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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal dOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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Computer-Assisted Path Planning for Minimally Invasive Vascular Surgery

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Chinese Journal of Electronics 2018年第6期27卷 1241-1249页

作者： HUANG dongjin TANG Pengbin WANG Yin LI Hejuan TANG Wen dING Youdong Shanghai Film Academy Shanghai University dpartement d'informatique et de recherche oprationnelle Universitde Montral department of Creative Technology University of Bournemouth

Path planning assisted by two-dimensional medical images is an essential part of minimally invasive diagnosis and treatment for cardiovascular diseases. due to the complex background of angiography images and intricate vascular structure with multi-branch and stenoses,creating accurate pathways from angiography image is a challenge task. We present a new path planning methodology based on angiography medical images using the steady fluid dynamics. Our novel approach is useful in many medical applications, such as for computer-assisted medical images analysis and the follow-on image-guided interventions. A graph-cuts based energy function was applied to the vessel segmentation of angiography images in order to obtain boundary information. We have adopted Finite volume method(FVM) to simulate the Newtonian fluid inside the segmented blood vessels, and a set of isobars under the steady fluid condition are obtained by Meandering Triangles algorithm. The selected center points of isobars are organized to generate the directed vessels-tree, from which the vascular stenoses are automatically detected and the final surgical path is generated with branches. Our method can be used for quantitative path analysis, and we show experimental results to demonstrate that the versatility and applicability of the algorithm in obtaining single-pixel surgical path with good performance, high accuracy and less manual interventions, especially it is robust on complex vascular structures.

关键词： Minimally invasive surgery Path planning Fluid dynamics Medical images analysis

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BEST APPROXIMATION FOR WEIERSTRASS TRANSFORM CONNECTEd WITH SPHERICAL MEAN OPERATOR

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Acta Mathematica Scientia 2012年第2期32卷 455-470页

作者： L.T.Rachdi N.Msehli département de Math'ematiques Facult'e des Sciences de Tunis2092 El-ManarTunisia département de Mathématiques et d'informatique Institut National des Sciences Appliquées et de Technologie de Tunis1080 TunisTunisia

Using reproducing kernels for Hilbert spaces, we give best approximation for Weierstrass transform associated with spherical mean operator. Also, estimates of extremal functions are checked.

关键词： Weierstrass transform spherical mean operator best approximation repro-ducing kernel extremal function

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Critical links detection in stochastic networks: application to the transport networks

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International Journal of Intelligent Computing and Cybernetics 2019年第1期12卷 42-69页

作者： Mourad Guettiche Hamamache Kheddouci département d’informatique Facultédes Sciences ExactesUniversitéde BejaiaBejaiaAlgeria and Département de Mathématiques et InformatiqueCentre Universitaire de MilaMilaAlgeria Universite Claude Bernard Lyon 1 VilleurbanneFrance

Purpose–The purpose of this paper is to study a multiple-origin-multiple-destination variant of dynamic critical nodes detection problem(dCNdP)and dynamic critical links detection problem(dCLdP)in stochastic *** and dCLdP consist of identifying the subset of nodes and links,respectively,whose deletion maximizes the stochastic shortest paths between all origins–destinations pairs,in the graph modeling the transport *** identification of such nodes(or links)helps to better control the road traffic and predict the necessary measures to avoid ***/methodology/approach–A Markovian decision process is used to model the shortest path problem underdynamic *** criticalnodes(links)whileconsideringthe dynamicity of the traffic network are ***,sensitivity analysis toward capacity reduction for critical links is ***,the complexity of the underlying algorithms is analyzed and the computational efficiency resulting from the decomposition operation of the network into communities is ***–The numerical results demonstrate that the use of dynamic shortest path(time dependency)as a metric has a significant impact on the identification of critical nodes/links and the experiments conducted on real world networks highlight the importance of sensitive links to dynamically detect critical links and elaborate smart transport *** limitations/implications–The research in this paper also revealed several challenges,which call for future ***,the authors have restricted our experimentation to a small network where the only focus is on the model behavior,in the absence of historical *** authors intend to extend this study to very large network using real ***,the authors have considered only congestion to assess network’s criticality;future research on this topic may include other factors,mainly *** implications–Taking i

关键词： Critical links Critical nodes Markovian decision process Transport networks

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Numerical Modelling Point-to-Plane of Negative Corona discharge in N_2 Under Non-Uniform Electric Field

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Plasma Science and Technology 2015年第6期17卷 469-474页

作者： A.K.FEROUANI M.LEMERINI L.MERAd M.HOUALEF Ecole Préparatoire en Sciences et Techniques Département de Physique LPT Université A.BelkaidFaculté des SciencesDépartement de Physique Ecole Préparatoire en Sciences et Techniques Département de Maths

The paper presents a simulation model of the negative corona discharge in N2 under various pressures. The simulated discharge is of a negative point-to-plane mass type, with an inter-electrode separation distance of 20 mm and a symmetry about the axis of discharge. This simulation investigates the behavior of the neutral density and temperature for different pressures in the range of 0.1-10.0 bar. The spatial and temporal evolution of the neutral gas is analyzed based upon the equations of continuity, momentum and energy in a two-dimensional cylindrical geometry model. For that geometry of the system, the FCT （Flux Corrected Transport） technique was adopted. The results show that the pressure plays a significant role of the neutrals dynamics.

关键词： dC corona discharge FCT method numerical simulation

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Existence of T-solution for degenerated Problem via Minty's Lemma

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Acta Mathematica Sinica,English Series 2008年第3期24卷 431-438页

作者： Y.AKdIME E.AZROUL M.RHOUdAF département de Mathématiques et informatique Facultédes Sciences dhar-Mahraz B. P 1796 Atlas Fès Maroc

We study the existence result of solutions for the nonlinear degenerated elliptic problem of the form, -div（a（x, u,△↓u）） = F in Ω, where Ω is a bounded domain of R^N, N≥2, a ：Ω×R×R^N→R^N is a Carathéodory function satisfying the natural growth condition and the coercivity condition, but they verify only the large monotonicity. The second term F belongs to W^-1,p′（Ω, w^＊）. The existence result is proved by using the L^1-version of Minty＇s lemma.

关键词： weighted Sobolev spaces truncations L^1-version of Minty's lemma

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Periodic Solutions of Evolution Variational Inequalities—a Method of Guiding Functions

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Chinese Annals of Mathematics,Series B 2009年第3期30卷 261-272页

作者： Samir AdLY daniel GOELEVEN Michel THRA département de Math'ematiques et informatique Laboratoire XLIM(Unité Mixte 6172 du CNRS)Université de Limoges123 Avenue A.Thomas87060 Limoges CedexFrance. Laboratoire d' informatique et de Mathématiques Université de La Réunion97400 Saint-DenisFrance.

This paper focuses on a part of the presentation given by the third author at the Shanghai Forum on Industrial and Applied Mathematics(Shanghai 2006).It is related to the existence of a periodic solution of evolution ... 详细信息

关键词： Variational inequality differential inclusion Topological degree Guiding function Periodic solution

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Central role of altered phosphodiesterase 2-dependent signaling in the pathophysiology of cognition-based brain disorders

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Neural Regeneration Research 2025年第8期20卷 2302-2303页

作者： Asma Boulksibat Alessandra Tempio Barbara Bardoni Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR7275Inserm U1323ValbonneFrance

The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular *** the brain,these processes include neurogenesis,neuronal differentiation,activation and function of microglia,and synaptic plasticity,finally resulting in memory formation.

关键词： formation processes finally

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On the Mechanization of Straightedge and Compass Constructions

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Journal of Systems Science & Complexity 2019年第1期32卷 124-149页

作者： SCHRECK Pascal Université de Strasbourg UFR de Mathématique et Informatique-ICube

The geometric constructions obtained with only straightedge and compass are famous and play a special role in the development of geometry. On the one hand, the constructibility of ?gures is a key ingredient in Euclid geometry and, on the other hand, unconstructibility gave birth to famous open problems of the ancient Greece which were unlocked only in the nineteenth century using discoveries in algebra. This paper discusses the mechanization of straightedge and compass constructions. It focuses on the algebraic approaches and presents two methods which are implemented; one is due to Lebesgue and the other one was jointly designed by Gao and Chou. Some links between the algebraic approach of constructions and synthetic geometry are described.

关键词： Geometric knowledge-based systems regular chains straightedge and compass constructibility triangle problems Wu's method

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Static Analysis of Functionally Graded Sandwich Plates Using an Efficient and Simple Refined Theory

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Chinese Journal of Aeronautics 2011年第4期24卷 432-433页

作者： Hadj Henni ABdeLAZIZ Hassen Ait ATMANE Ismail MECHAB Lakhdar BOUMIA Abdelouahed TOUNSI Adda Bedia El ABBAS Laboratoire des Matériaux et Hydrologie Université de Sidi Bel Abbes département de Génie Civil Université Ibn Khaldoun département de Génie Civil Faculté de Génie Civil et d'Architecture Univesité de Chlef département de Physique Université de Sidi Bel Abbes

In this paper, a new displacement based high-order shear deformation theory is introduced for the static response of functionally graded sandwich plate. Unlike any other theory, the number of unknown functions involved is only four, as against five in case of other shear deformation theories. The theory presented is variationally consistent, has strong similarity with classical plate theory in many aspects, does not require shear correction factor, and gives rise to transverse shear stress variation such that the transverse shear stresses vary parabolically across the thickness satisfying shear stress free surface conditions. Two common types of functionally graded sandwich plates, namely, the sandwich with fimctionally graded facesheet and homogeneous core and the sandwich with homogeneous facesheet and functionally graded core, are considered. Governing equations are derived from the principle of virtual displacements. The closed-form solution of a simply supported rectangular plate subjected to sinu- soidal loading has been obtained by using the Navier method. The validity of the present theory is investigated by comparing some of the present results with those of the classical, the first-order and the other higher-order theories. It can be concluded that the proposed theory is accurate and simple in solving the static bending behavior of functionally graded sandwich plates.

关键词： functionally graded materials sandwich plates refined plate theory bending Navier solution

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