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Acellular scaffold‑based approach for in situ genetic engineering of host T‑cells in solid tumor immunotherapy

Military Medical research 2025年第1期12卷 16-35页

作者： Hiren Y.dandia Mamatha M.Pillai deepak Sharma Meghna Suvarna Neha dalal Ayush Madhok Arvind Ingle Shubhada V.Chiplunkar Sanjeev Galande Prakriti Tayalia department of Biosciences and Bioengineering Indian Institute of Technology BombayPowaiMumbai 400076India Radiation Biology and Health Sciences division Bhabha Atomic Research CentreMumbai 400085India centre of Excellence in Epigenetics Department of BiologyIndian Institute of Science Education and ResearchPune 411008India Advanced centre for Treatment Research and Education in Cancer(ACTREC)Tata Memorial CentreKhargharMumbai 410210India

Background:Targeted T-cell therapy has emerged as a promising strategy for the treatment of hematological ***,its application to solid tumors presents significant challenges due to the limited accessibility and *** delivery of tumor-specific T-cells using biomaterials has shown promise,however,procedures required for genetic modification and generation of a sufficient number of tumor-specific T-cells ex vivo remain major obstacles due to cost and time ***:Polyethylene glycol(PEG)-based three-dimensional(3d)scaffolds were developed and conjugated with positively charged poly-L-lysine(PLL)using carbamide chemistry for efficient loading of lentiviruses(LVs)carrying tumor antigen-specific T-cell receptors(TCRs).The physical and biological properties of the scaffold were extensively ***,the scaffold loaded with OVA-TCR LVs was implanted in B16F10 cells expressing ovalbumin(B16-OVA)tumor model to evaluate the anti-tumor response and the presence of transduced ***:Our findings demonstrate that the scaffolds do not induce any systemic inflammation upon subcutaneous implantation and effectively recruit T-cells to the *** B16-OVA melanoma tumor-bearing mice,the scaffolds efficiently transduce host T-cells with OVA-specific *** genetically modified T-cells exhibit homing capability towards the tumor and secondary lymphoid organs,resulting in a significant reduction of tumor size and systemic increase in anti-tumor *** cell profiling revealed a significantly high percentage of transduced T-cells and a notable reduction in suppressor immune cells within the tumors of mice implanted with these ***:Our scaffold-based T-cell therapy presents an innovative in situ localized approach for programming T-cells to target solid *** approach offers a viable alternative to in vitro manipulation of T-cells,circumventing the need for large-scale in vitro generat

关键词： Polyethylene glycol diacrylate Poly-L-lysine Lentiviruses T-cell therapy B16F10-OVA melanoma

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Innovative dispersion techniques of graphene nanoplatelets(GNPs)through mechanical stirring and ultrasonication:Impact on morphological,mechanical,and thermal properties of epoxy nanocomposites

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defence Technology(防务技术) 2025年第1期43卷 13-25页

作者： Vasi Uddin Siddiqui S.M.Sapuan Mohd Roshdi Hassan Advanced Engineering materials and Composites research centre(AEMC) Department of Mechanical and Manufacturing EngineeringUniversiti Putra MalaysiaUPM SerdangSelangor 43400Malaysia department of Mechanical and Manufacturing Engineering Universiti Putra MalaysiaUPM SerdangSelangor 43400Malaysia

graphene nanoplatelets(GNPs)have attracted tremendous interest due to their unique properties and bonding *** study focuses on the effect of GNP dispersion on the mechanical,thermal,and morphological behavior of GNP/epoxy *** study aims to understand how the dispersion of GNPs affects the properties of epoxy nanocomposite and to identify the best dispersion approach for improving mechanical performance.A solvent mixing technique that includes mechanical stirring and ultrasonication was used for producing the *** transform infrared spectroscopy was used to investigate the interaction between GNPs and the epoxy *** measurements of density and moisture content were used to confirm that GNPs were successfully incorporated into the *** findings showed that GNPs are successfully dispersed in the epoxy matrix by combining mechanical stirring and ultrasonication in a single step,producing well-dispersed nanocomposites with improved mechanical ***,the nanocomposites at a low GNP loading of 0.1 wt%,demonstrate superior mechanical strength,as shown by increased tensile properties,including improved Young's modulus(1.86 GPa),strength(57.31 MPa),and elongation at break(4.98).The nanocomposite with 0.25 wt%GNP loading performs better,according to the viscoelastic analysis and flexural properties(113.18 MPa).Except for the nanocomposite with a 0.5 wt%GNP loading,which has a higher thermal breakdown temperature,the thermal characteristics do not significantly *** effective dispersion of GNPs in the epoxy matrix and low agglomeration is confirmed by the morphological *** findings help with filler selection and identifying the best dispersion approach,which improves mechanical *** effective integration of GNPs and their interaction with the epoxy matrix provides the doorway for additional investigation and the development of sophisticated *** fiel

关键词： graphene nanoplatelets Epoxy Nanocomposites Mechanical properties Thermal properties Mechanical stirrer Sonication

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A Greener Future: Carbon Nanomaterials from Lignocellulose

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Journal of Renewable materials 2025年第1期13卷 21-47页

作者： Hebat-Allah S.Tohamy Mohamed El-Sakhawy Samir Kamel Cellulose and Paper department National Research CentreDokkiGiza12622Egypt

Lignocellulosic materials(LCMs),abundant biomass residues,pose signiﬁcant environmental challenges when improperly disposed ***,such as sugarcane bagasse,rice straw,saw dust and agricultural residues,are abun-dant but often burned,contributing to air pollution and greenhouse gas *** review explores the potential of transforming these materials into high-value carbon nanomaterials(CNMs).We explore the potential of transforming these materials into high-value *** employing techniques like carbonization and activa-tion,LCMs can be converted into various CNMs,including carbon nanotubes(CNTs),graphene(G),graphene oxide(GO),carbon quantum dots(CQds),nanodiamonds(Nds),fullerenes(F),carbon nanoﬁbers(CNFs),and *** different carbon allotropes further enhances their *** derived from cellulose,lignin,and hemicellulose exhibit promising applications in diverseﬁ*** instance,CNTs can be used in energy storage devices like batteries and supercapacitors due to their exceptional electrical conductivity and mechanical ***,CNTs can be incorporated into recycled paper as aﬁre retardant additive,enhancing itsﬂame resistance.G,renowned for its high surface area and excellent electrical conductivity,ﬁnds applications in electronics,sensors,catalysis,and water treatment,where it can be used to adsorb heavy metal ***,owing to their unique optical properties,are used in bioimaging,drug delivery,and optoelectronic *** harnessing the potential of LCMs,we can not only mitigate environmental concerns but also contri-bute to a sustainable *** research is essential to optimize synthesis methods,explore novel applica-tions,and unlock the full potential of these versatile materials.

关键词： Lignocellulosic materials carbon-based nanomaterials carbon allotropes

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Constructing 2d bismuth-based heterostructure for highly efficient photocatalytic CO2 reduction

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Tungsten 2025年第1期7卷 71-79页

作者： Ruo-Hang Xu Hao-Yu Jiang dan-dan Cui Kun-Rong du Hong-Run Zhang Sheng-Jie Xu Ya-Qi Li Zhi-Zhen Ren Liang Wang Wei-Chang Hao Yi du School of Physics and BUAA-UOW Joint research centre Beihang University Shenzhen Institute of Beihang University centre for Catalysis and Clean Energy School of Environment and Science Griffith University

Reforming carbon dioxide（CO2） into fuels and valuable chemicals using solar energy holds significant potential for emission reduction and addressing energy supply *** recombination of photocarriers remains a major obstacle,however,to enhancing solar energy conversion efficiency in the photocatalytic reaction *** two-dimensional materials,constructing heterogeneous structures has emerged as an effective strategy to enhance the separation of photoexcited carriers by leveraging the internal electric field at the heterogeneous ***,we present a facile strategy for preparing Bi4NbO8Br/Bi2WO6plate-on-plate Z-scheme junctions with a strong internal electric field by in situ *** unique heterostructure facilitates efficient separation and transport of photoexcited charges by harnessing the internal electric field induced by chemical bonding at the lateral ***,the Bi4NbO8Br/Bi2WO6heterostructure exhibits enhanced CO2photoreduction properties,along with a CO yield rate of approximately 35 μmol·g-1·h-1under full light *** work offers novel insights into the synthesis of unique hetero structures intended to enhance the efficiency of photocatalytic CO2reduction.

关键词： Bi4NbO8Br/Bi2WO6 CO2 reduction Heterostructures Photocatalysts

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Printing perovskite and graphene parallel structure-based optical-mechanical sensors for human-machine interaction

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Science China(Technological Sciences) 2025年第2期68卷 65-72页

作者： Sisi CHEN Jiemin ZHANG Nan CHENG Wenbo LI Jing LIU Hongfei XIE Jie ZHANG Yueying CHENG Xiaotong ZHAO Meng SU Yanlin SONG Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of Sciences(ICCAS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China Weiyang College Tsinghua UniversityBeijing 100084China department of Cardiovascular Surgery First Medical CenterPLA General HospitalBeijing 100853China AECC Beijing Institute of Aeronautical materials Beijing 100095China Beijing Institute of graphene Technology Beijing 100094China Beijing Engineering research centre of graphene Application Beijing 100095China School of Integrated Circuit&Beijing National research Center for Information Science and Technology(BNRist) Tsinghua UniversityBeijing 100084China

Surgical robots are designed to provide enhanced precision and dexterity compared to manual surgical procedures,which mainly rely on multimodal sensing technologies for the surgeon to seamlessly operate the robotic arms and *** with single-mode sensors,optical and mechanical bi-modal sensors provide improved precision,enhanced safety,and robustness of human-machine interaction ***,the template-guided and pneumatic printing technologies are combined to construct perovskite and graphene parallel structures with both optical and mechanical sensing *** printed uniformly crystallized perovskite microstructure exhibits fast and sensitive photoelectric response characteristics,enabling shadow recognition *** combination of graphene and elastic rubber endows the great printability to prepare parallel structures near the perovskite arrays for force sensing ***,the printed perovskite and graphene structures possess non-contact optical sensing capabilities to detect hand position by recognizing shadows between the hand and the sensor,as well as contact mechanical sensing capabilities to detect touch force applied by the *** provides a synergistic platform for real-time and multidimensional feedback to improve human-machine interaction.

关键词： printing perovskite graphene optical and mechanical sensors human-machine interaction

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Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration research 2025年第2期20卷 598-608页

作者： daniella da Silva Madeleen Jansen van Rensburg Anine Crous Heidi Abrahamse Laser research centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

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Scalable preparation of asymmetrical bilayer sulfide/halide electrolyte membranes for all-solid-state batteries with high voltage

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Science China Technological Sciences 2025年第3期68卷 101-113页

作者： Shenghao JING Yanchen LIU Yang LU Hanzhou LIU Yang LIU Siliang LIU Zongliang ZHANG Fangyang LIU School of Metallurgy and Environment Central South University Engineering research centre of Advanced Battery materials Ministry of Education Hunan Provincial Key Laboratory of Nonferrous Value-added Metallurgy Hunan Energy Frontiers New materials Technology Co. Ltd. National Energy Metal Resources and New materials Key Laboratory

All-solid-state batteries （ASSBs） are considered to be the most promising candidates for improving battery safety and energy *** electrolytes have a narrow electrochemical window,which hinders their applications coupled with high-voltage *** electrolytes with high-voltage endurance can help solve this ***,the combination of spraying and slurry-coating methods was adopted as a practical route to process a free-standing Li6PS5Cl （LPSCl） asymmetrical electrolyte membrane （19.23Ωcm2,75μm） decorated with a 10μm Li3In Cl6（LICl） *** LICl-LPSCl asymmetrical electrolyte membranes enhanced the high-voltage stabilities to match those of LiNi0.83Co0.11Mn0.06O2（NCM811） and Li1.2Ni0.13Co0.13Mn0.54O2（LRMO） *** NCM811|LICl-LPSCl|n Si ASSB achieved an initial coulombic efficiency（ICE） of 85.13%and a capacity retention of 77.16%after 200 *** with the LPSCl membrane,the LICl-LPSCl membrane displayed high stability with the LRMO cathode as the charging cut-off voltage increased to 4.7 V,which improved the initial charge capacity from 143 to 270 mAh g-1and achieved stable cycling of 160 m Ah g-1at 0.5 ***,we attempted continuous LICl-LPSCl membrane production and utilized the product to fabricate a pouch-type ASSB based on *** fabrication of the LICl-LPSCl electrolyte membrane demonstrated its potential for controllable and industryadaptable applications in ASSBs.

关键词： all-solid-state batteries halide electrolyte sulfide electrolyte high-voltage asymmetrical

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Enhanced engineering and biocidal polypropylene filaments enabling melt reduction of AgNO_(3) through PVP agent:A scalable process for the defense industry with MEX additive manufacturing

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defence Technology(防务技术) 2025年第2期44卷 52-66页

作者： Markos Petousis Nikolaos Michailidis Vassilis Papadakis Apostolos Argyros Mariza Spiridaki Nikolaos Mountakis John Valsamos Nektarios K.Nasikas Amalia Moutsopoulou Nectarios Vidakis department of Mechanical Engineering Hellenic Mediterranean UniversityHeraklion 71410Greece Physical Metallurgy Laboratory Mechanical Engineering DepartmentSchool of EngineeringAristotle University of ThessalonikiThessaloniki 54124Greece centre for research&development of Advanced materials(CERdAM) Centre for Interdisciplinary Research and InnovationBalkan CentreBuilding B’10th Km Thessaloniki-Thermi RoadThessaloniki 57001Greece Institute of Electronic Structure and Laser of the Foundation for research and Technology-Hellas(IESL-FORTH)e Hellas N.Plastira 100mHeraklion 70013Greece department of Industrial design and Production Engineering University of West AtticaAthens 12243Greece division of Mathematics and Engineering Sciences Department of Military SciencesHellenic Army AcademyGR 16673VariAtticaGreece

This study focused on the production of polypropylene(PP)/silver(Ag)composites via additive *** study aimed to enhance the quality of medical-grade PP in material extrusion(MEX)three-dimensional printing(3dP)by improving its mechanical properties while simultaneously adding antibacterial *** latter can find extremely important and versatile properties that are applicable in defense and security ***/Ag nanocomposites were prepared using a novel method based on a reaction occurring while mixing appropriate quantities of the starting polymers and additives,namely polyvinylpyrrolidone(PVP)as the matrix material and silver nitrate(AgNO_(3))as the *** process produced three-dimensional(3d)printed filaments,which were then used to create specimens for a series of standardized *** was found that the mechanical properties of the nanocomposites were enhanced in relation to pristine PP,especially for the PP matrix with various loadings of AgNO_(3)and PVP,such as 5.0 wt%and 2.5 wt%,*** voids,inclusions,and actual-to-nominal dimensions also showed improved *** 3dP specimens exhibited a more effective biocidal performance against Staphylococcus aureus than Escherichia coli,which developed an inhibition zone only in the case of PP with filler loading percentages of AgNO_(3)and PVP at 10.0 wt%and 5.0 wt%,respectively Compounds possessing such properties can be beneficial for various applications requiring increased mechanical properties and biocidal capabilities,such as in the defence or medical industries.

关键词： Polypropylene(PP) Polyvinyl pyrrolidone(PVP) Silver nitride(AgNO_(3)) In-situ reactive melt mixing process Material extrusion(MEX)3d printing Biocidal performance

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CoPSe nanoparticles confined in nitrogen-doped dual carbon network towards high-performance lithium/potassium ion batteries

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Chinese Chemical Letters 2025年第1期36卷 568-573页

作者： Zhong-Hui Sun Yu-Qi Zhang Zhen-Yi Gu dong-Yang Qu Hong-Yu Guan Xing-Long Wu Guangdong Engineering Technology research Center for Photoelectric Sensing materials and devices c/o School of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhou 510006China MOE Key Laboratory for UV Light-Emitting materials and Technology Northeast Normal UniversityChangchun 130024China

The metal ion batteries have gained widespread attention for wearable electronics due to their competitive energy density and long cycling *** the advanced anode materials is significant for next generation energy storage ***,severe electrode volume changes and sluggish redox kinetics are the critical problems for lithium/potassium ion batteries(LIBs/PIBs)towards large-scale ***,we prepare a novel anode material,which consists of reduced graphene oxide wrapping one-dimensional(1d)N-doped porous carbon nanotube with cobalt phosphoselenide(CoPSe)nanoparticles embedded inside them(r GO@Co PSe/NC).Benefited from the dual carbon decorations and ultrafine nanoparticles structure,it achieves a reversible capacity of 245 mAh/g at 5 A/g after 2000 cycles for LIBs and 215 mAh/g at 1 A/g after 500 cycles for *** pseudocapacitance and GITT measurements are used to investigate the electrochemical kinetics of r GO@Co PSe/NC for *** addition,the lithium ion full cell also shows good electrochemical performance when paired with high capacity LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) *** work provides a feasible electrode design strategy for high-efficiency metal ion batteries based on multidimensional nanoarchitecture engineering and composition tailoring.

关键词： Cobalt phosphoselenide Lithium-ion batteries Potassium-ion batteries Reduced graphene oxide Structural stability Full cell

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Is dark energy necessary for the sustainability of traversable wormholes?

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Chinese Physics C 2025年第1期49卷 290-304页

作者： Ayan Banerjee Sudan Hansraj Anirudh Pradhan Abdelghani Errehymy Astrophysics research centre School of MathematicsStatistics and Computer ScienceUniversity of KwaZulu-NatalPrivate Bag X54001Durban 4000South Africa Atrophysics research centre School of MathematicsStatistics and Computer ScienceUniversity of KwaZulu-NatalPrivate Bag X54001Durban 4000South Africa centre for Cosmology Astrophysics and Space ScienceGLA UniversityMathura-281406Uttar PradeshIndia

dark energy is typically the principal component needed for the traversability of wormholes(WH),as it provides the negative gravity effect required to keep the throat ***,can this be achieved without dark energy?It turns out that if we couple the trace of energy-momentum with the standard Einstein-Hilbert Lagrangian and utilize a specific equation of state(EoS),dark energy may be *** Casimir stress energy is known to result in the violation of the null energy condition(NEC)on the energy momentum *** phenomenon makes such an EoS an ideal candidate for generating traversable WH *** laboratory proven phenomenon provides a natural mechanism to sustain an open WH throat without relying on dark ***,we generate two classes of WH solutions using this in energy-momentum trace-coupling *** the specific choice of the Casimir EoS relating the energy-momentum tensor components[Kar and Sahdev:***.d 52,2030(1995)]and different choices of redshift functions,we determine the WH geometry *** obtained WH solutions violate the NECs,and all qualitative constraints demanded for physically realizable WHs are *** is demonstrated via graphical plots for a suitably chosen range of coupling parameter ***,our study investigates the repulsive effect of gravity,revealing that its presence leads to a negative deflection angle for photons traveling along null ***,we observe a consistent pattern of negative values for the deflection angle across all values of in the three scenarios considered,thus indicating the clear manifestation of the repulsive gravity *** of this is possible without invoking the existence of dark energy.

关键词： wormholes traversability casimir f(R,T)gravity deflection angle

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