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Additive neurorestorative effects of exercise and docosahexaenoic acid intake in a mouse model of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 574-586页

作者： Olivier Kerdiles Méryl-Farelle Oye Mintsa Mi-mba Katherine Coulombe Cyntia Tremblay VincentÉmond Martine Saint-Pierre Clémence Rouxel Line Berthiaume Pierre Julien Francesca Cicchetti Frédéric Calon Facultéde pharmacie UniversitéLaval1050 Avenue de la MédecineQuebecQCCanada Axe Neuroscience Centre de recherche du CHU de Québec-UniversitéLaval(Pavillon CHUL)2705 Boulevard LaurierQuebecQCCanada Institute of Nutrition and Functional Foods QuebecQCCanada Optinutribrain International Associated Laboratory(NutriNeuro FranceINAFCanada)QuebecQCCanada Axe Endocrinologie et Néphrologie Centre de recherche du CHU de Québec-UniversitéLavalQuebecQCCanada département de Médecine Facultéde MédecineUniversitéLavalQuebecQCCanada département de Psychiatrie et Neurosciences Facultéde MédecineQuebecQCCanada

There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after *** that preclinical and clinical studies suggest benefits of dietary n-3 polyunsaturated fatty acids,such as docosahexaenoic acid,and exercise in Parkinson’s disease,we investigated whether both could synergistically interact to induce recovery of the dopaminergic ***,mice received a unilateral stereotactic injection of 6-hydroxydopamine into the striatum to establish an animal model of nigrostriatal *** weeks after lesion,animals were fed a docosahexaenoic acid-enriched or a control diet for the next 8 *** this period,the animals had access to a running wheel,which they could use or *** acid treatment,voluntary exercise,or the combination of both had no effect on(i)distance traveled in the open field test,(ii)the percentage of contraversive rotations in the apomorphine-induction test or(iii)the number of tyrosine-hydroxylase-positive cells in the substantia nigra pars ***,the docosahexaenoic acid diet increased the number of tyrosine-hydroxylase-positive terminals and induced a rise in dopamine concentrations in the lesioned *** to docosahexaenoic acid treatment or exercise alone,the combination of docosahexaenoic acid and exercise(i)improved forelimb balance in the stepping test,(ii)decreased the striatal dOPAC/dopamine ratio and(iii)led to increased dopamine transporter levels in the lesioned *** present results suggest that the combination of exercise and docosahexaenoic acid may act synergistically in the striatum of mice with a unilateral lesion of the dopaminergic system and provide support for clinical trials combining nutrition and physical exercise in the treatment of Parkinson’s disease.

关键词： 6-hydroxydopamine dopamine dopamine transporter exercise neurorestoration Parkinson’s disease polyunsaturated fatty acids omega-3

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Static Analysis of Functionally graded Sandwich Plates Using an Efficient and Simple Refined Theory

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Chinese Journal of Aeronautics 2011年第4期24卷 432-433页

作者： Hadj Henni ABdeLAZIZ Hassen Ait ATMANE Ismail MECHAB Lakhdar BOUMIA Abdelouahed TOUNSI Adda Bedia El ABBAS Laboratoire des Matériaux et Hydrologie Université de Sidi Bel Abbes département de génie Civil Université Ibn Khaldoun département de génie Civil Faculté de Génie Civil et d'Architecture Univesité de Chlef département de Physique Université de Sidi Bel Abbes

In this paper, a new displacement based high-order shear deformation theory is introduced for the static response of functionally graded sandwich plate. Unlike any other theory, the number of unknown functions involved is only four, as against five in case of other shear deformation theories. The theory presented is variationally consistent, has strong similarity with classical plate theory in many aspects, does not require shear correction factor, and gives rise to transverse shear stress variation such that the transverse shear stresses vary parabolically across the thickness satisfying shear stress free surface conditions. Two common types of functionally graded sandwich plates, namely, the sandwich with fimctionally graded facesheet and homogeneous core and the sandwich with homogeneous facesheet and functionally graded core, are considered. governing equations are derived from the principle of virtual displacements. The closed-form solution of a simply supported rectangular plate subjected to sinu- soidal loading has been obtained by using the Navier method. The validity of the present theory is investigated by comparing some of the present results with those of the classical, the first-order and the other higher-order theories. It can be concluded that the proposed theory is accurate and simple in solving the static bending behavior of functionally graded sandwich plates.

关键词： functionally graded materials sandwich plates refined plate theory bending Navier solution

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Phosphorus Use Efficiency of Bio-Based Fertilizers:Bioavailability and Fractionation

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Pedosphere 2016年第3期26卷 310-325页

作者： Céline VANEECKHAUTE Joery JANdA Peter A.VANROLLEgHEM Filip M.g.TACK Erik MEERS Laboratory for Analytical and Applied Ecochemistry Faculty of Bioscience EngineeringGhent University model EAU Département de Génie Civil et de Génie des EauxFaculté des Sciences et de GénieUniversité Laval

Although to date some technologies producing bio-based phosphorus(P) fertilizers have been proposed and implemented, the efficient use of the recovered products is still limited due to legislative constraints and lack of insights in the P release with time and in the corresponding mechanisms. The aim of this work was to evaluate the fertilizer performance in terms of P release and use efficiency of recovered struvite, FePO_4-sludge, digestate, and animal manure as compared to fossil reserve-based mineral triple superphosphate(TSP). First, product physicochemical characteristics and P fractions in the context of European fertilizer legislation were assessed. Next, a controlled greenhouse experiment was set up to evaluate plant reactions as well as changes of P availability in a sandy soil with high P status and a Rheinsand soil with low P status. Soil P fractions were determined in the extracts with water, ammonium lactate and CaCl_2, and in soil solution sampled with Rhizon soil moisture samplers. Based on all results, it is worth conducting long-term field trials to evaluate the P release effect of struvite and digestate as compared to animal manure and TSP on different soil types with varying P status. These products showed promise as sustainable substitutes for conventional P fertilizers and could contribute to a more efficient use of P in agriculture. A refined classification of P application standards/recommendations in terms of soil P status, soil texture, and fertilizer characteristics, next to the crop P demand, is recommended. Moreover, the additional use of Rhizon samplers for determination of direct available P, including dissolved organic P, is proposed for better understanding and categorization of different P fertilizers in environmental and fertilizer legislations.

关键词： chemical soil analysis digestate nutrient recovery Rhizon samplers struvite

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geochemistry of Pyrite from the gangcha gold deposit, West Qinling Orogen, China: Implications for Ore genesis

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Acta geologica Sinica(English Edition) 2017年第6期91卷 2164-2179页

作者： nie Xiao SHEN Junfeng LIU Haiming dU Baisong WANg Shuhao LI Jie XU Liwei WANg Ran School of Earth Sciences and Resources China University of Geosciences département de géologie et de génie géologique Université Laval Inner Mongolia Ninth geology Mineral Exploration and development Co. Ltd Jinyou geological Exploring Co. Ltd The gold of CAPF

The gangcha gold deposit was discovered in 2011 in the Xiahe-Hezuo region, West Qinling Orogen, China. Five types of pyrite have been identified in the ore according to the detailed mineral paragenetic studies. geochemical data are presented for type I pyrite （pyl） rim-core zonation and for the different types of pyrite based on in-situ laser ablation inductively coupled plasma mass spectrometry （LA-ICP-MS） and electron probe microanalysis （EPMA）. The results show that pyrites are characterized with heterogeneous Au concentrations, which indicate that Au occurs mainly as micro- or nano-particle native inclusions. Time-resolved depth profiles demonstrate that As, Co and Ni occur as solid solutions in pyrite, whereas Cu, Pb, Zn and Ag occur mainly as inclusions. Trace element concentrations differ between rims and cores in pyl, and the differences also exist within different pyrite types. These differences indicate complex chemical evolution of the ore-forming fluids, and the overall geology, geochronology, and stable isotope and pyrite data suggest that the ore-forming fluids were closely linked to magmatic activity during the Triassic Period in West Qinling orogenic belt.

关键词： pyrite geochemistry gangcha gold deposit West Qinling Qrogen

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degradation of direct azo dye by Cucurbita pepo free and immobilized peroxidase

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Journal of Environmental Sciences 2013年第6期25卷 1235-1244页

作者： Nabila Boucherit Mahmoud Abouseoud Lydia Adour Université Mouloud Mammeri Laboratoire de Biomatériaux et de Phénomènes deTransports Université Dr.Yahia Fares Laboratoire de Biomatériaux et de Phénomènes de Transports Université Dr.Yahia Fares Laboratoire de génie de la Réaction Faculté de Génie Mécanique et Génie des ProcédésUniversité Houari Boumediene Laboratoire des Biotechnologies Environnementales et génie des Procédés

Enzymatic decolourization of the azo dye, direct Yellow （dY 106） by Cucurbita pepo （courgette） peroxidase （CP） is a complex process, which is greatly affected by pH, temperature, enzyme activity and the concentrations of H202 and dye. Courgette peroxidase was extracted and its performance was evaluated by using the free-CP （FCP） and immobilized-CP （ICP） forms in the decolourization of dY106. Immobilization of peroxidase in calcium alginate beads was performed according to a strategy aiming to minimize enzyme leakage and keep its activity at a maximum value by optimizing sodium alginate content, enzyme loading and calcium chloride concentration. The initial conditions ~it which the highest dY106 decolourization yield was obtained were found at pH 2, temperature 20~C, H202 dose 1 mmol/L （FCP） and 100 mmol/L （ICP）. The highest decolourization rates were obtained for dye concentrations 50 mg/L （FCP） and 80 mg/L （ICP）. Under optimal conditions, the FCP was able to decolorize more than 87% of the dye within 2 min. While with ICP, the decolourization yield was 75% within 15 rain. The decolourization and removal of dY106 was proved by UV-Vis analysis. Fourier transform infrared （FF-IR） spectroscopy analysis was also performed on dY106 and enzymatic treatment precipitated byproduct.

关键词： Cucurbita pepo peroxidase immobilization decolourization azo dye

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Radiolarian and Planktic Foraminifera Biostratigraphy of the Early Albian Organic Rich Beds of Fahdene Formation,Northern Tunisia

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Journal of Earth Science 2014年第1期25卷 45-63页

作者： M Ben Fadhel T Zouaghi A Amri M Ben Youssef département de géologie Faculté des Sciences de Gafsa-Campus Universitaire Sidi Ahmed Zarrouk–2112 département des géoressources CERTE–Technopole de Borj Cédria

The lower part of Fahdene Formation outcropping in northeastern Tunisia is repre- sented by pelagic sequences and characterized by an important siliciclastic fraction that includes ra- diolarian and organic-rich beds of Allam Member. Litho-biostratigraphic analysis based on planktic foraminifera and radiolaria shows that deposition of organic-rich beds of Allam Member is confined to the Microhedbergella rischi Zone through the lower part of Ticinella primula Zone. Age diagnostic radiolaria recovered from these beds has been identified to constrain a direct age of black shale depo- sition. The assemblages can be correlated with the radiolarian biochronozone U.A.10-11 indicating an Early Albian to early Middle Albian in age. Radiolarian assemblages composed of species characteris- tic of U.A.10 biochronozone （A. montisserei, d. gracilis） are associated with radiolarian taxa belonging to Costata Zone （U.A.9 Pseudoeucyrtis hanni and Thanarla pseudodecora）, which can be correlated with dercourt Member in the Ionian Zone and Paquier level of the Vocontian Basin （southeast of France）. Biostratigraphic and abundance curves analysis has demonstrated significant diversification of cryptocephalic Nassellaria and Archaeodictyomitrae, probably adapted to eutrophic conditions that characterized the Aptian-Albian transition. Ecological conditions may have governed the stratigraphic range of many cosmopolitan taxa （i.e., Pseudodictyomitrae lodogaensis） compared with stratigraphic distributions schemes reported from other domains. The timing of black shales deposition was dia- chronic due to local geodynamic conditions and upwelling currents distribution. The Allam black shales are correlative with the oceanic anoxic event OAElb which is characterized by the widespread of supraregionnally organic-rich beds in the Mediterranean Tethys basins across the Aptian-Albian transition.

关键词： northeastern Tunisia Albian Allam Member black shale radiolaria planktic foraminifera.

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Chemical Availability of Cd, Pb and Zn in Anthropogenically Polluted Soil: Assessing the geochemical Reactivity and Oral Bioaccessibility

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Pedosphere 2017年第3期27卷 616-629页

作者： Christophe WATERLOT Francis dOUAY Aurélie PELFRENE Yncréa Hauts-de-France Laboratoire Génie Civil et géo Environnement (LGCgE)

The most recent in vitro tests used to determine metal bioaccessiblility are generally time-consuming and expensive. This study aimed at determining potential relationships between the concentrations of metals extracted using single-extraction methods and the concentrations of bioaccessible metals assessed by a harmonised in vitro test, the Unified BARgE Method （UBM）. A total number of 27 soil samples were collected from kitchen gardens and lawns with various physicochemical parameters and contamination levels. Significant relationships were obtained between Cd, Pb and Zn extracted in gastric and gastrointestinal phases and using single extractions. The best relationhips were established using acetic and citric acids for Cd, whereas for Pb, citric acid and ethylenedi- aminetetraacetic acid （EdTA） were identified as the best extractants. These relationships were improved by means of a linear multiple regression with a downward stepwise procedure involving agronomic parameters （soil cation exchange capacity and assimilated P）. This method highlighted the fact that the cation exchange capacity and P contents in soils were the two main parameters that controlled the human bioaccessibility of Cd, Pb and Zn in the gastric phase. Besides, the metal concentrations extracted with the acetic and citric acids correlated well with the metal concentrations in the gastric and gastrointestinal phases, suggesting that the bioaceessible metals were mainly in a soluble form, weakly bound to the organic matter and associated with the carbonates and the Fe and Mn oxides/hydroxides in soils.

关键词： gastric phase gastrointestinal phase linear multiple regression single extractant urban soil

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Improvement strategies for Ni-based alcohol steam reforming catalysts

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Journal of Energy Chemistry 2023年第11期86卷 447-479,I0010页

作者： Alex desgagnés Ommolbanin Alizadeh Sahraei Maria C.Iliuta UniversitéLaval Département de Génie Chimique1065 Avenue de la MédecineQuébecQC G1V 0A6Canada

Steam reforming(SR)of fossil methane is already a well-known,documented and established expertise in the industrial sector as it accounts for the vast majority of global hydrogen *** a sustainable development perspective,hydrogen production by SR of biomass-derived feedstock represents a promising alternative that could help to lower the carbon footprint of the traditional *** this regard,bio-alcohols such as methanol,ethanol or glycerol are among the attractive candidates that could serve as green hydrogen carriers as they decompose at relatively low temperatures in the presence of water compared to methane,allowing for improved H_(2)***,significant challenges remain regarding the activity and stability of nickel-based catalysts,which are most widely used in alcohol SR processes due to their affordability and ability to break C–C,O–H and C–H bonds,yet are prone to rapid deactivation primarily caused by coke deposition and metal particle *** this state-of-the-art review,a portfolio of strategies to improve the performance of Ni-based catalysts used in alcohol SR processes is unfolded with the intent of pinpointing the critical issues in catalyst *** examination of the literature reveals that the efforts tackling these recurring issues can be directed at the active metal,either by tuning Ni dispersion and Ni-support interactions or by targeting synergistic effects in bimetallic systems,while others focus on the support,either by modifying acid-base character,oxygen mobility,or by embedding Ni in specific crystallographic *** review provides a very useful tool to orient future work in catalyst development.

关键词： H2 production Alcohol steam reforming Ni-based catalysts Catalyst development Sintering Coke formation

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Electrical model parameters identification of radiofrequency discharge in argon through 1d3V/PIC-MC model

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Plasma Science and Technology 2018年第9期20卷 106-113页

作者： Mohamed MOSTAFAOUI djilali BENYOUCEF Laboratoire génie Electrique et Energies Renouvelables Université Hassiba Benbouali de Chlef

This work represents a contribution to the modeling of a radiofrequency（RF） discharge in argon at low pressure（from 25 to 200 mTorr）.It is started by the validation of the collision cross sections used in the particle model through a comparison between the transport coefficients calculated by these data and the measurements of the transport coefficients already exist in the literature,the particle model is also validated by a comparison between the calculated plasma density and that measured in the *** electrical model proposed in this work consists of replacing the RF discharge by a passive circuit（resistance in series with a capacitor）,where the resistance represents the plasma medium and the obstruction of the passage of the electronic current,and the capacitor represents the sheaths and the appearance of the displacement current in these *** parameters of the electrical model are obtained through particle *** electrical model presented accurately reproduces the current of the discharge,but without considering the phenomenon of *** total harmonic distortion rate follows the variation of the plasma density;its maximum value is 5.75% at 100 mTorr.

关键词： electrical model least square method particle model radiofrequency discharge static parameters identification

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AN AdAPTIVE VERSION OF gLIMM'S SCHEME

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Acta Mathematica Scientia 2010年第2期30卷 428-446页

作者： H.Kim M.Laforest d.Yoon department of Mathematics Korea University département de mathématiques et génie industriel cole Polytechnique de MontréalMontréalQuébec

This article describes a local error estimator for glimm＇s scheme for hyperbolic systems of conservation laws and uses it to replace the usual random choice in glimm＇s scheme by an optimal choice. As a by-product of the local error estimator, the procedure provides a global error estimator that is shown numerically to be a very accurate estimate of the error in L1 （R） for all times. Although there is partial mathematical evidence for the error estimator proposed, at this stage the error estimator must be considered ad- hoc. Nonetheless, the error estimator is simple to compute, relatively inexpensive, without adjustable parameters and at least as accurate as other existing error estimators. Numerical experiments in 1-d for Burgers＇ equation and for Euler＇s system are performed to measure the asymptotic accuracy of the resulting scheme and of the error estimator.

关键词： conservation laws finite difference methods adaptive error estimation aposteriori

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