 severity and their role in guiding clinical *** This retrospective study analyzed COVId-19 patients admitted to two hospitals in Gabon between March 2020 and december *** study included patients with confirmed COVId-19 diagnoses and available d-dimer measurements at *** on demographics,clinical outcomes,d-dimer levels,and healthcare costs were ***-19 severity was classified as non-severe(outpatients)or severe(inpatients).A multivariable logistic regression model was used to assess the relationship between d-dimer levels and disease severity,with adjusted odds ratios(OR)and 95%*** A total of 3004 patients were included,with a mean age of 50.17 years,and the majority were female(53.43%).Elevated d-dimer levels were found in 65.81%of patients,and 57.21%of these experienced severe *** analysis showed that patients with elevated d-dimer levels had 3.33 times higher odds of severe COVId-19(OR=3.33,95%CI:2.84-3.92,Pd this association remained significant in the multivariable analysis,adjusted for age,sex,and year of *** financial analysis revealed a substantial burden,particularly for uninsured *** d-dimer predicts COVId-19 severity and guides treatment,but the high cost of anticoagulant therapy highlights the need for policies ensuring affordable access in resource-limited settings like Gabon.

关键词： d-dimers COVId-19 Management disease severity Healthcare costs Gabon

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networks

引用

World Journal of Gastroenterology 2014年第1期20卷 22-30页

作者： Jean-Philippe Babeu Franois Boudreau département d’ Anatomie et de Biologie Cellulaire Faculté de Médecine et des Sciences de la SantéUniversité de SherbrookeSherbrooke J1E 4K8QuébecCanada

Hepatocyte nuclear factor 4-alpha (HNF4-α) is a nuclear receptor regulating metabolism, cell junctions, differentiation and proliferation in liver and intestinal epithelial cells. Mutations within the HNF4A gene are associated with human diseases such as maturity-onset diabetes of the young. Recently, HNF4A has also been described as a susceptibility gene for ulcerative colitis in genome-wide association studies. In addition, specific HNF4A genetic variants have been identified in pediatric cohorts of Crohn’s disease. Results obtained from knockout mice supported that HNF4-α can protect the intestinal mucosae against inflammation. However, the exact molecular links behind HNF4-α and inflammatory bowel diseases remains elusive. In this review, we will summarize the current knowledge about the role of HNF4-α and its isoforms in inflammation. Specific nature of HNF4-α P1 and P2 classes of isoforms will be summarized. HNF4-α role as a hepatocyte mediator for cytokines relays during liver inflammation will be integrated based on documented examples of the literature. Conclusions that can be made from these earlier liver studies will serve as a basis to extrapolate correlations and divergences applicable to intestinal inflammation. Finally, potential functional roles for HNF4-α isoforms in protecting the intestinal mucosae from chronic and pathological inflammation will be presented.

关键词： Hepatocyte nuclear factor 4-alpha Inflammatory bowel diseases Colitis-associated cancer Gastrointestinal tract Intestinal epithelium barrier Inflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anthelmintic activity of Saba senegalensis(***.) Pichon (Apocynaceae) extract against adult worms and eggs of Haemonchus contortus

引用

Asian Pacific Journal of Tropical Biomedicine 2016年第11期6卷 945-949页

作者： Mohamed Bonewendé Belemlilga Aristide Traoré Sylvin Ouédraogo Adama Kaboré Hamidou Hamadou Tamboura Innocent Pierre Guissou Laboratoire de développement du Médicament Centre de recherche sur le médicament Ecole Doctorale de la SantéUniversité de Ouagadougou Ecole Doctorale de Santé département Médecine Pharmacopée Traditionnelles–Pharmacie (mePHATRA-Ph) Institut de Recherche en Sciences de la Santé (IRSS/CNRST) département Productions Animales Institut de l’Environnement et de Recherches Agricoles(INERA/CNRST)

Objective: To evaluate the anthelmintic property of Saba senegalensis(***) Pichon(Apocynaceae)(S. senegalensis) on Haemonchus contortus that is traditionally used in Burkina Faso for its gastrointestinal parasites ***: The lyophilized aqueous decoction of leaves of S. senegalensis at concentrations of 0.10, 1.00, 3.00, 10.00 and 15.00 mg/m L was used on eggs and adult worms of Haemonchus contortus collected from gastrointestinal tract of small ***: The LC_(50) on adult worms was 6.79 mg/m L and 3.25 mg/m L for the leaves of S. senegalensis and the levamisole(reference drug), respectively. Inhibition of hatching assay showed a concentration-dependent manner with an inhibition of 93.63% at the concentration of 15.00 mg/m L of S. ***: These results indicate that the aqueous extract of S. senegalensis possesses an anthelmintic property and may justify its use in traditional medicine for the treatment of gastrointestinal parasites.

关键词： Saba senegalensis Anthelmintic properties Haemonchus contortus In vitro Burkina Faso

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of the Quality of Hospital-Based Management of Severe Acute Malnutrition in Children under 5 in Benin

引用

Food and Nutrition Sciences 2017年第11期8卷 1012-1021页

作者： Tchasso Serge Kenao Charles Sossa Jerome Yolaine Glèlè Ahanhanzo Ghislain Emmanuel Sopoh Patrick Makoutodé Victoire damienne Agueh département de Promotion de la santé Institut Régional de Santé Publique Université d’Abomey-Calavi Abomey Calavi Bénin département d’épidémiologie et de Biostatistique Institut Régional de Santé Publique Université d’Abomey-Calavi Abomey Calavi Bénin département de santé et Environnement Institut Régional de Santé Publique Université d’Abomey-Calavi Abomey Calavi Bénin département de politique et système de santé Institut Régional de Santé Publique Université d’Abomey-Calavi Abomey Calavi Bénin

Introduction: The aim of the study was to assess the quality of the management of severe acute malnutrition in the Mono departmental Hospital Center (CHd) in Benin. Methods: This was a cross-sectional and evaluative study which took place from 03 February to 20 July 2016. The study was carried out in the mono departmental hospital of Lokossa. The non-probabilistic sampling method was used to select all our study materials and all our targets were systematically selected. Our study materials involved observation checklist, guidelines documents and questionnaires to collect data. The assessment of the quality of the hospital management of severe acute malnutrition was based on national and international standards like Benin’s national protocol of acute malnutrition management. Results: In our study, 27 cases of severe acute malnutrition (SAM) in children were considered. The median age of those children was 12 months. The rates of the components inputs, process and results were 25% (poor), 58.33% (acceptable) and 40% (poor), respectively. The sub components with respect to the norms were all related to the management of severe acute malnutrition like, availability of therapeutic foods ready for use, availability of management protocol, availability of trained and supervised staff in the management of the severe acute malnutrition and the proportion of dead and cured children. The study showed that the quality of the management of severe acute malnutrition at the mono departmental hospital of Lokossa was poor with a rate of 41.38%. Conclusion: The quality of the management of severe acute malnutrition at the mono departmental hospital of Lokossa was poor. The sub components that need to improve were the availability of therapeutic foods ready for use, availability of management protocol, along with the training and supervision of staff in charge of the management of severe acute malnutrition.

关键词： Evaluation Severe Acute Malnutrition Benin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Psychological distress in Moroccan Patients with Hematological Malignancies and Its Impact on Their Quality of Life

引用

Psycho-Oncologie 2023年第4期17卷 235-244页

作者： Maha Ouazzani Zineb El Khammar Nawal Oubelkacem Youssef Aboussaleh Hajar Masrour Moncef Maiouak Rhizlane Berrady Laboratoire de Nutrition Santéet EnvironnementDépartement de BiologieFacultédes SciencesUniversitéIbn TofailKenitra14000Maroc Service de Médecine Interne et d’oncohématologie CHU Hassan IIFès30050Maroc Laboratoire d’épidémiologie Facultéde Médecine et de Médecine DentaireFès30050Maroc

Introduction:la qualitéde vie des patients suivis pour une hémopathie maligne dépend non seulement du type de la maladie,de ses caractéristiques cliniques,biologiques et thérapeutiques,mais aussi de la santémentale du patient.L’objectif de notreétude est d’évaluer l’état psychologique des patients au diagnostic,de rechercher les facteurs associésàson altération et de préciser son impact sur la qualitéde vie des patients.Méthode:nous avons menéuneétude monocentrique transversale quiévalue la dépression,l’anxiétéet la qualitéde vie d’une population de patients atteints de syndromes lymphoprolifératifs sur une période de *** questionnaires ontétéutilisés au moment du diagnostic:le HAdS pour rechercher la dépression et l’anxiétéet le SF12échelle pourévaluer la qualitéde vie liéeàla santé.Résultat:Les cent patients ont acceptéde répondre aux *** patients sont suivis pour un lymphome malin non hodgkinien,une maladie de Hodgkin,et une leucémie lymphoïde *** sex-ratio(H/F)est de 1,*** prévalence des symptômes anxieux est de 70%avec 95%CI(61,01%;78,99%)et des symptômes dépressifs de 76%avec 95%CI(49,4%;82,6%)des *** analyse univariée,le caractère féminin est associéaux symptômes anxieux(p=0,008),etàl’altération de qualitéde vie mentale(p=0,02).Alors qu’en analyse multivariée,Les symptômes anxio-dépressifs sont significativement associésàun score de qualitéde vie faible aussi bien mentale que *** plus les symptômes anxieux sont corrélés au sexe féminin(ORA=20,50;95%CI[1,58–264,48]);et la douleur(ORA=12,33;95%CI[1,07–141,77]).Conclusion:la recherche de comorbidités psychologiques doit faire partie du diagnostic initial de cette population vulnérable pour une meilleure qualitéde vie.

关键词： dépression anxiété qualitéde vie liéàla santé lymphome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Testing for hepatitis B virus alone does not increase vaccine coverage in non-immunized persons

引用

World Journal of Gastroenterology 2017年第38期23卷 7037-7046页

作者： Anders Boyd Julie Bottero Fabrice Carrat Joel Gozlan Hayette Rougier Pierre-Marie Girard Karine Lacombe Institute Pierre Louis d’épidémiologie et de santéPublique(IPLESP UMRS 1136) INSERMSorbonne Universités Service de maladies infectieuses Hopital Saint-AntoineAP-HP département de santépublique Hopital Saint-AntoineAP-HP Laboratoire de Virologie Hopital Saint-AntoineAP-HP INSERM UMR_S1135 CIMI

AIM To determine whether hepatitis B virus(HBV)-testing could serve as a gateway to vaccinate non-immunized individuals in a low-prevalent *** Non-immunized subjects participating in a multi-center, HBV-testing campaign in Paris, France were identified and contacted via telephone 3-9 mo after testing in order to determine vaccination status. Vaccination coverage was evaluated in per-protocol(for all respondents) and intent-to-treat analysis(assuming all non-responders did not vaccinate).RESULTS In total, 1215/4924(24.7%) enrolled subjects with complete HBV serology were identified as nonimmunized and eligible for analysis. There were 99/902 successfully contacted subjects who had initiated HBV vaccination after screening: per-protocol, 11.0%(95%CI: 9.0-13.2); intent-to-treat, 8.2%(95%CI: 6.7-9.8). In multivariable analysis, vaccination was more likely to be initiated in individuals originating from moderate or high HBV-endemic countries(P d healthcare coverage(P = 0.01) and men who have sex with men(P = 0.02). When asked about the reasons for not initiating HBV vaccination, the most frequent response was "will be vaccinated later"(33.4%), followed by "did not want to vaccinate"(29.8%), and "vaccination was not proposed by the physician"(21.5%). Sub-group analysis indicated a stark contrast in vaccination coverage across centers, ranging from 0%-56%.CONCLUSION HBV-vaccination after HBV screening was very low in this study, which appeared largely attributed to physician-patient motivation towards vaccination. Increased vaccination coverage might be achieved by emphasizing its need at the organizational level.

关键词： Health service organization Hepatitis B virus vaccination Public health Testing intervention Vaccine coverage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analogy between adsorption and sorption： An elementary mechanistic approach. I. Monolayer adsorption and sorption without solvent cluster formation

引用

Chinese Journal of Chemical Engineering 2017年第12期25卷 1740-1749页

作者： Pierre Schaetzel Sébastien Thomas Hasna Louahlia Gualous Laboratoire Universitaire des Sciences Appliquées de Cherbourg Université de Caen IUT de Caen Boulevard Marechal Juin 14032 Caen cedex France Institut de chimie et procédés pour l'énergie l'environnement et la santé Université de Strasbourg 25 rue Becquerel 67087 Strasbourg cedex 2 France

The elementary mechanistic model of adsorption and sorption is based on a simple hypothesis： the adsorption sites are uniformly distnbuted on the surface of the pore walls in the adsorbent, the sorption sites are uniformly distributed in the volume of the polymer. In this first paper we will analyze the simple case where one solute molecule is only allowed to occupy a single adsorption or sorption site. A common elementary occupation law of the free sites is assumed： the differential increase of the number of the adsorbed/sorbed molecules is proportional to the differential increase of the activity of the solute and the concentration of the free （non-occupied） sites in the solid. The proportionality coefficient is called affinity coefficient depending on the solid/solute couple and on the temperature and independent of the concentration of the solute. In adsorption the concentration of the free sites is a surface concentration on the pore walls and in sorption it is expressed by the molarity. The simple monolayer adsorption law of Jovanovic is obtained： n = no（1 - e KP） where n is the number of moles adsorbed when the pressure is P. no is the total number of adsorption sites and K the affinity coefficient for adsorption. The sorption law writes： a = 1/k [Ф/1-Ф] ＋ 1-r/k In [1 ＋ 1/r Ф/1-Ф] where Ф, r and k hold respectively for the volume fraction of the solvent in the polymer, for the ratio of the molar volumes of the solvent to the elementary polymer chain containing one single adsorption site and for the sorption affinity coefficient. The confrontation of these equations to experimental isotherms is satisfactory in comparison with the classical Langmuir and Flory-Huggins equations： the best results are obtained for adsorption of vapors on a 5A zeolite and for all analyzed sorption results.

关键词： Adsorption isotherms Sorption isotherms Flory-Huggins theory Langmuir equation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Three different low-temperature plasma-based methods for hydrophilicity improvement of polyethylene films at atmospheric pressure

引用

Chinese Physics B 2013年第11期22卷 411-417页

作者：陈光良郑旭黄俊司晓蕾陈致力薛飞 Sylvain Massey Key Laboratory of Advanced Textile Materials and Manufacturing Technology and Engineering Research Center for Eco-Dyeing & Finishing of Textiles Ministry of Education Zhejiang Sci-Tech University Groupe en Sciences des Radiations Faculte' de me'decine et des Sciences de la Sant Universite' de Sherbrooke

Three different low-temperature plasma-based methods were used to improve the surface hydrophilicity of polyethy- lene （PE） films, and all the modification processes were carried out by employing an atmospheric pressure plasma jet （APPJ） system. （a） PE films were directly modified by APPJ using a gas mixture of He and 02. （b） Acrylic acid （AA） was introduced into the system and a polymer acrylic acid （PAA） coating was deposited onto the PE films. （c） AA was grafted onto the PE surface activated by plasma pre-treatment. It was found that the hydrophilicity of the PE films was significantly improved for all the three methods. However, the samples modified by Process （a） showed hydrophobicity recovery after a storage time of 20 days while no significant change was found in samples modified by Process （b） and Process （c）. The Fourier transform infrared spectroscopy （FTIR） results indicated that the most intensive C=O peak was detected on the PE surface modified by Process （c）. According to the X-ray photoelectron spectroscopy （XPS） analysis, the ratios of oxygen-containing polar groups for samples modified by Process （b） and Process （c） were higher than that modified by Process （a）.

关键词： atmospheric pressure plasma jet plasma modification acrylic acid hydrophilicity improvement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Schistosomiasis control in Senegal:results from community data analysis for optimizing preventive chemotherapy intervention with praziquantel

引用

Infectious diseases of Poverty 2023年第6期12卷 101-102页

作者： Boubacar diop Khadime Sylla Ndèye MBackéKane Oumou Kaltoum Boh Babacar Guèye Mady Ba Idrissa Talla Malang Mané Rose Monteil Boniface Kinvi Honorat Gustave Marie Zoure Jorge Cano Ortega Pauline Mwinzi Moussa Sacko Babacar Faye Programme National de Lutte Contre les Bilharzioses et les Géo-Helminthiases Direction de la Lutte Contre la Maladie (DLM) Ministère de la Santé et de l’Action Sociale (MSAS) Dakar Senegal department of Parasitology and Mycology Faculty of medicine Pharmacy and Odontology Université Cheikh Anta Diop de Dakar (UCAD) Dakar Senegal WHO Country Office Dakar Senegal département de santé Publique Faculté des Sciences de la Santé Université Amadou Hampathé Ba Dakar Senegal FHI 360 Chargé des Enquêtes et Evaluation des Maladies et des Campagnes de DMM Dakar Senegal Expanded Special Project for Elimination of Neglected Tropical diseases (ESPEN) WHO Africa Regional Office Brazzaville Congo Service de Parasitologie Institut National de Santé Publique (INSP) Bamako Mali

Background Over the past two decades,preventive chemotherapy(PC)with praziquantel(PZQ)is the major strategy for controlling schistosomiasis in *** objective of this analysis was to update the endemicity of schistosomiasis at community level for better targeting mass treatment with PZQ in *** demographic and epidemiological data from 1610 community health areas were analyzed using the schistosomiasis community data analysis tool of Expanded Special Project for Elimination of Neglected Tropical diseases which developed by World Health Organization/Africa Ofce(WHO/AFRO).The tool uses a WHO/AFRO decision tree for areas without epidemiological data to determine whether mass treatment should be continued at community *** analysis was *** Overall,the endemicity of 1610 community health areas were updated based on the data from the district endemicity(33.5%)and the form of Join request for selected PC medicine(40.5%).Up to 282(17.5%)and 398(24.7%)of community health areas were classifed as moderate and high endemicity.41.1%of communities were non *** endemicity was more important in Tambacounda,Saint Louis,Matam,Louga and Kedougou.A change in endemicity category was observed when data was disagregted from district level to community *** units classifed non endemic were more important at community level(n=666)compared to district level(n=324).Among 540 areas previously classifed high endemic at district level,392(72.6%)remained high prevalence category,while 92(17.0%)became moderate,43(8.0%)low and 13(2.4%)non-endemics at community *** of implementation units requiring PC was more important at district level(1286)compared to community level(944).Number of school aged children requiring treatment was also more important at district level compared to community *** The analysis to disaggregate data from district level to community level using the WHO/AFRO schistosomiasis sub-distric

关键词： Schistosomiasis Community data analysis Endemicity Praziquantel Senegal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessing the Impact of Health Insurance on Household Financial Protection in Togo

引用

Health 2023年第6期15卷 507-516页

作者： Aboubakar Issa Yaovi Tossou Kodjo Evlo département d’politique et système de santé Institut Régional de Santé Publique Ouidah Bénin Programme Couverture Sanitaire Universelle Ministère de la Santé de l’Hygiène Publique et de l’Accès Universel Aux Soins Lomé Togo direction des études de la Planification et de la Programmation Ministère de la Santé de l’Hygiène Publique et de l’Accès Universel Aux Soins Lomé Togo département d’Economie Faculté des Sciences économiques et de Gestion Université de Lomé Lomé Togo

Context: To facilitate financial access to care for the population, health insurance mechanisms have been established, in particular the National Health Insurance Institute, which covers civil servants and their dependents. In addition, other voluntary and community mechanisms have been developed. After several years of implementation, the level of catastrophic health expenditures among insured individuals shows that there is still a considerable level of financial risk associated with health care. This study aims to assess the impact of health insurance in Togo on insured populations. Methodology: The data used in this study come from the harmonized survey on household living conditions carried out in 2018 by the National Institute of Statistics, Economic and demographic Studies. The propensity score matching method was used according to the following steps: estimation of propensity scores, verification of the conditional independence hypothesis (balancing property) and estimation of the average treatment effect on treated. Stata V14.2 software was used. Findings: The average effect of health insurance on household financial protection is −0.012 for the nearest neighbor method, −0.013 for the matching radius method, −0.015 for the Kernel and −0.016 for the stratification method. Results showed that health insurance contributes to reducing catastrophic health expenditures, but their effect remains very limited. This could be explained by the level of care package covered and the cost covered. Conclusion: Health insurance contributes to the reduction of catastrophic health expenses for households. However, it is important to widen the range of care covered and the cost covered. In addition, measures to extend this coverage to a larger proportion of the population will make it possible to have a greater impact.

关键词： Impact Health Insurance Catastrophic Expenditure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：